Skip to main content
SpringerLink
Log in

Ätiologie und Pathogenese

  • Chapter
  • First Online:
Tumorassoziierte Fatigue

  • 208 Accesses

Zusammenfassung

Erklärungsmodelle zur Ursache und Entstehung von Fatigue-Syndromen gehen von multifaktoriellen ätiologischen und pathogenetischen Vorgängen aus. Auslösende und aufrechterhaltende Prozesse sowie Schutz- und Risikofaktoren sind daran beteiligt, aber auch Regelungsprozesse von physiologischen Müdigkeits- und Erschöpfungszuständen. Die Tumorerkrankung und die antineoplastischen Therapien spielen bei der Entstehung zentrale Rollen, sowohl als auslösende als auch als aufrechterhaltende Faktoren. Sie können voneinander unabhängig oder gemeinsam wirken und über eine Vielzahl pathophysiologischer Prozesse zum Störungsbild führen. Weiterhin bestimmen erbliche und psychosoziale Faktoren die individuelle Vulnerabilität für Fatigue. Trotz intensiver Forschungsbemühungen und vieler neuer Erkenntnisse ist es bisher nicht möglich, die genauen Anteile der verschiedenen Einflussfaktoren zu bestimmen. Es deutet sich aber an, dass nicht einzelne von ihnen den Entstehungsprozess bestimmen, sondern erst ihre Wechselwirkungen zu den Veränderungen in den Regulationssystemen des Organismus führen, die als Fatiguesymptomatik wahrgenommen wird. Den bisherigen Erklärungsmodellen ist gemeinsam, dass sie noch nicht umfassend empirisch fundiert sind. Dennoch haben sie eine Bedeutung für die Grundlagen und Therapieforschung und einen heuristischen Wert für das Verständnis der Fatigue sowie die diagnostische und therapeutische Praxis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Abrahams, H. J., Gielissen, M. F., Schmits, I. C., Verhagen, C. A., Rovers, M. M., & Knoop, H. (2016). Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: A meta-analysis involving 12 327 breast cancer survivors. Annals of Oncology, 27(6), 965–974.

    Google Scholar 

  • Adam, E. K., Quinn, M. E., Tavernier, R., McQuillan, M. T., Dahlke, K. A., & Gilbert, K. E. (2017). Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis. Psychoneuroendocrinology, 83, 25–41. https://doi.org/10.1016/j.psyneuen.2017.05.018

  • Al Maqbali, M., Al Sinani, M., Al Naamani, Z., Al Badi, K., & Tanash, M. (2021). Prevalence of fatigue in patients with cancer: A systematic review and meta-analysis. Journal of Pain and Symptom Management, 61(1), 167–189.e114. https://doi.org/10.1016/j.jpainsymman.2020.07.037

  • Alcantara-Silva, T. R., Freitas-Junior, R., Freitas, N. M., & Machado, G. D. (2013). Fatigue related to radiotherapy for breast and/or gynaecological cancer: A systematic review. Journal of Clinical Nursing, 22(19–20), 2679–2686.

    Google Scholar 

  • Alcântara-Silva, T. R., de Freitas-Junior, R., Freitas, N. M. A., de Paula Junior, W., da Silva, D. J., Machado, G. D. P., Ribeiro, M. K. A., Carneiro, J. P., & Soares, L. R. (2018). Music therapy reduces radiotherapy-induced fatigue in patients with breast or gynecological cancer: A randomized trial. Integrative Cancer Therapies, 17(3), 628–635. https://doi.org/10.1177/1534735418757349

  • Allexandre, D., Seyidova-Khoshknabi, D., Davis, M. P., Ranganathan, V. K., Siemionow, V., Walsh, D., & Yue, G. H. (2020). EEG correlates of central origin of cancer-related fatigue. Neural Plasticity, 2020, 8812984. https://doi.org/10.1155/2020/8812984

  • Ancoli-Israel, S., Liu, L., Rissling, M., Natarajan, L., Neikrug, A. B., Palmer, B. W., Mills, P. J., Parker, B. A., Sadler, G. R., & Maglione, J. (2014). Sleep, fatigue, depression, and circadian activity rhythms in women with breast cancer before and after treatment: A 1-year longitudinal study. Supportive Care in Cancer, 22(9), 2535–2545. https://doi.org/10.1007/s00520-014-2204-5

  • Andrykowski, M. A., Donovan, K. A., Laronga, C., & Jacobsen, P. B. (2010). Prevalence, predictors, and characteristics of off-treatment fatigue in breast cancer survivors. Cancer, 116(24), 5740–5748.

    Google Scholar 

  • Arya, N., Vaish, A., Zhao, K., & Rao, H. (2021). Neural mechanisms underlying breast cancer related fatigue: A systematic review of neuroimaging studies. Frontiers in Neuroscience, 15, 735945. https://doi.org/10.3389/fnins.2021.735945

  • Behranvand, N., Nasri, F., Emmameh, Z., Khani, P., Hosseini, A., Garssen, J., & Falak, R. (2021). Chemotherapy: A double-edged sword in cancer treatment. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-021-03013-3

  • Bødtcher, H., Bidstrup, P. E., Andersen, I., Christensen, J., Mertz, B. G., Johansen, C., & Dalton, S. O. (2015). Fatigue trajectories during the first 8 months after breast cancer diagnosis. Quality of Life Research, 24(11), 2671–2679. https://doi.org/10.1007/s11136-015-1000-0

  • Bohlen, J., McLaughlin, S. L., Hazard-Jenkins, H., Infante, A. M., Montgomery, C., Davis, M., & Pistilli, E. E. (2018). Dysregulation of metabolic-associated pathways in muscle of breast cancer patients: Preclinical evaluation of interleukin-15 targeting fatigue. J Cachexia Sarcopenia Muscle, 9(4), 701–714. https://doi.org/10.1002/jcsm.12294

  • Bower, J. E. (2014). Cancer-related fatigue – Mechanisms, risk factors, and treatments. Nature Reviews: Clinical Oncology, 11(10), 597–609.

    Google Scholar 

  • Bower, J. E. (2019). The role of neuro-immune interactions in cancer-related fatigue: Biobehavioral risk factors and mechanisms. Cancer, 125(3), 353–364. https://doi.org/10.1002/cncr.31790

  • Bower, J. E., Ganz, P. A., Aziz, N., & Fahey, J. L. (2002). Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosomatic Medicine, 64(4), 604–611.

    Google Scholar 

  • Bower, J. E., Ganz, P. A., & Aziz, N. (2005a). Altered cortisol response to psychologic stress in breast cancer survivors with persistent fatigue. Psychosomatic Medicine, 67(2), 277–280.

    Google Scholar 

  • Bower, J. E., Ganz, P. A., Dickerson, S. S., Petersen, L., Aziz, N., & Fahey, J. L. (2005b). Diurnal cortisol rhythm and fatigue in breast cancer survivors. Psychoneuroendocrinology, 30(1), 92–100. https://doi.org/10.1016/j.psyneuen.2004.06.003

  • Bower, J. E., Ganz, P. A., Tao, M. L., Hu, W., Belin, T. R., Sepah, S., Cole, S., & Aziz, N. (2009). Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer. Clinical Cancer Research, 15(17), 5534–5540.

    Google Scholar 

  • Bower, J. E., Ganz, P. A., Irwin, M. R., Arevalo, J. M., & Cole, S. W. (2011). Fatigue and gene expression in human leukocytes: Increased NF-κB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue. Brain, Behavior, and Immunity, 25(1), 147–150. https://doi.org/10.1016/j.bbi.2010.09.010

  • Bower, J. E., Garet, D., Sternlieb, B., Ganz, P. A., Irwin, M. R., Olmstead, R., & Greendale, G. (2012). Yoga for persistent fatigue in breast cancer survivors: A randomized controlled trial. Cancer, 118(15), 3766–3775.

    Google Scholar 

  • Bower, J. E., Ganz, P. A., Irwin, M. R., Castellon, S., Arevalo, J., & Cole, S. W. (2013). Cytokine genetic variations and fatigue among patients with breast cancer. Journal of Clinical Oncology, 31(13), 1656–1661.

    Google Scholar 

  • Bower, J. E., Wiley, J., Petersen, L., Irwin, M. R., Cole, S. W., & Ganz, P. A. (2018). Fatigue after breast cancer treatment: Biobehavioral predictors of fatigue trajectories. Health Psychology, 37(11), 1025–1034. https://doi.org/10.1037/hea0000652

  • Bower, J. E., Ganz, P. A., Irwin, M. R., Cole, S. W., Garet, D., Petersen, L., Asher, A., Hurvitz, S. A., & Crespi, C. M. (2021). Do all patients with cancer experience fatigue? A longitudinal study of fatigue trajectories in women with breast cancer. Cancer, 127(8), 1334–1344. https://doi.org/10.1002/cncr.33327

  • Brook, R. D., & Julius, S. (2000). Autonomic imbalance, hypertension, and cardiovascular risk. American Journal of Hypertension, 13(6 Pt 2), 112S–122S. https://doi.org/10.1016/s0895-7061(00)00228-4

  • Brown, A. L., Sok, P., Taylor, O., Woodhouse, J. P., Bernhardt, M. B., Raghubar, K. P., Kahalley, L. S., Lupo, P. J., Hockenberry, M. J., & Scheurer, M. E. (2021). Cerebrospinal fluid metabolomic profiles associated with fatigue during treatment for pediatric acute lymphoblastic leukemia. Journal of Pain and Symptom Management, 61(3), 464–473. https://doi.org/10.1016/j.jpainsymman.2020.08.030

  • Bruera, E., Valero, V., Driver, L., Shen, L., Willey, J., Zhang, T., & Palmer, J. L. (2006). Patient-controlled methylphenidate for cancer fatigue: A double-blind, randomized, placebo-controlled trial. Journal of Clinical Oncology, 24(13), 2073–2078.

    Google Scholar 

  • Cai, B., Allexandre, D., Rajagopalan, V., Jiang, Z., Siemionow, V., Ranganathan, V. K., Davis, M. P., Walsh, D., Dai, K., & Yue, G. H. (2014). Evidence of significant central fatigue in patients with cancer-related fatigue during repetitive elbow flexions till perceived exhaustion. PloS One, 9(12), e115370. https://doi.org/10.1371/journal.pone.0115370

  • Cameron, B., Webber, K., Li, H., Bennett, B. K., Boyle, F., de Souza, P., Wilcken, N., Lynch, J., Friedlander, M., Goldstein, D., & Lloyd, A. R. (2021). Genetic associations of fatigue and other symptoms following breast cancer treatment: A prospective study. Brain Behav Immun Health, 10, 100189. https://doi.org/10.1016/j.bbih.2020.100189

  • Ceunen, E., Vlaeyen, J. W. S., & Van Diest, I. (2016). On the origin of interoception [Review]. Frontiers in Psychology, 7. https://doi.org/10.3389/fpsyg.2016.00743

  • Chartogne, M., Leclercq, A., Beaune, B., Boyas, S., Forestier, C., Martin, T., Thomas-Ollivier, V., Landry, S., Bourgeois, H., Cojocarasu, O., Pialoux, V., Zanna, O., Messonnier, L. A., Rahmani, A., & Morel, B. (2021). Building a biopsychosocial model of cancer-related fatigue: The BIOCARE FActory cohort study protocol. BMC Cancer, 21(1), 1140. https://doi.org/10.1186/s12885-021-08831-3

  • Chen, W. G., Schloesser, D., Arensdorf, A. M., Simmons, J. M., Cui, C., Valentino, R., Gnadt, J. W., Nielsen, L., Hillaire-Clarke, C. S., Spruance, V., Horowitz, T. S., Vallejo, Y. F., & Langevin, H. M. (2021). The emerging science of interoception: Sensing, integrating, interpreting, and regulating signals within the self. Trends in Neurosciences, 44(1), 3–16. https://doi.org/10.1016/j.tins.2020.10.007

  • Chrousos, G. P., & Gold, P. W. (1992). The concepts of stress and stress system disorders: Overview of physical and behavioral homeostasis. JAMA, 267(9), 1244–1252. https://doi.org/10.1001/jama.1992.03480090092034

  • Cohen, R. A., Gullett, J. M., Woods, A. J., Porges, E. C., Starkweather, A., Jackson-Cook, C. K., Lynch-Kelly, D. L., & Lyon, D. E. (2019). Cytokine-associated fatigue prior to, during, and post-chemotherapy for breast cancer. Journal of Neuroimmunology, 334, 577001. https://doi.org/10.1016/j.jneuroim.2019.577001

  • Coumbe, B. G. T., & Groarke, J. D. (2018). Cardiovascular autonomic dysfunction in patients with cancer. Current Cardiology Reports, 20(8), 69. https://doi.org/10.1007/s11886-018-1010-y

  • Crosswell, A. D., Lockwood, K. G., Ganz, P. A., & Bower, J. E. (2014). Low heart rate variability and cancer-related fatigue in breast cancer survivors. Psychoneuroendocrinology, 45, 58–66. https://doi.org/10.1016/j.psyneuen.2014.03.011

  • Cuneo, M. G., Schrepf, A., Slavich, G. M., Thaker, P. H., Goodheart, M., Bender, D., Cole, S. W., Sood, A. K., & Lutgendorf, S. K. (2017). Diurnal cortisol rhythms, fatigue and psychosocial factors in five-year survivors of ovarian cancer. Psychoneuroendocrinology, 84, 139–142. https://doi.org/10.1016/j.psyneuen.2017.06.019

  • Dantzer, R., & Kelley, K. W. (2007). Twenty years of research on cytokine-induced sickness behavior. Brain, Behavior, and Immunity, 21(2), 153–160. https://doi.org/10.1016/j.bbi.2006.09.006

  • Dantzer, R., O’Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews: Neuroscience, 9(1), 46–56. https://doi.org/10.1038/nrn2297

  • Dantzer, R., Heijnen, C. J., Kavelaars, A., Laye, S., & Capuron, L. (2014). The neuroimmune basis of fatigue. Trends in Neurosciences, 37(1), 39–46.

    Google Scholar 

  • Deary, V., Hagenaars, S. P., Harris, S. E., Hill, W. D., Davies, G., Liewald, D. C. M., McIntosh, A. M., Gale, C. R., Deary, I. J., & International Consortium for Blood Pressure, G., Aging, C. C., Longevity, G., & Group, C. C. I. (2018). Genetic contributions to self-reported tiredness. Molecular Psychiatry, 23(3), 609–620. https://doi.org/10.1038/mp.2017.5

    Article  PubMed  Google Scholar 

  • Devlin, B. A., Smith, C. J., & Bilbo, S. D. (2021). Sickness and the social brain: How the immune system regulates behavior across species. Brain, Behavior and Evolution. https://doi.org/10.1159/000521476

  • Di Meglio, A., Havas, J., Soldato, D., Presti, D., Martin, E., Pistilli, B., Menvielle, G., Dumas, A., Charles, C., Everhard, S., Martin, A.-L., Coutant, C., Tarpin, C., Vanlemmens, L., Levy, C., Rigal, O., Delaloge, S., Lin, N. U., Ganz, P. A., et al. (2022). Development and validation of a predictive model of severe fatigue after breast cancer diagnosis: Toward a personalized framework in survivorship care. Journal of Clinical Oncology, 40(10), 1111–1123. https://doi.org/10.1200/JCO.21.01252

    Article  PubMed  PubMed Central  Google Scholar 

  • Draper, A., Koch, R. M., van der Meer, J. W., Aj Apps, M., Pickkers, P., Husain, M., & van der Schaaf, M. E. (2018). Effort but not reward sensitivity is altered by acute sickness induced by experimental endotoxemia in humans. Neuropsychopharmacology, 43(5), 1107–1118. https://doi.org/10.1038/npp.2017.231

    Article  PubMed  Google Scholar 

  • Egger, J. W. (2008). Das biopsychosoziale Krankheitsmodell – Gründzüge eines wissenschaftlich begründenten ganzheitlichen Verständnisses von Krankheit., 16. Jahrgang, Nummer 12.

    Google Scholar 

  • Eshragh, J., Dhruva, A., Paul, S. M., Cooper, B. A., Mastick, J., Hamolsky, D., Levine, J. D., Miaskowski, C., & Kober, K. M. (2017). Associations between neurotransmitter genes and fatigue and energy levels in women after breast cancer surgery. Journal of Pain and Symptom Management, 53(1), 67–84.e67. https://doi.org/10.1016/j.jpainsymman.2016.08.004

    Article  PubMed  Google Scholar 

  • Fagundes, C. P., Murray, D. M., Hwang, B. S., Gouin, J. P., Thayer, J. F., Sollers, J. J., 3rd, Shapiro, C. L., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2011). Sympathetic and parasympathetic activity in cancer-related fatigue: More evidence for a physiological substrate in cancer survivors. Psychoneuroendocrinology, 36(8), 1137–1147. https://doi.org/10.1016/j.psyneuen.2011.02.005

    Article  PubMed  PubMed Central  Google Scholar 

  • Fava, G. A., McEwen, B. S., Guidi, J., Gostoli, S., Offidani, E., & Sonino, N. (2019). Clinical characterization of allostatic overload. Psychoneuroendocrinology, 108, 94–101. https://doi.org/10.1016/j.psyneuen.2019.05.028

    Article  PubMed  Google Scholar 

  • Feng, L. R., Fernández-Martínez, J. L., Zaal, K. J. M., deAndrés-Galiana, E. J., Wolff, B. S., & Saligan, L. N. (2018). mGluR5 mediates post-radiotherapy fatigue development in cancer patients. Translational Psychiatry, 8(1), 110. https://doi.org/10.1038/s41398-018-0161-3

    Article  PubMed  PubMed Central  Google Scholar 

  • Feng, L. R., Fuss, T., Dickinson, K., Ross, A., & Saligan, L. N. (2019). Co-occurring symptoms contribute to persistent fatigue in prostate cancer. Oncology, 96(4), 183–191. https://doi.org/10.1159/000494620

    Article  PubMed  Google Scholar 

  • Feng, L. R., Juneau, P., Regan, J. M., Liwang, J., Alshawi, S., Wang, A., & Saligan, L. N. (2020). Brain-derived neurotrophic factor polymorphism Val66Met protects against cancer-related fatigue. Translational Psychiatry, 10(1), 302. https://doi.org/10.1038/s41398-020-00990-4

    Article  PubMed  PubMed Central  Google Scholar 

  • Fernandez-de-Las-Penas, C., Cantarero-Villanueva, I., Fernandez-Lao, C., Ambite-Quesada, S., Diaz-Rodriguez, L., Rivas-Martinez, I., del Moral-Avila, R., & Arroyo-Morales, M. (2012a). Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors. Breast, 21(2), 199–203.

    Article  PubMed  Google Scholar 

  • Fernandez-de-Las-Penas, C., Fernandez-Lao, C., Cantarero-Villanueva, I., Ambite-Quesada, S., Rivas-Martinez, I., del Moral-Avila, R., & Arroyo-Morales, M. (2012b). Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. Breast Cancer Research and Treatment, 133(2), 405–412.

    Article  PubMed  Google Scholar 

  • Feyer, P., Steingräber, M., & Titlbach, O. (2004). Besonderheiten der Fatigue bei radioonkologischen Patienten. Journal Onkologie, 6, 16–19.

    Google Scholar 

  • Fosså, A., Smeland, K. H., Fluge, Ø., Tronstad, K. J., Loge, J. H., Midttun, Ø., Ueland, P. M., & Kiserud, C. E. (2020). Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue. PloS One, 15(1), e0227384. https://doi.org/10.1371/journal.pone.0227384

    Article  PubMed  PubMed Central  Google Scholar 

  • Ganz, P. A., & Bower, J. E. (2007). Cancer related fatigue: A focus on breast cancer and Hodgkin’s disease survivors. Acta Oncologica, 46(4), 474–479.

    Article  PubMed  Google Scholar 

  • Ganzel, B. L., Morris, P. A., & Wethington, E. (2010). Allostasis and the human brain: Integrating models of stress from the social and life sciences. Psychological Review, 117(1), 134–174. https://doi.org/10.1037/a0017773

    Article  PubMed  PubMed Central  Google Scholar 

  • Hajdarevic, R., Lande, A., Mehlsen, J., Rydland, A., Sosa, D. D., Strand, E. B., Mella, O., Pociot, F., Fluge, Ø., Lie, B. A., & Viken, M. K. (2022). Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci. Brain, Behavior, and Immunity, 102, 362–369. https://doi.org/10.1016/j.bbi.2022.03.010

  • Geraghty, K., Jason, L., Sunnquist, M., Tuller, D., Blease, C., & Adeniji, C. (2019). The “cognitive behavioural model” of chronic fatigue syndrome: Critique of a flawed model. Health Psychology Open, 6(1). https://doi.org/10.1177/2055102919838907

  • Goedendorp, M. M., Gielissen, M. F., Verhagen, C. A., Peters, M. E., & Bleijenberg, G. (2008). Severe fatigue and related factors in cancer patients before the initiation of treatment. British Journal of Cancer, 99(9), 1408–1414. https://doi.org/10.1038/sj.bjc.6604739

    Article  PubMed  PubMed Central  Google Scholar 

  • Goertzel, B. N., Pennachin, C., de Souza, C. L., Gurbaxani, B., Maloney, E. M., & Jones, J. F. (2006). Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome. Pharmacogenomics, 7(3), 475–483.

    Article  PubMed  Google Scholar 

  • Goto, T., Von Ah, D., Li, X., Xiang, L., Kwiat, C., Nguyen, C., Hsiao, C. P., & Saligan, L. N. (2023). Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors. Journal of Cancer Survivorship, https://doi.org/10.1007/s11764-023-01426-w

  • Greenhouse-Tucknott, A., Butterworth, J. B., Wrightson, J. G., Smeeton, N. J., Critchley, H. D., Dekerle, J., & Harrison, N. A. (2021). Toward the unity of pathological and exertional fatigue: A predictive processing model. Cognitive, Affective & Behavioral Neuroscience. https://doi.org/10.3758/s13415-021-00958-x

  • Grossberg, A. J., Vichaya, E. G., Gross, P. S., Ford, B. G., Scott, K. A., Estrada, D., Vermeer, D. W., Vermeer, P., & Dantzer, R. (2020). Interleukin 6-independent metabolic reprogramming as a driver of cancer-related fatigue. Brain, Behavior, and Immunity, 88, 230–241. https://doi.org/10.1016/j.bbi.2020.05.043

    Article  PubMed  PubMed Central  Google Scholar 

  • Guidi, J., Lucente, M., Sonino, N., & Fava, G. A. (2021). Allostatic load and its impact on health: A systematic review. Psychotherapy and Psychosomatics, 90(1), 11–27. https://doi.org/10.1159/000510696

    Article  PubMed  Google Scholar 

  • Hajj, A., Chamoun, R., Salameh, P., Khoury, R., Hachem, R., Sacre, H., Chahine, G., Kattan, J., & Rabbaa Khabbaz, L. (2022). Fatigue in breast cancer patients on chemotherapy: A cross-sectional study exploring clinical, biological, and genetic factors. BMC Cancer, 22(1), 16. https://doi.org/10.1186/s12885-021-09072-0

    Article  PubMed  PubMed Central  Google Scholar 

  • Hall, K. T., Battinelli, E., Chasman, D. I., Ridker, P. M., Psaty, B. M., Rotter, J. I., Kaptchuk, T. J., Tracy, R. P., Wassel, C. L., & Mukamal, K. J. (2019). Catechol-O-methyltransferase and cardiovascular disease: MESA. Journal of the American Heart Association, 8(24), e014986. https://doi.org/10.1161/JAHA.119.014986

    Article  PubMed  PubMed Central  Google Scholar 

  • Hampson, J. P., Zick, S. M., Khabir, T., Wright, B. D., & Harris, R. E. (2015). Altered resting brain connectivity in persistent cancer related fatigue. Neuroimage Clin, 8, 305–313.

    Article  PubMed  PubMed Central  Google Scholar 

  • Harrison, P. J., & Tunbridge, E. M. (2008). Catechol-O-methyltransferase (COMT): A gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 33(13), 3037–3045. https://doi.org/10.1038/sj.npp.1301543

    Article  PubMed  Google Scholar 

  • Harvey, S. B., & Wessely, S. (2009). Chronic fatigue syndrome: Identifying zebras amongst the horses. BMC Medicine, 7, 58.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hernandez, C., Huebener, P., & Schwabe, R. F. (2016). Damage-associated molecular patterns in cancer: A double-edged sword. Oncogene, 35(46), 5931–5941. https://doi.org/10.1038/onc.2016.104

    Article  PubMed  PubMed Central  Google Scholar 

  • Hoenemeyer, T. W., Baidwan, N. K., Hall, K., Kaptchuk, T. J., Fontaine, K. R., & Mehta, T. S. (2021). An exploratory analysis of the association between catechol-o-methyltransferase and response to a randomized open-label placebo treatment for cancer-related fatigue. Front Psychiatry, 12, 684556. https://doi.org/10.3389/fpsyt.2021.684556

    Article  PubMed  PubMed Central  Google Scholar 

  • Iftikhar, A., Islam, M., Shepherd, S., Jones, S., & Ellis, I. (2021). Cancer and stress: Does it make a difference to the patient when these two challenges collide? Cancers, 13(2). https://doi.org/10.3390/cancers13020163

  • Inoue, H., Tsutsumi, H., Tanaka, K., Iwama, E., Shiraishi, Y., Hirayama, A., Nakanishi, T., Ando, H., Nakajima, M., Shinozaki, S., Ogata, H., Uryu, K., Okamura, K., Kimura, S., Ogawa, T., Ota, K., Yoneshima, Y., Hamada, N., Nakanishi, Y., & Okamoto, I. (2021). Increased plasma levels of damage-associated molecular patterns during systemic anticancer therapy in patients with advanced lung cancer. Translational Lung Cancer Research, 10(6), 2475–2486.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jabir, R. S., Ho, G. F., Annuar, M., & Stanslas, J. (2018). association of allelic interaction of single nucleotide polymorphisms of influx and efflux transporters genes with nonhematologic adverse events of docetaxel in breast cancer patients. Clinical Breast Cancer, 18(5), e1173–e1179. https://doi.org/10.1016/j.clbc.2018.04.018

    Article  PubMed  Google Scholar 

  • Jason, L., Benton, M., Torres-Harding, S., & Muldowney, K. (2009). The impact of energy modulation on physical functioning and fatigue severity among patients with ME/CFS. Patient Education and Counseling, 77(2), 237–241. https://doi.org/10.1016/j.pec.2009.02.015

    Article  PubMed  PubMed Central  Google Scholar 

  • Junghaenel, D. U., Cohen, J., Schneider, S., Neerukonda, A. R., & Broderick, J. E. (2015). Identification of distinct fatigue trajectories in patients with breast cancer undergoing adjuvant chemotherapy. Supportive Care in Cancer, 23(9), 2579–2587. https://doi.org/10.1007/s00520-015-2616-x

    Article  PubMed  PubMed Central  Google Scholar 

  • Karshikoff, B., Sundelin, T., & Lasselin, J. (2017). Role of inflammation in human fatigue: Relevance of multidimensional assessments and potential neuronal mechanisms. Frontiers in Immunology, 8, 21. https://doi.org/10.3389/fimmu.2017.00021

    Article  PubMed  PubMed Central  Google Scholar 

  • Kelley, K. W., & Kent, S. (2020). The legacy of sickness behaviors. Front Psychiatry, 11, 607269. https://doi.org/10.3389/fpsyt.2020.607269

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim, S., Miller, B. J., Stefanek, M. E., & Miller, A. H. (2015). Inflammation-induced activation of the indoleamine 2,3-dioxygenase pathway: Relevance to cancer-related fatigue. Cancer, 121(13), 2129–2136.

    Article  PubMed  Google Scholar 

  • Kisiel-Sajewicz, K., Davis, M. P., Siemionow, V., Seyidova-Khoshknabi, D., Wyant, A., Walsh, D., Hou, J., & Yue, G. H. (2012). Lack of muscle contractile property changes at the time of perceived physical exhaustion suggests central mechanisms contributing to early motor task failure in patients with cancer-related fatigue. Journal of Pain and Symptom Management, 44(3), 351–361. https://doi.org/10.1016/j.jpainsymman.2011.08.007

    Article  PubMed  Google Scholar 

  • Kisiel-Sajewicz, K., Siemionow, V., Seyidova-Khoshknabi, D., Davis, M. P., Wyant, A., Ranganathan, V. K., Walsh, D., Yan, J. H., Hou, J., & Yue, G. H. (2013). Myoelectrical manifestation of fatigue less prominent in patients with cancer related fatigue. PloS One, 8(12), e83636. https://doi.org/10.1371/journal.pone.0083636

    Article  PubMed  PubMed Central  Google Scholar 

  • Kleckner, I. R., Zhang, J., Touroutoglou, A., Chanes, L., Xia, C., Simmons, W. K., Quigley, K. S., Dickerson, B. C., & Feldman Barrett, L. (2017). Evidence for a large-scale brain system supporting allostasis and interoception in humans. Nature Human Behaviour, 1(5), 0069. https://doi.org/10.1038/s41562-017-0069

    Article  PubMed  PubMed Central  Google Scholar 

  • Knoop, H., Prins, J. B., Moss-Morris, R., & Bleijenberg, G. (2010). The central role of cognitive processes in the perpetuation of chronic fatigue syndrome. Journal of Psychosomatic Research, 68(5), 489–494. https://doi.org/10.1016/j.jpsychores.2010.01.022

    Article  PubMed  Google Scholar 

  • Kober, K. M., Smoot, B., Paul, S. M., Cooper, B. A., Levine, J. D., & Miaskowski, C. (2016). Polymorphisms in cytokine genes are associated with higher levels of fatigue and lower levels of energy in women after breast cancer surgery. Journal of Pain and Symptom Management, 52(5), 695–708.e694. https://doi.org/10.1016/j.jpainsymman.2016.04.014

    Article  PubMed  PubMed Central  Google Scholar 

  • Kreissl, S., Mueller, H., Goergen, H., Mayer, A., Brillant, C., Behringer, K., Halbsguth, T. V., Hitz, F., Soekler, M., Shonukan, O., Rueffer, J. U., Flechtner, H. H., Fuchs, M., Diehl, V., Engert, A., & Borchmann, P. (2016). Cancer-related fatigue in patients with and survivors of Hodgkin’s lymphoma: A longitudinal study of the German Hodgkin Study Group. Lancet Oncology, 17(10), 1453–1462.

    Article  PubMed  Google Scholar 

  • Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013). Immunogenic cell death in cancer therapy. Annual Review of Immunology, 31, 51–72. https://doi.org/10.1146/annurev-immunol-032712-100008

    Article  PubMed  Google Scholar 

  • Kühl, T., Behrens, S., Jung, A. Y., Obi, N., Thöne, K., Schmidt, M. E., Becher, H., & Chang-Claude, J. (2018). Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort. Brain, Behavior, and Immunity, 73, 252–260. https://doi.org/10.1016/j.bbi.2018.05.009

    Article  PubMed  Google Scholar 

  • Kumari, R., & Jat, P. (2021). Mechanisms of cellular senescence: Cell cycle arrest and senescence associated secretory phenotype. Frontiers in Cell and Developmental Biology, 9, 645593. https://doi.org/10.3389/fcell.2021.645593

    Article  PubMed  PubMed Central  Google Scholar 

  • Kuppuswamy, A. (2017). The fatigue conundrum. Brain, 140(8), 2240–2245. https://doi.org/10.1093/brain/awx153

    Article  PubMed  PubMed Central  Google Scholar 

  • Lacourt, T. E., Vichaya, E. G., Chiu, G. S., Dantzer, R., & Heijnen, C. J. (2018a). The high costs of low-grade inflammation: Persistent fatigue as a consequence of reduced cellular-energy availability and non-adaptive energy expenditure. Frontiers in Behavioral Neuroscience, 12, 78. https://doi.org/10.3389/fnbeh.2018.00078

    Article  PubMed  PubMed Central  Google Scholar 

  • Lacourt, T. E., Vichaya, E. G., Escalante, C., Manzullo, E. F., Gunn, B., Hess, K. R., Heijnen, C. J., & Dantzer, R. (2018b). An effort expenditure perspective on cancer-related fatigue. Psychoneuroendocrinology, 96, 109–117. https://doi.org/10.1016/j.psyneuen.2018.06.009

    Article  PubMed  PubMed Central  Google Scholar 

  • Lacourt, T. E., Kavelaars, A., Tripathy, D., & Heijnen, C. J. (2022). Associations between fatigue and cellular metabolism in breast cancer patients: A longitudinal study. Psychoneuroendocrinology, 144, 105866. https://doi.org/10.1016/j.psyneuen.2022.105866

  • Lasselin, J., Treadway, M. T., Lacourt, T. E., Soop, A., Olsson, M. J., Karshikoff, B., Paues-Göranson, S., Axelsson, J., Dantzer, R., & Lekander, M. (2017). Lipopolysaccharide alters motivated behavior in a monetary reward task: A randomized trial. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 42(4), 801–810. https://doi.org/10.1038/npp.2016.191

    Article  PubMed  Google Scholar 

  • Lavigne, C., Lau, H., Francis, G., Culos-Reed, S. N., Millet, G. Y., & Twomey, R. (2020). Neuromuscular function and fatigability in people diagnosed with head and neck cancer before versus after treatment. European Journal of Applied Physiology, 120(6), 1289–1304. https://doi.org/10.1007/s00421-020-04362-0

    Article  PubMed  Google Scholar 

  • Lee, S., Deasy, J. O., Oh, J. H., Di Meglio, A., Dumas, A., Menvielle, G., Charles, C., Boyault, S., Rousseau, M., Besse, C., Thomas, E., Boland, A., Cottu, P., Tredan, O., Levy, C., Martin, A.-L., Everhard, S., Ganz, P. A., Partridge, A. H., et al. (2020). Prediction of breast cancer treatment-induced fatigue by machine learning using genome-wide association data. JNCI cancer spectrum, 4(5), pkaa039. https://doi.org/10.1093/jncics/pkaa039

    Article  PubMed  PubMed Central  Google Scholar 

  • Maes, M., & Twisk, F. N. (2010). Chronic fatigue syndrome: Harvey and Wessely’s (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Medicine, 8, 35.

    Article  PubMed  PubMed Central  Google Scholar 

  • Maloney, E. M., Boneva, R., Nater, U. M., & Reeves, W. C. (2009). Chronic fatigue syndrome and high allostatic load: Results from a population-based case-control study in Georgia. Psychosomatic Medicine, 71(5), 549–556. https://doi.org/10.1097/PSY.0b013e3181a4fea8

    Article  PubMed  Google Scholar 

  • Malyuchenko, N. V., Schegolkova, J. V., Kulikova, M. A., Timofeeva, M. A., Shlepzova, V. A., Sysoeva, O. V., Ivanitsky, A. M., & Tonevitsky, A. G. (2010). Effects of genetic variations in the dopaminergic system on fatigue in humans: Gender aspects. Bulletin of Experimental Biology and Medicine, 149(2), 226–232. https://doi.org/10.1007/s10517-010-0913-4

    Article  PubMed  Google Scholar 

  • Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008). Cancer-related inflammation. Nature, 454(7203), 436–444. https://doi.org/10.1038/nature07205

    Article  PubMed  Google Scholar 

  • Mantovani, G., Maccio, A., Madeddu, C., Serpe, R., Antoni, G., Massa, E., Dessi, M., & Panzone, F. (2010). Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia. Journal of Molecular Medicine (Berlin, Germany), 88(1), 85–92.

    Article  PubMed  Google Scholar 

  • Marcora, S. M., Staiano, W., & Manning, V. (2009). Mental fatigue impairs physical performance in humans. Journal of Applied Physiology, 106(3), 857–864. https://doi.org/10.1152/japplphysiol.91324.2008

    Article  PubMed  Google Scholar 

  • Matsumura, S., Wang, B., Kawashima, N., Braunstein, S., Badura, M., Cameron, T. O., Babb, J. S., Schneider, R. J., Formenti, S. C., Dustin, M. L., & Demaria, S. (2008). Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. Journal of Immunology (Baltimore, Md.: 1950), 181(5), 3099–3107. https://doi.org/10.4049/jimmunol.181.5.3099

    Article  PubMed  Google Scholar 

  • Matura, L. A., Malone, S., Jaime-Lara, R., & Riegel, B. (2018). A systematic review of biological mechanisms of fatigue in chronic illness. Biological Research for Nursing, 20(4), 410–421. https://doi.org/10.1177/1099800418764326

    Article  PubMed  PubMed Central  Google Scholar 

  • Maurer, T., Jaskulski, S., Behrens, S., Jung, A. Y., Obi, N., Johnson, T., Becher, H., & Chang-Claude, J. (2021). Tired of feeling tired – The role of circulating inflammatory biomarkers and long-term cancer related fatigue in breast cancer survivors. Breast (Edinburgh, Scotland), 56, 103–109. https://doi.org/10.1016/j.breast.2021.02.008

    Article  PubMed  Google Scholar 

  • McEwen, B. S. (2004). Protection and damage from acute and chronic stress: Allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Annals of the New York Academy of Sciences, 1032(1), 1–7. https://doi.org/10.1196/annals.1314.001

    Article  PubMed  Google Scholar 

  • McEwen, B. S. (2019). What is the confusion with cortisol? Chronic Stress, 3. https://doi.org/10.1177/2470547019833647

  • McEwen, B. S., & Wingfield, J. C. (2003). The concept of allostasis in biology and biomedicine. Hormones and Behavior, 43(1), 2–15. https://doi.org/10.1016/S0018-506X(02)00024-7

    Article  PubMed  Google Scholar 

  • Meraner, V., Gamper, E. M., Grahmann, A., Giesinger, J. M., Wiesbauer, P., Sztankay, M., Zeimet, A. G., Sperner-Unterweger, B., & Holzner, B. (2012). Monitoring physical and psychosocial symptom trajectories in ovarian cancer patients receiving chemotherapy. BMC Cancer, 12, 77.

    Article  PubMed  PubMed Central  Google Scholar 

  • Michiels, V., & Cluydts, R. (2001). Neuropsychological functioning in chronic fatigue syndrome: A review: Neuropsychological functioning in CFS. Acta Psychiatrica Scandinavica, 103(2), 84–93. https://doi.org/10.1034/j.1600-0447.2001.00017.x

    Article  PubMed  Google Scholar 

  • Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137(6), 959–997. https://doi.org/10.1037/a0024768

    Article  PubMed  PubMed Central  Google Scholar 

  • Minton, O., Alexander, S., & Stone, P. C. (2012). Identification of factors associated with cancer related fatigue syndrome in disease-free breast cancer patients after completing primary treatment. Breast Cancer Research and Treatment, 136(2), 513–520.

    Article  PubMed  Google Scholar 

  • Montoya, J. G., Holmes, T. H., Anderson, J. N., Maecker, H. T., Rosenberg-Hasson, Y., Valencia, I. J., Chu, L., Younger, J. W., Tato, C. M., & Davis, M. M. (2017). Cytokine signature associated with disease severity in chronic fatigue syndrome patients. Proceedings of the National Academy of Sciences of the United States of America, 114(34), E7150–E7158. https://doi.org/10.1073/pnas.1710519114

    Article  PubMed  PubMed Central  Google Scholar 

  • Nagarsheth, N., Wicha, M. S., & Zou, W. (2017). Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nature Reviews: Immunology, 17(9), 559–572. https://doi.org/10.1038/nri.2017.49

    Article  PubMed  Google Scholar 

  • Nater, U. M., Youngblood, L. S., Jones, J. F., Unger, E. R., Miller, A. H., Reeves, W. C., & Heim, C. (2008). Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome. Psychosomatic Medicine, 70(3), 298–305.

    Article  PubMed  Google Scholar 

  • National Comprehensive Cancer Network (NCCN). (2023). Cancer related fatigue NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ®). (Vol. Version 2.2023 – January 30, 2023).

    Google Scholar 

  • Noakes, T. D. (2012). Fatigue is a brain-derived emotion that regulates the exercise behavior to ensure the protection of whole body homeostasis. Frontiers in Physiology, 3(82), 1–13.

    Google Scholar 

  • Nunes, E. J., Randall, P. A., Estrada, A., Epling, B., Hart, E. E., Lee, C. A., Baqi, Y., Müller, C. E., Correa, M., & Salamone, J. D. (2014). Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: Studies with the concurrent fixed ratio 5/chow feeding choice task. Psychopharmacology, 231(4), 727–736. https://doi.org/10.1007/s00213-013-3285-4

    Article  PubMed  Google Scholar 

  • Nusslock, R., & Miller, G. E. (2016). Early-life adversity and physical and emotional health across the lifespan: A neuroimmune network hypothesis. Biological Psychiatry, 80(1), 23–32. https://doi.org/10.1016/j.biopsych.2015.05.017

    Article  PubMed  Google Scholar 

  • O’Higgins, C. M., Brady, B., O’Connor, B., Walsh, D., & Reilly, R. B. (2018). The pathophysiology of cancer-related fatigue: Current controversies. Supportive Care in Cancer, 26(10), 3353–3364. https://doi.org/10.1007/s00520-018-4318-7

    Article  PubMed  Google Scholar 

  • Omdal, R. (2020). The biological basis of chronic fatigue: Neuroinflammation and innate immunity. Current Opinion in Neurology, 33(3), 391–396. https://doi.org/10.1097/wco.0000000000000817

    Article  PubMed  Google Scholar 

  • Papadopoulos, A. S., & Cleare, A. J. (2011). Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Nature Reviews. Endocrinology, 8(1), 22–32. https://doi.org/10.1038/nrendo.2011.153

    Article  PubMed  Google Scholar 

  • Payne, J. K. (2006). The trajectory of biomarkers in symptom management for older adults with cancer. Seminars in Oncology Nursing, 22(1), 31–35.

    Article  PubMed  Google Scholar 

  • Pertl, M. M., Hevey, D., Collier, S., Lambe, K., & O’Dwyer, A.-M. (2014). Predictors of fatigue in cancer patients before and after chemotherapy. Journal of Health Psychology, 19(6), 699–710. https://doi.org/10.1177/1359105313477675

    Article  PubMed  Google Scholar 

  • Pompeu, F. A. M. S. (2022). Why Pheidippides could not believe in the ‘Central Governor Model’: Popper’s philosophy applied to choose between two exercise physiology theories. Sports Med Health Sci, 4(1), 1–7. https://doi.org/10.1016/j.smhs.2021.10.001

    Article  PubMed  Google Scholar 

  • Pyter, L. M. (2016). The influence of cancer on endocrine, immune, and behavioral stress responses. Physiology and Behavior, 166, 4–13. https://doi.org/10.1016/j.physbeh.2015.09.031

    Article  PubMed  Google Scholar 

  • Querido, N. R., Kenkhuis, M. F., van Roekel, E. H., Breukink, S. O., van Duijnhoven, F. J. B., Janssen-Heijnen, M. L. G., Keulen, E. T. P., Ueland, P. M., Vogelaar, F. J., Wesselink, E., Bours, M. J. L., & Weijenberg, M. P. (2022). Longitudinal associations between inflammatory markers and fatigue up to two years after colorectal cancer treatment. Cancer Epidemiology, Biomarkers and Prevention, 31(8), 1638–1649. https://doi.org/10.1158/1055-9965.Epi-22-0077

    Article  PubMed  Google Scholar 

  • Radin, A. S., Bower, J. E., Irwin, M. R., Asher, A., Hurvitz, S. A., Cole, S. W., Crespi, C. M., & Ganz, P. A. (2022). Acute health-related quality of life outcomes and systemic inflammatory markers following contemporary breast cancer surgery. NPJ Breast Cancer, 8(1), 91. https://doi.org/10.1038/s41523-022-00456-4

    Article  PubMed  PubMed Central  Google Scholar 

  • Raglan, G. B., & Schulkin, J. (2014). Introduction to allostasis and allostatic load. In M. Kent, C. Davis, & J. W. Reich (Hrsg.), The resilience handbook: Approaches to stress and trauma (S. 44–52). Routledge/Taylor & Francis Group.

    Google Scholar 

  • Reidunsdatter, R. J., Albrektsen, G., Hjermstad, M. J., Rannestad, T., Oldervoll, L. M., & Lundgren, S. (2013). One-year course of fatigue after post-operative radiotherapy in Norwegian breast cancer patients – Comparison to general population. Acta Oncologica, 52(2), 239–248.

    Article  PubMed  Google Scholar 

  • Reinertsen, K. V., Grenaker Alnaes, G. I., Landmark-Hoyvik, H., Loge, J. H., Wist, E., Kristensen, V. N., Fossa, S. D., & Edvardsen, H. (2011). Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway. Brain, Behavior, and Immunity, 25(7), 1376–1383.

    Article  PubMed  Google Scholar 

  • Roerink, M. E., van der Schaaf, M. E., Dinarello, C. A., Knoop, H., & van der Meer, J. W. M. (2017). Interleukin-1 as a mediator of fatigue in disease: A narrative review. Journal of Neuroinflammation, 14(1), 16. https://doi.org/10.1186/s12974-017-0796-7

    Article  PubMed  PubMed Central  Google Scholar 

  • Saligan, L. N., & Kim, H. S. (2012). A systematic review of the association between immunogenomic markers and cancer-related fatigue. Brain, Behavior, and Immunity.

    Google Scholar 

  • Saligan, L. N., Olson, K., Filler, K., Larkin, D., Cramp, F., Yennurajalingam, S., Escalante, C. P., del Giglio, A., Kober, K. M., Kamath, J., Palesh, O., & Mustian, K. (2015). The biology of cancer-related fatigue: A review of the literature. Supportive Care in Cancer, 23(8), 2461–2478. https://doi.org/10.1007/s00520-015-2763-0

    Article  PubMed  PubMed Central  Google Scholar 

  • Santos, J. C., & Pyter, L. M. (2018). Neuroimmunology of behavioral comorbidities associated with cancer and cancer treatments. Frontiers in Immunology, 9, 1195. https://doi.org/10.3389/fimmu.2018.01195

    Article  PubMed  PubMed Central  Google Scholar 

  • Schlauch, K. A., Khaiboullina, S. F., De Meirleir, K. L., Rawat, S., Petereit, J., Rizvanov, A. A., Blatt, N., Mijatovic, T., Kulick, D., Palotás, A., & Lombardi, V. C. (2016). Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome. Transl Psychiatry, 6(2), e730. https://doi.org/10.1038/tp.2015.208

  • Schmidt, M. E., Semik, J., Habermann, N., Wiskemann, J., Ulrich, C. M., & Steindorf, K. (2016). Cancer-related fatigue shows a stable association with diurnal cortisol dysregulation in breast cancer patients. Brain, Behavior, and Immunity, 52, 98–105.

    Article  PubMed  Google Scholar 

  • Scott, K., Phan, T. T., West, A. P., Taniguchi, C. M., & Dantzer, R. (2022). Neutralizing interleukin-6 in tumor-bearing mice does not abrogate behavioral fatigue induced by Lewis lung carcinoma. Behavioural Brain Research, 417, 113607. https://doi.org/10.1016/j.bbr.2021.113607

    Article  PubMed  Google Scholar 

  • Sephton, S., & Spiegel, D. (2003). Circadian disruption in cancer: A neuroendocrine-immune pathway from stress to disease? Brain, Behavior, and Immunity, 17(5), 321–328. https://doi.org/10.1016/S0889-1591(03)00078-3

    Article  PubMed  Google Scholar 

  • Sloan, J. A., de Andrade, M., Decker, P., Wampfler, J., Oswold, C., Clark, M., & Yang, P. (2012). Genetic variations and patient-reported quality of life among patients with lung cancer. Journal of Clinical Oncology, 30(14), 1699–1704. https://doi.org/10.1200/jco.2010.34.5629

    Article  PubMed  PubMed Central  Google Scholar 

  • Solomon, A. M., Doorenbos, A., Li, H., Jang, M., Park, C., & Bronas, U. (2020). Allostatic load in cancer: A systematic review and mini meta-analysis. Biological Research for Nursing, 23. https://doi.org/10.1177/1099800420969898

  • Song, S., & Jason, L. A. (2009). A population-based study of chronic fatigue syndrome (CFS) experienced in differing patient groups: An effort to replicate Vercoulen et al.’s model of CFS. Journal of Mental Health, 14(3), 277–289. https://doi.org/10.1080/09638230500076165

    Article  Google Scholar 

  • St Clair Gibson, A., Swart, J., & Tucker, R. (2018). The interaction of psychological and physiological homeostatic drives and role of general control principles in the regulation of physiological systems, exercise and the fatigue process – The Integrative Governor theory. Eur J Sport Sci, 18(1), 25–36. https://doi.org/10.1080/17461391.2017.1321688

    Article  PubMed  Google Scholar 

  • Stephan, K. E., Manjaly, Z. M., Mathys, C. D., Weber, L. A., Paliwal, S., Gard, T., Tittgemeyer, M., Fleming, S. M., Haker, H., Seth, A. K., & Petzschner, F. H. (2016). Allostatic self-efficacy: A metacognitive theory of dyshomeostasis-induced fatigue and depression. Frontiers in Human Neuroscience, 10, 550. https://doi.org/10.3389/fnhum.2016.00550

    Article  PubMed  PubMed Central  Google Scholar 

  • Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In Handbook of life stress, cognition and health (S. 629–649). John Wiley & Sons.

    Google Scholar 

  • Straub, R. H. (2017). The brain and immune system prompt energy shortage in chronic inflammation and ageing. Nature Reviews. Rheumatology, 13(12), 743–751. https://doi.org/10.1038/nrrheum.2017.172

    Article  PubMed  Google Scholar 

  • Sunnquist, M., & Jason, L. A. (2018). A reexamination of the cognitive behavioral model of chronic fatigue syndrome. Journal of Clinical Psychology, 74(7), 1234–1245. https://doi.org/10.1002/jclp.22593

    Article  PubMed  PubMed Central  Google Scholar 

  • Sura, W., Murphy, S. O., & Gonzales, I. (2006). Level of fatigue in women receiving dose-dense versus standard chemotherapy for breast cancer: A pilot study. Oncology Nursing Forum, 33(5), 1015–1021. https://doi.org/10.1188/06.ONF.1015-1021

    Article  PubMed  Google Scholar 

  • Thayer, J. F., & Sternberg, E. (2006). Beyond heart rate variability: Vagal regulation of allostatic systems. Annals of the New York Academy of Sciences, 1088, 361–372. https://doi.org/10.1196/annals.1366.014

    Article  PubMed  Google Scholar 

  • Theresa, T. D., Conway, K. A., Bender, C., Conley, Y. (2023). Genetic variability of oxidative stress and DNA repair genes associated with pre-treatment cancer-related fatigue in women with breast cancer. Supportive Care in Cancer, 31(6). https://doi.org/10.1007/s00520-023-07816-1

  • Toh, Y. L., Wong, E., Chae, J. W., Yap, N. Y., Yeo, A. H. L., Shwe, M., & Chan, A. (2020). Association of mitochondrial DNA content and displacement loop region sequence variations with cancer-related fatigue in breast cancer survivors receiving chemotherapy. Mitochondrion, 54, 65–71. https://doi.org/10.1016/j.mito.2020.07.004

  • Tornero-Aguilera, J. F., Jimenez-Morcillo, J., Rubio-Zarapuz, A., & Clemente-Suárez, V. J. (2022). Central and peripheral fatigue in physical exercise explained: A narrative review. International Journal of Environmental Research and Public Health, 19(7). https://doi.org/10.3390/ijerph19073909

  • Torossian, M., & Jacelon, C. S. (2021). Chronic illness and fatigue in older individuals: A systematic review. Rehabilitation Nursing, 46(3), 125–136. https://doi.org/10.1097/rnj.0000000000000278

    Article  PubMed  Google Scholar 

  • Venhorst, A., Micklewright, D., & Noakes, T. D. (2018). Towards a three-dimensional framework of centrally regulated and goal-directed exercise behaviour: A narrative review. British Journal of Sports Medicine, 52(15), 957–966. https://doi.org/10.1136/bjsports-2016-096907

    Article  PubMed  Google Scholar 

  • Vercoulen, J. H., Swanink, C. M., Galama, J. M., Fennis, J. F., Jongen, P. J., Hommes, O. R., van der Meer, J. W., & Bleijenberg, G. (1998). The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: Development of a model. Journal of Psychosomatic Research, 45(6), 507–517. https://doi.org/10.1016/s0022-3999(98)00023-3

    Article  PubMed  Google Scholar 

  • Vichaya, E. G., Chiu, G. S., Krukowski, K., Lacourt, T. E., Kavelaars, A., Dantzer, R., Heijnen, C. J., & Walker, A. K. (2015). Mechanisms of chemotherapy-induced behavioral toxicities. Frontiers in Neuroscience, 9, 131.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vichaya, E. G., Vermeer, D. W., Christian, D. L., Molkentine, J. M., Mason, K. A., Lee, J. H., & Dantzer, R. (2017). Neuroimmune mechanisms of behavioral alterations in a syngeneic murine model of human papilloma virus-related head and neck cancer. Psychoneuroendocrinology, 79, 59–66. https://doi.org/10.1016/j.psyneuen.2017.02.006

    Article  PubMed  PubMed Central  Google Scholar 

  • Vichaya, E. G., Grossberg, A. J., Molkentine, J., Estrada, D. J., Gross, P. S., Darpolor, J. K., Raj, P., Vermeer, D. W., Vermeer, P., Taniguchi, C., & Dantzer, R. (2019). Abstract # 3157 Elucidating the mechanisms of post-treatment cancer-related fatigue using a preclinical model. Brain, Behavior, and Immunity, 76, e32. https://doi.org/10.1016/j.bbi.2018.11.274

    Article  Google Scholar 

  • Vichaya, E. G., Ford, B. G., Quave, C. B., Rishi, M. R., Grossberg, A. J., & Dantzer, R. (2020). Toll-like receptor 4 mediates the development of fatigue in the murine Lewis Lung Carcinoma model independently of activation of macrophages and microglia. Psychoneuroendocrinology, 122, 104874. https://doi.org/10.1016/j.psyneuen.2020.104874

    Article  PubMed  PubMed Central  Google Scholar 

  • Vieira, E., Mirizio, G. G., Barin, G. R., de Andrade, R. V., Nimer, N. F. S., & La Sala, L. (2020). Clock genes, inflammation and the immune system – Implications for diabetes, obesity and neurodegenerative diseases. International Journal of Molecular Sciences, 21(24), E9743. https://doi.org/10.3390/ijms21249743

    Article  Google Scholar 

  • Wang, T., Yin, J., Miller, A. H., & Xiao, C. (2017). A systematic review of the association between fatigue and genetic polymorphisms. Brain, Behavior, and Immunity, 62, 230–244. https://doi.org/10.1016/j.bbi.2017.01.007

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, X. S., Shi, Q., Williams, L. A., Shah, N. D., Mendoza, T. R., Cohen, E. N., Reuben, J. M., Cleeland, C. S., & Orlowski, R. Z. (2015). Longitudinal analysis of patient-reported symptoms post-autologous stem cell transplant and their relationship to inflammation in patients with multiple myeloma. Leukemia and Lymphoma, 56(5), 1335–1341.

    Article  PubMed  Google Scholar 

  • Weinrib, A. Z., Sephton, S. E., Degeest, K., Penedo, F., Bender, D., Zimmerman, B., Kirschbaum, C., Sood, A. K., Lubaroff, D. M., & Lutgendorf, S. K. (2010). Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer. Cancer, 116(18), 4410–4419.

    Article  PubMed  Google Scholar 

  • Weis, J., & Horneber, M. (2015). Cancer-related fatigue. Springer Healthcare. 2015th edition (27 Nov. 2014). ISBN-13: 9781907673757.

    Google Scholar 

  • Wielgus, K. K., Berger, A. M., & Hertzog, M. (2009). Predictors of fatigue 30 days after completing anthracycline plus taxane adjuvant chemotherapy for breast cancer. Oncology Nursing Forum, 36(1), 38–48. https://doi.org/10.1188/09.ONF.38-48

    Article  PubMed  Google Scholar 

  • Woo, B., Dibble, S. L., Piper, B. F., Keating, S. B., & Weiss, M. C. (1998). Differences in fatigue by treatment methods in women with breast cancer. Oncology Nursing Forum, 25(5), 915–920.

    PubMed  Google Scholar 

  • Wood, L. J., Nail, L. M., Perrin, N. A., Elsea, C. R., Fischer, A., & Druker, B. J. (2006). The cancer chemotherapy drug etoposide (VP-16) induces proinflammatory cytokine production and sickness behavior–like symptoms in a mouse model of cancer chemotherapy–related symptoms. Biological Research for Nursing, 8(2), 157–169. https://doi.org/10.1177/1099800406290932

    Article  PubMed  Google Scholar 

  • Xian, X., Zhu, C., Chen, Y., Huang, B., & Xu, D. (2021). A longitudinal analysis of fatigue in colorectal cancer patients during chemotherapy. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 29(9), 5245–5252. https://doi.org/10.1007/s00520-021-06097-w

    Article  PubMed  Google Scholar 

  • Yang, G. S., Kumar, S., Dorsey, S. G., Starkweather, A. R., Kelly, D. L., & Lyon, D. E. (2019a). Systematic review of genetic polymorphisms associated with psychoneurological symptoms in breast cancer survivors. Supportive Care in Cancer, 27(2), 351–371. https://doi.org/10.1007/s00520-018-4508-3

    Article  PubMed  Google Scholar 

  • Yang, S., Chu, S., Gao, Y., Ai, Q., Liu, Y., Li, X., & Chen, N. (2019b). A narrative review of cancer-related fatigue (CRF) and its possible pathogenesis. Cells, 8(7). https://doi.org/10.3390/cells8070738

  • Yohn, S. E., Arif, Y., Haley, A., Tripodi, G., Baqi, Y., Müller, C. E., Miguel, N. S., Correa, M., & Salamone, J. D. (2016). Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: Pharmacological and neurochemical characterization. Psychopharmacology, 233(19–20), 3575–3586. https://doi.org/10.1007/s00213-016-4392-9

    Article  PubMed  Google Scholar 

  • You, J., Dong, R., Ying, M., He, Q., Cao, J., & Yang, B. (2019). cellular senescence and anti-cancer therapy. Current Drug Targets, 20(7), 705–715. https://doi.org/10.2174/1389450120666181217100833

    Article  PubMed  Google Scholar 

  • Zhang, C., Liang, Z., Ma, S., & Liu, X. (2021). Radiotherapy and cytokine storm: Risk and mechanism [Review]. Frontiers in Oncology, 11. https://doi.org/10.3389/fonc.2021.670464

  • Zick, S. M., Sen, A., Wyatt, G. K., Murphy, S. L., Arnedt, J. T., & Harris, R. E. (2016). Investigation of 2 types of self-administered acupressure for persistent cancer-related fatigue in breast cancer survivors: A randomized clinical trial. JAMA Oncology, 2(11), 1470. https://doi.org/10.1001/jamaoncol.2016.1867

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Innere Medizin 3 - Schwerpunkt Pneumologie, Universitätsklinik der Paracelsus Medizinischen Privatuniversität, Klinikum Nürnberg Campus Nord, Nürnberg, Deutschland

    Markus Horneber

  2. Comprehensive Cancer Centers Abteilung Selbsthilfeforschung Universitätsklinikum Freiburg, Freiburg, Deutschland

    Joachim Weis

Authors
  1. Markus Horneber
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joachim Weis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Markus Horneber .

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Horneber, M., Weis, J. (2023). Ätiologie und Pathogenese. In: Tumorassoziierte Fatigue. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-64615-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-64615-1_2

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-64614-4

  • Online ISBN: 978-3-662-64615-1

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation