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Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression

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Hypoxia in Cancer: Significance and Impact on Cancer Therapy

Abstract

Cellular senescence is a state of growth arrest implicated in both physiological and pathophysiological conditions. In aging cells, while senescence is induced via replicative exhaustion due to telomere shortening, in preneoplastic cells it emerges as a cellular failsafe program provoked by oncogenic activation and serves as an initial barrier constraining the malignant progression. Regulation of senescence is influenced by various intrinsic and extrinsic factors including tissue hypoxia, which apparently helps premalignant cells to evade instigation of “oncogene-induced senescence” (OIS). For a better understanding of the pathological consequences of senescence bypass, it is crucial and of great interest to explicit the hypoxia-related mechanisms and factors contributing to the modulation of oncogene-induced senescence. This chapter reviews the previous and recent data that contribute to the understanding of the fundamentals of cellular senescence as well as the mechanisms of hypoxia-induced modulation of OIS.

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Acknowledgments

The research was funded by TUBITAK 108S179 to MKE.

The author thanks Dr. G. Ercan Şencicek (Yale School of Medicine), for her comments on the manuscript.

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  1. Department of Medical Biology, Aydın Adnan Menderes University Medical School, Aydin, Turkey

    Mehtap Kilic Eren

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Correspondence to Mehtap Kilic Eren .

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  1. Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India

    Sukhes Mukherjee

  2. Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India

    Jagat Rakesh Kanwar

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Eren, M.K. (2023). Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression. In: Mukherjee, S., Kanwar, J.R. (eds) Hypoxia in Cancer: Significance and Impact on Cancer Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-99-0313-9_5

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