Abstract
Nanocellulose, as a native renewable material extracted from cellulosic biomass, has gained increased attention in biomedical applications due to its unique physical features, biocompatibility, low toxicity, and modifiable surface chemistry. However, as a candidate for biomedical uses, native nanocellulose still has some limitations, including mechanical properties that are incomparable to those of natural tissues, a lack of biodegradability in vivo, and insufficient cell adhesion support, all of which prevent the widespread use of nanocellulose in the biomedical field. Recently, surface or interface engineering has been advocated as a promising strategy for tailoring the bioactivities and physiochemical properties of native nanocellulose for specific biomedical applications. This review paper focuses on recent advances in nanocellulose surface and/or interface engineering strategies for potential biomedical applications. The features of native nanocellulose that are similar to those of biomaterials have been emphasized. It also proposed a roadmap for the development of nanocellulose-based biomaterials, along with bottlenecks and prospects. This review paper emphasizes a new concept for nanocellulose-based biomaterials development strategies based on nanocellulose surface and interface properties for potential biomedical applications.
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Funding
This work was funded by the National Key R&D Program of China (Grant No. 2018YFE0107100, 2021YFA0910400), Jiangsu Agriculture Science and Technology Innovation Fund (CX(22)3190), the Start-up Fund for Introduced Scholar of Jiangsu University (4111370004), the Priority of Academic Program Development of Jiangsu Higher Education Institutions (PAPD 4013000011), and the Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou 215009, China, Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX22_3687), Postdoctoral Innovative Projects of Shandong Province (SDCX-ZG-202203005), National Natural Science Foundation of China (22278195).
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Jiao, H., Sun, J., Shi, Y. et al. Recent advances in strategies of nanocellulose surface and/or interface engineering for potential biomedical applications as well as its ongoing challenges: a review. Cellulose 30, 6741–6771 (2023). https://doi.org/10.1007/s10570-023-05302-9
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DOI: https://doi.org/10.1007/s10570-023-05302-9