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Effects of Genetic Variations in the Dopaminergic System on Fatigue in Humans: Gender Aspects

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Bulletin of Experimental Biology and Medicine Aims and scope

Changes in the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes. The volunteers (n=140) performed 3-h monotonous mental work (information processing and logical problem solving). The degree of fatigue was evaluated before and after exercise by the HAM (Health status– Activity–Moods) and AMF (Acute Mental Fatigue) questionnaires. A signifi cant relationship between the DAT1, DRD2, and COMT gene polymorphism and changes in the mental sphere status were revealed. The effects of these polymorphisms were the most pronounced in girls. The results are discussed within the framework of hypothesis on the effects of changes in the phasic/tonic dopamine proportion on the studied functions.

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Authors and Affiliations

  1. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    N. V. Malyuchenko, J. V. Schegolkova, M. A. Kulikova & M. A. Timofeeva

  2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    O. V. Sysoeva & A. M. Ivanitsky

  3. Institute of Physical Culture, Ministry of Sport, Tourism, and Youth Policy of the Russian Federation, Moscow, Russia

    V. A. Shlepzova & A. G. Tonevitsky

Authors
  1. N. V. Malyuchenko
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  2. J. V. Schegolkova
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  3. M. A. Kulikova
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  4. M. A. Timofeeva
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  5. V. A. Shlepzova
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  6. O. V. Sysoeva
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  7. A. M. Ivanitsky
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  8. A. G. Tonevitsky
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Corresponding author

Correspondence to N. V. Malyuchenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 2, pp. 187-193, February, 2010

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Malyuchenko, N.V., Schegolkova, J.V., Kulikova, M.A. et al. Effects of Genetic Variations in the Dopaminergic System on Fatigue in Humans: Gender Aspects. Bull Exp Biol Med 149, 226–232 (2010). https://doi.org/10.1007/s10517-010-0913-4

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  • DOI: https://doi.org/10.1007/s10517-010-0913-4

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