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Curcuminoids with Antineurodegenerative Properties: Current Trends and Future Perspectives

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Curcumin and Neurodegenerative Diseases

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Abstract

Curcuminoids are bioactive compounds found in Curcuma longa Linn. (Zingiberaceae), a species commonly known as turmeric or turmeric root, widely used in traditional medicine for centuries. Recent research has demonstrated the potential of these metabolites as antineurodegenerative agents, substances that can help prevent or treat neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Studies have focused on understanding the molecular mechanisms by which curcuminoids exert their antineurodegenerative properties, as well as developing more effective and bioaccessible formulations of these compounds to improve their bioavailability and ability to cross the blood–brain barrier. Additionally, research has explored the combination of curcuminoids with other substances or therapies, such as combining them with other natural compounds, conventional drugs, or non-pharmacological therapies like deep brain stimulation. This chapter aims to provide a literature review focused on the advancements in the use of curcumin in the treatment of neurodegenerative diseases from January 2018 to April 2023. A total of 71 studies were selected, reporting on experiments with curcumin in its free form, with nanocarriers, and combined with other substances to treat various neurodegenerative conditions, primarily Alzheimer’s disease and Parkinson’s disease. The review also includes the use of curcumin analogs and clinical studies. Furthermore, this review contributes to expanding and updating current trends and providing future perspectives on the topic.

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References

  • Abrahams S, Miller HC, Lombard C, van der Westhuizen FH, Bardien S (2021) Curcumin pre-treatment may protect against mitochondrial damage in LRRK2-mutant Parkinson’s disease and healthy control fibroblasts. Biochem Biophys Rep 27:101035

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ahmadi M, Agah E, Nafissi S, Jaafari MR, Harirchian MH, Sarraf P, Faghihi Kashani S, Hosseini SJ, Ghoreishi A, Aghamollaii V, Hosseini M, Tafakhori A (2018) Safety and efficacy of nanocurcumin as add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a pilot randomized clinical trial. Neurotherapeutics 15(2):430–438

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ahmed A, Ghallab EH, Shehata M, Zekri A-RN, Ahmed OS (2020) Impact of nano-conjugate on Drosophila for early diagnosis of Alzheimer’s disease. Nanotechnology 31(36):365102

    Article  CAS  PubMed  Google Scholar 

  • Akram M, Shahab-Uddin AA, Usmanghani K, Hannan A, Mohiuddin E, Asif M (2010) Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol 55(2):65–70

    Google Scholar 

  • Alamro AA, Alsulami EA, Almutlaq M, Alghamedi A, Alokail M, Haq SH (2020) Therapeutic potential of vitamin D and curcumin in an in vitro model of Alzheimer disease. J Cent Nerv Syst Dis 12:1–8

    Article  Google Scholar 

  • Alonso J (2016) Curcuma. In: Alonso J (ed) Tratado de Fitofarmácos e Nutracêuticos. A C Farmacêutica, São Paulo, pp 364–373

    Google Scholar 

  • Arya N, Prakash O, Verma AK, Vivekanand, Pant AK (2015) Variation in antioxidant potential of Curcuma longa L. collected from different ecological niches of western Himalayan region. Int J Pharm Pharm Sci 7:85–89

    CAS  Google Scholar 

  • Assi A, Farrag MMY, Badary DM, Allam EAH, Nicola MA (2023) Protective effects of curcumin and Ginkgo biloba extract combination on a new model of Alzheimer’s disease. Inflammopharmacology 31(3):1449–1464

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Benameur T, Giacomucci G, Panaro MA, Ruggiero M, Trotta T, Monda V, Pizzolorusso I, Lofrumento DD, Porro C, Messina G (2021) New promising therapeutic avenues of curcumin in brain diseases. Molecules 27(1):236

    Article  PubMed  PubMed Central  Google Scholar 

  • Bernardo A, Plumitallo C, De Nuccio C, Visentin S, Minghetti L (2021) Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ. Sci Rep 11(1):4952

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bertazzi RN, Martins FR, Saade SZZ, Guedes VR (2017) Esclerose lateral amiotrófica. Rev Patol Tocantins 4(3):54–65

    Article  Google Scholar 

  • Bertoncello KT, Aguiar GPS, Oliveira JV, Siebel AM (2018) Micronization potentiates curcumin’s anti-seizure effect and brings an important advance in epilepsy treatment. Sci Rep 8(1):2645

    Article  PubMed  PubMed Central  Google Scholar 

  • Brasil (2020) Biblioteca Virtual em Saúde. http://bvsms.saude.gov.br/bvs/publicacoes/. Accessed 19 May 2023

  • Chen F, He Y, Wang P, Wei P, Feng H, Rao X, Shi J, Tian J (2018) Curcumin can influence synaptic dysfunction in APPswe/PS1dE9 mice. J Trad Chin Med Sci 5:168–176

    Google Scholar 

  • Cheng C, Chien F, Mou C, Wu S, Che Y (2019) Codelivery of plasmid and curcumin with mesoporous silica nanoparticles for promoting neurite outgrowth. ACS Appl Mater Interfaces 17(11):15322–15331

    Article  Google Scholar 

  • Chico L, Ienco EC, Bisordi C, Lo Gerfo A, Petrozzi L, Petrucci A, Mancuso M, Siciliano G (2018) Amyotrophic lateral sclerosis and oxidative stress: a double-blind therapeutic trial after curcumin supplementation. CNS Neurol Disord Drug Targets 17:767–779

    Article  CAS  PubMed  Google Scholar 

  • Coradine K, Andrade DF, Altenhofe S, Reolon GK, Nery LR, Silva NE, Vianna MRR, Bona CD, Beck RCR (2021) Free and nanoencapsulated curcumin prevents scopolamine-induced cognitive impairment in adult zebrafish. J Drug Deliv Sci Technol 66:102781

    Article  Google Scholar 

  • Cores Á, Carmona-Zafra N, Martín-Cámara O, Sánchez JD, Duarte P, Villacampa M, Bermejo-Bescós P, Martín-Aragón S, León R, Menéndez JC (2022) Curcumin-piperlongumine hybrids with a multitarget profile elicit neuroprotection in in vitro models of oxidative stress and hyperphosphorylation. Antioxidants 11(1):28

    Article  CAS  Google Scholar 

  • Dao TT, Nguyen PH, Won HK, Kim EH, Park J, Won BY, Oh WK (2012) Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases. Food Chem 134(1):21–28

    Article  CAS  Google Scholar 

  • Dolati S, Ahmadi M, Aghebati-Maleki L, Nikmaram A, Marofi F, Rikhtegar R, Ayromlou H, Yousefi M (2018a) Nanocurcumin is a potential novel therapy for multiple sclerosis by influencing inflammatory mediators. Pharmacol Rep 70(6):1158–1167

    Article  CAS  PubMed  Google Scholar 

  • Dolati S, Ahmadi M, Rikhtegar R, Babaloo Z, Ayromlou H, Aghebati-Maleki L, Nouri M, Yousefi M (2018b) Changes in Th17 cells function after nanocurcumin use to treat multiple sclerosis. Int Immunopharmacol 61:74–81

    Article  CAS  PubMed  Google Scholar 

  • Dolati S, Aghebati-Maleki L, Ahmadi M, Marofi F, Babaloo Z, Ayramloo H, Jafarisavari Z, Oskouei H, Afkham A, Younesi V, Nouri M, Yousefi M (2018c) Nanocurcumin restores aberrant miRNA expression profile in multiple sclerosis: a randomized, double-blind, placebo-controlled trial. J Cell Physiol 233(6):5222–5230

    Article  CAS  PubMed  Google Scholar 

  • Dolati S, Babaloo Z, Ayromlou H, Ahmadi M, Rikhtegar R, Rostamzadeh D, Roshangar L, Nouri M, Mehdizadeh A, Younesi V, Yousefi M (2019) Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis. J Neuroimmunol 327:15–21

    Article  CAS  PubMed  Google Scholar 

  • Donadio V, Incensi A, Rizzo G, Fileccia E, Ventruto F, Riva A, Tiso D, Recchia M, Vacchiano V, Infante R, Petrangolini G, Allegrini P, Avino S, Pantieri R, Mostacci B, Avoni P, Liguori R (2022) The effect of curcumin on idiopathic Parkinson disease: a clinical and skin biopsy study. J Neuropathol Exp Neurol 81(7):545–552

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dong CM, Guo AS, Tom A, Chan KWY, Chow ASF, Bian L, Leong ATL, Wu EX, Fellow H (2020) Early detection of amyloid beta pathology in Alzheimer’s disease by molecular MRI. IEEE Eng Med Biol Soc 2020:1100–1103

    Google Scholar 

  • Dubey T, Sonawane SK, Mannava MKC, Nangia AK, Chandrashekhar M, Chinnathambi S (2023) The inhibitory effect of curcumin-artemisinin co-amorphous on Tau aggregation and Tau phosphorylation. Colloids Surf B: Biointerfaces 221:112970

    Article  CAS  PubMed  Google Scholar 

  • El Nebrisi E, Javed H, Ojha SK, Oz M, Shehab S (2020) Neuroprotective effect of curcumin on the nigrostriatal pathway in a 6-hydroxydopamine-induced rat model of Parkinson’s disease is mediated by α7-nicotinic receptors. Int J Mol Sci 21(19):7329

    Article  PubMed  PubMed Central  Google Scholar 

  • Elbini-Dhouib I, Manai M, Neili NE, Marzouki S, Sahraoui G, Ben Achour W, Zouaghi S, Benahmed M, Doghri R, Srairi-Abid N (2022) Dual mechanism of action of curcumin in experimental models of multiple sclerosis. Int J Mol Sci 23(15):8658

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • El-Shamarka MES, Abdel-Salam OME, Shafee N, Zeidan HM (2023) Curcumin modulation of L-dopa and rasagiline-induced neuroprotection in rotenone model of Parkinson’s disease. Iran J Basic Med Sci 26:139–147

    PubMed  PubMed Central  Google Scholar 

  • Esmaeilzadeh E, Soleimani M, Zare-Abdollahi D, Jameie B, Khorshid HRK (2019) Curcumin ameliorates experimental autoimmune encephalomyelitis in a C57BL/6 mouse model. Drug Dev Res 80(5):629–636

    Article  CAS  PubMed  Google Scholar 

  • Fan S, Zheng Y, Liu X, Fang W, Chen X, Liao W, Jing X, Lei M, Tao E, Ma Q, Zhang X, Guo R, Liu J (2018) Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease. Drug Deliv 25(1):1044–1055

    Article  Google Scholar 

  • Fidelis EM, Savall ASP, Abreu EL, Carvalho F, Teixeira FEG, Haas SE, Sampaio TB, Pinton S (2019) Curcumin-loaded nanocapsules reverse the depressant-like behavior and oxidative stress induced by beta-amyloid in mice. Neuroscience 423:122130

    Article  Google Scholar 

  • Fikry H, Saleh L, Gawad SA (2022) Neuroprotective effects of curcumin on the cerebellum in a rotenone-induced Parkinson’s disease model. CNS Neurosci Ther 28(5):732–748

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fuloria S, Mehta J, Chandel A, Sekar M, Rani NNIM, Begum MY, Subramaniyan V, Chidambaram K, Thangavelu L, Nordin R, Wu YS, Sathasivam KV, Lum PT, Meenakshi DU, Kumarasamy V, Azad AK, Fuloria NK (2022) A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent curcumin. Front Pharmacol 13:820806

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gao C, Chu X, Gong W, Zheng J, Xie X, Wang Y, Yang M, Li Z, Gao C, Yang Y (2020) Neuron tau-targeting biomimetic nanoparticles for curcumin delivery to delay progression of Alzheimer’s disease. J Nanobiotechnol 18(1):71

    Article  CAS  Google Scholar 

  • Giacomeli R, Izoton JC, Santos RB, Boeira SP, Jesse CR, Haas SE (2019) Neuroprotective effects of curcumin lipid-core nanocapsules in a model Alzheimer’s disease induced by β-amyloid 1-42 peptide in aged female mice. Brain Res 1721:146325

    Article  CAS  PubMed  Google Scholar 

  • Gil-Mohapel JM, Rego AC (2011) Doença de Huntington: uma revisão dos aspectos fisiopatológicos. Rev Neurosci 19(4):724–734

    Google Scholar 

  • Hajipour S, Vastegani SM, Sarkaki A, Basir Z, Navabi SP, Farbood Y, Khoshnam SE (2023) Curcumin attenuates memory impairments and long-term potentiation deficits by damping hippocampal inflammatory cytokines in lipopolysaccharide-challenged rats. Metab Brain Dis 38(4):1379–1388

    Article  CAS  PubMed  Google Scholar 

  • Hamilton J, Michael J et al (2019) The economic burden of Parkinson’s disease

    Google Scholar 

  • Han Y, Chen R, Lin Q, Liu Y, Ge W, Cao H, Li J (2021) Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-κB signaling pathway in APPswe/PS1dE9 transgenic mice hippocampus. J Cell Mol Med 25:8947–8956

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He R, Jiang Y, Shi Y, Liang J, Zhao L (2020) Curcumin-laden exosomes target ischemic brain tissue and alleviate cerebral ischemia-reperfusion injury by inhibiting ROS-mediated mitochondrial apoptosis. Mater Sci Eng C 117:111314

    Article  CAS  Google Scholar 

  • Hewlings SJ, Kalman DS (2017) Curcumin: a review of its effects on human health. Foods 6(10):92

    Article  PubMed  PubMed Central  Google Scholar 

  • Huang W, Yong J, Wang DT, She YQ, Zhou J, Gao H (2019) Curcumin inhibits memory retrieval dysfunction in adult mice induced by sevoflurane via activation of autophagy in hippocampal neurons. Chin J Integr Med 39:838–841

    Google Scholar 

  • Huo X, Zhang Y, Jin X, Li Y, Zhang L (2019) A novel synthesis of selenium nanoparticles encapsulated PLGA nanospheres with curcumin molecules for the inhibition of amyloid beta aggregation in Alzheimer’s disease. J Photochem Photobiol B Biol 190:98–102

    Article  CAS  Google Scholar 

  • Hussain H, Ahmad S, Shah SWA, Ullah A, Rahman SU, Ahmad M, Almehmadi M, Abdulaziz O, Allahyani M, AlSaiari AA, Halawi M, Alamer E (2022) Synthetic mono-carbonyl curcumin analogues attenuate oxidative stress in mouse models. Biomedicine 10:2597

    CAS  Google Scholar 

  • Jiang Z, Dong X, Yan X, Liu Y, Sun Y (2018) Nanogels of dual inhibitor-modified hyaluronic acid function as a potent inhibitor of amyloid β-protein aggregation and cytotoxicity. Sci Rep 8:3505

    Article  PubMed  PubMed Central  Google Scholar 

  • Jithavech P, Suwattananuruk P, Hasriadi, Muangnoi C, Thitikornpong W, Towiwat P, Vajragupta O, Rojsitthisak P (2022) Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced antineuroinflammatory activity. PLoS One 17(3):e0265689

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kato H, Sato H, Okuda M, Wu J, Koyama S, Izumi Y, Waku T, Iino M, Aoki M, Arawaka S, Ohta Y, Ishizawa K, Kawasaki K, Urano Y, Miyasaka T, Noguchi N, Kume T, Akaike A, Sugimoto H, Kato T (2022) Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis. Amyotrop Lateral Sclerosis Frontotemp Degen 23(7):489–495

    Article  CAS  Google Scholar 

  • Khadka S, Omura S, Sato F, Nishio K, Kakeya H, Tsunoda I (2021) Curcumin β-D-glucuronide modulates an autoimmune model of multiple sclerosis with altered gut microbiota in the ileum and feces. Front Cell Infect Microbiol 11:772962

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khan TK, You Y, Nelson TJ, Kundu S, Pramanik SK, Das J (2022) Modulation of proteasome activity by curcumin and didemethylcurcumin. J Biomol Struct Dyn 40(18):8332–8339

    Article  CAS  PubMed  Google Scholar 

  • Khyati IM, Agrawal N, Kumar V (2021) Melatonin and curcumin reestablish disturbed circadian gene expressions and restore locomotion ability and eclosion behavior in Drosophila model of Huntington’s disease. Chronobiol Int 38(1):61–78

    Article  CAS  PubMed  Google Scholar 

  • Krup V, Prakash LH, Harini A (2013) Pharmacological activities of turmeric (Curcuma longa Linn): a review. J Homeopathy Ayurved Med 2(4):1–4

    Article  Google Scholar 

  • Kuang Y, Zhang J, Xiong M, Zeng W, Lin X, Yi X et al (2020) A novel nanosystem realizing curcumin delivery based on Fe3O4@carbon dots nanocomposite for Alzheimer’s disease therapy. Front Bioeng Biotechnol 8:614906

    Article  PubMed  PubMed Central  Google Scholar 

  • Kumar A, Singh M, Singh PP, Singh SK (2016) Antioxidant efficacy and curcumin content of turmeric (Curcuma longa L.) flower. Int J Curr Pharm Res 8(3):112–114

    CAS  Google Scholar 

  • Lee Y, Park HR, Lee JY, Kim J, Yang S, Lee C, Kim K, Kim HS, Shang S, Lee J (2023) Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice. Arch Pharm Res 46:423–437

    Article  CAS  PubMed  Google Scholar 

  • Lei L, Tu Q, Zhang X, Xiang S, Xiao B, Zhai S, Tang L, Guo B, Chen X, Zhang C (2023) Stimulus-responsive curcumin-based polydopamine nanoparticles for targeting Parkinson’s disease by modulating α-synuclein aggregation and reactive oxygen species. Chem Eng J 461:141606

    Article  CAS  Google Scholar 

  • Liu J, Gao D, Hu D, Lan S, Liu Y, Zheng H, Yuan Z, Sheng Z (2023) Delivery of biomimetic liposomes via meningeal lymphatic vessels route for targeted therapy of Parkinson’s disease. Research 6:30

    Article  CAS  Google Scholar 

  • Lu W, Sun S, Li Y, Xu S, Gan S, Xu J, Qiu G, Zhuo F, Huang S, Jiang X, Huang J (2019a) Curcumin ameliorates memory deficits by enhancing lactate content and MCT2 expression in APP/PS1 transgenic mouse model of Alzheimer’s disease. Anat Rec 302(2):332–338

    Article  CAS  Google Scholar 

  • Lu Y, Guo Z, Zhang Y, Li C, Zhang Y, Guo Q, Chen Q, Che X, He X, Liu L, Ruan C, Sun T, Ji B, Lu W, Jiang C (2019b) Microenvironment remodeling micelles for Alzheimer’s disease therapy by early modulation of activated microglia. Adv Sci 6:1801586

    Article  Google Scholar 

  • Lv H, Wang Y, Yang X, Ling G, Zhang P (2022) Application of curcumin nanoformulations in Alzheimer’s disease: prevention, diagnosis and treatment. Nutr Neurosci 2022:1–11

    Google Scholar 

  • Ma Z, Wang N, He H, Tang X (2019) Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. J Control Release 316:359–380

    Article  CAS  PubMed  Google Scholar 

  • Maiti P, Bowers Z, Bourcier-Schultz A, Morse J, Dunbar GL (2021) Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis. Alzheimers Res Ther 13(1):37

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Malvajerd SS, Izadi Z, Azadi A, Kurd M, Derakhshankhah H, Zadeh MS, Javar HA, Hamidi M (2019) Neuroprotective potential of curcumin-loaded nanostructured lipid carrier in an animal model of Alzheimer’s disease: behavioral and biochemical evidence. J Alzheimers Dis 69(3):671–686

    Article  Google Scholar 

  • Marchi JP, Tedesco L, Melo ADC, Frasson AC, França VF, Sato SW, Lovato ECW (2016) Curcuma longa L., o açafrão da terra, e seus benefícios medicinais. Arquivos Ciên Saúde 20(3):189–194

    Google Scholar 

  • Mavaddatiyan L, Khezri S, Froushani SMA (2021) Molecular effects of curcumin on the experimental autoimmune encephalomyelitis. Vet Res Forum 12(1):47–52

    PubMed  PubMed Central  Google Scholar 

  • Milobedzka J, Kostanecki V, Lampe V (1910) Structure of curcumin. Ber Dtsch Chem Ges 43:2163–2170

    CAS  Google Scholar 

  • Mirakabad FST, Khoramgah MS, Tahmasebinia F, Darabi S, Abdi S, Abbaszadeh HA, Khoshsirat S (2020) The effect of low-level laser therapy and curcumin on the expression of LC3, ATG10 and BAX/BCL2 ratio in PC12 cells induced by 6-hydroxide dopamine. J Lasers Med Sci 11(3):299–304

    Article  Google Scholar 

  • More S, Pawar A (2023) Brain targeted curcumin loaded turmeric oil microemulsion protects against trimethyltin induced neurodegeneration in adult zebrafish: a pharmacokinetic and pharmacodynamic insight. Pharm Res 40:675–687

    Article  CAS  PubMed  Google Scholar 

  • Motavaf M, Sadeghizadeh M, Babashah S, Zare L, Javan M (2020a) Protective effects of a nano-formulation of curcumin against cuprizone-induced demyelination in the mouse corpus callosum. Iran J Pharm Res 19(3):310–320

    CAS  PubMed  PubMed Central  Google Scholar 

  • Motavaf M, Sadeghizadeh M, Babashah S, Zare L, Javan M (2020b) Dendrosomal nanocurcumin promotes remyelination through induction of oligodendrogenesis in experimental demyelination animal model. J Tissue Eng Regen Med 14:1449–1464

    Article  CAS  PubMed  Google Scholar 

  • Motawi TK, Sadik NAH, Hamed MA, Ali SA, Khalil WKB, Ahmed YR (2020) Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson’s disease mice model. Mol Cell Biochem 465:89–102

    Article  CAS  PubMed  Google Scholar 

  • Muta K, Inomata S, Fukuhara T, Nomura J, Nishiyama T, Tagawa Y, Amano S (2018) Inhibitory effect of the extract of rhizome of Curcuma longa L in gelatinase activity and its effect on human skin. J Biosci Bioeng 125(3):353–358

    Article  CAS  PubMed  Google Scholar 

  • Namratha K, Shenai P, Chatra L, Rao P, Veena K, Prabhu R (2013) Antioxidant and anticancer effects of curcumin – a review. J Contemp Med 3(2):136–143

    Google Scholar 

  • Naser A, Aziz WM, Ahmed YR, Khalil W, Hamed M (2022) Parkinsonism-like disease induced by rotenone in rats: treatment role of curcumin, dopamine agonist and adenosine A2A receptor antagonist. Curr Aging Sci 15(1):65–76

    Article  CAS  PubMed  Google Scholar 

  • Ogunsuyi OB, Aro OP, Oboh G, Olagoke OC (2022) Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems. Drug Chem Toxicol 2022:1–9

    Google Scholar 

  • Olotu F, Agoni C, Soremekun O, Soliman MES (2020) An update on the pharmacological usage of curcumin: has it failed in the drug discovery pipeline? Cell Biochem Biophys 78:267–289

    Article  CAS  PubMed  Google Scholar 

  • Orsolin PC, Nepomuceno JC (2009) Potencial carcinogênico do açafrão (Curcuma longa L.) identificado por meio de teste para detecção de clones de tumor em Drosophila melanogaster. Rev Núcl Interdiscip Pesqui Extens UNIPAM 6:55–69

    Google Scholar 

  • Panknin TM, Howe CL, Haauer M, Bucchireddigari B, Rossi AM, Funk JL (2023) Curcumin supplementation and human disease: a scoping review of clinical trials. Int J Mol Sci 24(5):4476

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Parikh A, Kathawala K, Li J, Chen C, Shan Z, Cao X, Zhou X, Garg S (2018) Curcumin-loaded self-nanomicellizing solid dispersion system: part II: In vivo safety and efficacy assessment against behavior deficit in Alzheimer’s disease. Drug Deliv Transl Res 8(5):1406–1420

    Article  CAS  PubMed  Google Scholar 

  • Priyadarsini KI (2014) The chemistry of curcumin: from extraction to therapeutic agent. Molecules 19(12):20091–20112

    Article  PubMed  PubMed Central  Google Scholar 

  • Ramirez-Ahumada MC, Timmermann BN, Gang DR (2006) Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases. Phytochemistry 67:2017–2029

    Article  CAS  PubMed  Google Scholar 

  • Reich DS, Lucchinetti CF, Calabresi PA (2018) Multiple sclerosis. N Engl J Med 378(2):169–180

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Salehi B, Calina D, Docea AO, Koirala N, Aryal S, Lombardo D, Sharifi-Rad J (2020) Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases. J Clin Med 9(2):430

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Santos CS, Bessa TA, Xavier AJ (2020) Fatores associados à demência em idosos. Ciên Saúde Coletiva 25(2):603–611

    Article  Google Scholar 

  • Sato T, Hotsumi M, Makabe K, Konno H (2018) Design, synthesis and evaluation of curcumin-based fluorescent probes to detect A beta fibrils. Bioorg Med Chem Lett 28(22):3520–3525

    Article  CAS  PubMed  Google Scholar 

  • Simões CMO, Schenkel EP, Gosmann G, Mello JCP, Mentz LA, Petrovick PR (2010) Farmacognosia: Da planta ao medicamento, 6th edn. Universidade Federal do Rio Grande do Sul, Porto Alegre

    Google Scholar 

  • Slowing K, Gomez F, Delgado M, Rosa RF, Hernández-Martín N, Pozo MA, García-García L (2023) PET imaging and neurohistochemistry reveal that curcumin attenuates brain hypometabolism and hippocampal damage induced by status epilepticus in rats. Planta Med 89(4):364–376

    Article  CAS  PubMed  Google Scholar 

  • Song H, Chen Y, Chen Y, Park J, Zheng M, Surh Y, Joe Y (2020) GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative activity in human neuroblastoma cells. Free Radic Res 54(11-12):918–930

    Article  CAS  PubMed  Google Scholar 

  • Soukhaklari R, Moezi L, Pirsalami F, Moosavi M (2018) The effect of BSA-based curcumin nanoparticles on memory and hippocampal MMP-2, MMP-9, and MAPKs in adult mice. J Mol Neurosci 65(3):319–326

    Article  CAS  PubMed  Google Scholar 

  • Sueth-Santiago V, Mendes-Silva GP, Decoté-Ricardo D, Lima MEF (2015) Curcumina, o pó dourado do açafrão-da-terra: introspecções sobre química e atividades biológicas. Quím Nova 38(4):538–552

    CAS  Google Scholar 

  • Torra J, Viela F, Megías D, Sot B, Flors C (2022) Versatile near-infrared super-resolution imaging of amyloid fibrils with the fluorogenic probe CRANAD-2. Chem Eur J 28:e202200026

    Article  CAS  PubMed  Google Scholar 

  • Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J (2013) Renoprotective effect of the antioxidant curcumin: recent findings. Redox Biol 1(1):448–456

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vogel H, Pelletier J (1815) Curcumin-biological and medicinal properties. J Pharm 1:289

    Google Scholar 

  • Voulgaropoulou SD, van Amelsvoort TAMJ, Prickaerts J, Vingerhoets C (2019) The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: a systematic review of pre-clinical and clinical studies. Brain Res 1725:146476

    Article  CAS  PubMed  Google Scholar 

  • Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, Lin JK (1997) Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal 15(12):1867–1876

    Article  CAS  PubMed  Google Scholar 

  • Wang Z, Yang C, Liu J, Chun-Kit Tong B, Zhu Z, Malampati S, Li M (2020) A curcumin derivative activates TFEB and protects against Parkinsonian neurotoxicity in vitro. Int J Mol Sci 21(15):1515

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu Y, Liang S, Xu B, Zhang R, Xu L (2018) Protective effect of curcumin on dopamine neurons in Parkinson’s disease and its mechanism. J Zhejiang Univ Sci B 19(6):480–486

    Google Scholar 

  • Xiao YC, Xie J, Yu M, Liu M, Ran J, Xi Z, Huang J (2011) Bisabocurcumin, a new skeleton curcuminoid from the rhizomes of Curcuma longa L. Chin Chem Lett 22:1457–1460

    Article  CAS  Google Scholar 

  • Xu Y, Hu R, He D, Zhou G, Wu H, Xu C, Xiao Z (2020) Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer’s disease by up-regulating SIRT1. Brain Behav 10:e01655

    Article  PubMed  PubMed Central  Google Scholar 

  • Yan Y, Chen Y, Liu Z, Cai F, Niu W, Song L, Yan F (2021) Brain delivery of curcumin through low intensity ultrasound-induced blood–brain barrier opening via lipid-PLGA nanobubbles. Int J Nanomedicine 16:7433–7447

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yavarpour-Bali H, Ghasemi-Kasman M, Pirzadeh M (2019) Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders. Int J Nanomedicine 14:4449–4460

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yilmaz EN, Bay S, Ozturk G, Ucisik MH (2020) Neuroprotective effects of curcumin-loaded emulsomes in a laser-induced CNS injury model. Int J Nanomedicine 15:9211–9229

    Article  PubMed  PubMed Central  Google Scholar 

  • Zeng Y, Lv Y, Hu M, Guo F, Zhang C (2022) Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment. Xenobiotica 52(7):718–728

    Article  CAS  PubMed  Google Scholar 

  • Zhang L, Yang S, Wong LR, Xie H, Ho PCL (2020) In vitro and In vivo comparison of curcumin-encapsulated chitosan-coated poly(lactic-co-glycolic acid) nanoparticles and curcumin/hydroxypropyl-beta-cyclodextrin inclusion complexes administered intranasally as therapeutic strategies for Alzheimer’s disease. Mol Pharm 17(11):4256–4269

    Article  CAS  PubMed  Google Scholar 

  • Zhang J, Li K, Wang X, Smith AM, Ning B, Liu Z, Smith WW (2021) Curcumin reduced H2O2- and G2385R-LRRK2-induced neurodegeneration. Front Aging Neurosci 13:754956

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhong L, Cai B, Wang Q, Li X, Xu W, Chen T (2023) Exploring the neuroprotective mechanism of curcumin inhibition of intestinal inflammation against Parkinson’s disease based on the gut-brain axis. Pharmaceutics 16(1):39

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Center for Natural Sciences, Federal University of Piauí, Teresina, Brazil

    Lucivania Rodrigues dos Santos, Gerardo Magela Vieira Junior & Mariana Helena Chaves

  2. Federal Institute of Piauí - Piripiri Campus, Piripiri, PI, Brazil

    Adonias Almeida Carvalho

  3. Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

Authors
  1. Lucivania Rodrigues dos Santos
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  2. Adonias Almeida Carvalho
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  3. Mahendra Rai
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  4. Gerardo Magela Vieira Junior
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  5. Mariana Helena Chaves
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Corresponding author

Correspondence to Mariana Helena Chaves .

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Editors and Affiliations

  1. Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

  2. Department of Chemistry, Federal University of Piauí, Teresina, Brazil

    Chistiane M. Feitosa

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dos Santos, L.R., Carvalho, A.A., Rai, M., Vieira Junior, G.M., Chaves, M.H. (2023). Curcuminoids with Antineurodegenerative Properties: Current Trends and Future Perspectives. In: Rai, M., Feitosa, C.M. (eds) Curcumin and Neurodegenerative Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-99-7731-4_6

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  • DOI: https://doi.org/10.1007/978-981-99-7731-4_6

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