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The prevalence and odds of bipolar disorder in women with polycystic ovary syndrome (PCO) disease: a systematic review and meta-analysis

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Abstract

Background

Women with polycystic ovary syndrome (PCO) suffer from psychological difficulties like bipolar disorder.

Various studies in the literature report several prevalence rates of bipolar disorder in women with PCO, while there is no systematic review in this field. So, we designed this systematic review and meta-analysis to estimate the pooled prevalence and odds of bipolar disorder in women with PCO disease.

Method

PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and references of the references, conference abstracts were comprehensively searched by two independent researchers. The search was done on May 1st, 2023.

Results

A literature search revealed 438 records, 35 full texts were evaluated, and finally, 11 studies remained for systematic review. Totally, 73,102 women with PCO and 340,724 controls were evaluated. Among cases, 1471 had bipolar diagnosis vs. 4321 controls. The prevalence of bipolar disorder in women with PCO ranged between 0 and 27%, and the pooled prevalence was estimated as 4% (95% CI, 2–5%; I2, 99.3%, p < 0.001). The odds of bipolar disorder in women with PCO ranged between 0.98 and 8.78, and the pooled estimate was 2.06 (95% CI, 1.61–2.63) (I2, 85.6%; p < 0.001).

Conclusions

This systematic review and meta-analysis show that the pooled prevalence of bipolar disorder in women with PCO is 4%, and women with PCO are at a 2-fold higher risk of bipolar disorder.

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Authors and Affiliations

  1. Zabol Medical Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran

    Zahra Shahraki

  2. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Mohsen Rastkar

  3. Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran

    Mohammad-Reza Ramezanpour

  4. Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran

    Mahsa Ghajarzadeh

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  1. Zahra Shahraki
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  2. Mohsen Rastkar
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  3. Mohammad-Reza Ramezanpour
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  4. Mahsa Ghajarzadeh
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Correspondence to Mahsa Ghajarzadeh.

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Shahraki, Z., Rastkar, M., Ramezanpour, MR. et al. The prevalence and odds of bipolar disorder in women with polycystic ovary syndrome (PCO) disease: a systematic review and meta-analysis. Arch Womens Ment Health (2024). https://doi.org/10.1007/s00737-024-01420-w

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  • DOI: https://doi.org/10.1007/s00737-024-01420-w

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