Abstract
There are at least eight aquaporins (AQPs) expressed in the kidney. Including AQP1 expressed in proximal tubules, thin descending limb of Henle and vasa recta; AQP2, AQP3, AQP4, AQP5, and AQP6 expressed in collecting ducts; AQP7 expressed in proximal tubules; AQP8 expressed in proximal tubules and collecting ducts; and AQP11 expressed in the endoplasmic reticulum of proximal tubular epithelial cells. Over years, researchers have constructed different AQP knockout mice and explored the effect of AQP knockout on kidney function. Thus, the roles of AQPs in renal physiology are revealed, providing very useful information for addressing fundamental questions about transepithelial water transport and the mechanism of near isoosmolar fluid reabsorption. This chapter introduces the localization and function of AQPs in the kidney and their roles in different kidney diseases to reveal the prospects of AQPs in further basic and clinical studies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Field M, Pollock C, Harris D (2011) Basic science and clinical conditions. Renal Syst 2011:1–44
Kortenoeven MLA, Fenton RA (2014) Renal aquaporins and water balance disorders. Biochim Biophys Acta 1840:1533–1549
Michalek K (2016) Aquaglyceroporins in the kidney: present state of knowledge and prospects. J Physiol Pharmacol 67:185–193
Nielsen S, Frør J, Knepper MA (1998) Renal aquaporins: key roles in water balance and water balance disorders. Curr Opin Nephrol Hypertens 7:509–516
Verkman AS (1998) Role of aquaporin water channels in kidney and lung. Am J Med Sci 316:310–320
Yamamoto T, Sasaki S (1998) Aquaporins in the kidney: emerging new aspects. Kidney Int 54:1041–1051
Spector DA, Wade JB, Dillow R, Steplock DA, Weinman EJ (2002) Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Am J Physiol Renal Physiol 282:1034–1042
Spector DA, Yang Q, Liu J, Wade JB (2004) Expression, localization, and regulation of urea transporter B in rat urothelia. Am J Physiol Renal Physiol 287:F102–F1F8
Verkman AS, Shi LB, Frigeri A, Hasegawa H, Farinas J, Mitra A, Skach W, Brown D, Van Hoek AN, Ma T (1995) Structure and function of kidney water channels. Kidney Int 48:1069–1081
Seyahian EA, Cacciagiu L, Damiano AE, Zotta E (2020) AQP1 expression in the proximal tubule of diabetic rat kidney. Heliyon 6:e03192
Nielsen S, Pallone T, Smith BL, Christensen EI, Agre P, Maunsbach AB (1995) Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 268:1023–1037
Maeda Y, Smith BL, Agre P, Knepper MA (1995) Quantification of aquaporin-CHIP water channel protein in microdissected renal tubules by fluorescence-based ELISA. J Clin Investig 95:422–428
Mobasheri A, Marples D (2004) Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology. Am J Physiol Cell Physiol 286:529–537
Christensen BM, Marples D, Jensen UB, Frøkiaer J, Sheikh-Hamad D, Knepper M, Nielsen S (1998) Acute effects of vasopressin V2-receptor antagonist on kidney AQP2 expression and subcellular distribution. Am J Physiol Renal Physiol 275:285–297
Marples D, Knepper MA, Christensen EI, Nielsen S (1995) Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct. Am J Physiol Cell Physiol 269:655–664
Olesen ETB, Fenton RA (2021) Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases. Nat Rev Nephrol 17:765–781
Mobasheri A, Wray S, Marples D (2005) Distribution of AQP2 and AQP3 water channels in human tissue microarrays. J Mol Histol 36:1–14
He J, Yang B (2019) Aquaporins in renal diseases. Int J Mol Sci 20:366
Rubenwolf PC, Georgopoulos NT, Clements LA, Feather S, Holland P, Thomas DFM, Southgate J (2009) Expression and localisation of aquaporin water channels in human urothelium in situ and in vitro. Eur Urol 56:1013–1024
Deen PM, Van Os CH (1998) Epithelial aquaporins. Curr Opin Cell Biol 10:435–442
Kim YH, Earm JH, Ma T, Verkman AS, Knepper MA, Madsen KM, Kim J (2001) Aquaporin-4 expression in adult and developing mouse and rat kidney. J Am Soc Nephrol 12:1795–1804
Terris J, Ecelbarger CA, Marples D, Knepper MA, Nielsen S (1995) Distribution of aquaporin-4 water channel expression within rat kidney. Am J Physiol 269:775–785
Van Hoek AN, Ma T, Yang B, Verkman AS, Brown D (2000) Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am J Physiol Renal Physiol 278:310–316
Yang B, Brown D, Verkman AS (1996) The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells. J Biol Chem 271:4577–4580
Procino G, Mastrofrancesco L, Sallustio F, Costantino V, Barbieri C, Pisani F, Schena FP, Svelto M, Valenti G (2011) AQP5 is expressed in type-B intercalated cells in the collecting duct system of the rat, mouse and human kidney. Cell Physiol Biochem 28:683–692
Yasui M, Kwon TH, Knepper MA, Nielsen S, Agre P (1999) Aquaporin-6: an intracellular vesicle water channel protein in renal epithelia. Proc Natl Acad Sci U S A 96:5808–5813
Yasul M, Hazama A, Kwon TH, Nielsen S, Guggino WB, Agre P (1999) Rapid gating and artion permeability of an intracellular aquaporin. Nature 402:184–187
Ishibashi K, Imai M, Sasaki S (2000) Cellular localization of aquaporin 7 in the rat kidney. Exp Nephrol 8:252–257
Nejsum LN, Elkjar ML, Hager H, Frokiar J, Kwon TH, Nielsen S (2000) Localization of aquaporin-7 in rat and mouse kidney using RT-PCR, immunoblotting, and immunocytochemistry. Biochem Biophys Res Commun 277:164–170
Elkjær ML, Nejsum LN, Gresz V, Kwon TH, Jensen UB, Frøkiær J, Nielsen S (2001) Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways. Am J Physiol Renal Physiol 281:1047–1057
Nishimura H, Yang Y (2013) Aquaporins in avian kidneys: function and perspectives. Am J Physiol Regul Integr Comp Physiol 305:1201–1214
Ikeda M, Andoo A, Shimono M, Takamatsu N, Taki A, Muta K, Matsushita W, Uechi T, Matsuzaki T, Kenmochi N, Takata K, Sasaki S, Ito K, Ishibashi K (2011) The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function. J Biol Chem 286:3342–3350
Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S (2014) Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model. J Am Soc Nephrol 25:2789–2799
Morishita Y, Matsuzaki T, Hara-Chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K (2005) Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol 25:7770–7779
Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (1998) Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem 273:4296–4299
Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, Verkman AS (1998) Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci U S A 95:9660–9664
Verkman AS (2008) Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice. Semin Nephrol 28:217–226
Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS (1999) Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am J Physiol Cell Physiol 276:76–81
Yang B, Ma T, Dong JY, Verkman AS (2000) Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum Gene Ther 11:567–575
Cai Q, McReynolds MR, Keck M, Greer KA, Hoying JB, Brooks HL (2007) Vasopressin receptor subtype 2 activation increases cell proliferation in the renal medulla of AQP1 null mice. Am J Physiol Renal Physiol 293:1858–1864
Chou CL, Knepper MA, Van Hoek AN, Brown D, Yang B, Ma T, Verkman AS (1999) Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Investig 103:491–496
Moore LC, Marsh DJ (1980) How descending limb of Henle’s loop permeability affects hypertonic urine formation. Am J Physiol Renal Fluid Electrolyte Physiol 8:57–71
Knepper MA (1997) Molecular physiology of urinary concentrating mechanism: regulation of aquaporin water channels by vasopressin. Am J Physiol Renal Physiol 272:3–12
Jen JF, Stephenson JL (1994) Externally driven countercurrent multiplication in a mathematical model of the urinary concentrating mechanism of the renal inner medulla. Bull Math Biol 56:491–514
Tajika Y, Matsuzaki T, Suzuki T, Aoki T, Hagiwara H, Tanaka S, Kominami E, Takata K (2002) Immunohistochemical characterization of the intracellular pool of water channel aquaporin-2 in the rat kidney. Anat Sci Int 77:189–195
Wu Q, Moeller HB, Stevens DA, Sanchez-Hodge R, Childers G, Kortenoeven MLA, Cheng L, Rosenbaek LL, Rubel C, Patterson C, Pisitkun T, Schisler JC, Fenton RA (2018) CHIP regulates aquaporin-2 quality control and body water homeostasis. J Am Soc Nephrol 29:936–948
Noda Y, Sasaki S (2006) Regulation of aquaporin-2 trafficking and its binding protein complex. Biochim Biophys Acta Biomembr 1758:1117–1125
Zhang XY, Wang B, Guan YF (2016) Nuclear receptor regulation of aquaporin-2 in the kidney. Int J Mol Sci 17:1105
Trimpert C, Wesche D, de Groot T, Pimentel Rodriguez MM, Wong V, van den Berg DTM, Cheval L, Ariza CA, Doucet A, Stagljar I, Deen PMT (2017) NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation. PLoS One 12:e0183774
Moeller HB, Fuglsang CH, Pedersen CN, Fenton RA (2018) Basolateral cholesterol depletion alters Aquaporin-2 post-translational modifications and disrupts apical plasma membrane targeting. Biochem Biophys Res Commun 495:157–162
Bichet DG, Bockenhauer D (2016) Genetic forms of nephrogenic diabetes insipidus (NDI): Vasopressin receptor defect (X-linked) and aquaporin defect (autosomal recessive and dominant). Best Pract Res Clin Endocrinol Metab 30:263–276
Deen PMT, Verdijk MAJ, Knoers NVAM, Wieringa B, Monnens LAH, Van Os CH, Van Oost BA (1994) Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science 264:92–95
Rojek A, Füchtbauer EM, Kwon TH, Frøkiær J, Nielsen S (2006) Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A 103:6037–6042
Murali SK, Aroankins TS, Moeller HB, Fenton RA (2019) The deubiquitylase USP4 interacts with the water channel AQP2 to modulate its apical membrane accumulation and cellular abundance. Cell 8:265
Tingskov SJ, Choi HJ, Holst MR, Hu S, Li C, Wang W, Frokiaer J, Nejsum LN, Kwon TH, Norregaard R (2019) Vasopressin-independent regulation of aquaporin-2 by tamoxifen in kidney collecting ducts. Front Physiol 10:948
Wong KY, Wang WL, Su SH, Liu CF, Yu MJ (2020) Intracellular location of aquaporin-2 serine 269 phosphorylation and dephosphorylation in kidney collecting duct cells. Am J Physiol Renal Physiol 319:F592–F602
Procino G, Carmosino M, Tamma G, Gouraud S, Laera A, Riccardi D, Svelto M, Valenti G (2004) Extracellular calcium antagonizes forskolin-induced aquaporin 2 trafficking in collecting duct cells. Kidney Int 66:2245–2255
Sasaki S, Yui N, Noda Y (2014) Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model. Biochim Biophys Acta Biomembr 1838:514–520
Whiting JL, Ogier L, Forbush KA, Bucko P, Gopalan J, Seternes OM, Langeberg LK, Scott JD (2016) AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A 113:E4328–E4E37
Carney EF (2016) Cell biology: vasopressin-independent AQP2 trafficking. Nat Rev Nephrol 12:509
Fushimi K, Sasaki S, Marumo F (1997) Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel. J Biol Chem 272:14800–14804
Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Lu HAJ, Brown D, Bouley R (2016) EGF receptor inhibition by erlotinib increases aquaporin 2-mediated renal water reabsorption. J Am Soc Nephrol 27:3105–3116
Fenton RA, Moeller HB, Hoffert JD, Yu MJ, Nielsen S, Knepper MA (2008) Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin. Proc Natl Acad Sci U S A 105:3134–3139
Hoffert JD, Fenton RA, Moeller HB, Simons B, Tchapyjnikov D, McDill BW, Yu MJ, Pisitkun T, Chen F, Knepper MA (2008) Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. J Biol Chem 283:24617–24627
Park EJ, Kwon TH (2015) A minireview on vasopressin-regulated aquaporin-2 in kidney collecting duct cells. Electrolyte Blood Pressure 13:1–6
Hoffert JD, Pisitkun T, Saeed F, Song JH, Chou CL, Knepper MA (2012) Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics. Mol Cell Proteomics 11:014613
Ren H, Yang B, Ruiz JA, Efe O, Ilori TO, Sands JM, Klein JD (2016) Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. Am J Physiol Renal Physiol 311:F1189–F1F97
Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA (2006) Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci U S A 103:7159–7164
Hoffert JD, Nielsen J, Yu MJ, Pisitkun T, Schleicher SM, Nielsen S, Knepper MA (2007) Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol 292:F691–F700
Lu HJ, Matsuzaki T, Bouley R, Hasler U, Qin QH, Brown D (2008) The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol 295:F290–F2F4
Li S, Qiu M, Kong Y, Zhao X, Choi HJ, Reich M, Bunkelman BH, Liu Q, Hu S, Han M, Xie H, Rosenberg AZ, Keitel V, Kwon TH, Levi M, Li C, Wang W (2018) Bile acid G protein-coupled membrane receptor TGR5 modulates aquaporin 2-mediated water homeostasis. J Am Soc Nephrol 29:2658–2670
Luo R, Hu S, Liu Q, Han M, Wang F, Qiu M, Li S, Li X, Yang T, Fu X, Wang W, Li C (2019) Hydrogen sulfide upregulates renal AQP-2 protein expression and promotes urine concentration. FASEB J 33:469–483
Lei L, Huang M, Su L, Xie D, Mamuya FA, Ham O, Tsuji K, Paunescu TG, Yang B, Lu HAJ (2018) Manganese promotes intracellular accumulation of AQP2 via modulating F-actin polymerization and reduces urinary concentration in mice. Am J Physiol Renal Physiol 314:F306–FF16
Ando F, Sohara E, Morimoto T, Yui N, Nomura N, Kikuchi E, Takahashi D, Mori T, Vandewalle A, Rai T, Sasaki S, Kondo Y, Uchida S (2016) Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway. Nat Commun 7:13636
Jung HJ, Raghuram V, Lee JW, Knepper MA (2018) Genome-wide mapping of DNA accessibility and binding sites for CREB and C/EBPbeta in vasopressin-sensitive collecting duct cells. J Am Soc Nephrol 29:1490–1500
Noda Y, Sohara E, Ohta E, Sasaki S (2010) Aquaporins in kidney pathophysiology. Nat Rev Nephrol 6:168–178
Yang B, Ma T, Verkman AS (2001) Erythrocyte water permeability and renal function in double knock out mice lacking aquaporin-1 and aquaporin-3. J Biol Chem 276:624–628
Verbavatz JM, Ma T, Gobin R, Verkman AS (1997) Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4. J Cell Sci 110:2855–2860
Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (1997) Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Investig 100:957–962
Chou CL, Ma T, Yang B, Knepper MA, Verkman AS (1998) Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. Am J Physiol Cell Physiol 274:C549–CC54
Yang B, Van Hoek AN, Verkman AS (1997) Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4. Biochemistry 36:7625–7632
Karlberg L, Källskog Ö, Öjteg G, Wolgast M (1982) Renal medullary blood flow studied with the 86-Rb extraction method Methodological considerations. Acta Physiol Scand 115:11–18
Tamma G, Procino G, Svelto M, Valenti G (2012) Cell culture models and animal models for studying the patho-physiological role of renal aquaporins. Cell Mol Life Sci 69:1931–1946
Agre P, Preston GM, Smith BL, Jin Sup J, Raina S, Moon C, Guggino WB, Nielsen S (1993) Aquaporin CHIP: the archetypal molecular water channel. Am J Physiol Renal Fluid Electrolyte Physiol 265:F463–FF76
Hazama A, Kozono D, Guggino WB, Agre P, Yasui M (2002) Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation. J Biol Chem 277:29224–29230
Holm LM, Klaerke DA, Zeuthen T (2004) Aquaporin 6 is permeable to glycerol and urea. Pflugers Arch - Eur J Physiol 448:181–186
Promeneur D, Kwon TH, Yasui M, Kim GH, Frøkiæer J, Knepper MA, Agre P, Nielsen S (2000) Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance. Am J Physiol Renal Physiol 279:F1014–F1F26
Ohshiro K, Yaoita E, Yoshida Y, Fujinaka H, Matsuki A, Kamiie J, Kovalenko P, Yamamoto T (2001) Expression and immunolocalization of AQP6 in intercalated cells of the rat kidney collecting duct. Arch Histol Cytol 64:329–338
Rabaud NE, Song L, Wang Y, Agre P, Yasui M, Carbrey JM (2009) Aquaporin 6 binds calmodulin in a calcium-dependent manner. Biochem Biophys Res Commun 383:54–57
Madsen KM, Tisher CC (1984) Response of intercalated cells of rat outer medullary collecting duct to chronic metabolic acidosis. Lab Investig 51:268–276
Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M (2002) Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. J Biol Chem 277:39873–39879
Jun JG, Maeda S, Kuwahara-Otani S, Tanaka K, Hayakawa T, Seki M (2014) Expression of adrenergic and cholinergic receptors in murine renal intercalated cells. J Vet Med Sci 76:1493–1500
Sohara E, Rai T, Miyazaki JI, Verkman AS, Sasaki S, Uchida S (2005) Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol 289:F1195–FF200
Lin EC (1977) Glycerol utilization and its regulation in mammals. Annu Rev Biochem 46:765–795
Maeda N, Funahashi T, Hibuse T, Nagasawa A, Kishida K, Kuriyama H, Nakamura T, Kihara S, Shimomura I, Matsuzawa Y (2004) Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc Natl Acad Sci U S A 101:17801–17806
Sohara E, Rai T, Sasaki S, Uchida S (2006) Physiological roles of AQP7 in the kidney: Lessons from AQP7 knockout mice. Biochim Biophys Acta Biomembr 1758:1106–1110
Geyer RR, Musa-Aziz R, Qin X, Boron WF (2013) Relative CO2/NH3 selectivities of mammalian aquaporins 0-9. Am J Physiol Cell Physiol 304:C985–CC94
Zeuthen T, Litman T, Søgaard R (2009) Ammonia and urea permeability of mammalian aquaporins. Handb Exp Pharmacol 190:327–358
Koeppen BM (2009) The kidney and acid-base regulation. Am J Physiol Adv Physiol Educ 33:275–281
Yang B, Song Y, Zhao D, Verkman AS (2005) Phenotype analysis of aquaporin-8 null mice. Am J Physiol Cell Physiol 288:C1161–C1C70
Jahn TP, Møller ALB, Zeuthen T, Holm LM, Klærke DA, Mohsin B, Kühlbrandt W, Schjoerring JK (2004) Aquaporin homologues in plants and mammals transport ammonia. FEBS Lett 574:31–36
Saparov SM, Liu K, Agre P, Pohl P (2007) Fast and selective ammonia transport by aquaporin-8. J Biol Chem 282:5296–5301
Soria LR, Fanelli E, Altamura N, Svelto M, Marinelli RA, Calamita G (2010) Aquaporin-8-facilitated mitochondrial ammonia transport. Biochem Biophys Res Commun 393:217–221
Molinas SM, Trumper L, Marinelli RA (2012) Mitochondrial aquaporin-8 in renal proximal tubule cells: evidence for a role in the response to metabolic acidosis. Am J Physiol Renal Physiol 303:F458–FF66
Hoshino Y, Sonoda H, Nishimura R, Mori K, Ishibashi K, Ikeda M (2019) Involvement of the NADPH oxidase 2 pathway in renal oxidative stress in Aqp11 (-/-) mice. Biochem Biophys Rep 17:169–176
Li Q, Lu B, Yang J, Li C, Li Y, Chen H, Li N, Duan L, Gu F, Zhang J, Xia W (2021) Molecular characterization of an aquaporin-2 mutation causing nephrogenic diabetes insipidus. Front Endocrinol 12:665145
Ren H, Yang B, Molina PA, Sands JM, Klein JD (2015) NSAIDs alter phosphorylated forms of AQP2 in the inner medullary tip. PLoS One 10:e0141714
Schernthaner-Reiter MH, Stratakis CA, Luger A (2017) Genetics of diabetes insipidus. Endocrinol Metab Clin N Am 46:305–334
Mahia J, Bernal A (2021) Animal models for diabetes insipidus. Handb Clin Neurol 181:275–288
Eichet DG (1998) Nephrogenic diabetes insipidus. Am J Med 105:431–442
Marples D, Christensen S, Christensen EI, Ottosen PD, Nielsen S (1995) Lithium-induced downregulation of Aquaporin-2 water channel expression in rat kidney medulla. J Clin Investig 95:1838–1845
Tingskov SJ, Hu S, Frokiaer J, Kwon TH, Wang W, Norregaard R (2018) Tamoxifen attenuates development of lithium-induced nephrogenic diabetes insipidus in rats. Am J Physiol Renal Physiol 314:1020–1025
Dollerup P, Thomsen TM, Nejsum LN, Færch M, Österbrand M, Gregersen N, Rittig S, Christensen JH, Corydon TJ (2015) Partial nephrogenic diabetes insipidus caused by a novel AQP2 variation impairing trafficking of the aquaporin-2 water channel. BMC Nephrol 16:217
Klein N, Kümmerer N, Hobernik D, Schneider D (2015) The AQP2 mutation V71M causes nephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog. FEBS Open Biol 5:640–646
Tamarappoo BK, Verkman AS (1998) Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. J Clin Investig 101:2257–2267
Yang B, Ma T, Xu Z, Verkman AS (1999) cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics 57:79–83
Lin Y, Zhang T, Feng P, Qiu M, Liu Q, Li S, Zheng P, Kong Y, Levi M, Li C, Wang W (2017) Aliskiren increases aquaporin-2 expression and attenuates lithium-induced nephrogenic diabetes insipidus. Am J Physiol Renal Physiol 313:914–925
Sauer B (1998) Inducible gene targeting in mice using the Cre/lox system. Methods: A Companion to. Methods Enzymol 14:381–392
Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (2001) Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem 276:2775–2779
Yang B, Zhao D, Qian L, Verkman AS (2006) Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol 291:465–472
Yang B, Zhao D, Verkman AS (2009) Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. FASEB J 23:503–512
Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V (2010) Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. J Am Soc Nephrol 21:2059–2068
Rao R, Patel S, Hao C, Woodgett J, Harris R (2010) GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. J Am Soc Nephrol 21:428–437
Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S (2018) AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nat Commun 9:1411
Gao M, Cao R, Du S, Jia X, Zheng S, Huang S, Han Q, Liu J, Zhang X, Miao Y, Kang J, Gustafsson JA, Guan Y (2015) Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts. Proc Natl Acad Sci U S A 112:8397–8402
Suzuki T, Seki S, Hiramoto K, Naganuma E, Kobayashi EH, Yamaoka A, Baird L, Takahashi N, Sato H, Yamamoto M (2017) Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus. Nat Commun 8:14577
Hatem-Vaquero M, Griera M, Giermakowska W, Luengo A, Calleros L, Gonzalez Bosc LV, Rodriguez-Puyol D, Rodriguez-Puyol M, De Frutos S (2017) Integrin linked kinase regulates the transcription of AQP2 by NFATC3. Biochim Biophys Acta Gene Regul Mech 1860:922–935
Bonfrate L, Procino G, Wang DQ, Svelto M, Portincasa P (2015) A novel therapeutic effect of statins on nephrogenic diabetes insipidus. J Cell Mol Med 19:265–282
Preston GM, Smith BL, Zeidel ML, Moulds JJ, Agre P (1994) Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. Science 265:1585–1587
Bachinsky DR, Sabolic I, Emmanouel DS, Jefferson DM, Carone FA, Brown D, Perrone RD (1995) Water channel expression in human ADPKD kidneys. Am J Physiol Renal Fluid Electrolyte Physiol 268:398–403
Wang W, Li F, Sun Y, Lei L, Zhou H, Lei T, Xia Y, Verkman AS, Yang B (2015) Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling. FASEB J 29:1551–1563
Devuyst O (1998) The expression of water channels AQP1 and AQP2 in a large series of ADPKD kidneys. Nephron 78:116–117
Devuyst O, Burrow CR, Smith BL, Agre P, Knepper MA, Wilson PD (1996) Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease. Am J Physiol 271:169–183
Aboudehen K, Noureddine L, Cobo-Stark P, Avdulov S, Farahani S, Gearhart MD, Bichet DG, Pontoglio M, Patel V, Igarashi P (2017) Hepatocyte nuclear factor-1beta regulates urinary concentration and response to hypertonicity. J Am Soc Nephrol 28:2887–2900
Noitem R, Yuajit C, Soodvilai S, Muanprasat C, Chatsudthipong V (2018) Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation. Biomed Pharmacother 101:754–762
Wang W, Geng X, Lei L, Jia Y, Li Y, Zhou H, Verkman AS, Yang B (2019) Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease. FASEB J 33:6185–6196
Saito T, Tanaka Y, Morishita Y, Ishibashi K (2018) Proteomic analysis of AQP11-null kidney: Proximal tubular type polycystic kidney disease. Biochem Biophys Rep 13:17–21
Ohshiro K, Yaoita E, Yoshida Y, Fujinaka H, Matsuki A, Kamiie J, Kovalenko P, Yamamoto T (2001) Expression and immunto I, Ishibashi K, Sasaki S, Abe K (2008) Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation. FASEB J 22:3672–3684
Atochina-Vasserman EN, Biktasova A, Abramova E, Cheng DS, Polosukhin VV, Tanjore H, Takahashi S, Sonoda H, Foye L, Venkov C, Ryzhov SV, Novitskiy S, Shlonimskaya N, Ikeda M, Blackwell TS, Lawson WE, Gow AJ, Harris RC, Dikov MM, Tchekneva EE (2013) Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress. Am J Physiol Renal Physiol 304:1295–1307
Matsuzaki T, Yaguchi T, Shimizu K, Kita A, Ishibashi K, Takata K (2016) The distribution and function of aquaporins in the kidney: resolved and unresolved questions. Anat Sci Int 92:187–199
Wang W, Li C, Summer SN, Falk S, Wang W, Ljubanovic D, Schrier RW (2008) Role of AQP1 in endotoxemia-induced acute kidney injury. Am J Physiol Renal Physiol 294:F1473–F1480
Liu C, Li B, Tang K, Dong X, Xue L, Su G, Jin Y (2020) Aquaporin 1 alleviates acute kidney injury via PI3K-mediated macrophage M2 polarization. Inflamm Res 69:509–521
Hussein AA, El-Dken ZH, Barakat N, Abol-Enein H (2012) Renal ischaemia/reperfusion injury: possible role of aquaporins. Acta Physiol 204:308–316
Asvapromtada S, Sonoda H, Kinouchi M, Oshikawa S, Takahashi S, Hoshino Y, Sinlapadeelerdkul T, Yokota-Ikeda N, Matsuzaki T, Ikeda M (2018) Characterization of urinary exosomal release of aquaporin-1 and -2 after renal ischemia-reperfusion in rats. Am J Physiol Renal Physiol 314:F584–F601
Fan Y, Ma M, Feng X, Song T, Wei Q, Lin T (2021) Overexpression of aquaporin 2 in renal tubular epithelial cells alleviates pyroptosis. Transl Androl Urol 10:2340–2350
Chan MJ, Chen YC, Fan PC, Lee CC, Kou G, Chang CH (2022) Predictive value of urinary aquaporin 2 for acute kidney injury in patients with acute decompensated heart failure. Biomedicine 10:613
Lei L, Wang W, Jia Y, Su L, Zhou H, Verkman AS, Yang B (2017) Aquaporin-3 deletion in mice results in renal collecting duct abnormalities and worsens ischemia-reperfusion injury. Biochim Biophys Acta Mol basis Dis 1863:1231–1241
Abo-Elmaaty AMA, Behairy A, El-Naseery NI, Abdel-Daim MM (2020) The protective efficacy of vitamin E and cod liver oil against cisplatin-induced acute kidney injury in rats. Environ Sci Pollut Res Int 27:44412–44426
Li J, Zhang M, Mao Y, Li Y, Zhang X, Peng X, Yu F (2018) The potential role of aquaporin 1 on aristolochic acid I induced epithelial mesenchymal transition on HK-2 cells. J Cell Physiol 233:4919–4925
Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R (2015) Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med 21:998–1009
Ampawong S, Klincomhum A, Likitsuntonwong W, Singha O, Ketjareon T, Panavechkijkul Y, Zaw KM, Kengkoom K (2012) Expression of aquaporin-1, -2 and -4 in mice with a spontaneous mutation leading to hydronephrosis. J Comp Pathol 146:332–337
Wang W, Luo R, Lin Y, Wang F, Zheng P, Levi M, Yang T, Li C (2015) Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome. Am J Physiol Renal Physiol 308:910–922
Liu N, Zhang Y, Su H, Wang J, Liu Z, Kong J (2018) Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction. Biomed Pharmacother 102:633–638
MacManes MD (2017) Severe acute dehydration in a desert rodent elicits a transcriptional response that effectively prevents kidney injury. Am J Physiol Renal Physiol 313:262–272
Li ZZ, Xing L, Zhao ZZ, Li JS, Xue R, Chandra A, Nørregaard R, Wen JG (2012) Decrease of renal aquaporins 1-4 is associated with renal function impairment in pediatric congenital hydronephrosis. World J Pediatr 8:335–341
Procino G, Romano F, Torielli L, Ferrari P, Bianchi G, Svelto M, Valenti G (2011) Altered expression of renal aquaporins and α-adducin polymorphisms may contribute to the establishment of salt-sensitive hypertension. Am J Hypertens 24:822–828
King LS, Agre P (1996) Pathophysiology of the aquaporin water channels. Annu Rev Physiol 58:619–648
Liu J, Zhang WY, Ding DG (2015) Expression of aquaporin 1 in bladder uroepithelial cell carcinoma and its relevance to recurrence. Asian Pac J Cancer Prev 16:3973–3976
Morrissey JJ, Mobley J, Figenshau RS, Vetter J, Bhayani S, Kharasch ED (2015) Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer. Mayo Clin Proc 90:35–42
Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS (2005) Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 434:786–792
Kourghi M, Pei JV, De Ieso ML, Nourmohammadi S, Chow PH, Yool AJ (2018) Fundamental structural and functional properties of aquaporin ion channels found across the kingdoms of life. Clin Exp Pharmacol Physiol 45:401–409
Mazal PR, Exner M, Haitel A, Krieger S, Thomson RB, Aronson PS, Susani M (2005) Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol 36:22–28
Mobasheri A, Airley R, Hewitt SM, Marples D (2005) Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: a study using high density multiple human tumor tissue microarrays. Int J Oncol 26:1149–1158
Yu S, Li LH, Lee CH, Jeyakannu P, Wang JJ, Hong CH (2021) Arsenic leads to autophagy of keratinocytes by increasing aquaporin 3 expression. Sci Rep 11:17523
Tan MH, Wong CF, Tan HL, Yang XJ, Ditlev J, Matsuda D, Khoo SK, Sugimura J, Fujioka T, Furge KA, Kort E, Giraud S, Ferlicot S, Vielh P, Amsellem-Ouazana D, Debré B, Flam T, Thiounn N, Zerbib M, Benoît G, Droupy S, Molinié V, Vieillefond A, Tan PH, Richard S, Teh BT (2010) Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. BMC Cancer 10:196
Yusenko MV, Zubakov D, Kovacs G (2009) Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours. Int J Biol Sci 5:517–527
Rocchetti MT, Tamma G, Lasorsa D, Suriano IV, D’Apollo A, Papale M, Mastrofrancesco L, Grandaliano G, Svelto M, Valenti G, Gesualdo L, Di Paolo S (2011) Altered urinary excretion of aquaporin 2 in IgA nephropathy. Eur J Endocrinol 165:657–664
Rodionova EA, Kuznetsova AA, Shakhmatova EI, Prutskova N, Nielsen S, Holtback U, Natochin Y, Zelenina M (2006) Urinary aquaporin-2 in children with acute pyelonephritis. Pediatr Nephrol 21:361–367
Landegren N, Pourmousa Lindberg M, Skov J, Hallgren A, Eriksson D, Lisberg Toft-Bertelsen T, MacAulay N, Hagforsen E, Raisanen-Sokolowski A, Saha H, Nilsson T, Nordmark G, Ohlsson S, Gustafsson J, Husebye ES, Larsson E, Anderson MS, Perheentupa J, Rorsman F, Fenton RA, Kampe O (2016) Autoantibodies targeting a collecting duct-specific water channel in tubulointerstitial nephritis. J Am Soc Nephrol 27:3220–3228
Gao C, Zhang W (2019) Urinary AQP5 is independently associated with eGFR decline in patients with type 2 diabetes and nephropathy. Diabetes Res Clin Pract 155:107805
Rossi L, Nicoletti MC, Carmosino M, Mastrofrancesco L, Di Franco A, Indrio F, Lella R, Laviola L, Giorgino F, Svelto M, Gesualdo L, Procino G (2017) Urinary excretion of kidney aquaporins as possible diagnostic biomarker of diabetic nephropathy. J Diabetes Res 2017:4360357
Han B, Wu X, Huang PP, Zhu FX, Liu S (2019) Aquaporin 11 rs2276415 variant and progression of chronic kidney disease. Nephrol Dial Transplant 34:970–973
Acknowledgments
The work was supported by the National Natural Science Foundation of China grants 81974083, 81620108029, 81330074 and the Beijing Natural Science Foundation grant 7212151.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Qiu, Z., Jiang, T., Li, Y., Wang, W., Yang, B. (2023). Aquaporins in Urinary System. In: Yang, B. (eds) Aquaporins. Advances in Experimental Medicine and Biology, vol 1398. Springer, Singapore. https://doi.org/10.1007/978-981-19-7415-1_11
Download citation
DOI: https://doi.org/10.1007/978-981-19-7415-1_11
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-7414-4
Online ISBN: 978-981-19-7415-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)