Skip to main content

Advertisement

Log in

Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review

  • Review Article
  • Published:
Medicinal Chemistry Research Aims and scope Submit manuscript

Abstract

Polygonum aviculare is a plant widely distributed in all continents and very common in temperate regions of the world. The different parts of this plant are used as an anthelmintic, antidiabetic and to treat kidney disorders and skin problems. In order to highlight the importance of P. aviculare L., This review is undertaken with the aim to highlight some aspects of this plant, specifically the taxonomy, ethnomedicinal, morphological, phytochemical and biological studies of the plant. The taxonomic analysis indicated that the plant is descended from an inbred line and the cytogenetic results showed that P. aviculare L. is dominated by the number of chromosomes x = 10, therefore it was found that this herb has a rich phytochemical composition and many biological activities have been discussed in this review, mainly antioxidant, anti-inflammatory, anti-diabetic, anti-cancer, and dermato-protective activities.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hafik CZ, Errichi BA, Aleb TA. Etude des mauvaises herbes des céréales dans la plaine de la Moulouya (Maroc). Rev Marocaine Prot des Plantes. 2012; 3:1–12.

  2. Koopman WJM, Kuiper I, Klein-Geltink DJA, Sabatino GJH, Smulders MJM. Botanical DNA evidence in criminal cases: Knotgrass (Polygonum aviculare L.) as a model species. Forensic Sci Int Genet [Internet]. 2012;6:366–74. https://doi.org/10.1016/j.fsigen.2011.07.013.

    Article  CAS  PubMed  Google Scholar 

  3. Costea M, Tardif FJ. Polygonum aviculare subsp. rurivagum (Polygonaceae) in North America. SIDA. Contrib Bot. 2003;20:1709–11.

    Google Scholar 

  4. Costea M, Tardif FJ. The biology of Canadian weeds. 131. Polygonum aviculare L. Can J Plant Sci. 2005;85:481–506.

    Article  Google Scholar 

  5. Meerts P, Briane J-P, C L. A numerical taxonomic study of the Polygonum aviculare complex (Polygonaceae) in Belgium. Plant Syst Evol. 1990;173:71–89.

    Article  Google Scholar 

  6. Koopman WJM, Kuiper I, Klein-geltink DJA, Sabatino GJH, Smulders MJM. Botanical DNA evidence in criminal cases: Knotgrass (Polygonum aviculare L.) as a model species. Forensic Sci Int Genet. 2012;6:366–74.

    Article  CAS  PubMed  Google Scholar 

  7. Masullo M, Montoro P, Mari A, Pizza C, Piacente S. Medicinal plants in the treatment of women’s disorders: Analytical strategies to assure quality, safety and efficacy. J Pharm Biomed Anal. 2015;113:189–11.

    Article  CAS  PubMed  Google Scholar 

  8. Avazxanovna SF, Alisherovna UF, Qizi RSS, Saminjonqizi KN, Sanjar N. The results of the study ofanti-inflammatory action of the gel Polygonum aviculare, chamomile, cortex quercus. Present Sci Work Vestn. 2020;3:18–21.

    Google Scholar 

  9. Sang-Uk C, Buk-G, Yong-Seo P, Ja-YC, Shela G. Characteristics of the leaf parts of some traditional Korean salad plants used for food. J Sci Food Agric. 2008;88:1963–8.

    Article  Google Scholar 

  10. Shin H, Chung H, Park B, Lee KY. Identification of antioxidative constituents from polygonum aviculare using LC-MS coupled with DPPH assay. Nat Prod Sci. 2016;22:64–9.

    Article  CAS  Google Scholar 

  11. Sangsefidi M, Jadid RR, Roustaiyan A. Detection of constituent compound and antioxidant effects of essence oil of Polygonum aviculare in Sabzevar city. Int J Adv Biotechnol Res. 2015;16:468–74.

    Google Scholar 

  12. Sung Y, Yoon T, Yang W, Kim SJ, Kim D, Kim HK. The Antiobesity Effect of Polygonum aviculare L. Ethanol Extract in High-Fat Diet-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine. 2013;2013.

  13. Granica S, Czerwi ME, Barbara Ż, Kiss AK. Antioxidant and anti-in fl ammatory fl avonol glucuronides from Polygonum aviculare L. Fitoterapia 2013;91:180–8.

    Article  CAS  PubMed  Google Scholar 

  14. Tunon H, Olavsdotter CLB. Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin Biosynthesis and PAF-Induced exocytosis. J Ehnopharmacol. 1995;8741:61–76.

    Article  Google Scholar 

  15. Hao M, Gill D, Ho D, Oh T, Sub H. Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines. Journal of Ethnopharmacolog. 2005;99:113–7.

  16. Saremi J, Jahromi HK, Pourahmadi M. Effect of Polygonum Aviculare L. on Nephrolithiasis Induced by Ethylene Glycol and Ammonium Chloride in Rats. Urol J. 2018;15:1–4.

    Google Scholar 

  17. Seimandi G, Álvarez N, Stegmayer MI, Fernández L, Ruiz V, Favaro MA, et al. An update on phytochemicals and pharmacological activities of the genus persicaria and polygonum. Molecules 2021;26:1–37.

    Article  Google Scholar 

  18. Wu L, Chen Z, Li S, Wang L, Zhang J. Eco-friendly and high-efficient extraction of natural antioxidants from Polygonum aviculare leaves using tailor-made deep eutectic solvents as extractants. Sep Purif Technol. 2021;262:118339 https://doi.org/10.1016/j.seppur.2021.118339.

    Article  CAS  Google Scholar 

  19. Boullard B. Plantes Medicinales Du Monde: Croyances et Realites. De Boeck Secundair. ESTEM. 7, rue Jacquemont-75017 Paris; 2001.

  20. Bussmann RW, Batsatsashvili K, Kikvidze Z, Ghorbani A, Khajoei NF, Paniagua-Zambrana NY, et al. Polygonum aviculare L. POLYGONACEAE. Ethnobotany of the Mountain Regions of Far Eastern Europe: Ural, Northern Caucasus, Turkey, and Iran. Springer. 2020:1–8.

  21. Muthaiyan MC. Principles and practices of Plant Quarantine. ALLIED PUB. Published by Sunil sachdev; 1; 2009.

  22. Fennane M, Moh R. Aromatic and medicinal plants of Morocco: Richness, diversity and threats Plantes aromatiques et médicinales du Maroc: Richesse, diversité et menaces. Bull l’Institut Sci Rabat. 2016;38:27–42.

    Google Scholar 

  23. Mosaferi S, Sheidai M, Keshavarzi M, Noormohammadi Z. Genetic diversity and morphological variability in Polygonum aviculare s.l. (Polygonaceae) of Iran. Phytotaxa. 2015;233:166–78.

    Article  Google Scholar 

  24. Ehler LE, Wilson T. Effect of Common Knotweed (Polygonum aviculare) on Abundance and Efficiency of Insect Predators of Crop Pests. J Agric Sci Publ by Calif. 1987;55:1–52.

  25. Diego B, RB A. Sensitivity of Polygonum aviculare Seeds to Light as Affected by Soil Moisture Conditions. Ann Bot. 2007;99:915–24.

    Article  Google Scholar 

  26. Diego B, Agostinelli AM. Thermal regulation of secondary dormancy induction in Polygonum aviculare seeds: a quantitative analysis using the hydrotime model. Seed Sci Res. 2017;27:1–12.

  27. Bourdöt GW, Hurrell GA, Saville DJ. Weed flora of cereal crops in Canterbury, New Zealand. N. Zeal J Crop Hortic Sci. 1998;26:233–47.

    Article  Google Scholar 

  28. Izquierdo J, Blanco-Moreno JM, Chamorro L, Recasens J, Sans FX. Spatial Distribution and Temporal Stability of Prostrate Knotweed (Polygonum aviculare) and Corn Poppy (Papaver rhoeas) Seed Bank in a Cereal Field. Weed Sci. 2009;57:505–11.

    Article  CAS  Google Scholar 

  29. Małgorzata P, Krzystof Z, Aleksandra S-C, Krzysztof K, Agnieeszka K, Jôzef K. Evaluation of the bioindicator suitability of Polygonum aviculare in urban areas. Ecol Indic. 2013;24:552–6.

    Article  Google Scholar 

  30. Dorota K, Krzysztof Gediga ZS. Heavy metal and nutrient uptake in plants colonizing post-flotation copper tailings. Environ Sci Pollut Res. 2018;25: 824–35.

  31. Zhongyuan L, Azeguli H, Abdulla F, Zhang XM. Accumulation of metallic elements by native species thriving in two mine tailings in Aletai, China. Environ Earth Sci. 2016;75:781.

    Article  Google Scholar 

  32. Mihai C, Tardif FJ. Nomenclatural changes in the genus Polygonum section Polygonum (Polygonaceae). Bot Res Inst Tex, Inc. 2003;20:987–97.

    Google Scholar 

  33. Mcneill J. The taxonomy and distribution in eastern Canada of Polygonum arenastrum (4x = 40) and P. monspeliense (6x = 60), introduced members of the P. aviculare complex. Can J Bot. 1981;59:2744–51.

  34. Love Alad and Love Doris. Chromosomes And Taxonomy Of Eastern North American Polygonum. Canadian Journal of Botany. 1956;34;501–521.

  35. Styles BT. The Taxonomy of Polygonum aviculare and its Allies in Britain. Watsonia 1962;5:177–14.

    Google Scholar 

  36. Mosaferi S, Sheidai M, Keshavarzi M, Noormohammadi Z. Karyological study of some annual Polygonum species in Iran. Bot Lett. 2018;65:1–6.

  37. Meerts R, Baya T, Lefebvre C. Allozyme variation in the annual weed species complex Polygonum aviculare (Polygonaceae) in relation to ploidy level and colonizing ability. Plant Syst Evol. 1998;211:239–40.

    Article  Google Scholar 

  38. Meerts P. Phenotypic Plasticity in the Annual Weed Polygonum aviculare. Bot Acta. 1995;108:414–24.

    Article  Google Scholar 

  39. Ji H, Shengji P, Chunlin L. An ethnobotanical study of medicinal plants used by the lisu people in Nujiang, northwest yunnan, china I. Econ Bot. 2004;58:S253–64.

    Article  Google Scholar 

  40. Yegilada E, Hondab G, Sezik E, Tabatab M, Goto K. Traditional medicine in Turkey IV. Folk medicine in the Mediterranean subdivision. J Ethnopharmacol. 1993;39:31–8.

    Article  Google Scholar 

  41. Habibi Roudkenar M, Mohammadi Roushandeh A, Delazar A, Halabian R, Soleimani Rad J, Mehdipour A, et al. Effects of polygonum aviculare herbal extract on proliferation and apoptotic gene expression of MCF-7. DARU. J Pharm Sci. 2011;19:326–31.

    CAS  Google Scholar 

  42. Egamberdieva D, Mamadalieva NZ, Khojimatov OK, Tiezzi A. Medicinal plants from Chatkal Biosphere Reserve used for folk medicine in Uzbekistan. Med Aromat Plant Sci Biotechnol. 2012;7:56–64.

  43. Shen B, Yang Y, Yasamin S, Liang N, Su W, Chen S. Analysis of the Phytochemistry and Bioactivity of the Genus Polygonum of Polygonaceae. Digit Chin Med. 2018;1:19–36.

    Article  Google Scholar 

  44. Narasimhulu G, Reddy KK, Mohamed J. The genus Polygonum (Polygonaceae): An ethnopharmacological and phytochemical perspectives – review. Int J Pharm Pharm Sci. 2014;6:21–45.

    Google Scholar 

  45. Varga E, Fülöp I, Farczádi L, Croitoru MD. Polyphenolic determination from medicinal plants used in veterinary medicine by an UHPLC-LC-MS/MS method. Farmacia 2020;68:1129–35.

    Article  CAS  Google Scholar 

  46. Ciavoi G, Dobjanschi L, Jurca T, Osser G, Scrobota I, Marian E, et al. Comparative Effectiveness of a Commercial Mouthwash and an Herbal Infusion in Oral Health Care. Appl Sci. 2021;11:3008.

    Article  CAS  Google Scholar 

  47. Granica S, Piwowarski JP, Popławska M, Jakubowska M, Borzym J, Kiss AK. Novel insight into qualitative standardization of Polygoni avicularis herba (Ph. Eur.). J Pharm BiomedAnal. 2013;72:216–22.

    Article  CAS  Google Scholar 

  48. Granica S. Quantitative and qualitative investigations of pharmacopoeial plant material polygoni avicularis herba by UHPLC-CAD and UHPLC-ESI-MS methods. Phytochem Anal. 2015;26:374–82.

  49. Walker JM, Maitra A, Walker J, Ehrnhoefer-Ressler MM, Inui T, Somoza V. Identification of magnolia officinalis L. Bark extract as the most potent anti-inflammatory of four plant extracts. Am J Chin Med. 2013;41:531–44.

    Article  PubMed  Google Scholar 

  50. Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol. 2002;83:153–9.

    Article  PubMed  Google Scholar 

  51. Seo SH, Lee SH, Cha PH, Kim MY, Min DS, Choi KY. Polygonum aviculare L. And its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing. Phyther Res. 2016;30:848–54.

    Article  CAS  Google Scholar 

  52. Luo X, Xue L, Xu H, Zhao QY, Wang Q, She YS, et al. Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle. Sci Rep. 2018;8:1–12.

    Google Scholar 

  53. Goun EA, Petrichenko VM, Solodniko SU, Suhinina TV, Kline A, Cunningham G, et al. Anticancer and antithrombin activity of Russian plants. J Ethnopharmacol. 2002;81:337–42.

    Article  PubMed  Google Scholar 

  54. De Medeiros JMR, Macedo M, Contancia JP, Nguyen C, Cunningham G, Miles DH. Antithrombin activity of medicinal plants of the Azores. J Ethnopharmacol. 2000;72:157–65.

    Article  PubMed  Google Scholar 

  55. Jovanović M, Tenji D, Nikolić B, Srdić-Rajić T, Svirčev E, Mitić-ćulafić D. In vitro study of two edible polygonoideae plants: Phenolic profile, cytotoxicity, and modulation of keap1-nrf2 gene expression. Foods. 2021;10;811.

  56. Chen L, Xiong YQ, Xu J, Wang JP, Meng ZL, Hong YQ. Juglanin inhibits lung cancer by regulation of apoptosis, ROS and autophagy induction. Oncotarget 2017;8:93878.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Hou GR, Zeng K, Lan HM, Wang Q. Juglanin ameliorates UVB-induced skin carcinogenesis via anti-inflammatory and proapoptotic effects in vivo and in vitro. Int J Mol Med. 2018;42:41–52.

    CAS  PubMed  PubMed Central  Google Scholar 

  58. Sohn SH, Lee EY, Lee JH, Kim Y, Shin M, Hong M, et al. Screening of herbal medicines for recovery of acetaminophen-induced nephrotoxicity. Environ Toxicol Pharm. 2009;27:225–30.

    Article  CAS  Google Scholar 

  59. Zhang F, Xu R. Juglanin ameliorates LPS-induced neuroin fl ammation in animal models of Parkinson’ s disease and cell culture via inactivating TLR4 / NF- κ B pathway. Biomed Pharmacother. 2018;97:1011–9.

    Article  CAS  PubMed  Google Scholar 

  60. Haeng S, Jang S, Son E, Woo S, Dong S, Sung Y. Phytomedicine Polygonum aviculare L. extract reduces fatigue by inhibiting neuroinflammation in restraint-stressed mice. Phytomedicine 2018;42:180–9.

    Article  Google Scholar 

  61. Ji-Xing N, Park E-J, Lee SH, Park P-H, Kim JY, Geonil Ko DHS. Antifibrotic Effects of the Methanol Extract of Polygonum aviculare in Fibrotic Rat Induced by Bile Duct Ligation and Scission. Pharm Toxicol Pharm. 2000;23:501–6.

    Google Scholar 

  62. Park SH, Sung Y, Nho KJ, Kyoung H. Anti-atherosclerotic effects of Polygonum aviculare L. ethanol extract in ApoE knock-out mice fed a Western diet mediated via the MAPK pathway. J Ethnopharmacol. 2014;151:1109–15.

    Article  Google Scholar 

  63. Roh C, Jung U. Screening of crude plant extracts with anti-obesity activity. Int J Mol Sci. 2012;13:1710–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Ben SA, Harzallah-skhiri F, Aouni M. Investigation of Some Medicinal Plants from Tunisia for Antimicrobial Activities. Pharm Biol. 2007;45:421–8.

    Article  Google Scholar 

  65. Salama HMH, Marraiki N. Antimicrobial activity and phytochemical analyses of Polygonum aviculare L. (Polygonaceae), naturally growing in Egypt. Saudi J Biol Sci. 2010;17:57–63.

    Article  CAS  PubMed  Google Scholar 

  66. Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, et al. Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs. Asian Pac J Trop Med. 2013;6:673–81.

    Article  PubMed  Google Scholar 

  67. Do JR, Kim KJ, Park SY, Lee OH, Kim BS, Kang S. Antimicrobial and Antioxidant Activities of Exstract of Medicinal Plants. J Food Nutr. 2005;10:81–7.

    Google Scholar 

  68. Millar BC, Rao JR, Moore JE. Fighting antimicrobial resistance (AMR): Chinese herbal medicine as a source of novel antimicrobials – an update. Lett Appl Microbiol. 2021;73:400–7.

    Article  CAS  PubMed  Google Scholar 

  69. Zhou GY, Yi YX, Jin LX, Lin W, Fang PP, Lin XZ, et al. The protective effect of juglanin on fructose-induced hepatitis by inhibiting inflammation and apoptosis through TLR4 and JAK2/STAT3 signaling pathways in fructose-fed rats. Biomed Pharmacother. 2016;81:318–28.

    Article  CAS  PubMed  Google Scholar 

  70. Czemerys R, Oszmian J. Food Chemistry Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chem. 2007;105:940–9.

    Article  Google Scholar 

  71. Ravipati AS, Zhang L, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, et al. Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content. BMC Complementary Alternative Med. 2012;12:5–10.

    Article  Google Scholar 

  72. Gan RY, Kuang L, Xu XR, Zhang Y, Xia EQ, Song FL, et al. Screening of natural antioxidants from traditional Chinese medicinal plants associated with treatment of rheumatic disease. Molecules 2010;15:5988–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Hsu C. Antioxidant activity of extract from Polygonum aviculare L. Biol Res. 2006;93:281–8.

    Google Scholar 

  74. Granica S, Czerwi ME, Barbara Ż, Kiss AK. Fitoterapia Antioxidant and anti-infl ammatory fl avonol glucuronides from. Fitoterapia 2013;91:180–8.

    Article  CAS  PubMed  Google Scholar 

  75. Telichowska A, Kucharska A, Kobus-cisowska J, Betka M, Szulc P, Stachowiak B. Evaluation of antioxidation properties of natural polyphenol water extracts from selected plants in a model system. J Res Appl Agric Eng. 2021;66:25–9.

    Google Scholar 

  76. Farahani ZK. The effect of extraction method (ultrasonic, maceration, and soxhlet) and solvent type on the extraction rate of phenolic compounds and extraction efficiency of Arctium lappa L. roots and Polygonum aviculare L. grass. Food Heal. 2021;4:28–34.

    Google Scholar 

  77. Mahmoudi M, Abdellaoui R, Feki E, Boughalleb F, Zaidi S, Nasri N. Analysis of Polygonum Aviculare and Polygonum Maritimum for Minerals by Flame Atomic Absorption Spectrometry (FAAS), Polyphenolics by High-Performance Liquid Chromatography-Electrospray Ionization–Mass Spectrometry (HPLC-ESI-MS), and Antioxidant Properties by spectrophotometry. Anal Lett. 2021;54:2940–55.

    Article  CAS  Google Scholar 

  78. Nugroho A, Kim EJ, Choi JS, Park HJ. Simultaneous quantification and peroxynitrite-scavenging activities of flavonoids in Polygonum aviculare L. herb. J Pharm Biomed Anal. 2014;89:93–8. https://doi.org/10.1016/j.jpba.2013.10.037.

    Article  CAS  PubMed  Google Scholar 

  79. Cai Y, Wu L, Lin X, Hu X, Wang L. Phenolic profiles and screening of potential α-glucosidase inhibitors from Polygonum aviculare L. leaves using ultra-filtration combined with HPLC-ESI-qTOF-MS/MS and molecular docking analysis. Ind Crops Prod. 2020;154:112673 https://doi.org/10.1016/j.indcrop.2020.112673.

    Article  CAS  Google Scholar 

  80. Park JY, Kim CS, Park KM, Chang PS. Inhibitory characteristics of flavonol-3-O-glycosides from Polygonum aviculare L. (common knotgrass) against porcine pancreatic lipase. Sci Rep. 2019;9:1–10. https://doi.org/10.1038/s41598-019-54546-8.

    Article  CAS  Google Scholar 

  81. Xing X, Chun C, Qiang H, Xiong F, Rui-Hai L. Investigation into the mechanisms of quercetin-3-: O -glucuronide inhibiting α-glucosidase activity and non-enzymatic glycation by spectroscopy and molecular docking. Food Funct. 2021;12:7825–35. https://doi.org/10.1039/d1fo01042e.

    Article  CAS  PubMed  Google Scholar 

  82. Yang HH, Hwangbo K, Zheng MS, Cho JH, Son JK, Kim HY, et al. Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts. Arch Pharm Res. 2015;38:876–84.

    Article  CAS  PubMed  Google Scholar 

  83. Kwon SS, Kim SY, Kong BJ, Kim KJ, Noh GY, Im NR, et al. Cell penetrating peptide conjugated liposomes as transdermal delivery system of Polygonum aviculare L. extract. Int J Pharm. 2015;483:26–37.

    Article  CAS  PubMed  Google Scholar 

  84. Bnouham M, Mekhfi H, Legssyer A. Ethnopharmacology Forum Medicinal plants used in the treatment of diabetes in Morocco Ethnopharmacology Forum Medicinal plants used in the treatment of diabetes in Morocco. Int J Diabetes Metab. 2002;10:33–50.

    Google Scholar 

  85. Said O, Khalil K, Fulder S, Azaizeh H. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region. J Ethnopharmacol. 2002;83:251–65.

    Article  CAS  PubMed  Google Scholar 

  86. Kayani S, Ahmad M, Sultana S, Khan Z. Ethnobotany of medicinal plants among the communities of Alpine and Sub-alpine regions of Pakistan. J Ethnopharmacol. 2015;164:186–202.

    Article  PubMed  Google Scholar 

  87. Ma M, Djurdjevi L, Mitrovi M, Kosti O, Karad B, Pavlovi P. An ethnobotanical survey of traditionally used plants on Suva planina mountain (south-eastern Serbia). J Ethnopharmacol. 2015;175:93–108.

    Article  Google Scholar 

  88. Matejić JS, Stefanović N, Ivković M, Živanović N, Marin PD, Džamić AM. Traditional uses of autochthonous medicinal and ritual plants and other remedies for health in Eastern and South-Eastern Serbia. J Ethnopharmacol. 2020; 261;113–186.

  89. Ballabh B, Chaurasia OP, Ahmed Z, Singh SB. Traditional medicinal plants of cold desert Ladakh — Used against kidney and urinary disorders. J Ethnopharmacol. 2008;118:331–9.

    Article  PubMed  Google Scholar 

  90. Darias V, Bravo L, Barquin E, Herrera DM, Fraile C, Farmacia D. Contribution to the ethnopharmacological the canary islands study of Canary islands. J Ethnopharmacol. 1986;15:169–93.

    Article  CAS  PubMed  Google Scholar 

  91. Molan A, Faraj AM, Mahdy AS. Antioxidant activity and phenolic content of some medicinal plants traditionally used in Northern Iraq. Phytopharmacoloy. 2012;2:224–33.

    Google Scholar 

  92. Shin Y-S. Medicinal Plants in Mongolia. In: Flora of North America. 2013. p. 169–72. Published by WHO Regional Office for the Western Pacific.

  93. Neves JM, Matos C, Moutinho C, Queiroz G, Gomes LR. Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal). J Ethnopharmacol. 2009;124:270–83.

    Article  PubMed  Google Scholar 

  94. Altundag E, Ozturk M. Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia - Soc Behav Sci. 2011;19:756–77.

    Article  Google Scholar 

  95. Sargin SA, Selvi S, López V. Ethnomedicinal plants of Sarigöl district (Manisa), Turkey. J Ethnopharmacol. 2015;171:64–84.

    Article  PubMed  Google Scholar 

  96. Cakilcioglu U, Khatun S, Turkoglu I, Hayta S. Ethnopharmacological survey of medicinal plants in Maden (Elazig-Turkey). J Ethnopharmacol. 2011;137:469–86.

  97. Leto C, Tuttolomondo T, La Bella S, Licata M. Ethnobotanical study in the Madonie Regional Park (Central Sicily, Italy) - Medicinal use of wild shrub and herbaceous plant species. J Ethnopharmacol. 2013;146:90–12.

    Article  PubMed  Google Scholar 

  98. Sezik E, Yesilada E, Shadidoyatov H, Kulivey Z, Nigmatullaev AM, Aripov HN, et al. Folk medicine in Uzbekistan: I. Toshkent, Djizzax, and Samarqand provinces. J Ethnopharmacol. 2004;92:197–207.

    Article  PubMed  Google Scholar 

  99. Ardalani H. Ethnomedicinal plants of Farouj district, North Khorasan province, Iran Atena. J Herb Drug. 2016;7:9–13.

    Google Scholar 

  100. Marc EB, Nelly A, Annick DD, Frederic D. Plants used as remedies antirheumatic and antineuralgic in the traditional medicine of Lebanon. J Ethnopharmacol. 2008;120:315–34.

    Article  Google Scholar 

  101. Al-Hazimi HMA, Haque SN. A new naphthoquinone from Polygonum aviculare. Nat Prod Lett. 2002;16:115–8.

    Article  CAS  PubMed  Google Scholar 

  102. Futuro DO, Ferreira PG, Nicoletti CD, Borba LP. The Antifungal Activity of Naphthoquinones: An Integrative Review. Acad Bras Cienc. 2018;90:1187–214.

    Article  CAS  Google Scholar 

  103. Mone NS, Bhagwat SA, Sharma D, Chaskar M, Patil RH, Zamboni P, et al. Naphthoquinones and Their Derivatives: Emerging Trends in Combating Microbial Pathogens. Coatings 2021;11:434.

    Article  CAS  Google Scholar 

  104. Hyun H, Kyoung Y, Ming H, Zheng S, Hee J. Quercetin-3- O - b - D -glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells. Arch Pharm Res. 2014;37:1219–233.

    Article  Google Scholar 

  105. Smolarz HD. Flavonoid glycosides in nine Polygonum L.Taxons. Acta Soc Bot Pol. 2002;71:29–33.

    Article  CAS  Google Scholar 

  106. Kutovaya AM, Davydova VN, Perova IB, Eller KI. Flavonoid-profile determination for a hypoglycemic collection by high-performance liquid chromatography. Fine Chem Technol. 2020;15:39–46.

    Article  CAS  Google Scholar 

  107. Huang W, Fu L, Li C, Xu L, Zhang L, Zhang W. Quercetin, Hyperin, and Chlorogenic Acid Improve Endothelial Function by Antioxidant, Antiinflammatory, and ACE Inhibitory Effects. J Food Sci. 2017;82:1239–46.

    Article  CAS  PubMed  Google Scholar 

  108. Han X, Jiang Y, Liu N, Wu J, Yang J, Li Y, et al. Biomedicine & Pharmacotherapy Protective effects of Astragalin on spermatogenesis in streptozotocin- induced diabetes in male mice by improving antioxidant activity and inhibiting inflammation. Biomed Pharmacother. 2019;110:561–70.

    Article  CAS  PubMed  Google Scholar 

  109. Theofylaktou D, Takan I, Karakülah G, Biz GM, Zanni V, Pavlopoulou A, and Georgakilas, Alexandros G. Mining Natural Products with Anticancer Biological Activity through a Systems Biology Approach. Oxidative medicine and cellular longevity. 2021;2021.

  110. Smolarz HD, Budzianowski J, Kocki J, Mendyk E. Flavonoid Glucuronides with Anti-leukaemic Activity from Polygonum amphibium L. Phytochem Anal. 2008;513:506–13.

    Article  Google Scholar 

  111. Joaquín J, Di PR, Santos-buelga AMGC. Preparation of quercetin glucuronides and characterization by HPLC – DAD – ESI / MS. Eur Food Res Technol. 2008;227:1069–76.

    Article  Google Scholar 

  112. Hyoung JK, Eun-R W, Hokoon P. A novel lignan and flavonoids from Polygonum aviculare. J Nat Prod. 1994;57:581–6.

    Article  Google Scholar 

  113. Lee D, Lee YH, Lee KH, Lee BS, Alishir A. Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through. Molecules 2020;25:1708.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. Kim CS, Subedi L, Kim SY, Choi SU, Kim KH, Lee KR. Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities. J Nat Prod. 2015;67:7–11.

    Google Scholar 

  115. Hyun K, Moon E, Yeou S, Un S, Ro K. Lignan constituents of Tilia amurensis and their biological evaluation on antitumor and anti-inflammatory activities. FOOD Chem Toxicol [Internet]. 2012;50:3680–6. https://doi.org/10.1016/j.fct.2012.07.014.

    Article  CAS  Google Scholar 

  116. Aneta W, Jan Oszmianski RC. Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chem. 2007;105:940–9.

    Article  Google Scholar 

  117. Jiang R, Lau K, Hon P, Mak TCW, Woo K. Chemistry and Biological Activities of Caffeic Acid Derivatives from Salvia miltiorrhiza. Curr Med Chem. 2005;12:237–46.

    Article  CAS  PubMed  Google Scholar 

  118. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 2004;74:2157–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  119. Srinivas G, Babykutty S, Sathiadevan PP, Srinivas P. Molecular Mechanism of Emodin Action: Transition from Laxative Ingredient to an AntitumorAgent. Med Res Rev. 2006;27:591–608.

    Article  Google Scholar 

  120. Ambavade SD, Ashwini V. Pharmacological, nutritional, and analytical aspects of β -sitosterol: a review. Orient Pharm Exp Med. 2014;14:193–11.

    Article  Google Scholar 

  121. José MC, Sara Ramos-R JS. Oleanolic Acid: Extraction, Characterization and Biological Activity. Nutrients 2022;14:1–29.

    Google Scholar 

  122. Yunuskhodzhaeva NA, Abdullabekova VN. Polysaccharide composition of Polygonum hydropiperis and P. aviculare. Chemistry of natural compounds. 2006;42:600–1.

  123. Sakoguchi H, Yoshihara A, Shintani T, Okuma K, Izumori K, Sato M. Bioorganic & Medicinal Chemistry Letters Growth inhibitory effect of D -arabinose against the nematode Caenorhabditis elegans: discovery of a novel bioactive monosaccharide. Bioorg Med Chem Lett [Internet]. 2016;26:726–9. https://doi.org/10.1016/j.bmcl.2016.01.007.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Authors are expected to present author contributions statement to their paper such as; KB: Investigation, Resources, and Writing—original draft. MD: Investigation, Resources, and Writing, Formal analysis. OElG: Investigation, Resources, and Writing, Formal analysis. HNM: Investigation, Resources, and Writing. YC: Visualization, Formal Analysis, Supervision. MElAF: Visualization, Formal Analysis, Supervision.

Corresponding author

Correspondence to Kaoutar Benrahou.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Benrahou, K., Driouech, M., El Guourrami, O. et al. Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review. Med Chem Res 32, 409–423 (2023). https://doi.org/10.1007/s00044-023-03021-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00044-023-03021-1

Keywords

Navigation