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Characterization of muoniated spin probes in cholesterol by avoided level crossing muon spin resonance

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Abstract

Avoided level crossing muon spin resonance (ALC-μ SR) has been used to characterize muoniated radicals formed by the reaction of muonium (Mu) with cholesterol in the solid state and in solution. Mu adds to the secondary carbon of the C=C bond and the observed radical has Mu in the 6β position. The isotropic hyperfine coupling constant (Aμ) and dipolar muon hyperfine coupling constant (\(\boldsymbol {D}_{\boldsymbol {\mu }}^{\parallel }\)) were determined in solid cholesterol between 318 and 398 K from the position and shape of the Δ1 resonance. Aμ and \(\boldsymbol {D}_{\boldsymbol {\mu }}^{\parallel }\) decrease with increasing temperature; the former due to intramolecular motion and the latter due to both intramolecular motion and wobbling of the molecule. A Δ0 resonance due to the proton in the 4β position was observed in the ALC-μ SR spectra of dilute solutions of cholesterol in tetrahydrofuran and methanol. The position of the Δ0 resonance is sensitive to the polarity of the solvent and its width depends on the viscosity of the solution.

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Acknowledgments

ALC-μ SR measurements were performed under experiment M1628 at the Centre for Molecular and Material Science at TRIUMF. The CMMS staff are thanked for their assistance in running these experiments.

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Authors and Affiliations

  1. Centre for Molecular and Material Science, TRIUMF, 4004 Wesbrook Mall, Vancouver, V6T 2A3, BC, Canada

    Iain McKenzie & Danaan Cordoni-Jordan

  2. Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, V5A 1S6, BC, Canada

    Iain McKenzie

  3. Department of Physics and Astronomy, University of Waterloo, 200 University Avenue West, Waterloo, N2L 3G1, ON, Canada

    Iain McKenzie

  4. School of Physics and Astronomy, Cardiff University, The Parade, Cardiff, CF24 3AA, Wales, UK

    Joseph Cannon

  5. Department of Physics, Simon Fraser University, 8888 University Drive, Burnaby, V5A 1S6, BC, Canada

    Danaan Cordoni-Jordan

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  1. Iain McKenzie
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  2. Joseph Cannon
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  3. Danaan Cordoni-Jordan
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Correspondence to Iain McKenzie.

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We acknowledge the support of the Natural Sciences and Engineering Research Council of Canada (NSERC), [RGPIN-2019-04249]. This research was enabled in part by support provided by WestGrid (www.westgrid.ca) and Compute Canada (www.computecanada.ca). The authors have no conflicts to disclose. Raw data were generated at the TRIUMF μ SR facility. Derived data supporting the findings of this study are available from the corresponding author upon reasonable request. IM, JC and DCJ performed the ALC-μ SR measurements. IM and JC analyzed the ALC-μ SR spectra. IM performed the DFT calculations and wrote the paper.

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This article is part of the Topical Collection on Proceedings of the International Conference on Hyperfine Interactions (HYPERFINE 2021), 5-10 September 2021, Brasov, Romania

Edited by Ovidiu Crisan

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McKenzie, I., Cannon, J. & Cordoni-Jordan, D. Characterization of muoniated spin probes in cholesterol by avoided level crossing muon spin resonance. Hyperfine Interact 242, 13 (2021). https://doi.org/10.1007/s10751-021-01740-8

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  • DOI: https://doi.org/10.1007/s10751-021-01740-8

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