Abstract
While many of the movements we make throughout our day involve just one upper limb, most daily movements require a certain degree of coordination between both upper limbs. Historically, sex differences in eye-hand coordination have been observed. As well, there are demonstrated sex-specific differences in hemisphere symmetry, interhemispheric connectivity, and motor cortex organization. While it has been suggested that these anatomical differences may underlie sex-related differences in performance, sex differences in the functional neural correlate underlying bimanual performance have not been explicitly investigated. In the current study we tested the hypothesis that the functional connectivity underlying bimanual movement control differed depending on the sex of an individual. Participants underwent MRI scanning to acquire anatomical and functional brain images. During the functional runs, participants performed unimanual and bimanual coordination tasks using two button boxes. The tasks included pressing the buttons in time to an auditory cue with either their left or their right hand individually (unimanual), or with both hands simultaneously (bimanual). The bimanual task was further divided into either an in-phase (mirror/symmetrical) or anti-phase (parallel/asymmetrical) condition. Participants were provided with extensive training to ensure task comprehension, and performance error rates were found to be equivalent between men and women. A generalized psychophysiological interaction (gPPI) analysis was implemented to examine how functional connectivity in each condition was modulated by sex. In support of our hypothesis, women and men demonstrated differences in the neural correlates underlying unimanual and bimanual movements. In line with previous literature, functional connectivity patterns showed sex-related differences for right- vs left-hand movements. Sex-specific functional connectivity during bimanual movements was not a sum of the functional connectivity underlying right- and left-hand unimanual movements. Further, women generally showed greater interhemispheric functional connectivity across all conditions compared to men and had greater connectivity between task-related cortical areas, while men had greater connectivity involving the cerebellum. Sex differences in brain connectivity were associated with both unimanual and bimanual movement control. Not only do these findings provide novel insight into the fundamentals of how the brain controls bimanual movements in both women and men, they also present potential clinical implications on how bimanual movement training used in rehabilitation can best be tailored to the needs of individuals.
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Acknowledgements
The authors wish to thank Joy Williams, MRT(MR), for her MR image acquisition expertise. This work was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (grant number RG-2016-05336 to L.E.S.).
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AR: software, formal analysis, writing—original draft, writing—review & editing, visualization. DJG: conceptualization, methodology, investigation, software, formal analysis, resources, writing—review & editing. LES: conceptualization, methodology, resources, writing—review & editing, supervision, project administration, funding acquisition.
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Communicated by Bill J Yates.
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Rogojin, A., Gorbet, D.J. & Sergio, L.E. Sex differences in the neural underpinnings of unimanual and bimanual control in adults. Exp Brain Res 241, 793–806 (2023). https://doi.org/10.1007/s00221-023-06561-5
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DOI: https://doi.org/10.1007/s00221-023-06561-5