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Facile microwave-assisted synthesis of Ti3C2 MXene quantum dots for ratiometric fluorescence detection of hypochlorite

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Abstract

A dual-channel “naked-eye” colorimetric and ratio fluorescent probe has been developed based on titanium carbide quantum dots for the detection of curcumin and hypochlorite (ClO−). The fluorescence emission of Ti3C2 MXene quantum dots (Ti3C2 MQDs) is in the range 350–600 nm, and the maximum emission peak is at 430 nm that overlaps with the UV absorption of curcumin at 430 nm to a large extent. This facilitates the fluorescence resonance energy transfer (FRET) between Ti3C2 MQDs and curcumin. When ClO− is added, the phenolic and methoxy groups of curcumin are oxidized to quinones, resulting in the restoration of the fluorescence of Ti3C2 MQD. In addition, the probe designed makes it easier to distinguish colors with the naked eye to detect curcumin and ClO−. The linear detection range of curcumin was 0.05–10 μM, and the detection limit was 20 nM. The linear detection ranges of ClO− are 25–150 μM and 150–275 μM, and the detection limit is 5 μM. This study is the first report on the determination of curcumin and ClO− based on Ti3C2 MQDs by dual-channel “naked-eye” colorimetric and ratio fluorescence method.

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References

  1. Shao BB, Liu ZF, Zeng GM, Wang H, Liang QH, He QY, Cheng M, Zhou CY, Jiang LB, Song B (2020) Two-dimensional transition metal carbide and nitride (MXene) derived quantum dots (QDs): synthesis, properties, applications and prospects. J Mater Chem A Mater Energy Sustain 8:7508–7535

    Article  CAS  Google Scholar 

  2. Xue Q, Zhang HJ, Zhu MS, Pei ZX, Li HF, Wang ZF, Huang Y, Deng QH, Zhou J, Du SY, Huang Q, Zhi CY (2017) Photoluminescent Ti3C2 MXene quantum dots for multicolor cellular imaging. Adv Mater 29:1604847

    Article  Google Scholar 

  3. Lu SY, Sui LZ, Liu Y, Yong X, Xiao GJ, Yuan KJ, Liu ZY, Liu BZ, Zou B, Yang B (2019) White photoluminescent Ti3C2 MXene quantum dots with two-photon fluorescence. Adv Sci 6:1801470

    Article  Google Scholar 

  4. Yu XH, Cai XK, Cui HD, Lee SW, Yu XF, Liu BL (2017) Fluorine-free preparation of titanium carbide MXene quantum dots with high near-infrared photothermal performances for cancer therapy. Nanoscale 9:17859–17864

    Article  CAS  Google Scholar 

  5. Rafieerad A, Yan W, Sequiera GL, Sareen N, Abu-El-Rub E, Moudgil M, Dhingra S (2019) Application of Ti3C2 MXene quantum dots for immunomodulation and regenerative medicine. Adv Healthcare Mater 8(16):1900569

    Article  Google Scholar 

  6. Xu Q, Ding L, Wen YY, Yang WJ, Zhou HJ, Chen XZ, Jason S, Zhou AG, Wee-Jun O, Li N (2018) High photoluminescence quantum yield of 18.7% by nitrogen-doped Ti3C2 MXene quantum dots. J Mater Chem 6:6360–6369

    Article  CAS  Google Scholar 

  7. Liang Z, Kang M, Payne GF, Wang X, Sun R (2016) Probing energy and electron transfer mechanisms in fluorescence quenching of biomass carbon quantum dots. ACS Appl Mater Interface 8(27):17478–17488

    Article  CAS  Google Scholar 

  8. Guo Z, Zhu X, Wang S, Lei C, Huang Y, Nie Z, Yao S (2018) Fluorescent Ti3C2 MXene quantum dots for an alkaline phosphatase assay and embryonic stem cell identification based on the inner filter effect. Nanoscale 10:19579–19585

    Article  CAS  Google Scholar 

  9. Chen X, Li J, Pan G, Xu W, Zhu J, Zhou D, Li D, Chen C, Lu G, Song H (2019) Ti3C2 MXene quantum dots/TiO2 inverse opal heterojunction electrode platform for superior photoelectrochemical biosensing. Sensors Actuators B Chem 289:131–137

    Article  CAS  Google Scholar 

  10. Cai GN, Yu ZZ, Tong P, Tang DP (2019) Ti3C2 MXene quantum dots-encapsulated liposome for photothermal immunoassay using a portable near-infrared imaging camera on smartphone. Nanoscale 11:15659–15667

    Article  CAS  Google Scholar 

  11. Liu MW, He Y, Zhou J, Ge YL, Zhou JG, Song GW (2020) A “naked-eye” colorimetric and ratiometric fluorescence probe for uric acid based on Ti3C2 MXene quantum dots. Anal Chim Acta 1103:134–142

    Article  CAS  Google Scholar 

  12. Xu Q, Yang W, Wen Y, Liu S, Liu Z, Ong W-J, Li N (2019) Hydrochromic full-color MXene quantum dots through hydrogen bonding toward ultrahigh-efficiency white light-emitting diodes. Appl Mater Today 16:90–101

    Article  Google Scholar 

  13. Huang D, Xie Y, Lu D, Wang Z, Wang J, Yu H, Zhang H (2019) Demonstration of a white laser with V2C MXene-based quantum dots. Adv Mater 31:1901117

    Article  Google Scholar 

  14. Zeng Z, Yan Y, Chen J, Zan P, Tian Q, Chen P (2019) Boosting the photocatalytic ability of Cu2O nanowires for CO2 conversion by MXene quantum dots. Adv Funct Mater 29:1806500

    Article  Google Scholar 

  15. Tang R, Zhou S, Li C, Chen R, Zhang L, Zhang Z, Yin L (2020) Janus-structured co-Ti3C2 MXene quantum dots as a Schottky catalyst for high-performance photoelectrochemical water oxidation. Adv Funct Mater 2000637

  16. Xu G, Niu Y, Yang X, Jin Z, Wang Y, Xu Y, Niu H (2018) Preparation of Ti3C2Tx MXene-derived quantum dots with white/blue-emitting photoluminescence and Electrochemiluminescence. Adv Opt Mater 6:1800951

    Article  Google Scholar 

  17. Zhou L, Wu FM, Yu JH, Deng QH, Zhang FA, Wang G (2017) Titanium carbide (Ti3C2Tx) MXene: a novel precursor to amphiphilic carbide-derived graphene quantum dots for fluorescent ink, light-emitting composite and bioimaging. Carbon 118:50–57

    Article  CAS  Google Scholar 

  18. Zhang T, Jiang X, Li G, Yao Q, Lee JY (2018) A red phosphorous-assisted ball-milling synthesis of few layered Ti3C2Tx (MXene) nanodot composite. Chem Nano Mat 4:56–60

    CAS  Google Scholar 

  19. Desai ML, Basu H, Singhal RK, Saha S, Kailasa SK (2018) Microwave-assisted synthesis of water-soluble Eu3+ hybrid carbon dots with enhanced fluorescence for the sensing of Hg2+ ions and imaging of fungal cells. New J Chem 42(8):6125–6133

    Article  CAS  Google Scholar 

  20. Yang G, Wan X, Su Y, Zeng X, Tang J (2016) Acidophilic S-doped carbon quantum dots derived from cellulose fibers and their fluorescence sensing performance for metal ions in an extremely strong acid environment. J Mater Chem A 4(33):12841–12849

    Article  CAS  Google Scholar 

  21. Lou Z, Li P, Han K (2015) Redox-responsive fluorescent probes with different design strategies. Acc Chem Res 48:1358–1368

    Article  CAS  Google Scholar 

  22. Xu QL, Heo CH, Kim G, Lee HW, Kim HM, Yoon J (2015) Development of imidazoline-2-thiones based two-photon fluorescence probes for imaging hypochlorite generation in a co-culture system. Angew Chem Int Ed 54:4890–4894

    Article  CAS  Google Scholar 

  23. Chen XQ, Wang F, Hyun JY, Wei TW, Qiang J, Ren XT, Shin I, Yoon J (2016) Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species. Chem Soc Rev 45:2976–3016

    Article  CAS  Google Scholar 

  24. Zhang PS, Wang H, Hong YX, Yu ML, Zeng RJ, Long YF, Chen J (2018) Selective visualization of endogenous hypochlorous acid in zebrafish during lipopolysaccharide-induced acute liver injury using a polymer micelles-based ratiometric fluorescent probe. Biosens Bioelectron 99:318–324

    Article  CAS  Google Scholar 

  25. Guo JQ, Ye S, Li H, Song J, Qu JL (2020) One-pot synthesized nitrogen-fluorine-codoped carbon quantum dots for ClO- ions detection in water samples. Dyes Pigments 175:108178

    Article  CAS  Google Scholar 

  26. Yue YK, Yin CX, Huo FJ, Chao JB, Zhang YB (2014) The application of natural drug-curcumin in the detection hypochlorous acid of real sample and its bioimaging. Sensors Actuators B Chem 202:551–556

    Article  CAS  Google Scholar 

  27. Zhou Z, Gu JP, Qiao XG, Wu HX, Fu HR, Wang L, Li HY, Ma LF (2019) Double protected lanthanide fluorescence core@shell colloidal hybrid for the selective and sensitive detection of ClO−. Sensors Actuators B Chem 282:437–442

    Article  CAS  Google Scholar 

  28. Wang L, Li WX, Zhi WJ, Ye DD, Zhang WL, Ni L (2018) Rapid detection of hypochlorite by a coumarin-based hydrazide inaqueous solution and its application in live-cell imaging. Sensors Actuators B Chem 255:1112–1118

    Article  CAS  Google Scholar 

  29. Tan HL, Wu XY, Weng YH, Lu YJ, Huang ZZ (2020) A self-assembled FRET nanoprobe with metal-organic framework as a scaffold for ratiometric detection of hypochlorous acid. Anal Chem 92(4):3447–3454

    Article  CAS  Google Scholar 

  30. Wei ZN, Li HQ, Liu SB, Wang W, Chen HL, Xiao LH, Ren CL, Chen XG (2019) Carbon dots as fluorescent/colorimetric probe for real time detection of hypochlorite and ascorbic acid in body fluid and cell. Anal Chem 91(24):15477–15483

    Article  CAS  Google Scholar 

  31. Lan JS, Liu L, Zeng RF, Qin YH, Liu Y, Jiang XY, Aihemaiti A, Ding Y, Zhang T, Ho RJY (2020) Rational modulation of coumarin-hemicyanine platform based on OH substitution for higher selective detection of hypochlorite. Chem Commun 56(8):1219–1222

    Article  CAS  Google Scholar 

  32. Zhon XL, Yang Q, Chen YS, Jiang YL, Wang BX, Shen J (2019) A mitochondria-targeted fluorescent probe based on coumarin-pyridine derivatives for hypochlorite imaging in living cells and zebrafish. J Mater Chem B 7(46):7332–7337

    Article  Google Scholar 

  33. Shiraishi Y, Yamada C, Hirai T (2019) A coumarin-dihydroperimidine dye as a fluorescent chemosensor for hypochlorite in 99% water. RSC Adv 9(49):28636–28641

    Article  CAS  Google Scholar 

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Funding

This work was financially supported by Supported by National Natural Science Foundation of China (21707030) and Wuhan Youth Science and technology plan (2016070204010133).

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Authors and Affiliations

  1. Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China

    Mingwang Liu, Yuxuan Bai, Yu He, Ji Zhou, Yili Ge & Gongwu Song

  2. Hubei Province Key Laboratory of Regional Development and Environment Response, Wuhan, 430062, China

    Yuxuan Bai, Yu He & Jiangang Zhou

Authors
  1. Mingwang Liu
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  2. Yuxuan Bai
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  3. Yu He
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  4. Ji Zhou
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  5. Yili Ge
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  6. Jiangang Zhou
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  7. Gongwu Song
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Correspondence to Yu He.

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Liu, M., Bai, Y., He, Y. et al. Facile microwave-assisted synthesis of Ti3C2 MXene quantum dots for ratiometric fluorescence detection of hypochlorite. Microchim Acta 188, 15 (2021). https://doi.org/10.1007/s00604-020-04668-y

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  • DOI: https://doi.org/10.1007/s00604-020-04668-y

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