Skip to main content
SpringerLink
Log in

Optimization of green extraction methods for cinnamic acid and cinnamaldehyde from Cinnamon (Cinnamomum cassia) by response surface methodology

  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

The major compounds of cinnamon are cinnamic acid and cinnamaldehyde, for which the conditions of microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), and reflux extraction (RE) were optimized using response surface methodology for comparing their efficiencies in terms of extraction yield, consumption of time and energy, and CO2 emission. The results indicated MAE superiority to UAE and RE owing to the highest yield of target compounds (total yield: 0.89%, cinnamic acid: 6.48 mg/100 mL, and cinnamaldehyde: 244.45 mg/100 mL) at optimum MAE conditions: 59% ethanol, 147.5 W microwave power and 3.4 min of extraction time. RE resulted in comparable yields with the highest consumption of time, energy, and solvent, and least CO2 emission. Therefore, it is concluded that MAE is the most efficient method for green extraction of cinnamic acid and cinnamaldehyde from cinnamon powder compared to UAE and RE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Ameer K, Bae SW, Jo Y, Chung N, Gao Y, Kwon JH. Optimization and modeling for heat reflux extraction of total yield, stevioside and rebaudioside-A from Stevia rebaudiana (Bertoni) leaves. Sep. Sci. Technol. 52: 1193–1205 (2017a)

    Article  CAS  Google Scholar 

  • Ameer K, Bae SW, Jo Y, Lee HG, Ameer A, Kwon JH. Optimization of microwave-assisted extraction of total extract, stevioside and rebaudioside-A from Stevia rebaudiana (Bertoni) leaves using response surface methodology (RSM) and artificial neural network (ANN) modelling. Food Chem. 229: 198–207 (2017b)

    Article  CAS  Google Scholar 

  • Ameer K, Shahbaz HM, Kwon JH. Green extraction methods for polyphenols from plant matrices and their byproducts: A review. Compr. Rev. Food Sci. F. 16: 295–315 (2017c)

    Article  Google Scholar 

  • Askari F, Rashidkhani B, Hekmatdoost A. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutr. Res. 34: 143–148 (2014)

    Article  CAS  Google Scholar 

  • Cravotto G, Binello A, Orio L. Green extraction techniques. Agro Food Ind. Hi-tech. 22: 57–59 (2011)

    CAS  Google Scholar 

  • Das A, Golder AK, Das C. Enhanced extraction of rebaudioside-A: Experimental, response surface optimization and prediction using artificial neural network. Ind. Crops Prod. 65: 415–421 (2015)

    Article  CAS  Google Scholar 

  • Frydman-Marom A, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M. Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer’s disease animal models. PLoS One 6: e16564–e16564 (2011)

    Article  CAS  Google Scholar 

  • Ghafoor K, Choi YH, Jeon JY, Jo IH. Optimization of ultrasound-assisted extraction of phenolic compounds, antioxidants, and anthocyanins from grape (Vitis vinifera) seeds. J. Agric. Food Chem. 57: 4988–4994 (2009)

    Article  CAS  Google Scholar 

  • Ghasemzadeh A, Jaafar HZE. Optimization of reflux conditions for total flavonoid and total phenolic extraction and enhanced antioxidant capacity in Pandan (Pandanus amaryllifolius Roxb.) using response surface methodology. Sci. World J. 2014: 1–10 (2014)

    Article  Google Scholar 

  • Hamidpour R, Hamidpour M, Hamidpour S, Shahlari M. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. J. Tradit. Complement. Med. 5: 66–70 (2015)

    Article  Google Scholar 

  • Hayta M, İşçimen EM. Optimization of ultrasound-assisted antioxidant compounds extraction from germinated chickpea using response surface methodology. LWT-Food Sci. Technol. 77: 208–216 (2017)

    Article  CAS  Google Scholar 

  • Kim HK, Do JR, Lim TS, Akram K, Yoon SR, Kwon JH. Optimisation of microwave-assisted extraction for functional properties of Vitis coignetiae extract by response surface methodology. J. Sci. Food Agric. 92: 1780–1785 (2012)

    Article  CAS  Google Scholar 

  • Korea Power Exchange (KPX). http://www.kpx.or.kr/Korean/htdocs/popup/pop_1224.html. Accessed Oct. 2, 2017.

  • Kwon JH, Belanger JM, Pare JJ, Yaylayan VA. Application of the microwave-assisted process (MAP™) to the fast extraction of ginseng saponins. Food Res. Int. 36: 491–498 (2003)

    Article  CAS  Google Scholar 

  • Maeng JH, Shahbaz HM, Ameer K, Jo Y, Kwon JH. Optimization of microwave-assisted extraction of bioactive compounds from Coriolus versicolor mushroom using response surface methodology. J. Food Process. Eng. 40: e12421 (2017)

    Article  Google Scholar 

  • Martino E, Ramaiola I, Urbano M, Bracco F, Collina S. Microwave-assisted extraction of coumarin and related compounds from Melilotus officinalis (L.) Pallas as an alternative to Soxhlet and ultrasound-assisted extraction. J. Chromatogr. A. 1125: 147–151 (2006)

    Article  CAS  Google Scholar 

  • Mathew S, Abraham TE. Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts through various in vitro models. Food Chem. 94: 520–528 (2006)

    Article  CAS  Google Scholar 

  • Ministry of Food and Drug Safety (MFDS). The Korean Pharmacopoeia. 10th ed. The Society of Korean Official Compendium for Public Health, The Yakup Shinmoon Inc., Seoul, Korea. p. 84 (2013)

  • Ministry of Trade, Industry and Energy (MTIE). Implementing regulations in energy law, Sejong, Republic of Korea (2011)

  • Pires RH, Montanari LB, Martins CHG, Zaia JE, Almeida AMF, Matsumoto MT, Mendes-Giannini MJS. Anticandidal efficacy of cinnamon oil against planktonic and biofilm cultures of Candida parapsilosis and Candida orthopsilosis. Mycopathologia 172: 453–464 (2011)

    Article  CAS  Google Scholar 

  • Ranasinghe P, Pigera S, Premakumara GAS, Galappaththy P, Constantine GR, Katulanda P. Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement. Altern. Med. 13: 275 (2013)

    Article  Google Scholar 

  • SAS Institute, Inc. SAS User’s Guide. Statistical Analysis Systems Institute, Cary, NC, USA (1990)

    Google Scholar 

  • Seo CS, Kim JH, Shin HK. Simultaneous determination of albiflorin, cinnamaldehyde, cinnamic acid, daidzin, glycyrrhizin, liquiritin, paeoniflorin and puerarin in galgeun-tang by HPLC-PDA. J. Korean Orien. Med. 31: 8–15 (2010)

    Google Scholar 

  • Xiao W, Han L, Shi B. Microwave-assisted extraction of flavonoids from Radix Astragali. Sep. Purif. Technol. 62: 614–618 (2008)

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This research was supported by Kyungpook National University Bokhyeon Research Fund, 2015.

Author information

Authors and Affiliations

  1. School of Food Science and Biotechnology and Food Bio-industry Research Institute, Kyungpook National University, Daegu, 41566, Korea

    Hyun-Gyu Lee, Yunhee Jo, Kashif Ameer & Joong-Ho Kwon

  2. World Institute of Kimchi, Gwangju, 61755, Korea

    Hyun-Gyu Lee

  3. Department of Food Science and Technology and BK 21 Plus Program, Graduate School of Chonnam National University, Gwangju, 61186, Korea

    Kashif Ameer

Authors
  1. Hyun-Gyu Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yunhee Jo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kashif Ameer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Joong-Ho Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Joong-Ho Kwon.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, HG., Jo, Y., Ameer, K. et al. Optimization of green extraction methods for cinnamic acid and cinnamaldehyde from Cinnamon (Cinnamomum cassia) by response surface methodology. Food Sci Biotechnol 27, 1607–1617 (2018). https://doi.org/10.1007/s10068-018-0441-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-018-0441-y

Keywords

Search

Navigation