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Roles of extracellular vesicles on macrophages in inflammatory bone diseases

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Abstract

Inflammatory bone disease is a general term for a series of diseases caused by chronic inflammation, which leads to the destruction of bone homeostasis, that is, the osteolytic activity of osteoclasts increases, and the osteogenic activity of osteoblasts decreases, leading to osteolysis. Macrophages are innate immune cell with plasticity, and their polarization is related to inflammatory bone diseases. The dynamic balance of macrophages between the M1 phenotype and the M2 phenotype affects the occurrence and development of diseases. In recent years, an increasing number of studies have shown that extracellular vesicles existing in the extracellular environment can act on macrophages, affecting the progress of inflammatory diseases. This process is realized by influencing the physiological activity or functional activity of macrophages, inducing macrophages to secrete cytokines, and playing an anti-inflammatory or pro-inflammatory role. In addition, by modifying and editing extracellular vesicles, the potential of targeting macrophages can be used to provide new ideas for developing new drug carriers for inflammatory bone diseases.

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Funding

This study was supported by grants from Guangdong Science and Technology Department grant number2021A0505030079; the Key Project of Science and Technology of Liwan District, Guangzhou City (No. 2201006).

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  1. Guangzhou Medical University, Guangzhou, Guangdong, China

    Yifan Lin, Ziyan Wang, Shirong Liu, Jiaohong Liu, Zhiyi Zhang, Yuanting Ouyang, Zhikang Su, Ding Chen, Lvhua Guo & Tao Luo

  2. Department of Prosthodontics, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

    Yifan Lin, Ziyan Wang, Shirong Liu, Jiaohong Liu, Zhiyi Zhang, Yuanting Ouyang, Zhikang Su, Ding Chen, Lvhua Guo & Tao Luo

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  1. Yifan Lin
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YL has made substantial contributions to conception, design, draft, and revise the manuscript. ZW and SL were involved in drafting the manuscript and revising it critically for important intellectual content. JL, ZZ, YO, ZS, and DC gave final approval of the version to be published. LG and TL agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors read and approved the final manuscript.

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Lin, Y., Wang, Z., Liu, S. et al. Roles of extracellular vesicles on macrophages in inflammatory bone diseases. Mol Cell Biochem (2023). https://doi.org/10.1007/s11010-023-04809-w

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