Abstract
A great number of malignancies are relatively resistant to radiotherapy, chemotherapy and other non-surgical treatment modalities. A variety of factors are involved in the lack of responsiveness of these neoplasms including an intrinsic, genetically determined resistance and physiological, extrinsic (epigenetic, environmental) factors primarily created by inadequate and heterogeneous vascular networks1–3. Thus, properties such as tumor blood flow and tissue oxygen supply, factors which usually go hand in hand, can markedly influence the therapeutic response. Data on these parameters are mostly derived from rodent tumors. However, fast-growing rodent tumors might not adequately represent the multitude of neoplastic growths encountered in patients. Unfortunately, data on human tumors in situ are scarce and there may be significant errors associated with the techniques used for measurements. This should be kept in mind when comparing available results from the literature.
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References
P. Vaupel and W. Miiller-Klieser, Interstitieller Raum und Mikro-milieu in malignen Tumoren. Progr. Appl. Microcirc. 2:78 (1983).
P. Vaupel and F. Kallinowski, Microcirculation and metabolic micro-milieu in malignant tumors. Funktionsanalyse biolos. Systeme 18: 265 (1988).
R. M. Sutherland, Cell and environment interactions in tumor micro-regions. The multiceli spheroid model. Science 240:177 (1988).
R. K. Jain and K. Ward-Hartley, Tumor blood flow — Characterization, modifications, and role in hyperthermia. IEEE Trans. Sonics Ultrasonics SU-31:5Q4 (1984).
P. Vaupel, Pathophysiologie der Durchblutung maligner Tumoren. Funktionsanalyse biolog. Systeme 8:155 (1982).
M. Mäntylä, J. Heikkonen, and J. Perkkiö, Regional blood flow in human tumours measured with argon, krypton and xenon. Brit. J. Radiol. 61:379 (1988).
II. S. Reinhold, Physiological effects of hyperthermia. Rec. Res. Cancer Res. 107:32 (1988).
P. Vaupel, F. Kallinowski, and P. Okunieff, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors. A review. Cancer Res, (in press).
P. Vaupel, F. Kallinowski, and P. Okunieff, Blood flow, metabolic micromilieu and bioenergetics of human tumors: Critical parameters in hyperthermic treatment. Progr. Hyperthermia 1 (in press).
O. Warburg, On respiratory impairment in cancer cells. Science 124: 269 (1956).
P. Wendling, R. Manz, G. Thews, and P. Vaupel, Inhomogeneous oxygenation of rectal carcinomas in humans. A critical parameter for preoperative irradiation? Adv. Exp. Med. Biol. 180: 293 (1984).
P. Vaupel and F. Kallinowski, Tissue oxygenation of primary and xenotransplanted human tumours. In: “Radiation Research”, E.M. Fiel-den, J.F. Fowler, J.H. Hendry, and D. Scott (eds.), London, New York, Philadelphia, Taylor & Francis (1987).
W. Mueller-Klieser, P. Vaupel, R. Manz, and R. Schmidseder, Intra-capillary oxyhemoglobin saturation of malignant tumors in humans. Int. J. Radiat. Oncol. Biol. Phys. 7:1397 (1981).
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© 1990 Plenum Press, New York
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Vaupel, P., Kallinowski, F., Okunieff, P. (1990). Blood Flow, Oxygen Consumption and Tissue Oxygenation of Human Tumors. In: Piiper, J., Goldstick, T.K., Meyer, M. (eds) Oxygen Transport to Tissue XII. Advances in Experimental Medicine and Biology, vol 277. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8181-5_103
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DOI: https://doi.org/10.1007/978-1-4684-8181-5_103
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