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Circulating extracellular vesicles and rheumatoid arthritis: a proteomic analysis

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Abstract

Circulating extracellular vesicles (EVs) are membrane-bound nanoparticles secreted by most cells for intracellular communication and transportation of biomolecules. EVs carry proteins, lipids, nucleic acids, and receptors that are involved in human physiology and pathology. EV cargo is variable and highly related to the type and state of the cellular origin. Three subtypes of EVs have been identified: exosomes, microvesicles, and apoptotic bodies. Exosomes are the smallest and the most well-studied class of EVs that regulate different biological processes and participate in several diseases, such as cancers and autoimmune diseases. Proteomic analysis of exosomes succeeded in profiling numerous types of proteins involved in disease development and prognosis. In rheumatoid arthritis (RA), exosomes revealed a potential function in joint inflammation. These EVs possess a unique function, as they can transfer specific autoantigens and mediators between distant cells. Current proteomic data demonstrated that exosomes could provide beneficial effects against autoimmunity and exert an immunosuppressive action, particularly in RA. Based on these observations, effective therapeutic strategies have been developed for arthritis and other inflammatory disorders.

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Acknowledgements

This report is apart from the Ph.D. thesis of M. Alghamdi.

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Authors and Affiliations

  1. Biological Sciences Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia

    Mohammed Alghamdi, Vladimir N. Uversky & Elrashdy M. Redwan

  2. Laboratory Department, University Medical Services Center, King Abdulaziz University, P.O. Box 80200, Jeddah, 21589, Saudi Arabia

    Mohammed Alghamdi

  3. Immunology Diagnostic Laboratory Department, King Abdulaziz University Hospital, P.O Box 80215, Jeddah, 21589, Saudi Arabia

    Sultan Abdulmughni Alamry

  4. Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah, 21589, Saudi Arabia

    Sami M. Bahlas

  5. Department of Molecular Medicine and USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

    Vladimir N. Uversky

  6. Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications, New Borg EL-Arab, 21934, Alexandria, Egypt

    Elrashdy M. Redwan

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  1. Mohammed Alghamdi
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  2. Sultan Abdulmughni Alamry
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  3. Sami M. Bahlas
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  4. Vladimir N. Uversky
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  5. Elrashdy M. Redwan
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Contributions

Conceived the idea, edited and revised the manuscript, and managed the project: EMR; wrote the primary manuscript and edited it: MA; SB and SA participated in the collection of literature data, data curation, formal analysis, and evaluation. VNU participated in manuscript writing, editing, and revision.

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Correspondence to Elrashdy M. Redwan.

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Alghamdi, M., Alamry, S.A., Bahlas, S.M. et al. Circulating extracellular vesicles and rheumatoid arthritis: a proteomic analysis. Cell. Mol. Life Sci. 79, 25 (2022). https://doi.org/10.1007/s00018-021-04020-4

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  • DOI: https://doi.org/10.1007/s00018-021-04020-4

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