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Beneficial and Detrimental Effects of Antioxidants in Allergic Contact Dermatitis

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Plant Antioxidants and Health

Part of the book series: Reference Series in Phytochemistry ((RSP))

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Abstract

Free radicals play a relevant role in the pathogenesis of allergic contact dermatitis (ACD). With this regard, antioxidants emerge as a promising option in the prevention and therapy of ACD. We discuss possible targets for antioxidants in counteracting the induction and pathogenesis of ACD. In the scientific literature, we have found 28 animal and 5 human studies suggesting beneficial effects of antioxidants in ACD. On the other hand, cases of contact allergy to antioxidants have also been reported, including 931 patients with ACD to tocopherol (vitamin E). We conclude therefore that more clinical studies are necessary in order to assess the risk-benefit ratio and to select antioxidants best suited for the prevention or treatment of ACD.

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Acknowledgments

This work was a part of the research project N42/DBS/000108 of the Jagiellonian University Medical College. We cordially thank dr Dorota Zelaszczyk for drawing the chemical structures used in this chapter.

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Authors and Affiliations

  1. Department of Experimental Dermatology and Cosmetology, Jagiellonian University Medical College, Krakow, Poland

    Radoslaw Spiewak & Danuta Plichta

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  1. Radoslaw Spiewak
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  2. Danuta Plichta
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Editors and Affiliations

  1. Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Kraków, Poland

    Halina Maria Ekiert

  2. Department of Botany, Mohanlal Sukhadia University, Udaipur, India

    Kishan Gopal Ramawat

  3. Department of Botany, Mohanlal Sukhadia University, Udaipur, India

    Jaya Arora

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  1. Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland

    Halina Ekiert

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Spiewak, R., Plichta, D. (2021). Beneficial and Detrimental Effects of Antioxidants in Allergic Contact Dermatitis. In: Ekiert, H.M., Ramawat, K.G., Arora, J. (eds) Plant Antioxidants and Health. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-030-45299-5_15-1

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  • DOI: https://doi.org/10.1007/978-3-030-45299-5_15-1

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