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Isoprenylated Flavones from the Twigs of Artocarpus chama and Their Anti-Viral Activities

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Chemistry of Natural Compounds Aims and scope

A new isoprenylated flavone, 8,4′-dimethoxy-6-(4′′-methylfuran-2-yl)-flavone (1), together with five known isoprenylated flavones (2–6) were isolated from the twigs of Artocarpus chama. Interestingly, compound 1 is a rare flavone bearing an unusual 4-methylfuran-2-yl moiety. The anti-tobacco mosaic virus (anti-TMV) activities assay revealed that compound 1 showed obvious anti-TMV activity with an inhibition rate of 40.2% ± 2.8, and this rate is obviously higher than that of the positive control (with an inhibition rate of 35.1 ± 2.6). Compounds 2–6 also showed potential anti-TMV activities with inhibition rates in the range of 23.5–30.2%, respectively. In addition, to evaluate whether the isoprenylated flavones have more broad antiviral activity, compounds 1–6 were also tested for their anti-rotavirus activities. The results revealed that compounds 1–6 exhibited potential anti-rotavirus activities with therapeutic index (TI) values in the range of 13.0–19.9. These values are lower than that of positive control (with TI valve of 22.7).

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Acknowledgment

This project was supported financially by the National Natural Science Foundation of China (No. 32260111), the Yunnan Applied Basic Research Projects for Excellent Young Scholars (No. 202001AW079992), and the Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Resources, State Ethnic Affairs Commission, Yunnan Minzu University, 650031, Kunming, P. R. China

    Sui Yao, Gui Pu, Rui-Feng Xiong, Yue-Yu Ma, Yin-Ke Li, Zhou Min, Wei-Guang Wang & Qiu-Fen Hu

  2. Yunnan Key Laboratory of Tobacco Chemistry, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Sui Yao, Yi-Qin Wu, Xiao-Wei Ma, Wen Xiong & Yong Li

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  1. Sui Yao
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  2. Yi-Qin Wu
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  4. Rui-Feng Xiong
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  9. Zhou Min
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Corresponding authors

Correspondence to Qiu-Fen Hu or Yong Li.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2023, pp. 911–914.

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Yao, S., Wu, YQ., Pu, G. et al. Isoprenylated Flavones from the Twigs of Artocarpus chama and Their Anti-Viral Activities. Chem Nat Compd 59, 1079–1083 (2023). https://doi.org/10.1007/s10600-023-04200-7

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  • DOI: https://doi.org/10.1007/s10600-023-04200-7

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