Skip to main content
SpringerLink
Log in

Time to Eliminate “Normal Tension” in Primary Open-Angle Glaucoma

  • Chapter
  • First Online:
Intraocular and Intracranial Pressure Gradient in Glaucoma

Part of the book series: Advances in Visual Science and Eye Diseases ((AVSED,volume 1))

Abstract

Glaucoma affects more than 70 million people worldwide with approximately 10% being bilaterally blind. It is the leading cause of irreversible blindness in the world [1]. Primary open-angle glaucoma (POAG), perhaps the most common type of glaucoma, is an optic neuropathy characterized by an accelerated loss of retinal ganglion cells [2]. There is a characteristic excavated appearance of the optic disc associated with visual field loss.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311(18):1901–11.

    Article  Google Scholar 

  2. Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004;363(9422):1711–20.

    Article  Google Scholar 

  3. Hollands H, Johnson D, Hollands S, Simel DL, Jinapriya D, Sharma S. Do findings on routine examination identify patients at risk for primary open-angle glaucoma? JAMA. 2013;309(19):2035–42.

    Article  CAS  Google Scholar 

  4. Lee BL, Bathija R, Weinreb RN. The definition of normal-tension glaucoma. J Glaucoma. 1998;7(6):366–71.

    Article  CAS  Google Scholar 

  5. Sommer A. Ocular hypertension and normal-tension glaucoma: time for banishment and burial. Arch Ophthalmol. 2011;129(6):785–7.

    Article  Google Scholar 

  6. Von Graefe A. Uber die iridectomie bei glaucoma und uber den glaucomatosen prozess. Graefes Arch Clin Exp Ophthalmol. 1857;3:456–65.

    Article  Google Scholar 

  7. Von Graefe A. Uber die glaucomatose Natur der “Amaurosen mit Sehnervenexkavation” und uber das Wesen und die Classification des Glaucoms. Graefe. Arch Ophthalmol. 1862;8:271.

    Google Scholar 

  8. Schiotz H. Ein neuer Tonometer: Tonometrie. Arch Augenheilkd. 1905;52:401.

    Google Scholar 

  9. Pickard R. Glaucoma and low tension disc cup enlargements. Br J Ophthalmol. 1931;15(6):323–33.

    Article  CAS  Google Scholar 

  10. Drance SM, Sweeney VP, Morgan RW, Feldman F. Studies of factors involved in the production of low tension glaucoma. Arch Ophthalmol. 1973;89(6):457–65.

    Article  CAS  Google Scholar 

  11. Drance SM, Morgan RW, Sweeney VP. Shock-induced optic neuropathy: a cause of nonprogressive glaucoma. N Engl J Med. 1973;288(8):392–5.

    Article  CAS  Google Scholar 

  12. King D, Drance SM, Douglas G, Schulzer M, Wijsman K. Comparison of visual field defects in normal-tension glaucoma and high-tension glaucoma. Am J Ophthalmol. 1986;101(2):204–7.

    Article  CAS  Google Scholar 

  13. Cartwright MJ, Anderson DR. Correlation of asymmetric damage with asymmetric intraocular pressure in normal-tension glaucoma (low-tension glaucoma). Arch Ophthalmol. 1988;106(7):898–900.

    Article  CAS  Google Scholar 

  14. Shields MB. Textbook of glaucoma. Lippincott, Williams & Wilkins, 1992.

    Google Scholar 

  15. Hollows FC, Graham PA. Intra-ocular pressure, glaucoma, and glaucoma suspects in a defined population. Br J Ophthalmol. 1966;50(10):570–86.

    Article  CAS  Google Scholar 

  16. Jonas JB, Wang N, Yang D, Ritch R, Panda-Jonas S. Facts and myths of cerebrospinal fluid pressure for the physiology of the eye. Prog Retin Eye Res. 2015;46:67–83.

    Article  Google Scholar 

  17. Zhang Z, Liu D, Jonas JB, Wu S, Kwong JM, Zhang J, Liu Q, Li L, Lu Q, Yang D, Wang J, Wang N. Axonal transport in the rat optic nerve following short-term reduction in cerebrospinal fluid pressure or elevation in intraocular pressure. Invest Ophthalmol Vis Sci. 2015;56(8):4257–66.

    Article  Google Scholar 

  18. Ren R, Jonas JB, Tian G, Zhen Y, Ma K, Li S, Wang H, Li B, Zhang X, Wang N. Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology. 2010;117(2):259–66.

    Article  Google Scholar 

  19. Wang N, Xie X, Yang D, Xian J, Li Y, Ren R, Peng X, Jonas JB, Weinreb RN. Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study. Ophthalmology. 2012;119(10):2065–73.

    Article  Google Scholar 

  20. Liu H, Yang D, Ma T, Shi W, Zhu Q, Kang J, Wang N. Measurement and associations of the optic nerve subarachnoid space in Normal tension and primary open-angle Glaucoma. Am J Ophthalmol. 2018;186:128–37.

    Article  Google Scholar 

  21. Yang D, Fu J, Hou R, Liu K, Jonas JB, Wang H, Chen W, Li Z, Sang J, Zhang Z, Liu S, Cao Y, Xie X, Ren R, Lu Q, Weinreb RN, Wang N. Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys. Invest Ophthalmol Vis Sci. 2014;55(5):3067–73.

    Article  Google Scholar 

  22. Stone EM, Fingert JH, Alward WL, Nguyen TD, Polansky JR, Sunden SL, Nishimura D, Clark AF, Nystuen A, Nichols BE, Mackey DA, Ritch R, Kalenak JW, Craven ER, Sheffield VC. Identification of a gene that causes primary open angle glaucoma. Science. 1997;275(5300):668–70.

    Article  CAS  Google Scholar 

  23. Wiggs JL, Allingham RR, Vollrath D, Jones KH, De La Paz M, Kern J, Patterson K, Babb VL, Del Bono EA, Broomer BW, Pericak-Vance MA, Haines JL. Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma. Am J Hum Genet. 1998;63(5):1549–52.

    Article  CAS  Google Scholar 

  24. Fingert JH, Héon E, Liebmann JM, Yamamoto T, Craig JE, Rait J, Kawase K, Hoh ST, Buys YM, Dickinson J, Hockey RR, Williams-Lyn D, Trope G, Kitazawa Y, Ritch R, Mackey DA, Alward WL, Sheffield VC, Stone EM. Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Hum Mol Genet. 1999;8(5):899–905.

    Article  CAS  Google Scholar 

  25. Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Héon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science. 2002;295(5557):1077–9.

    Article  CAS  Google Scholar 

  26. Thonginnetra O, Greenstein VC, Chu D, Liebmann JM, Ritch R, Hood DC. Normal versus high tension glaucoma: a comparison of functional and structural defects. J Glaucoma. 2010;19(3):151–7.

    Article  Google Scholar 

  27. Shields MB. Normal-tension glaucoma: is it different from primary open-angle glaucoma? Curr Opin Ophthalmol. 2008;19(2):85–8.

    Article  Google Scholar 

  28. Sommer A, Tielsch JM, Katz J, Quigley HA, Gottsch JD, Javitt J, Singh K. Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey. Arch Ophthalmol. 1991;109(8):1090–5.

    Article  CAS  Google Scholar 

  29. Liu JH, Zhang X, Kripke DF, Weinreb RN. Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes. Invest Ophthalmol Vis Sci. 2003;44(4):1586–90.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Diya Yang

  2. Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China

    Diya Yang

  3. Hamilton Glaucoma Center and the Department of Ophthalmology, University of California, San Diego, La Jolla, CA, USA

    Robert N. Weinreb

Authors
  1. Diya Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert N. Weinreb
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert N. Weinreb .

Editor information

Editors and Affiliations

  1. Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Ningli Wang

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Yang, D., Weinreb, R.N. (2019). Time to Eliminate “Normal Tension” in Primary Open-Angle Glaucoma. In: Wang, N. (eds) Intraocular and Intracranial Pressure Gradient in Glaucoma. Advances in Visual Science and Eye Diseases, vol 1. Springer, Singapore. https://doi.org/10.1007/978-981-13-2137-5_2

Download citation

  • DOI: https://doi.org/10.1007/978-981-13-2137-5_2

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2136-8

  • Online ISBN: 978-981-13-2137-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation