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Chromosomal polymorphisms and susceptibility to menstrual disorders: a retrospective analysis of 24,578 women

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the association between the polymorphic variants of chromosomes and menstrual disorders.

Methods

The data from our previous retrospective, single-center cohort study were re-analyzed. Women with regular menstruation were included as controls. Women with menstrual cycle abnormalities were subgrouped according to reproductive causes. The frequency of chromosomal polymorphisms was compared between groups. Regression analysis was used to adjust for potential confounding variables.

Result

A total of 24,578 women composed of 8062 women with regular cycles as the control group and 16,516 women as the menstrual cycle irregularity group were included. When compared with the control group, the incidence of chromosomal polymorphisms in the total menstrual cycle irregularity group, Polycystic ovary syndrome group, and Primary ovarian insufficiency group were significantly higher (4.49% versus 5.34%, P = 0.004, 4.49% versus 5.35%, P = 0.018 and 4.49% versus 5.94%, P = 0.002, respectively). The incidences of inv(9) in the Primary ovarian insufficiency group were significantly higher than that in the control individuals (1.0% versus 1.6%, P = 0.024). Logistic regression analysis showed an effect of chromosomal polymorphisms on menstrual cycle irregularity (OR: 1.62, 95% CI: 1.234–2.187, P = 0.007; adjusted OR: 1.46, 95% CI: 1.153–1.819, P < 0.001). The result demonstrated an effect of chromosomal polymorphisms on the Primary ovarian insufficiency group (OR: 2.52, 95% CI: 1.307–5.177, P < 0.001; adjusted OR: 2.61, 95% CI: 1.371–4.605, P < 0.001).

Conclusion

The study suggests chromosomal polymorphisms adversely affect female menstrual cycle irregularity.

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Acknowledgements

We appreciate the contribution of patients, doctors, researchers and teachers to our study. In particular, we would like to thank Wu Hong for counselling and analyzing data.

Funding

The study was supported by National Natural Science Funds (No. 81971354 and No. 81671421), the Korea Research Centre Fund, Sichuan Regional and National Key Research Bases (No. hgzx201803) and Sichuan province natural science foundation, Sichuan Science and Technology Program (No. 2022NSFSC0701).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, 20 Renmin South Road, Chengdu, 610041, Sichuan, People’s Republic of China

    Cheng Ran, Luo Xiaoyan, Zhou Xiaoyang, Nie Ying, Qiao Xiaoyong, Yang Zhilan & Xu Liangzhi

  2. The Joint Laboratory for Reproductive Medicine of Sichuan University-The Chinese University of Hong Kong, Chengdu, 610041, Sichuan, People’s Republic of China

    Cheng Ran, Luo Xiaoyan, Zhou Xiaoyang, Nie Ying, Qiao Xiaoyong, Yang Zhilan & Xu Liangzhi

  3. Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, People’s Republic of China

    Cheng Ran, Luo Xiaoyan, Zhou Xiaoyang, Nie Ying, Qiao Xiaoyong, Yang Zhilan & Xu Liangzhi

  4. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, People’s Republic of China

    Cheng Ran, Luo Xiaoyan, Zhou Wenjie, Zhou Xiaoyang, Nie Ying, Qiao Xiaoyong, Yang Zhilan & Xu Liangzhi

  5. Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China

    Zhou Wenjie

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  1. Cheng Ran
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Contributions

XL and CR participated in study design, statistical analysis, interpretation of data and manuscript writing. Material preparation and data collection were performed by LX, ZW, ZX, NY, YZ and QX. The first draft of the manuscript was written by CR and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Xu Liangzhi.

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Ran, C., Xiaoyan, L., Wenjie, Z. et al. Chromosomal polymorphisms and susceptibility to menstrual disorders: a retrospective analysis of 24,578 women. Arch Gynecol Obstet 308, 1577–1585 (2023). https://doi.org/10.1007/s00404-023-07124-3

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