Abstract
This chapter summarizes the follow-up problems of earlier traumatic situations. Particular weight is given to the alcohol problem, drug abuse, smoking, depression, anxiety disorder, obesity, heart attack, lung disease (e.g. asthma), gastrointestinal disorders (e.g. irritable bowel syndrome) and the chronic inflammatory situation. Large epidemiological studies clearly show the connections between early traumatic adversities and follow-up problems. Dose-effect relationships have been recognized, as the presence of multiple traumas is associated with a more severe problem. The consequences affect the brain and the body periphery. Finally, the presence and extent of increased inflammation after early trauma is illuminated. Various autoimmune diseases are more common after early traumatic experiences.
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References
Abarca NE, Garro AC, Pearlman DN (2019) Relationship between breastfeeding and asthma prevalence in young children exposed to adverse childhood experiences. J Asthma 56:142–151
Ader R (2007) Psychoneuroimmunology. Elsevier/Academic, San Diego
Afifi TO, Mather A, Boman J, Fleisher W, Enns MW, Macmillan H, Sareen J (2011) Childhood adversity and personality disorders: results from a nationally representative population-based study. J Psychiatr Res 45:814–822
Airagnes G, Lemogne C, Hoertel N, Goldberg M, Limosin F, Zins M (2016) Childhood adversity and depressive symptoms following retirement in the Gazel cohort. J Psychiatr Res 82:80–90
Ajnakina O, Trotta A, Forti MD et al (2018) Different types of childhood adversity and 5-year outcomes in a longitudinal cohort of first-episode psychosis patients. Psychiatry Res 269:199–206
Alastalo H, Räikkönen K, Pesonen AK, Osmond C, Barker DJ, Heinonen K, Kajantie E, Eriksson JG (2013a) Early life stress and blood pressure levels in late adulthood. J Hum Hypertens 27:90–94
Alastalo H, von Bonsdorff MB, Räikkönen K, Pesonen AK, Osmond C, Barker DJ, Heinonen K, Kajantie E, Eriksson JG (2013b) Early life stress and physical and psychosocial functioning in late adulthood. PLoS One 8:e69011
Ali I, O’Brien P, Kumar G et al (2013) Enduring effects of early life stress on firing patterns of hippocampal and thalamocortical neurons in rats: implications for limbic epilepsy. PLoS One 8:e66962
Alkon A, Boyce WT, Neilands TB, Eskenazi B (2017) Children’s autonomic nervous system reactivity moderates the relations between family adversity and sleep problems in latino 5-year olds in the CHAMACOS study. Front Public Health 5:155
Alvarez P, Green PG, Levine JD (2013) Stress in the adult rat exacerbates muscle pain induced by early-life stress. Biol Psychiatry 74:688–695
Amemiya A, Fujiwara T, Shirai K, Kondo K, Oksanen T, Pentti J, Vahtera J (2019) Association between adverse childhood experiences and adult diseases in older adults: a comparative cross-sectional study in Japan and Finland. BMJ Open 9:e024609
Anderson EL, Heron J, Ben-Shlomo Y, Kuh D, Cooper R, Lawlor DA, Fraser A, Howe LD (2017) Adversity in childhood and measures of aging in midlife: findings from a cohort of british women. Psychol Aging 32:521–530
Angelakis I, Gillespie EL, Panagioti M (2019) Childhood maltreatment and adult suicidality: a comprehensive systematic review with meta-analysis. Psychol Med 49:1057–1078
Appleton AA, Holdsworth E, Ryan M, Tracy M (2017) Measuring childhood adversity in life course cardiovascular research: a systematic review. Psychosom Med 79:434–440
April-Sanders A, Duarte CS, Wang S, McGlinchey E, Alcántara C, Bird H, Canino G, Suglia SF (2020) Childhood adversity and sleep disturbances: longitudinal results in Puerto Rican children. Int J Behav Med 28:107–115
Atlas LY, al’Absi M (2018) The neuroscience of pain: biobehavioral, developmental, and psychosocial mechanisms relevant to intervention targets. Psychosom Med 80:788–790
Austin MK, Chen E, Ross KM, McEwen LM, Maclsaac JL, Kobor MS, Miller GE (2018) Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes. Psychoneuroendocrinology 97:131–134
Bae D, Wickrama KA, O’Neal CW (2014) Social consequences of early socioeconomic adversity and youth BMI trajectories: gender and race/ethnicity differences. J Adolesc 37:883–892
Bailey MT, Lubach GR, Coe CL (2004) Prenatal stress alters bacterial colonization of the gut in infant monkeys. J Pediatr Gastroenterol Nutr 38:414–421
Barrett B (2009) The impact of childhood sexual abuse and other forms of childhood adversity on adulthood parenting. J Child Sex Abus 18:489–512
Bartley M, Kelly Y, Sacker A (2012) Early life financial adversity and respiratory function in midlife: a prospective birth cohort study. Am J Epidemiol 175:33–42
Bath KG (2020) Synthesizing views to understand sex differences in response to early life adversity. Trends Neurosci 43:300–310
Baumeister D, Akhtar R, Ciufolini S, Pariante CM, Mondelli V (2016) Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol Psychiatry 21:642–649
Beach SRH, Ong ML, Lei MK et al (2020) Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated. Dev Psychopathol 6:1–18
Beck JE, Shaw DS (2005) The influence of perinatal complications and environmental adversity on boys’ antisocial behavior. J Child Psychol Psychiatry 46:35–46
Belsky J, Shalev I (2016) Contextual adversity, telomere erosion, pubertal development, and health: two models of accelerated aging, or one? Dev Psychopathol 28:1367–1383
Bengtsson J, Rieckmann A, Carstensen B, Svensson J, Jørgensen ME, Rod NH (2021) Trajectories of childhood adversity and type 1 diabetes: a nationwide study of one million children. Diabetes Care 44:740–747
Benson S, Kattoor J, Wegner A et al (2012) Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans. Pain 153:794–799
Berens S, Banzhaf P, Baumeister D, Gauss A, Eich W, Schaefert R, Tesarz J (2020) Relationship between adverse childhood experiences and illness anxiety in irritable bowel syndrome – the impact of gender. J Psychosom Res 128:109846
Berg KL, Shiu CS, Acharya K, Stolbach BC, Msall ME (2016) Disparities in adversity among children with autism spectrum disorder: a population-based study. Dev Med Child Neurol 58:1124–1131
Berufsverbände und Fachgesellschaften für Psychiatrie; Kinder- und Jugendpsychiatrie; Psychotherapie; Psychosomatik; Nervenheilkunde und Neurologie aus Deutschland und der Schweiz. Persönlichkeitsstörungen. 2021. https://www.neurologen-und-psychiater-im-netz.org/psychiatrie-psychosomatik-psychotherapie/erkrankungen/persoenlichkeitsstoerungen/was-sind-persoenlichkeitsstoerungen/. Accessed 13 Jan 2021
Bhan N, Glymour MM, Kawachi I, Subramanian SV (2014) Childhood adversity and asthma prevalence: evidence from 10 US states (2009–2011). BMJ Open Respir Res 1:e000016
Biggs AM, Aziz Q, Tomenson B, Creed F (2004) Effect of childhood adversity on health related quality of life in patients with upper abdominal or chest pain. Gut 53:180–186
Björkenstam C, Kosidou K, Björkenstam E (2017a) Childhood adversity and risk of suicide: cohort study of 548 721 adolescents and young adults in Sweden. BMJ 357:j1334
Björkenstam E, Burström B, Vinnerljung B, Kosidou K (2016) Childhood adversity and psychiatric disorder in young adulthood: an analysis of 107,704 Swedes. J Psychiatr Res 77:67–75
Björkenstam E, Ekselius L, Burström B, Kosidou K, Björkenstam C (2017b) Association between childhood adversity and a diagnosis of personality disorder in young adulthood: a cohort study of 107,287 individuals in Stockholm County. Eur J Epidemiol 32:721–731
Björkenstam E, Björkenstam C, Jablonska B, Kosidou K (2018) Cumulative exposure to childhood adversity, and treated attention deficit/hyperactivity disorder: a cohort study of 543 650 adolescents and young adults in Sweden. Psychol Med 48:498–507
Blackburn EH, Epel ES (2012) Telomeres and adversity: too toxic to ignore. Nature 490:169–171
Bock J, Breuer S, Poeggel G, Braun K (2017) Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions: functional imaging of methylphenidate treatment in a novel rodent model. Brain Struct Funct 222:765–780
Bose S, Chiu YM, Hsu HL et al (2017) Prenatal nitrate exposure and childhood asthma. Influence of maternal prenatal stress and fetal sex. Am J Respir Crit Care Med 196:1396–1403
Bower JE, Crosswell AD, Slavich GM (2014) Childhood adversity and cumulative life stress: risk factors for cancer-related fatigue. Clin Psychol Sci 2:108–115
Bowman RE, MacLusky NJ, Sarmiento Y, Frankfurt M, Gordon M, Luine VN (2004) Sexually dimorphic effects of prenatal stress on cognition, hormonal responses, and central neurotransmitters. Endocrinology 145:3778–3787
Brannigan R, Tanskanen A, Huttunen MO, Cannon M, Leacy FP, Clarke MC (2020) The role of prenatal stress as a pathway to personality disorder: longitudinal birth cohort study. Br J Psychiatry 216:85–89
Brenhouse HC, Lukkes JL, Andersen SL (2013) Early life adversity alters the developmental profiles of addiction-related prefrontal cortex circuitry. Brain Sci 3:143–158
Bromis K, Calem M, Reinders A, Williams SCR, Kempton MJ (2018) meta-analysis of 89 structural MRI studies in posttraumatic stress disorder and comparison with major depressive disorder. Am J Psychiatry 175:989–998
Brown DW, Anda RF, Felitti VJ, Edwards VJ, Malarcher AM, Croft JB, Giles WH (2010) Adverse childhood experiences are associated with the risk of lung cancer: a prospective cohort study. BMC Public Health 10:20
Brunson KL, Eghbal-Ahmadi M, Bender R, Chen Y, Baram TZ (2001) Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress. Proc Natl Acad Sci U S A 98:8856–8861
Brunson KL, Kramár E, Lin B, Chen Y, Colgin LL, Yanagihara TK, Lynch G, Baram TZ (2005) Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci 25:9328–9338
Buitelaar JK, Huizink AC, Mulder EJ, de Medina PG, Visser GH (2003) Prenatal stress and cognitive development and temperament in infants. Neurobiol Aging 24:S53–S60
Burgueno AL, Juarez YR, Genaro AM, Tellechea ML (2020) Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes. Int J Obes 44:1–12
Calem M, Bromis K, McGuire P, Morgan C, Kempton MJ (2017) meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples. Neuroimage Clin 14:471–479
Campbell JA, Farmer GC, Nguyen-Rodriguez S, Walker R, Egede L (2018) Relationship between individual categories of adverse childhood experience and diabetes in adulthood in a sample of US adults: does it differ by gender? J Diabetes Complicat 32:139–143
Carballedo A, Lisiecka D, Fagan A, Saleh K, Ferguson Y, Connolly G, Meaney J, Frodl T (2012) Early life adversity is associated with brain changes in subjects at family risk for depression. World J Biol Psychiatry 13:569–578
Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH (2010) Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 35:2617–2623
Carr CP, Martins CM, Stingel AM, Lemgruber VB, Juruena MF (2013) The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. J Nerv Ment Dis 201:1007–1020
Chaloner A, Greenwood-Van Meerveld B (2013) Early life adversity as a risk factor for visceral pain in later life: importance of sex differences. Front Neurosci 7:13
Chen A, Panter-Brick C, Hadfield K, Dajani R, Hamoudi A, Sheridan M (2019) Minds under siege: cognitive signatures of poverty and trauma in refugee and non-refugee adolescents. Child Dev 90:1856–1865
Cheval B, Chabert C, Sieber S et al (2019) Association between adverse childhood experiences and muscle strength in older age. Gerontology 65:474–484
Chisari AN, Giovambattista A, Perelló M, Gaillard RC, Spinedi ES (2001) Maternal undernutrition induces neuroendocrine immune dysfunction in male pups at weaning. Neuroimmunomodulation 9:41–48
Cho HJ, Bower JE, Kiefe CI, Seeman TE, Irwin MR (2012) Early life stress and inflammatory mechanisms of fatigue in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Brain Behav Immun 26:859–865
Chou PH, Koenen KC (2019) Associations between childhood maltreatment and risk of myocardial infarction in adulthood: results from the national epidemiologic survey on alcohol and related conditions. J Psychiatr Res 116:172–177
Cisler JM, James GA, Tripathi S, Mletzko T, Heim C, Hu XP, Mayberg HS, Nemeroff CB, Kilts CD (2013) Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress. Psychol Med 43:507–518
Clark C, Caldwell T, Power C, Stansfeld SA (2010) Does the influence of childhood adversity on psychopathology persist across the lifecourse? A 45-year prospective epidemiologic study. Ann Epidemiol 20:385–394
Clarke-Walper K, Riviere LA, Wilk JE (2014) Alcohol misuse, alcohol-related risky behaviors, and childhood adversity among soldiers who returned from Iraq or Afghanistan. Addict Behav 39:414–419
Coe CL, Kramer M, Kirschbaum C, Netter P, Fuchs E (2002) Prenatal stress diminishes the cytokine response of leukocytes to endotoxin stimulation in juvenile rhesus monkeys. J Clin Endocrinol Metab 87:675–681
Cole SW, Conti G, Arevalo JM, Ruggiero AM, Heckman JJ, Suomi SJ (2012) Transcriptional modulation of the developing immune system by early life social adversity. Proc Natl Acad Sci U S A 109:20578–20583
Cozier YC, Barbhaiya M, Castro-Webb N, Conte C, Tedeschi S, Leatherwood C, Costenbader KH, Rosenberg L (2020) Association of child abuse with systemic lupus erythematosus in black women during adulthood. Arthritis Care Res 13:24188
Crawley E, Hughes R, Northstone K, Tilling K, Emond A, Sterne JA (2012) Chronic disabling fatigue at age 13 and association with family adversity. Pediatrics 130:e71–e79
Crosta ML, De Simone C, Di Pietro S et al (2018) Childhood trauma and resilience in psoriatic patients: a preliminary report. J Psychosom Res 106:25–28
Dahl SK, Larsen JT, Petersen L, Ubbesen MB, Mortensen PB, Munk-Olsen T, Musliner KL (2017) Early adversity and risk for moderate to severe unipolar depressive disorder in adolescence and adulthood: a register-based study of 978,647 individuals. J Affect Disord 214:122–129
Dancause KN, Laplante DP, Hart KJ, O’Hara MW, Elgbeili G, Brunet A, King S (2015) Prenatal stress due to a natural disaster predicts adiposity in childhood: the Iowa Flood Study. J Obes 2015:570541
Danese A, Pariante CM, Caspi A, Taylor A, Poulton R (2007) Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci U S A 104:1319–1324
Danielewicz J, Hess G (2014) Early life stress alters synaptic modification range in the rat lateral amygdala. Behav Brain Res 265:32–37
Davis CR, Dearing E, Usher N et al (2014) Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors. Metabolism 63:199–206
Davis DA, Luecken LJ, Zautra AJ (2005) Are reports of childhood abuse related to the experience of chronic pain in adulthood? A meta-analytic review of the literature. Clin J Pain 21:398–405
Davis EP, Pfaff D (2014) Sexually dimorphic responses to early adversity: implications for affective problems and autism spectrum disorder. Psychoneuroendocrinology 49:11–25
Davis L, Barnes AJ, Gross AC, Ryder JR, Shlafer RJ (2019) Adverse childhood experiences and weight status among adolescents. J Pediatr 204:71–76.e71
Delpierre C, Fantin R, Barboza-Solis C, Lepage B, Darnaudéry M, Kelly-Irving M (2016) The early life nutritional environment and early life stress as potential pathways towards the metabolic syndrome in mid-life? A lifecourse analysis using the 1958 British Birth cohort. BMC Public Health 16:815
Derks NA, Krugers HJ, Hoogenraad CC, Joëls M, Sarabdjitsingh RA (2016) Effects of early life stress on synaptic plasticity in the developing hippocampus of male and female rats. PLoS One 11:e0164551
Deutsche Gesellschaft für Suizidprävention. Bundesweite Beratungsangebote bei Krisen. 2021. https://www.suizidprophylaxe.de/hilfsangebote/adressen/. Accessed 13 Jan 2021
DeWit DJ, Chandler-Coutts M, Offord DR, King G, McDougall J, Specht J, Stewart S (2005) Gender differences in the effects of family adversity on the risk of onset of DSM-III-R social phobia. J Anxiety Disord 19:479–502
Dieckmann L, Cole S, Kumsta R (2020) Stress genomics revisited: gene co-expression analysis identifies molecular signatures associated with childhood adversity. Transl Psychiatry 10:34
Donley GAR, Lönnroos E, Tuomainen TP, Kauhanen J (2018) Association of childhood stress with late-life dementia and Alzheimer’s disease: the KIHD study. Eur J Pub Health 28:1069–1073
Drossman DA (2016) Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology 150:1262–1279
Dubé CM, Molet J, Singh-Taylor A, Ivy A, Maras PM, Baram TZ (2015) Hyper-excitability and epilepsy generated by chronic early-life stress. Neurobiol Stress 2:10–19
Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, Giles WH (2001) Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study. JAMA 286:3089–3096
Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB (2009) Cumulative childhood stress and autoimmune diseases in adults. Psychosom Med 71:243–250
Edwards HE, Dortok D, Tam J, Won D, Burnham WM (2002) Prenatal stress alters seizure thresholds and the development of kindled seizures in infant and adult rats. Horm Behav 42:437–447
Ehrlich KB, Ross KM, Chen E, Miller GE (2016) Testing the biological embedding hypothesis: is early life adversity associated with a later proinflammatory phenotype? Dev Psychopathol 28:1273–1283
Eiland L, McEwen BS (2012) Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling. Hippocampus 22:82–91
Eller OC, Morris EM, Thyfault JP, Christianson JA (2020) Early life stress reduces voluntary exercise and its prevention of diet-induced obesity and metabolic dysfunction in mice. Physiol Behav 223:113000
Ellis L, Cole-Harding S (2001) The effects of prenatal stress, and of prenatal alcohol and nicotine exposure, on human sexual orientation. Physiol Behav 74:213–226
Elsenbruch S, Rosenberger C, Bingel U, Forsting M, Schedlowski M, Gizewski ER (2010a) Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli. Gastroenterology 139:1310–1319
Elsenbruch S, Rosenberger C, Enck P, Forsting M, Schedlowski M, Gizewski ER (2010b) Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study. Gut 59:489–495
El-Sheikh M, Keiley M, Bagley EJ, Chen E (2015) Socioeconomic adversity and women’s sleep: stress and chaos as mediators. Behav Sleep Med 13:506–523
Elwenspoek MMC, Kuehn A, Muller CP, Turner JD (2017) The effects of early life adversity on the immune system. Psychoneuroendocrinology 82:140–154
Entringer S, Buss C, Wadhwa PD (2010) Prenatal stress and developmental programming of human health and disease risk: concepts and integration of empirical findings. Curr Opin Endocrinol Diabetes Obes 17:507–516
Entringer S, Epel ES, Kumsta R, Lin J, Hellhammer DH, Blackburn EH, Wüst S, Wadhwa PD (2011) Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. Proc Natl Acad Sci U S A 108:E513–E518
Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM (2004) Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A 101:17312–17315
Eriksson M, Räikkönen K, Eriksson JG (2014) Early life stress and later health outcomes – findings from the Helsinki Birth Cohort Study. Am J Hum Biol 26:111–116
Evans EA, Grella CE, Upchurch DM (2017) Gender differences in the effects of childhood adversity on alcohol, drug, and polysubstance-related disorders. Soc Psychiatry Psychiatr Epidemiol 52:901–912
Exley D, Norman A, Hyland M (2015) Adverse childhood experience and asthma onset: a systematic review. Eur Respir Rev 24:299–305
Fagundes CP, Glaser R, Malarkey WB, Kiecolt-Glaser JK (2013) Childhood adversity and herpesvirus latency in breast cancer survivors. Health Psychol 32:337–344
Farewell CV, Thayer ZM, Tracer DP, Morton S (2018) Prenatal stress exposure and early childhood BMI: exploring associations in a New Zealand context. Am J Hum Biol 30:e23116
Farr OM, Ko BJ, Joung KE et al (2015) Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk. Nutr Metab Cardiovasc Dis 25:479–488
Favaro A, Tenconi E, Degortes D, Manara R, Santonastaso P (2015) Neural correlates of prenatal stress in young women. Psychol Med 45:2533–2543
Feldman CH, Malspeis S, Leatherwood C, Kubzansky L, Costenbader KH, Roberts AL (2019) Association of childhood abuse with incident systemic lupus erythematosus in adulthood in a longitudinal cohort of women. J Rheumatol 46:1589–1596
Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS (1998) Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) study. Am J Prev Med 14:245–258
Finy MS, Christian LM (2018) Pathways linking childhood abuse history and current socioeconomic status to inflammation during pregnancy. Brain Behav Immun 74:231–240
Fiorito G, Polidoro S, Dugué PA et al (2017) Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation. Sci Rep 7:16266
Flanigan C, Sheikh A, DunnGalvin A, Brew BK, Almqvist C, Nwaru BI (2018) Prenatal maternal psychosocial stress and offspring’s asthma and allergic disease: a systematic review and meta-analysis. Clin Exp Allergy 48:403–414
Fonseca ES, Sakai M, Carvalho-Freitas MI, Palermo NJ (2005) Naloxone treatment prevents prenatal stress effects on peritoneal macrophage activity in mice offspring. Neuroendocrinology 81:322–328
Ford E, Clark C, Stansfeld SA (2011) The influence of childhood adversity on social relations and mental health at mid-life. J Affect Disord 133:320–327
Fride E, Dan Y, Feldon J, Halevy G, Weinstock M (1986) Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats. Physiol Behav 37:681–687
Frodl T, Carballedo A, Fagan AJ, Lisiecka D, Ferguson Y, Meaney JF (2012) Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression. J Psychiatry Neurosci 37:37–45
Frodl T, Skokauskas N, Frey EM, Morris D, Gill M, Carballedo A (2014) BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields. Hum Brain Mapp 35:5776–5783
Fuller-Thomson E, Stefanyk M, Brennenstuhl S (2009) The robust association between childhood physical abuse and osteoarthritis in adulthood: findings from a representative community sample. Arthritis Rheum 61:1554–1562
Gilbert LK, Breiding MJ, Merrick MT, Thompson WW, Ford DC, Dhingra SS, Parks SE (2015) Childhood adversity and adult chronic disease: an update from ten states and the District of Columbia, 2010. Am J Prev Med 48:345–349
Goff B, Gee DG, Telzer EH, Humphreys KL, Gabard-Durnam L, Flannery J, Tottenham N (2013) Reduced nucleus accumbens reactivity and adolescent depression following early-life stress. Neuroscience 249:129–138
Goldney RD (1981) Parental loss and reported childhood stress in young women who attempt suicide. Acta Psychiatr Scand 64:34–47
Golubeva AV, Crampton S, Desbonnet L et al (2015) Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood. Psychoneuroendocrinology 60:58–74
Goodman JB, Freeman EE, Chalmers KA (2019) The relationship between early life stress and working memory in adulthood: a systematic review and meta-analysis. Memory 27:868–880
Graham AM, Pfeifer JH, Fisher PA, Carpenter S, Fair DA (2015) Early life stress is associated with default system integrity and emotionality during infancy. J Child Psychol Psychiatry 56:1212–1222
Gray JP, Müller VI, Eickhoff SB, Fox PT (2020) Multimodal abnormalities of brain structure and function in major depressive disorder: a meta-analysis of neuroimaging studies. Am J Psychiatry 177:422–434
Green MK, Rani CS, Joshi A, Soto-Piña AE, Martinez PA, Frazer A, Strong R, Morilak DA (2011) Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress. Neuroscience 192:438–451
Grigoryan G, Segal M (2013) Prenatal stress alters noradrenergic modulation of LTP in hippocampal slices. J Neurophysiol 110:279–285
Groenewald CB, Murray CB, Palermo TM (2020) Adverse childhood experiences and chronic pain among children and adolescents in the United States. Pain Rep 5:e839
Gur TL, Palkar AV, Rajasekera T, Allen J, Niraula A, Godbout J, Bailey MT (2019) Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring. Behav Brain Res 359:886–894
Haapanen MJ, Perälä MM, Salonen MK et al (2018) Early life stress and frailty in old age: the Helsinki birth cohort study. BMC Geriatr 18:179
Hackman DA, Farah MJ, Meaney MJ (2010) Socioeconomic status and the brain: mechanistic insights from human and animal research. Nat Rev Neurosci 11:651–659
Halonen JI, Stenholm S, Pentti J, Kawachi I, Subramanian SV, Kivimäki M, Vahtera J (2015) Childhood psychosocial adversity and adult neighborhood disadvantage as predictors of cardiovascular disease: a cohort study. Circulation 132:371–379
Harrington M, Robinson J, Bolton SL, Sareen J, Bolton J (2011) A longitudinal study of risk factors for incident drug use in adults: findings from a representative sample of the US population. Can J Psychiatr 56:686–695
Hartwell KJ, Moran-Santa Maria MM, Twal WO, Shaftman S, DeSantis SM, McRae-Clark AL, Brady KT (2013) Association of elevated cytokines with childhood adversity in a sample of healthy adults. J Psychiatr Res 47:604–610
Hassan R, MacMillan HL, Saigal S, Schmidt LA (2020) Brain, interrupted: alpha/delta EEG ratio in survivors of pre- and post-natal adversity. Int J Neurosci 4:1–7
Hausknecht K, Haj-Dahmane S, Shen RY (2013) Prenatal stress exposure increases the excitation of dopamine neurons in the ventral tegmental area and alters their reponses to psychostimulants. Neuropsychopharmacology 38:293–301
Hemmingsson E (2018) Early childhood obesity risk factors: socioeconomic adversity, family dysfunction, offspring distress, and junk food self-medication. Curr Obes Rep 7:204–209
Henoch MJ, Batson JW, Baum J (1978) Psychosocial factors in juvenile rheumatoid arthritis. Arthritis Rheum 21:229–233
Herrmann M, Schölmerich J, Straub RH (2000) Stress and rheumatic diseases. Rheum Dis Clin N Am 26:737–763
Herzberg MP, Gunnar MR (2020) Early life stress and brain function: activity and connectivity associated with processing emotion and reward. NeuroImage 209:116493
Hines M, Johnston KJ, Golombok S, Rust J, Stevens M, Golding J (2002) Prenatal stress and gender role behavior in girls and boys: a longitudinal, population study. Horm Behav 42:126–134
Hitze B, Hubold C, van Dyken R, Schlichting K, Lehnert H, Entringer S, Peters A (2010) How the selfish brain organizes its supply and demand. Front Neuroenerg 2:7–17
Hjern A, Haglund B, Bremberg S, Ringbäck-Weitoft G (1999) Social adversity, migration and hospital admissions for childhood asthma in Sweden. Acta Paediatr 88:1107–1112
Hodson C, Newcomb MD, Locke TF, Goodyear RK (2006) Childhood adversity, poly-substance use, and disordered eating in adolescent Latinas: mediated and indirect paths in a community sample. Child Abuse Negl 30:1017–1036
Holschneider DP, Guo Y, Mayer EA, Wang Z (2016) Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats. Neurobiol Stress 3:8–22
Hope S, Micali N, Deighton J, Law C (2019) Maternal mental health at 5 years and childhood overweight or obesity at 11 years: evidence from the UK Millennium Cohort Study. Int J Obes 43:43–52
Hostinar CE, Stellern SA, Schaefer C, Carlson SM, Gunnar MR (2012) Associations between early life adversity and executive function in children adopted internationally from orphanages. Proc Natl Acad Sci U S A 109(Suppl 2):17208–17212
Hostinar CE, Lachman ME, Mroczek DK, Seeman TE, Miller GE (2015) Additive contributions of childhood adversity and recent stressors to inflammation at midlife: findings from the MIDUS study. Dev Psychol 51:1630–1644
Hsu YT, Kawachi I (2019) Timing of family adversity during adolescence and its impact on alcohol and tobacco initiation: a longitudinal study among Taiwanese adolescents. Child Psychiatry Hum Dev 50:257–267
Humphreys KL, King LS, Sacchet MD, Camacho MC, Colich NL, Ordaz SJ, Ho TC, Gotlib IH (2019) Evidence for a sensitive period in the effects of early life stress on hippocampal volume. Dev Sci 22:e12775
Iakunchykova OP, Andreeva TI, Nordstrom DL, Shkiryak-Nizhnyk ZA, Antipkin YG, Hryhorczuk DO, Zvinchuk AV, Chislovska NV (2015) The impact of early life stress on risk of tobacco smoking initiation by adolescents. Addict Behav 50:222–228
Icenhour A, Witt ST, Elsenbruch S, Lowén M, Engström M, Tillisch K, Mayer EA, Walter S (2017) Brain functional connectivity is associated with visceral sensitivity in women with Irritable Bowel Syndrome. Neuroimage Clin 15:449–457
Igosheva N, Taylor PD, Poston L, Glover V (2007) Prenatal stress in the rat results in increased blood pressure responsiveness to stress and enhanced arterial reactivity to neuropeptide Y in adulthood. J Physiol 582:665–674
Jakubowski KP, Cundiff JM, Matthews KA (2018) Cumulative childhood adversity and adult cardiometabolic disease: a meta-analysis. Health Psychol 37:701–715
Janusek LW, Tell D, Gaylord-Harden N, Mathews HL (2017) Relationship of childhood adversity and neighborhood violence to a proinflammatory phenotype in emerging adult African American men: an epigenetic link. Brain Behav Immun 60:126–135
Jaskelioff M, Muller FL, Paik JH et al (2011) Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469:102–106
Jensen SK, Dickie EW, Schwartz DH, Evans CJ, Dumontheil I, Paus T, Barker ED (2015) Effect of early adversity and childhood internalizing symptoms on brain structure in young men. JAMA Pediatr 169:938–946
John-Henderson NA, Williams SE, Brindle RC, Ginty AT (2018) Changes in sleep quality and levels of psychological distress during the adaptation to university: the role of childhood adversity. Br J Psychol 109:694–707
Jones GT (2016) Psychosocial vulnerability and early life adversity as risk factors for central sensitivity syndromes. Curr Rheumatol Rev 12:140–153
Jones NC, O’Brien TJ, Carmant L (2014) Interaction between sex and early-life stress: influence on epileptogenesis and epilepsy comorbidities. Neurobiol Dis 72:233–241
Kaiser RH, Clegg R, Goer F, Pechtel P, Beltzer M, Vitaliano G, Olson DP, Teicher MH, Pizzagalli DA (2018) Childhood stress, grown-up brain networks: corticolimbic correlates of threat-related early life stress and adult stress response. Psychol Med 48:1157–1166
Kawamoto T, Miyake Y, Tanaka K, Nagano J, Sasaki S, Hirota Y (2020) Maternal prenatal stress and infantile wheeze and asthma: the Osaka Maternal and Child Health Study. J Psychosom Res 135:110143
Kay G, Tarcic N, Poltyrev T, Weinstock M (1998) Prenatal stress depresses immune function in rats. Physiol Behav 63:397–402
Kelly-Irving M, Lepage B, Dedieu D et al (2013) Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study. BMC Public Health 13:767
Kessler RC, Pecora PJ, Williams J et al (2008) Effects of enhanced foster care on the long-term physical and mental health of foster care alumni. Arch Gen Psychiatry 65:625–633
Khashan AS, Wicks S, Dalman C, Henriksen TB, Li J, Mortensen PB, Kenny LC (2012) Prenatal stress and risk of asthma hospitalization in the offspring: a Swedish population-based study. Psychosom Med 74:635–641
Kiecolt-Glaser JK, Gouin JP, Weng NP, Malarkey WB, Beversdorf DQ, Glaser R (2011) Childhood adversity and personality disorders: results from a nationally representative population-based study. Psychosom Med 73:16–22
Kiff CJ, Cortes R, Lengua L, Kosterman R, Hawkins JD, Mason WA (2012) Effects of timing of adversity on adolescent and young adult adjustment. J Res Adolesc 22:284–300
Kim MJ, Farber MJ, Knodt AR, Hariri AR (2019) Corticolimbic circuit structure moderates an association between early life stress and later trait anxiety. Neuroimage Clin 24:102050
Kim ST, Hwang SS, Kim HW, Hwang EH, Cho J, Kang JI, Kim SJ (2018) Multidimensional impulsivity as a mediator of early life stress and alcohol dependence. Sci Rep 8:4104
Kinney DK, Munir KM, Crowley DJ, Miller AM (2008) Prenatal stress and risk for autism. Neurosci Biobehav Rev 32:1519–1532
Kircanski K, Sisk LM, Ho TC, Humphreys KL, King LS, Colich NL, Ordaz SJ, Gotlib IH (2019) Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty. Dev Psychopathol 31:1011–1022
Klein SL, Rager DR (1995) Prenatal stress alters immune function in the offspring of rats. Dev Psychobiol 28:321–336
Kleinhaus K, Harlap S, Perrin M, Manor O, Margalit-Calderon R, Opler M, Friedlander Y, Malaspina D (2013) Prenatal stress and affective disorders in a population birth cohort. Bipolar Disord 15:92–99
Kopec JA, Sayre EC (2004) Traumatic experiences in childhood and the risk of arthritis: a prospective cohort study. Can J Public Health 95:361–365
Kraaijenvanger EJ, Pollok TM, Monninger M, Kaiser A, Brandeis D, Banaschewski T, Holz NE (2020) Impact of early life adversities on human brain functioning: a coordinate-based meta-analysis. Neurosci Biobehav Rev 113:62–76
Kraszpulski M, Dickerson PA, Salm AK (2006) Prenatal stress affects the developmental trajectory of the rat amygdala. Stress 9:85–95
Kuhlman KR, Horn SR, Chiang JJ, Bower JE (2020) Early life adversity exposure and circulating markers of inflammation in children and adolescents: a systematic review and meta-analysis. Brain Behav Immun 86:30–42
Kuhn M, Scharfenort R, Schümann D et al (2016) Mismatch or allostatic load? Timing of life adversity differentially shapes gray matter volume and anxious temperament. Soc Cogn Affect Neurosci 11:537–547
Kuzminskaite E, Vinkers CH, Elzinga BM, Wardenaar KJ, Giltay EJ, Penninx B (2020) Childhood trauma and dysregulation of multiple biological stress systems in adulthood: results from the Netherlands Study of Depression and Anxiety (NESDA). Psychoneuroendocrinology 121:104835
Lacey RE, Pinto Pereira SM, Li L, Danese A (2020) Adverse childhood experiences and adult inflammation: single adversity, cumulative risk and latent class approaches. Brain Behav Immun 87:820–830
Lajud N, Torner L (2015) Early life stress and hippocampal neurogenesis in the neonate: sexual dimorphism, long term consequences and possible mediators. Front Mol Neurosci 8:3
Laloux C, Mairesse J, Van Camp G et al (2012) Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress. Psychoneuroendocrinology 37:1646–1658
Lambert HK, Sheridan MA, Sambrook KA, Rosen ML, Askren MK, McLaughlin KA (2017) Hippocampal contribution to context encoding across development is disrupted following early-life adversity. J Neurosci 37:1925–1934
Lane RD, Anderson FS, Smith R (2018) Biased competition favoring physical over emotional pain: a possible explanation for the link between early adversity and chronic pain. Psychosom Med 80:880–890
Lange I, Goossens L, Bakker J et al (2019) Neurobehavioural mechanisms of threat generalization moderate the link between childhood maltreatment and psychopathology in emerging adulthood. J Psychiatry Neurosci 44:185–194
Laplante DP, Brunet A, Schmitz N, Ciampi A, King S (2008) Project Ice Storm: prenatal maternal stress affects cognitive and linguistic functioning in 5 1/2-year-old children. J Am Acad Child Adolesc Psychiatry 47:1063–1072
Laplante DP, Hart KJ, O’Hara MW, Brunet A, King S (2018) Prenatal maternal stress is associated with toddler cognitive functioning: the Iowa Flood Study. Early Hum Dev 116:84–92
Lawn RB, Anderson EL, Suderman M et al (2018) Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies. Hum Mol Genet 27:1301–1308
Lee AG, Chiu YM, Rosa MJ, Cohen S, Coull BA, Wright RO, Morgan WJ, Wright RJ (2017a) Association of prenatal and early childhood stress with reduced lung function in 7-year-olds. Ann Allergy Asthma Immunol 119:153–159
Lee C, Doo E, Choi JM, Jang SH, Ryu HS, Lee JY, Oh JH, Park JH, Kim YS (2017b) The increased level of depression and anxiety in irritable bowel syndrome patients compared with healthy controls: systematic review and meta-analysis. J Neurogastroenterol Motil 23:349–362
Lehman BJ, Taylor SE, Kiefe CI, Seeman TE (2009) Relationship of early life stress and psychological functioning to blood pressure in the CARDIA study. Health Psychol 28:338–346
Lemaire V, Koehl M, Le Moal M, Abrous DN (2000) Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci U S A 97:11032–11037
Lemche E (2018) Early life stress and epigenetics in late-onset Alzheimer’s dementia: a systematic review. Curr Genomics 19:522–602
Lesage J, Del-Favero F, Leonhardt M, Louvart H, Maccari S, Vieau D, Darnaudery M (2004) Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat. J Endocrinol 181:291–296
Lewis CR, Bastle RM, Manning TB et al (2016) Interactions between early life stress, nucleus accumbens MeCP2 expression, and methamphetamine self-administration in male rats. Neuropsychopharmacology 41:2851–2861
Li J, Olsen J, Vestergaard M, Obel C, Baker JL, Sørensen TI (2010) Prenatal stress exposure related to maternal bereavement and risk of childhood overweight. PLoS One 5:e11896
Li N, Wang Y, Zhao X et al (2015) Long-term effect of early-life stress from earthquake exposure on working memory in adulthood. Neuropsychiatr Dis Treat 11:2959–2965
Lin JE, Neylan TC, Epel E, O’Donovan A (2016) Associations of childhood adversity and adulthood trauma with C-reactive protein: a cross-sectional population-based study. Brain Behav Immun 53:105–112
Liu X, Olsen J, Agerbo E, Yuan W, Sigsgaard T, Li J (2015) Prenatal stress and childhood asthma in the offspring: role of age at onset. Eur J Pub Health 25:1042–1046
Llorente E, Brito ML, Machado P, González MC (2002) Effect of prenatal stress on the hormonal response to acute and chronic stress and on immune parameters in the offspring. J Physiol Biochem 58:143–149
Longden E, Read J (2016) Social adversity in the etiology of psychosis: a review of the evidence. Am J Psychother 70:5–33
Loria AS, D’Angelo G, Pollock DM, Pollock JS (2010a) Early life stress downregulates endothelin receptor expression and enhances acute stress-mediated blood pressure responses in adult rats. Am J Phys Regul Integr Comp Phys 299:R185–R191
Loria AS, Pollock DM, Pollock JS (2010b) Early life stress sensitizes rats to angiotensin II-induced hypertension and vascular inflammation in adult life. Hypertension 55:494–499
Loria AS, Brands MW, Pollock DM, Pollock JS (2013) Early life stress sensitizes the renal and systemic sympathetic system in rats. Am J Physiol Ren Physiol 305:F390–F395
Loudermilk E, Loudermilk K, Obenauer J, Quinn MA (2018) Impact of adverse childhood experiences (ACEs) on adult alcohol consumption behaviors. Child Abuse Negl 86:368–374
Lovallo WR, Acheson A, Cohoon AJ, Sorocco KH, Vincent AS, Hodgkinson CA, Goldman D (2019) Working memory reflects vulnerability to early life adversity as a risk factor for substance use disorder in the FKBP5 cortisol cochaperone polymorphism, rs9296158. PLoS One 14:e0218212
Low LA, Schweinhardt P (2012) Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. Pain Res Treat 2012:140832
Lown EA, Lui CK, Karriker-Jaffe K, Mulia N, Williams E, Ye Y, Li L, Greenfield TK, Kerr WC (2019) Adverse childhood events and risk of diabetes onset in the 1979 National longitudinal survey of youth cohort. BMC Public Health 19:1007
Luby JL, Tillman R, Barch DM (2019) Association of timing of adverse childhood experiences and caregiver support with regionally specific brain development in adolescents. JAMA Netw Open 2:e1911426
Machado TD, Dalle Molle R, Laureano DP, Portella AK, Werlang IC, Benetti Cda S, Noschang C, Silveira PP (2013) Early life stress is associated with anxiety, increased stress responsivity and preference for „comfort foods“ in adult female rats. Stress 16:549–556
MacKinnon N, Kingsbury M, Mahedy L, Evans J, Colman I (2018) The association between prenatal stress and externalizing symptoms in childhood: evidence from the avon longitudinal study of parents and children. Biol Psychiatry 83:100–108
Mahamat-Saleh Y, Fiolet T, Rebeaud ME et al (2021) Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: a systematic review and meta-analysis of observational studies. BMJ Open 11:e052777
MartÃnez-Téllez RI, Hernández-Torres E, Gamboa C, Flores G (2009) Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring. Synapse 63:794–804
Mastorci F, Vicentini M, Viltart O et al (2009) Long-term effects of prenatal stress: changes in adult cardiovascular regulation and sensitivity to stress. Neurosci Biobehav Rev 33:191–203
Matheson SL, Shepherd AM, Pinchbeck RM, Laurens KR, Carr VJ (2013) Childhood adversity in schizophrenia: a systematic meta-analysis. Psychol Med 43:225–238
Mathur A, Graham-Engeland JE, Slavish DC, Smyth JM, Lipton RB, Katz MJ, Sliwinski MJ (2018) Recalled early life adversity and pain: the role of mood, sleep, optimism, and control. J Behav Med 41:504–515
Mayer SE, Prather AA, Puterman E, Lin J, Arenander J, Coccia M, Shields GS, Slavich GM, Epel ES (2019) Cumulative lifetime stress exposure and leukocyte telomere length attrition: the unique role of stressor duration and exposure timing. Psychoneuroendocrinology 104:210–218
McIntyre RS, Soczynska JK, Liauw SS et al (2012) The association between childhood adversity and components of metabolic syndrome in adults with mood disorders: results from the international mood disorders collaborative project. Int J Psychiatry Med 43:165–177
McLaughlin KA, Hatzenbuehler ML, Xuan Z, Conron KJ (2012) Disproportionate exposure to early-life adversity and sexual orientation disparities in psychiatric morbidity. Child Abuse Negl 36:645–655
McLaughlin KA, Basu A, Walsh K, Slopen N, Sumner JA, Koenen KC, Keyes KM (2016) Childhood exposure to violence and chronic physical conditions in a national sample of US adolescents. Psychosom Med 78:1072–1083
McWhorter KL, Parks CG, D’Aloisio AA, Rojo-Wissar DM, Sandler DP, Jackson CL (2019) Traumatic childhood experiences and multiple dimensions of poor sleep among adult women. Sleep 42:zsz108
Meek LR, Schulz KM, Keith CA (2006) Effects of prenatal stress on sexual partner preference in mice. Physiol Behav 89:133–138
Middlebrook N, Rushton AB, Abichandani D, Kuithan P, Heneghan NR, Falla D (2021) Measures of central sensitization and their measurement properties in musculoskeletal trauma: a systematic review. Eur J Pain 25:71–87
Miller AL, Gearhardt AN, Retzloff L, Sturza J, Kaciroti N, Lumeng JC (2018) Early childhood stress and child age predict longitudinal increases in obesogenic eating among low-income children. Acad Pediatr 18:685–691
Miller JG, Ho TC, Humphreys KL, King LS, Foland-Ross LC, Colich NL, Ordaz SJ, Lin J, Gotlib IH (2020) Early life stress, frontoamygdala connectivity, and biological aging in adolescence: a longitudinal investigation. Cereb Cortex 30:4269–4280
Miranda A (2009) Early life stress and pain: an important link to functional bowel disorders. Pediatr Ann 38:279–282
Mittal C, Griskevicius V, Simpson JA, Sung S, Young ES (2015) Cognitive adaptations to stressful environments: when childhood adversity enhances adult executive function. J Pers Soc Psychol 109:604–621
Moloney RD, Sajjad J, Foley T, Felice VD, Dinan TG, Cryan JF, O’Mahony SM (2016) Estrous cycle influences excitatory amino acid transport and visceral pain sensitivity in the rat: effects of early-life stress. Biol Sex Differ 7:33
Morgan CP, Bale TL (2011) Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage. J Neurosci 31:11748–11755
Moussaoui N, Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Taché Y (2017) Chronic early-life stress in rat pups alters basal corticosterone, intestinal permeability, and fecal microbiota at weaning: influence of sex. J Neurogastroenterol Motil 23:135–143
Mueller BR, Bale TL (2006) Impact of prenatal stress on long term body weight is dependent on timing and maternal sensitivity. Physiol Behav 88:605–614
Murphy MO, Cohn DM, Loria AS (2017) Developmental origins of cardiovascular disease: impact of early life stress in humans and rodents. Neurosci Biobehav Rev 74:453–465
Murthy S, Gould E (2020) How early life adversity influences defensive circuitry. Trends Neurosci 43:200–212
Muscatell KA, Brosso SN, Humphreys KL (2020) Socioeconomic status and inflammation: a meta-analysis. Mol Psychiatry 25:2189–2199
Nanni V, Uher R, Danese A (2012) Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 169:141–151
Navratilova E, Atcherley CW, Porreca F (2015) Brain circuits encoding reward from pain relief. Trends Neurosci 38:741–750
Nelson S, Simons LE, Logan D (2018) The incidence of adverse childhood experiences (ACEs) and their association with pain-related and psychosocial impairment in youth with chronic pain. Clin J Pain 34:402–408
Nettle D (2009) Personality – what makes you the way you are. Oxford University Press, Oxford
Neufeld KM, Karunanayake CP, Maenz LY, Rosenberg AM (2013) Stressful life events antedating chronic childhood arthritis. J Rheumatol 40:1756–1765
Nielsen T, Carr M, Picard-Deland C, Marquis LP, Saint-Onge K, Blanchette-Carrière C, Paquette T (2019) Early childhood adversity associations with nightmare severity and sleep spindles. Sleep Med 56:57–65
Nogovitsyn N, Addington J, Souza R et al (2020) Childhood trauma and amygdala nuclei volumes in youth at risk for mental illness. Psychol Med 17:1–8
Nogueira PJ, Ferreira HH, Antunes E, Teixeira NA (1999) Chronic mild prenatal stress exacerbates the allergen-induced airway inflammation in rats. Mediat Inflamm 8:119–122
Norton MC, Smith KR, Østbye T et al (2011) Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: the Cache County study. Am J Geriatr Psychiatry 19:814–824
O’Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho AM, Quigley EM, Cryan JF, Dinan TG (2009) Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry 65:263–267
O’Mahony SM, Clarke G, Dinan TG, Cryan JF (2017) Early-life adversity and brain development: is the microbiome a missing piece of the puzzle? Neuroscience 342:37–54
O’Neill S, O’Connor RC (2020) Suicide in Northern Ireland: epidemiology, risk factors, and prevention. Lancet Psychiatry 7:538–546
O’Rand AM, Hamil-Luker J (2005) Processes of cumulative adversity: childhood disadvantage and increased risk of heart attack across the life course. J Gerontol B Psychol Sci Soc Sci 60:117–124
Opendak M, Gould E, Sullivan R (2017) Early life adversity during the infant sensitive period for attachment: programming of behavioral neurobiology of threat processing and social behavior. Dev Cogn Neurosci 25:145–159
Ordway MR, Sadler LS, Jeon S, O’Connell M, Banasiak N, Fenick AM, Crowley AA, Canapari C, Redeker NS (2020) Sleep health in young children living with socioeconomic adversity. Res Nurs Health 43:329–340
Oren E, Gerald L, Stern DA, Martinez FD, Wright AL (2017) Self-reported stressful life events during adolescence and subsequent asthma: a longitudinal study. J Allergy Clin Immunol Pract 5:427–434
Østergaard SD, Larsen JT, Dalsgaard S, Wilens TE, Mortensen PB, Agerbo E, Mors O, Petersen L (2016) Predicting ADHD by assessment of Rutter’s indicators of adversity in infancy. PLoS One 11:e0157352
Oswald LM, Wand GS, Kuwabara H, Wong DF, Zhu S, Brasic JR (2014) History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine. Psychopharmacology 231:2417–2433
Otten R, Mun CJ, Shaw DS, Wilson MN, Dishion TJ (2019) A developmental cascade model for early adolescent-onset substance use: the role of early childhood stress. Addiction 114:326–334
Ouchi R, Kawano T, Yoshida H, Ishii M, Miyasaka T, Ohkawara Y, Takayanagi M, Takahashi T, Ohno I (2018) Maternal separation as early-life stress causes enhanced allergic airway responses by inhibiting respiratory tolerance in mice. Tohoku J Exp Med 246:155–165
Ozieh MN, Garacci E, Campbell JA, Walker RJ, Egede LE (2020) Adverse childhood experiences and decreased renal function: impact on all-cause mortality in U.S. adults. Am J Prev Med 59:e49–e57
Pace TW, Wingenfeld K, Schmidt I, Meinlschmidt G, Hellhammer DH, Heim CM (2012) Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder. Brain Behav Immun 26:13–17
Packard CJ, Bezlyak V, McLean JS et al (2011) Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study. BMC Public Health 11:42
Palmier-Claus JE, Berry K, Bucci S, Mansell W, Varese F (2016) Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. Br J Psychiatry 209:454–459
Park SH, Videlock EJ, Shih W, Presson AP, Mayer EA, Chang L (2016) Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity. Neurogastroenterol Motil 28:1252–1260
Pastor V, Antonelli MC, Pallarés ME (2017) Unravelling the link between prenatal stress, dopamine and substance use disorder. Neurotox Res 31:169–186
Pastor V, Pallarés ME, Antonelli MC (2018) Prenatal stress increases adult vulnerability to cocaine reward without affecting pubertal anxiety or novelty response. Behav Brain Res 339:186–194
Peh OH, Rapisarda A, Lee J (2019) Childhood adversities in people at ultra-high risk (UHR) for psychosis: a systematic review and meta-analysis. Psychol Med 49:1089–1101
Pepper GV, Bateson M, Nettle D (2018) Telomeres as integrative markers of exposure to stress and adversity: a systematic review and meta-analysis. R Soc Open Sci 5:180744
Perry RE, Blair C, Sullivan RM (2017) Neurobiology of infant attachment: attachment despite adversity and parental programming of emotionality. Curr Opin Psychol 17:1–6
Persson G, Skoog I (1996) A prospective population study of psychological risk factors for late onset dementia. Int J Geriatr Psychiatry 11:15–22
Pesonen AK, Eriksson JG, Heinonen K et al (2013) Cognitive ability and decline after early life stress exposure. Neurobiol Aging 34:1674–1679
Peters AT, Burkhouse KL, Kinney KL, Phan KL (2019) The roles of early-life adversity and rumination in neural response to emotional faces amongst anxious and depressed adults. Psychol Med 49:2267–2278
Petruccelli K, Davis J, Berman T (2019) Adverse childhood experiences and associated health outcomes: a systematic review and meta-analysis. Child Abuse Negl 97:104127
Phillips NK, Hammen CL, Brennan PA, Najman JM, Bor W (2005) Early adversity and the prospective prediction of depressive and anxiety disorders in adolescents. J Abnorm Child Psychol 33:13–24
Pierce JB, Kershaw KN, Kiefe CI, Jacobs DR Jr, Sidney S, Merkin SS, Feinglass J (2020) Association of childhood psychosocial environment with 30-year cardiovascular disease incidence and mortality in middle age. J Am Heart Assoc 9:e015326
Pincus-Knackstedt MK, Joachim RA, Blois SM, Douglas AJ, Orsal AS, Klapp BF, Wahn U, Hamelmann E, Arck PC (2006) Prenatal stress enhances susceptibility of murine adult offspring toward airway inflammation. J Immunol 177:8484–8492
Pinto Pereira SM, Stein Merkin S, Seeman T, Power C (2019) Understanding associations of early-life adversities with mid-life inflammatory profiles: evidence from the UK and USA. Brain Behav Immun 78:143–152
Pohl CS, Medland JE, Moeser AJ (2015) Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications. Am J Physiol Gastrointest Liver Physiol 309:G927–G941
Pohl CS, Medland JE, Mackey E, Edwards LL, Bagley KD, DeWilde MP, Williams KJ, Moeser AJ (2017) Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity. Neurogastroenterol Motil 29:e13118
Popova NK, Morozova MV, Amstislavskaya TG (2011) Prenatal stress and ethanol exposure produces inversion of sexual partner preference in mice. Neurosci Lett 489:48–52
Ports KA, Holman DM, Guinn AS, Pampati S, Dyer KE, Merrick MT, Lunsford NB, Metzler M (2019) Adverse childhood experiences and the presence of cancer risk factors in adulthood: a scoping review of the literature from 2005 to 2015. J Pediatr Nurs 44:81–96
Post RM, Altshuler LL, Kupka R et al (2016) Age of onset of bipolar disorder: combined effect of childhood adversity and familial loading of psychiatric disorders. J Psychiatr Res 81:63–70
Poulton R, Caspi A, Milne BJ, Thomson WM, Taylor A, Sears MR, Moffitt TE (2002) Association between children’s experience of socioeconomic disadvantage and adult health: a life-course study. Lancet 360:1640–1645
Provençal N, Booij L, Tremblay RE (2015) The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity. J Exp Biol 218:123–133
Prusator DK, Greenwood-Van Meerveld B (2016) Sex-related differences in pain behaviors following three early life stress paradigms. Biol Sex Differ 7:29
Prusator DK, Greenwood-Van Meerveld B (2017) Amygdala-mediated mechanisms regulate visceral hypersensitivity in adult females following early life stress: importance of the glucocorticoid receptor and corticotropin-releasing factor. Pain 158:296–305
Puterman E, Gemmill A, Karasek D, Weir D, Adler NE, Prather AA, Epel ES (2016) Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study. Proc Natl Acad Sci U S A 113:E6335–E6342
Quilliot D, Brunaud L, Mathieu J, Quenot C, Sirveaux MA, Kahn JP, Ziegler O, Witkowski P (2019) Links between traumatic experiences in childhood or early adulthood and lifetime binge eating disorder. Psychiatry Res 276:134–141
Rajindrajith S, Hettige S, Gulegoda I, Jayawickrama N, De Silva SC, Samarakoon HK, de Silva RL, Abeyagunawardena S, Devanarayana NM (2018) Aerophagia in adolescents is associated with exposure to adverse life events and psychological maladjustment. Neurogastroenterol Motil 30:e13224
Rao U, Chen LA, Bidesi AS, Shad MU, Thomas MA, Hammen CL (2010) Hippocampal changes associated with early-life adversity and vulnerability to depression. Biol Psychiatry 67:357–364
Rasmussen LJH, Moffitt TE, Eugen-Olsen J et al (2019) Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood. J Child Psychol Psychiatry 60:199–208
Rau AR, Chappell AM, Butler TR, Ariwodola OJ, Weiner JL (2015) Increased basolateral amygdala pyramidal cell excitability may contribute to the anxiogenic phenotype induced by chronic early-life stress. J Neurosci 35:9730–9740
Rauschecker JP, May ES, Maudoux A, Ploner M (2015) Frontostriatal gating of tinnitus and chronic pain. Trends Cogn Sci 19:567–578
Ravona-Springer R, Beeri MS, Goldbourt U (2012) Younger age at crisis following parental death in male children and adolescents is associated with higher risk for dementia at old age. Alzheimer Dis Assoc Disord 26:68–73
Richards M, Wadsworth ME (2004) Long term effects of early adversity on cognitive function. Arch Dis Child 89:922–927
Ridout KK, Levandowski M, Ridout SJ, Gantz L, Goonan K, Palermo D, Price LH, Tyrka AR (2018) Early life adversity and telomere length: a meta-analysis. Mol Psychiatry 23:858–871
Robert Koch-Institut (2013) Beiträge zur Gesundheitsberichterstattung des Bundes—Referenzperzentile für anthropometrische Maßzahlen und Blutdruck aus der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS). Berlin, RKI-Hausdruckerei
Robson E, Norris T, Wulaningsih W, Hamer M, Hardy R, Johnson W (2020) The relationship of early-life adversity with adulthood weight and cardiometabolic health status in the 1946 national survey of health and development. Psychosom Med 82:82–89
Rosa MJ, Lee AG, Wright RJ (2018) Evidence establishing a link between prenatal and early-life stress and asthma development. Curr Opin Allergy Clin Immunol 18:148–158
Rosenman S, Rodgers B (2006) Childhood adversity and adult personality. Aust N Z J Psychiatry 40:482–490
Said N, Lakehayli S, El Khachibi M, El Ouahli M, Nadifi S, Hakkou F, Tazi A (2015) Prenatal stress induces vulnerability to nicotine addiction and alters D2 receptors’ expression in the nucleus accumbens in adult rats. Neuroscience 304:279–285
Salas J, van den Berk-Clark C, Skiöld-Hanlin S, Schneider FD, Scherrer JF (2019) Adverse childhood experiences, depression, and cardiometabolic disease in a nationally representative sample. J Psychosom Res 127:109842
Santavirta T, Santavirta N, Gilman SE (2018) Association of the world war II finnish evacuation of children with psychiatric hospitalization in the next generation. JAMA Psychiatry 75:21–27
Savolainen K, Eriksson JG, Kananen L, Kajantie E, Pesonen AK, Heinonen K, Räikkönen K (2014) Associations between early life stress, self-reported traumatic experiences across the lifespan and leukocyte telomere length in elderly adults. Biol Psychol 97:35–42
Scheinost D, Sinha R, Cross SN, Kwon SH, Sze G, Constable RT, Ment LR (2017) Does prenatal stress alter the developing connectome? Pediatr Res 81:214–226
Schmidt U, Slone G, Tiller J, Treasure J (1993) Childhood adversity and adult defence style in eating disorder patients – a controlled study. Br J Med Psychol 66:353–362
Schneider ML, Roughton EC, Koehler AJ, Lubach GR (1999) Growth and development following prenatal stress exposure in primates: an examination of ontogenetic vulnerability. Child Dev 70:263–274
Schneper LM, Brooks-Gunn J, Notterman DA, Suomi SJ (2016) Early-life experiences and telomere length in adult rhesus monkeys: an exploratory study. Psychosom Med 78:1066–1071
Schoenaker D, Callaway LK, Mishra GD (2019) the role of childhood adversity in the development of gestational diabetes. Am J Prev Med 57:302–310
Schreier HMC, Jones EJ, Nayman S, Smyth JM (2019) Associations between adverse childhood family environments and blood pressure differ between men and women. PLoS One 14:e0225544
Schrepf A, Naliboff B, Williams DA et al (2018) Adverse childhood experiences and symptoms of urologic chronic pelvic pain syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study. Ann Behav Med 52:865–877
Schroeder K, Langeland W, Fisher HL, Huber CG, Schäfer I (2016) Dissociation in patients with schizophrenia spectrum disorders: what is the role of different types of childhood adversity? Compr Psychiatry 68:201–208
Schwabe L, Bohbot VD, Wolf OT (2012) Prenatal stress changes learning strategies in adulthood. Hippocampus 22:2136–2143
Scott KM, Von Korff M, Alonso J et al (2008) Childhood adversity, early-onset depressive/anxiety disorders, and adult-onset asthma. Psychosom Med 70:1035–1043
Sen P, Molinero-Perez A, O’Riordan KJ, McCafferty CP, O’Halloran KD, Cryan JF (2021) Microbiota and sleep: awakening the gut feeling. Trends Mol Med 27:935–945
Shalev I, Moffitt TE, Sugden K, Williams B, Houts RM, Danese A, Mill J, Arseneault L, Caspi A (2013) Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Mol Psychiatry 18:576–581
Shaw DS, Vondra JI (1993) Chronic family adversity and infant attachment security. J Child Psychol Psychiatry 34:1205–1215
Shaw DS, Vondra JI, Hommerding KD, Keenan K, Dunn M (1994) Chronic family adversity and early child behavior problems: a longitudinal study of low income families. J Child Psychol Psychiatry 35:1109–1122
Sheehan CM, Li L, Friedman EM (2020) Quantity, timing, and type of childhood adversity and sleep quality in adulthood. Sleep Health 6:246–252
Sheikh MA (2018) Retrospectively reported childhood adversity is associated with asthma and chronic bronchitis, independent of mental health. J Psychosom Res 114:50–57
Sheridan MA, Peverill M, Finn AS, McLaughlin KA (2017) Dimensions of childhood adversity have distinct associations with neural systems underlying executive functioning. Dev Psychopathol 29:1777–1794
Shrira A, Litwin H (2014) The effect of lifetime cumulative adversity and depressive symptoms on functional status. J Gerontol B Psychol Sci Soc Sci 69:953–965
Sideli L, Murray RM, Schimmenti A, Corso M, La Barbera D, Trotta A, Fisher HL (2020) Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators. Psychol Med 50:1761–1782
Slopen N, Lewis TT, Gruenewald TL, Mujahid MS, Ryff CD, Albert MA, Williams DR (2010) Early life adversity and inflammation in African Americans and whites in the midlife in the United States survey. Psychosom Med 72:694–701
Slopen N, Koenen KC, Kubzansky LD (2012) Childhood adversity and immune and inflammatory biomarkers associated with cardiovascular risk in youth: a systematic review. Brain Behav Immun 26:239–250
Slopen N, Kubzansky LD, McLaughlin KA, Koenen KC (2013) Childhood adversity and inflammatory processes in youth: a prospective study. Psychoneuroendocrinology 38:188–200
Slopen N, Loucks EB, Appleton AA, Kawachi I, Kubzansky LD, Non AL, Buka S, Gilman SE (2015) Early origins of inflammation: an examination of prenatal and childhood social adversity in a prospective cohort study. Psychoneuroendocrinology 51:403–413
Smith PH, Oberleitner LM, Smith KM, McKee SA (2016) Childhood adversity interacts with adult stressful events to predict reduced likelihood of smoking cessation among women but not men. Clin Psychol Sci 4:183–193
Sorocco KH, Carnes NC, Cohoon AJ, Vincent AS, Lovallo WR (2015) Risk factors for alcoholism in the Oklahoma Family Health Patterns project: impact of early life adversity and family history on affect regulation and personality. Drug Alcohol Depend 150:38–45
de Souza JA, da Silva MC, Costa FCO et al (2020) Early life stress induced by maternal separation during lactation alters the eating behavior and serotonin system in middle-aged rat female offspring. Pharmacol Biochem Behav 192:172908
Speakman JR, Westerterp KR (2010) Associations between energy demands, physical activity, and body composition in adult humans between 18 and 96 y of age. Am J Clin Nutr 92:826–834
Spencer SJ (2013) Perinatal programming of neuroendocrine mechanisms connecting feeding behavior and stress. Front Neurosci 7:109
Spitzer C, Bouchain M, Winkler LY, Wingenfeld K, Gold SM, Grabe HJ, Barnow S, Otte C, Heesen C (2012) Childhood trauma in multiple sclerosis: a case-control study. Psychosom Med 74:312–318
Spitzer C, Wegert S, Wollenhaupt J, Wingenfeld K, Barnow S, Grabe HJ (2013) Gender-specific association between childhood trauma and rheumatoid arthritis: a case-control study. J Psychosom Res 74:296–300
Stein DJ, Scott K, Haro Abad JM et al (2010) Early childhood adversity and later hypertension: data from the World Mental Health Survey. Ann Clin Psychiatry 22:19–28
Stojek MM, Maples-Keller JL, Dixon HD, Umpierrez GE, Gillespie CF, Michopoulos V (2019) Associations of childhood trauma with food addiction and insulin resistance in African-American women with diabetes mellitus. Appetite 141:104317
Straub RH (2007) The complex role of estrogens in inflammation. Endocr Rev 28:521–574
Straub RH (2018) Altern, Müdigkeit und Entzündungen verstehen – Wenn Immunsystem und Gehirn um die Energie im Körper ringen. Springer, Berlin/Heidelberg
Straub RH (2020) Drei Gedächtnisse für den Körper. Springer Nature, Berlin
Straub RH, Cutolo M, Zietz B, Schölmerich J (2001) The process of aging changes the interplay of the immune, endocrine and nervous systems. Mech Ageing Dev 122:1591–1611
Su S, Wang X, Pollock JS, Treiber FA, Xu X, Snieder H, McCall WV, Stefanek M, Harshfield GA (2015) Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood: the Georgia stress and Heart study. Circulation 131:1674–1681
Su X, Liang H, Yuan W, Olsen J, Cnattingius S, Li J (2016) Prenatal and early life stress and risk of eating disorders in adolescent girls and young women. Eur Child Adolesc Psychiatry 25:1245–1253
Suglia SF, Koenen KC, Boynton-Jarrett R et al (2018) Childhood and adolescent adversity and cardiometabolic outcomes: a scientific statement from the American Heart Association. Circulation 137:e15–e28
Suglia SF, Chen C, Wang S et al (2020) Childhood adversity and pubertal development among Puerto Rican boys and girls. Psychosom Med 82:487–494
Sullivan K, Rochani H, Huang LT, Donley DK, Zhang J (2019) Adverse childhood experiences affect sleep duration for up to 50 years later. Sleep 42:zsz087
Sumner JA, Colich NL, Uddin M, Armstrong D, McLaughlin KA (2019) Early experiences of threat, but not deprivation, are associated with accelerated biological aging in children and adolescents. Biol Psychiatry 85:268–278
Surtees PG, Wainwright NW, Pooley KA, Luben RN, Khaw KT, Easton DF, Dunning AM (2011) Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study. J Gerontol A Biol Sci Med Sci 66:1152–1162
Suzuki H, Luby JL, Botteron KN, Dietrich R, McAvoy MP, Barch DM (2014) Early life stress and trauma and enhanced limbic activation to emotionally valenced faces in depressed and healthy children. J Am Acad Child Adolesc Psychiatry 53:800–813.e810
System IFI (2021) Iowa Flood Center. https://iowafloodcenter.org/
Tanenbaum HC, Li Y, Felicitas-Perkins JQ, Zhang M, Palmer P, Johnson CA, Xie B (2017) A longitudinal analysis of the impact of childhood stress on weight status among Chinese youth. Int J Obes 41:820–823
Tang W, Xu D, Xu J (2020) Impact of earthquake exposure, family adversity and peer problems on anxiety-related emotional disorders in adolescent survivors three years after the Ya’an earthquake. J Affect Disord 273:215–222
Tani Y, Fujiwara T, Kondo K (2020) Association between adverse childhood experiences and dementia in older Japanese adults. JAMA Netw Open 3:e1920740
Tavares GA, Torres A, de Souza JA (2020) Early life stress and the onset of obesity: proof of microRNAs’ involvement through modulation of serotonin and dopamine systems’ homeostasis. Front Physiol 11:925
Taylor SE, Lehman BJ, Kiefe CI, Seeman TE (2006) Relationship of early life stress and psychological functioning to adult C-reactive protein in the coronary artery risk development in young adults study. Biol Psychiatry 60:819–824
Tesarz J, Eich W, Treede RD, Gerhardt A (2016) Altered pressure pain thresholds and increased wind-up in adult patients with chronic back pain with a history of childhood maltreatment: a quantitative sensory testing study. Pain 157:1799–1809
Thapar A, Pine DS, Leckman JF, Scott S, Snowling MJ, Taylor E (2015) Rutter’s child and adolescent psychiatry, 6. Aufl. Wiley, Chichester/West Sussex
Thomas C, Hyppönen E, Power C (2008) Obesity and type 2 diabetes risk in midadult life: the role of childhood adversity. Pediatrics 121:e1240–e1249
Tuchscherer M, Kanitz E, Otten W, Tuchscherer A (2002) Effects of prenatal stress on cellular and humoral immune responses in neonatal pigs. Vet Immunol Immunopathol 86:195–203
Tursich M, Neufeld RW, Frewen PA, Harricharan S, Kibler JL, Rhind SG, Lanius RA (2014) Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis. Transl Psychiatry 4:e413
van Bodegom M, Homberg JR, Henckens M (2017) Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure. Front Cell Neurosci 11:87
van Campen JS, Jansen FE, de Graan PN, Braun KP, Joels M (2014) Early life stress in epilepsy: a seizure precipitant and risk factor for epileptogenesis. Epilepsy Behav 38:160–171
van Dammen L, Bush NR, de Rooij SR, Mol BWJ, Groen H, Hoek A, Roseboom TJ (2019) Childhood adversity and women’s cardiometabolic health in adulthood: associations with health behaviors, psychological distress, mood symptoms, and personality. BMC Womens Health 19:102
van Dammen L, Bush NR, de Rooij S, Mol BW, Mutsaerts M, van Oers A, Groen H, Hoek A, Roseboom T (2021) A lifestyle intervention randomized controlled trial in obese women with infertility improved body composition among those who experienced childhood adversity. Stress Health 37:93–102
van Dijken S (1998) John Bowlby: his early life: a biographical journey into the roots of attachment theory. Free Association Books, London/New York
Van Someren EJW (2021) Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev 101:995–1046
Vanbesien-Mailliot CC, Wolowczuk I, Mairesse J, Viltart O, Delacre M, Khalife J, Chartier-Harlin MC, Maccari S (2007) Prenatal stress has pro-inflammatory consequences on the immune system in adult rats. Psychoneuroendocrinology 32:114–124
Vartanian LR, Smyth JM, Zawadzki MJ, Heron KE, Coleman SR (2014) Early adversity, personal resources, body dissatisfaction, and disordered eating. Int J Eat Disord 47:620–629
Veenema AH, Reber SO, Selch S, Obermeier F, Neumann ID (2008) Early life stress enhances the vulnerability to chronic psychosocial stress and experimental colitis in adult mice. Endocrinology 149:2727–2736
Venta A (2020) Attachment facilitates acculturative learning and adversity moderates: validating the theory of epistemic trust in a natural experiment. Child Psychiatry Hum Dev 51:471–477
Vig R, Gordon JR, Thébaud B, Befus AD, Vliagoftis H (2010) The effect of early-life stress on airway inflammation in adult mice. Neuroimmunomodulation 17:229–239
von Bonsdorff MB, Kokko K, Salonen M, von Bonsdorff ME, Poranen-Clark T, Alastalo H, Kajantie E, Osmond C, Eriksson JG (2019) Association of childhood adversities and home atmosphere with functioning in old age: the Helsinki birth cohort study. Age Ageing 48:80–86
Waehrer GM, Miller TR, Silverio Marques SC, Oh DL, Burke HN (2020) Disease burden of adverse childhood experiences across 14 states. PLoS One 15:e0226134
Wainwright NW, Surtees PG (2002) Childhood adversity, gender and depression over the life-course. J Affect Disord 72:33–44
Wajid A, van Zanten SV, Mughal MK, Biringer A, Austin MP, Vermeyden L, Kingston D (2020) Adversity in childhood and depression in pregnancy. Arch Womens Ment Health 23:169–180
Walker RA, Andreansky C, Ray MH, McDannald MA (2018) Early adolescent adversity inflates threat estimation in females and promotes alcohol use initiation in both sexes. Behav Neurosci 132:171–182
Wan Y, Chen R, Ma S, McFeeters D, Sun Y, Hao J, Tao F (2019) Associations of adverse childhood experiences and social support with self-injurious behaviour and suicidality in adolescents. Br J Psychiatry 214:146–152
Wang XD, Labermaier C, Holsboer F, Wurst W, Deussing JM, Müller MB, Schmidt MV (2012) Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1. Eur J Neurosci 36:2360–2367
Wang Y, Raffeld MR, Slopen N, Hale L, Dunn EC (2016) Childhood adversity and insomnia in adolescence. Sleep Med 21:12–18
Wanner B, Vitaro F, Tremblay RE, Turecki G (2012) Childhood trajectories of anxiousness and disruptiveness explain the association between early-life adversity and attempted suicide. Psychol Med 42:2373–2382
Ward IL (1972) Prenatal stress feminizes and demasculinizes the behavior of males. Science 175:82–84
Ward IL (1984) The prenatal stress syndrome: current status. Psychoneuroendocrinology 9:3–11
Weldegiorgis M, Smith M, Herrington WG, Bankhead C, Woodward M (2020) Socioeconomic disadvantage and the risk of advanced chronic kidney disease: results from a cohort study with 1.4 million participants. Nephrol Dial Transplant 35:1562–1570
Wickrama KA, Kwon JA, Oshri A, Lee TK (2014) Early socioeconomic adversity and young adult physical illness: the role of body mass index and depressive symptoms. J Adolesc Health 55:556–563
Wickrama KAS, Bae D, O’Neal CW (2017) Explaining the association between early adversity and young adults’ diabetes outcomes: physiological, psychological, and behavioral mechanisms. J Youth Adolesc 46:2407–2420
Wickrama KK, O‘Neal CW, Lee TK, Wickrama T (2015) Early socioeconomic adversity, youth positive development, and young adults’ cardio-metabolic disease risk. Health Psychol 34:905–914
Wicks S, Hjern A, Gunnell D, Lewis G, Dalman C (2005) Social adversity in childhood and the risk of developing psychosis: a national cohort study. Am J Psychiatry 162:1652–1657
Williams LM, Gatt JM, Schofield PR, Olivieri G, Peduto A, Gordon E (2009) ‚Negativity bias‘ in risk for depression and anxiety: brain-body fear circuitry correlates, 5-HTT-LPR and early life stress. NeuroImage 47:804–814
Wilson CA, Vazdarjanova A, Terry AV Jr (2013) Exposure to variable prenatal stress in rats: effects on anxiety-related behaviors, innate and contextual fear, and fear extinction. Behav Brain Res 238:279–288
Winsper C, Zanarini M, Wolke D (2012) Prospective study of family adversity and maladaptive parenting in childhood and borderline personality disorder symptoms in a non-clinical population at 11 years. Psychol Med 42:2405–2420
Witek Janusek L, Tell D, Albuquerque K, Mathews HL (2013) Childhood adversity increases vulnerability for behavioral symptoms and immune dysregulation in women with breast cancer. Brain Behav Immun 30(Suppl):S149–S162
Witt ST, Bednarska O, Keita Ã…V et al (2019) Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome. Neuroimage Clin 21:101602
Wong HLX, Qin HY, Tsang SW et al (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nat Commun 10:1745
Yang J, Han H, Cao J, Li L, Xu L (2006) Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring. Hippocampus 16:431–436
Yeh CM, Huang CC, Hsu KS (2012) Prenatal stress alters hippocampal synaptic plasticity in young rat offspring through preventing the proteolytic conversion of pro-brain-derived neurotrophic factor (BDNF) to mature BDNF. J Physiol 590:991–1010
You DS, Meagher MW (2016) Childhood adversity and pain sensitization. Psychosom Med 78:1084–1093
You DS, Meagher MW (2018) Childhood adversity and pain facilitation. Psychosom Med 80:869–879
Zazara DE, Perani CV, Solano ME, Arck PC (2018) Prenatal stress challenge impairs fetal lung development and asthma severity sex-specifically in mice. J Reprod Immunol 125:100–105
Zhang L, Zhang D, Sun Y (2019) Adverse childhood experiences and early pubertal timing among girls: a meta-analysis. Int J Environ Res Public Health 16:2887
Zhu J, Lowen SB, Anderson CM, Ohashi K, Khan A, Teicher MH (2019) Association of prepubertal and postpubertal exposure to childhood maltreatment with adult amygdala function. JAMA Psychiatry 76:843–853
Zhu P, Hao JH, Tao RX, Huang K, Jiang XM, Zhu YD, Tao FB (2015) Sex-specific and time-dependent effects of prenatal stress on the early behavioral symptoms of ADHD: a longitudinal study in China. Eur Child Adolesc Psychiatry 24:1139–1147
Zijlmans MA, Korpela K, Riksen-Walraven JM, de Vos WM, de Weerth C (2015) Maternal prenatal stress is associated with the infant intestinal microbiota. Psychoneuroendocrinology 53:233–224
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Straub, R.H. (2023). Consequences of Early Traumatic Experiences. In: Early Trauma as the Origin of Chronic Inflammation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-66751-4_3
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