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Associations amongst genes, molecules, cells, and organs in breast cancer metastasis

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Abstract

This paper is a cross fertilization of ideas about the importance of molecular aspects of breast cancer metastasis by basic scientists, a pathologist, and clinical oncologists at the Henry Ford Health symposium. We address four major topics: (i) the complex roles of lymphatic endothelial cells and the molecules that stimulate them to enhance lymph node and systemic metastasis and influence the anti-tumor immunity that might inhibit metastasis; (ii) the interaction of molecules and cells when breast cancer spreads to bone, and how bone metastases may themselves spread to internal viscera; (iii) how molecular expression and morphologic subtypes of breast cancer assist clinicians in determining which patients to treat with more or less aggressive therapies; (iv) how the outcomes of patients with oligometastases in breast cancer are different from those with multiple metastases and how that could justify the aggressive treatment of these patients with the hope of cure.

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Funding

SDN supported by the Nathanson/Rands Breast Cancer Research Chair, Detroit, MI. LD supported by a Heisenberg Fellowship (DI 2861/1–1) awarded by Deutsche Forschungsgemeinschaft (DFG). L.P receives funding from the Breast Cancer Research Foundation (BCRF-22-133) and is a Susan G. Komen Scholar funded through a Leadership Award (SAC220225). A.R-H supported by a grant from the Spanish Society of Medical Oncology. XHZ supported by NIH grants R01CA221946; R01CA183878; R01CA251950; U01CA253553; DoD BC201371P1.

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Authors and Affiliations

  1. Department of Surgery, Henry Ford Health, 2799 W. Grand Blvd, Detroit, MI, 48202, USA

    S. David Nathanson

  2. Cancer Center, Henry Ford Health, Detroit, MI, USA

    S. David Nathanson

  3. European Center for Angioscience (ECAS), Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany

    Lothar C. Dieterich & Emma Reynaud

  4. Lester and Sue Smith Breast Center, Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

    Xiang H-F. Zhang & Yi-Hsuan Wu

  5. Department of Pathology, Henry Ford Health, Detroit, MI, USA

    Dhananjay A. Chitale

  6. Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA

    Lajos Pusztai & Alejandro Ríos-Hoyo

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S. David Nathanson conceived the idea for this review article. All the co-authors performed their own literature searches and concept analysis and drafted and critically revised their own work. All authors read and approved the final manuscript.

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Nathanson, S.D., Dieterich, L.C., Zhang, X.HF. et al. Associations amongst genes, molecules, cells, and organs in breast cancer metastasis. Clin Exp Metastasis (2023). https://doi.org/10.1007/s10585-023-10230-w

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