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The connectivity-based parcellation of the angular gyrus: fiber dissection and MR tractography study

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Abstract

The angular gyrus (AG) wraps the posterior end of the superior temporal sulcus (STS), so it is considered a continuation of the superior temporal gyrus (STG)/ middle temporal gyrus (MTG) and forms the inferior parietal lobule (IPL) with the supramarginal gyrus (SMG). The AG was functionally divided in the literature, but there is no fiber dissection study in this context. This study divided AG into superior (sAG) and inferior (iAG) parts by focusing on STS. Red, blue silicone-injected eight and four non-silicone-injected human cadaveric cerebrums were dissected via the Klingler method focusing on the AG. White matter (WM) tracts identified during dissection were then reconstructed on the Human Connectome Project 1065 individual template for validation. According to this study, superior longitudinal fasciculus (SLF) II and middle longitudinal fasciculus (MdLF) are associated with sAG; the anterior commissure (AC), optic radiation (OR) with iAG; the arcuate fasciculus (AF), inferior frontooccipital fasciculus (IFOF), and tapetum (Tp) with both parts. In cortical parcellation of AG based on STS, sAG and iAG were associated with different fiber tracts. Although it has been shown in previous studies that there are functionally different subunits with AG parcellation, here, for the first time, other functions of the subunits have been revealed with cadaveric dissection and tractography images.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

This research was made possible due to the selfless gift from donor-cadaver patients. We are very grateful for their sacrifice.

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The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Neurosurgery, Pamukkale University School of Medicine, Çamlaraltı, Kınıklı Cd No. 37, 20160, Pamukkale/Denizli, Turkey

    Fatih Yakar & Emrah Egemen

  2. Department of Radiology, Ankara City Hospital, Üniversiteler Mahallesi 1604. Cadde No. 9, 06800, Çankaya/Ankara, Turkey

    Pınar Çeltikçi

  3. Department of Neurosurgery, Yeditepe University School of Medicine, İçerenköy Mahallesi Hastane Sokak No. 4 D:4/1, 34854, Istanbul, Turkey

    Yücel Doğruel & Abuzer Güngör

  4. Department of Neurosurgery, Bakirköy Research and Training Hospital for Psychiatry, Neurology, and Neurosurgery, Zuhuratbaba Mah, Dr. Tevfik Sağlam Cd No. 11, 34147, Bakırköy/Istanbul, Turkey

    Abuzer Güngör

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  1. Fatih Yakar
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Correspondence to Abuzer Güngör.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the. Ethics Committee of Pamukkale University (Date: 30.11.2021/No: 21).

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Yakar, F., Çeltikçi, P., Doğruel, Y. et al. The connectivity-based parcellation of the angular gyrus: fiber dissection and MR tractography study. Brain Struct Funct 228, 121–130 (2023). https://doi.org/10.1007/s00429-022-02555-1

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