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Is there any association between migraine headache and polycystic ovary syndrome (PCOS)? A review article

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Abstract

Background

Polycystic ovary syndrome (PCOS) and migraine headaches are considered to be common health problems that may share some risk factors. This study aimed to discuss the possible association between migraine headache and polycystic ovary syndrome.

Methods and results

In this narrative review, PubMed, Scopus, Web of Science, and Google Scholar were systematically searched for retrieving and summarizing published studies up to January 2021 to explore the possible interplay between migraine headache and PCOS. We discuss the possible pathways that may explain the association between migraine headaches and PCOS signs/symptoms and complications. While genetic factors have profound effects on the pathogenesis of migraine headaches, sex hormones, including estrogen and progesterone may also play an important role in inducing migraine headaches. Some disorders, such as sleep apnea, amenorrhea, and vascular disease that are more likely to occur in women with PCOS, may cause or exacerbate migraine headaches in women with PCOS.

Conclusions

Future comprehensive studies are needed to investigate the exact underlining mechanisms related to the association between PCOS and migraine headaches.

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Data availability

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Funding

The study has been supported and funded by the Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Authors and Affiliations

  1. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Nahid Sarahian, Mahsa Noroozzadeh, Marzieh Saei Ghare Naz, Fatemeh Mahboobifard & Fahimeh Ramezani Tehrani

  2. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Nahid Sarahian

  3. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Narges Eskandari-Roozbahani

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  1. Nahid Sarahian
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  2. Mahsa Noroozzadeh
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Contributions

SN: concepts, design, definition of intellectual content, research studies, manuscript preparation, manuscript editing, manuscript review, data acquisition; FRT: concepts, design, definition of intellectual content, research studies, manuscript preparation, manuscript editing, manuscript review, data acquisition, guarantor; ERN: literature search, manuscript preparation, manuscript editing, manuscript review; MN: literature search, data acquisition, manuscript preparation, manuscript review, FM: manuscript editing, manuscript review, data acquisition, manuscript review; MSG: manuscript editing, manuscript review, data acquisition, manuscript review.

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Correspondence to Fahimeh Ramezani Tehrani.

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Unethical issues (including plagiarism, informed consent, misconduct, data fabrication, and/or forgery, duplication and/or submission, redundancy, etc.) have been investigated by the authors. Procedures adopted in this study have been approved by the local ethics committee and are according to the Declaration of Helsinki principles. This study was approved by the Ethics Committee of the Research Institute of Endocrine Sciences Shahid Beheshti University of Medical Sciences.

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Sarahian, N., Noroozzadeh, M., Saei Ghare Naz, M. et al. Is there any association between migraine headache and polycystic ovary syndrome (PCOS)? A review article. Mol Biol Rep 49, 595–603 (2022). https://doi.org/10.1007/s11033-021-06799-8

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