Abstract
It has been shown that polymorphism is the reason for the occurrence of (+)N-tosyl-L-glutamic acid 1 with various melting points. 1 occurs in two crystalline forms: α and β. Form α-1 (prisms) having a melting point of 145–147°C is chemically pure and stable. Form β-1, however, is unstable and is formed as a result of the stabilizing effect of an organic solvent not introduced into the structure of the crystal. At about 125°C the β forms is transformed to the α form. The melting point of the β form depends on the amount and type of solvent contained in the crystal, which, during measurement cannot leave the system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
P. Bergell, Z. Physiol. Chem., 104 (1994) 182.
K. Sakota, K. Koine and O. Okita, Nippon Kagaku Zasshi, 90 (1969) 77.
F. Goodman, Biochemistry, 3 (1964) 1529.
P. Badyopadhyay, Indian J. Chem. Sect. A, 19 (1980) 10, 920.
C. R. Harington and R. C. Moggridge, J. Chem. Soc., (1940) 706.
N. M. Nandi, J. Choudhury and S. Tarat, Indian J. Chem. Sect. A, 29 (1990) 3, 288.
E. Knoop and H. Oesterlin, Z. Physiol. Chem., 170 (1927) 205.
J. Rudinger and K. Poduska, Collect. Czech. Chem. Commun., 24 (1959) 2013.
J. Rudinger, Collect. Czech. Chem. Commun., 19 (1954) 366.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hajmowicz, H., Synoradzki, L., Bujnowski, K. et al. Polymorphism of (+)N-tosyl-L-glutamic acid. Journal of Thermal Analysis 48, 1385–1392 (1997). https://doi.org/10.1007/BF01983449
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01983449