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Prognostic impact of renal sinus fat accumulation in patients with chronic kidney disease

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Abstract

Background

Obesity is associated with the development and progression of chronic kidney disease (CKD). In the general population, the amount of renal sinus fat was associated with hypertension and renal impairment. However, its impact upon those with CKD remains uncertain.

Methods

We prospectively included CKD patients who underwent renal biopsy and simultaneously measured their renal sinus fat volume. The association between the percentage of renal sinus fat volume, which was adjusted by kidney volume, and renal outcomes was investigated.

Results

A total of 56 patients (median 55 years old, 35 men) were included. Among baseline characteristics, age and visceral fat volume were positively correlated with the percentage of renal sinus fat volume (p < 0.05). The percentage of renal sinus fat volume was associated with hypertension (p < 0.01) and tended to be associated with max glomerular diameter (p = 0.078) and urine angiotensinogen creatinine ratio (p = 0.064) after adjustment with several clinical factors. The percentage of renal sinus fat volume was significantly associated with a future > 50% decline in estimated glomerular filtration rate (p < 0.05).

Conclusions

Among those with CKD who required renal biopsy, the amount of renal sinus fat was associated with poor renal outcomes accompanied by systemic hypertension.

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Data availability

Data are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan

    Hayato Fujioka, Tsutomu Koike, Teruhiko Imamura, Kota Kakeshita, Hidenori Yamazaki & Koichiro Kinugawa

Authors
  1. Hayato Fujioka
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  2. Tsutomu Koike
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  3. Teruhiko Imamura
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  4. Kota Kakeshita
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  5. Hidenori Yamazaki
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  6. Koichiro Kinugawa
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Contributions

Conceptualization: HF; methodology: HF and TK; formal analysis and investigation: HF, KK and HY; writing—original draft preparation: HF; writing—review and editing: TI and TK; supervision: KK.

Corresponding author

Correspondence to Teruhiko Imamura.

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Conflict of interest

All the authors have declared no conflict of interest.

Ethical approval

This study was approved by our institutional review board (IRB Approval No. 27-162) and carried out following the Declaration of Helsinki.

Informed consent

Written informed consent was obtained from all patients before the inclusion in this study.

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Cite this article

Fujioka, H., Koike, T., Imamura, T. et al. Prognostic impact of renal sinus fat accumulation in patients with chronic kidney disease. Clin Exp Nephrol 27, 613–621 (2023). https://doi.org/10.1007/s10157-023-02350-0

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  • DOI: https://doi.org/10.1007/s10157-023-02350-0

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