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The updated view on induced pluripotent stem cells for cardiovascular precision medicine

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Abstract

Cardiovascular diseases have consistently been one of the leading causes of mortality, despite investigations by many scientists and clinicians. Animal models are versatile platforms to illustrate various mechanisms of different diseases, but are lacking in accurately portraying cardiovascular disease phenotypes. The advent of human pluripotent stem cells (PSCs) has led to much development in the construction of cardiovascular disease models. In this review, we provide a brief overview of the history and utilization of PSCs for cardiovascular precision medicine, including disease modeling, drug screening, and gene editing, and elaborate on the current updated research status of patient-specific induced pluripotent stem cell (iPSC)-based disease models for cardiac channelopathies, cardiomyopathies, and other cardiovascular diseases. Furthermore, we highlight the development of novel human iPSC-derived engineered heart tissues for cardiovascular disease modeling. Finally, we put forward our own views on the existing advantages and difficulties for moving forward in this field.

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Funding

This work was funded by the National Key R&D Program of China (2017YFA0103700), the National Natural Science Foundation of China (91949111, 81770257, 81970223), Natural Science Foundation of Jiangsu Province (BK20201409), Top Six Talents in Jiangsu Province (SWYY-081), the Space Medical Experiment Project of China Manned Space Program (HYZHXM01018), Jiangsu Province’s Key Discipline/Laboratory of Medicine (XK201118), National Center for International Research (2017B01012), and Introduction Project of Clinical Medicine Expert Team for Suzhou (SZYJTD201704)

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  1. Yong Wang, Wei Lei, and Jingsi Yang contributed equally to this work.

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  1. Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Medical College, Soochow University, Suzhou, 215000, China

    Yong Wang, Wei Lei, Jingsi Yang, Xuan Ni, Lingqun Ye, Zhenya Shen & Shijun Hu

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This article is part of the special issue on Recent Progress with hPSCs for Drug Discovery in Pflügers Archiv—European Journal of Physiology

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Wang, Y., Lei, W., Yang, J. et al. The updated view on induced pluripotent stem cells for cardiovascular precision medicine. Pflugers Arch - Eur J Physiol 473, 1137–1149 (2021). https://doi.org/10.1007/s00424-021-02530-5

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