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Development of Robust Yeast Strains for Lignocellulosic Biorefineries Based on Genome-Wide Studies

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Yeasts in Biotechnology and Human Health

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 58))

Abstract

Lignocellulosic biomass has been widely studied as the renewable feedstock for the production of biofuels and biochemicals. Budding yeast Saccharomyces cerevisiae is commonly used as a cell factory for bioconversion of lignocellulosic biomass. However, economic bioproduction using fermentable sugars released from lignocellulosic feedstocks is still challenging. Due to impaired cell viability and fermentation performance by various inhibitors that are present in the cellulosic hydrolysates, robust yeast strains resistant to various stress environments are highly desired. Here, we summarize recent progress on yeast strain development for the production of biofuels and biochemical using lignocellulosic biomass. Genome-wide studies which have contributed to the elucidation of mechanisms of yeast stress tolerance are reviewed. Key gene targets recently identified based on multiomics analysis such as transcriptomic, proteomic, and metabolomics studies are summarized. Physiological genomic studies based on zinc sulfate supplementation are highlighted, and novel zinc-responsive genes involved in yeast stress tolerance are focused. The dependence of host genetic background of yeast stress tolerance and roles of histones and their modifications are emphasized. The development of robust yeast strains based on multiomics analysis benefits economic bioconversion of lignocellulosic biomass.

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Authors and Affiliations

  1. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China

    Ming-Ming Zhang, Hong-Qi Chen, Pei-Liang Ye, Feng-Wu Bai & Xin-Qing Zhao

  2. Pilot Plant Development and Training Institute, King Mongkut’s University of Technology, Thonburi, 49 Soi Thianthale 25, Bangkhunthian-Chaithale Road, Thakham, Bangkhunthian, Bangkok, 10150, Thailand

    Songsak Wattanachaisaereekul

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  1. Ming-Ming Zhang
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  2. Hong-Qi Chen
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  3. Pei-Liang Ye
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  4. Songsak Wattanachaisaereekul
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  5. Feng-Wu Bai
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  6. Xin-Qing Zhao
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Correspondence to Xin-Qing Zhao .

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  1. Institute for Bioengineering and Biosciences (iBB) and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

    Isabel Sá-Correia

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Zhang, MM., Chen, HQ., Ye, PL., Wattanachaisaereekul, S., Bai, FW., Zhao, XQ. (2019). Development of Robust Yeast Strains for Lignocellulosic Biorefineries Based on Genome-Wide Studies. In: Sá-Correia, I. (eds) Yeasts in Biotechnology and Human Health. Progress in Molecular and Subcellular Biology, vol 58. Springer, Cham. https://doi.org/10.1007/978-3-030-13035-0_3

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