Abstract
According to estimates, more than 800 mushroom species have been confirmed to possess various pharmacological properties. While the primary research focus has been on immunomodulatory and, more recently, on direct antitumor effects, many other therapeutic properties have also become important research subjects. Systems biology approaches, which include various omics methods coupled with bioinformatics, have begun to enter the field of medicinal mushroom research. Proteomics is a well-established hypothesis-generating discipline focused on the systemic study of proteins, used in discovering new pathways and processes resulting from physiological and pathological states or pharmacological interventions. It is particularly powerful in new potential therapeutic target discovery of “druggable proteins” or disease biomarkers of prognostic or therapeutic significance. Despite challenges in proteomics’ extensive data analysis and interpretation, proteomics remains indispensable for the detailed understanding and characterization of pharmacological effects.
In comparison with genomics, proteomics generates more accurate data since several protein products may result from only one gene. This results from differential splicing and more than 200 posttranslational modifications, which affect protein function, stability, protein-protein, and other interactions. This chapter provides a current overview of proteomic research on medicinal mushrooms concerning anticancer, immunomodulatory, antidiabetic, hypolipidemic, antiatherosclerotic, hepatoprotective, and neuroprotective properties.
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Abbreviations
- 2-DE:
-
Two-dimensional gel electrophoresis
- ALT:
-
Alanine transaminase or alanine aminotransferase
- AST:
-
Aspartate transaminase or aspartate aminotransferase
- Cy:
-
Cyclophosphamide
- DEP:
-
Differentially expressed protein
- DIGE:
-
Difference gel electrophoresis
- ECM:
-
Extracellular matrix
- ESI:
-
Electrospray ionization
- GL-SP:
-
Ganoderma lucidum spore polysaccharides
- GSH:
-
Glutathione
- HPLC:
-
High-performance liquid chromatography
- IARC:
-
International agency for research on cancer
- IL-2:
-
Interleukin 2
- iTRAQ:
-
Isobaric tag for relative and absolute quantitation
- KEGG:
-
Kyoto encyclopedia of genes and genomes
- LC-MS:
-
Liquid chromatography-mass spectrometry
- LPS:
-
Lipopolysaccharide
- MALDI:
-
Matrix-assisted laser desorption/ionization
- MAPK:
-
Mitogen-activated protein kinase
- NMR:
-
Nuclear magnetic resonance
- NSCLS:
-
Non-small-cell lung carcinoma
- PPI:
-
Protein-protein interactions
- PRDX:
-
Peroxiredoxins
- ROS:
-
Reactive oxygen species
- SOD:
-
Superoxide dismutase
- SWATH:
-
Sequential windowed acquisition of all theoretical mass spectra
- TCA cycle:
-
Tricarboxylic acid cycle or citric acid cycle
- TMT:
-
Tandem mass tag
- UPR:
-
Unfolded protein response
- WHO:
-
World Health Organization
References
Abulizi A, Hu L, Ma A et al (2021a) Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor. Acta Pharmacol Sin 42:1703–1713. https://doi.org/10.1038/s41401-021-00669-6
Abulizi A, Ran J, Ye Y et al (2021b) Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice. Food Funct 12:12325–12337. https://doi.org/10.1039/d1fo03055h
Ahmad A (2019) Breast cancer statistics: recent trends in advances in experimental medicine and biology. In: Ahmad A (ed) Breast cancer metastasis and drug resistance: challenges and progress, 2nd edn. Springer, New York. https://doi.org/10.1007/978-3-030-20301-6_1
Ahmed N (2005) 23 years of the discovery of Helicobacter pylori: is the debate over? Ann Clin Microbiol Antimicrob 4:17. https://doi.org/10.1186/1476-0711-4-17
Allen TM, Cullis PR (2013) Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev 65:36–48. https://doi.org/10.1016/j.addr.2012.09.037
Augusti PR, Ruviaro AR, Quatrin A et al (2012) Imbalance in superoxide dismutase/thioredoxin reductase activities in hypercholesterolemic subjects: relationship with low density lipoprotein oxidation. Lipids Health Dis 11:79. https://doi.org/10.1186/1476-511X-11-79
Ayene IS, Ford LP, Koch CJ (2005) Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation. Mol Cancer Ther 4:529–536. https://doi.org/10.1158/1535-7163.MCT-04-0130
Badolato R, Wang JM, Murphy WJ et al (1994) Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J Exp Med 180:203–209. https://doi.org/10.1084/jem.180.1.203
Bailly C, Gao JM (2020) Erinacine A and related cyathane diterpenoids: molecular diversity and mechanisms underlying their neuroprotection and anticancer activities. Pharmacol Res 159:104953. https://doi.org/10.1016/j.phrs.2020.104953
Barni S, Cabiddu M, Ghilardi M et al (2011) A novel perspective for an orphan problem: old and new drugs for the medical management of malignant ascites. Crit Rev Oncol Hematol 79:144–153. https://doi.org/10.1016/j.critrevonc.2010.07.016
Bischoff PL, Holl V, Coelho D et al (2000) Apoptosis at the interface of immunosuppressive and anticancer activities: the examples of two classes of chemical inducers, oxysterols and alkylating agents. Curr Med Chem 7:693–713. https://doi.org/10.2174/0929867003374769
Blask DE (2009) Melatonin, sleep disturbance and cancer risk. Sleep Med Rev 13:257–264. https://doi.org/10.1016/j.smrv.2008.07.007
Cai H, Li J, Gu B et al (2018) Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression. J Ethnopharmacol 214:106–112. https://doi.org/10.1016/j.jep.2017.12.012
Casares N, Pequignot MO, Tesniere A et al (2005) Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med 202:1691–1701. https://doi.org/10.1084/jem.20050915
Chai Y, Wang G, Fan L et al (2016) A proteomic analysis of mushroom polysaccharide-treated HepG2 cells. Sci Rep 6:23565. https://doi.org/10.1038/srep23565
Chatila R, West AB (1996) Hepatomegaly and abnormal liver tests due to glycogenosis in adults with diabetes. Medicine (Baltimore) 75:327–333. https://doi.org/10.1097/00005792-199611000-00003
Chen FW, Ioannou YA (1999) Ribosomal proteins in cell proliferation and apoptosis. Int Rev Immunol 18:429–448. https://doi.org/10.3109/08830189909088492
Chen CN, Chang CC, Su TE et al (2009) Identification of calreticulin as a prognosis marker and angiogenic regulator in human gastric cancer. Ann Surg Oncol 16:524–533. https://doi.org/10.1245/s10434-008-0243-1
Chen LC, Chung IC, Hsueh C et al (2010) The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients. Cell Death Differ 17:1463–1473. https://doi.org/10.1038/cdd.2010.24
Chen YW, Hu DJ, Cheong KL et al (2013) Quality evaluation of lentinan injection produced in China. J Pharm Biomed Anal 78–79:176–182. https://doi.org/10.1016/j.jpba.2013.02.012
Chen JF, Tsai YT, Lai YH et al (2020) Proteomic analysis of Antrodia Cinnamomea-induced ER stress in liver cancer cells. J Pharm Biomed Anal 187:113142. https://doi.org/10.1016/j.jpba.2020.113142
Cheung KJ, Tilleman K, Deforce D et al (2009) The HCV serum proteome: a search for fibrosis protein markers. J Viral Hepat 16:418–429. https://doi.org/10.1111/j.1365-2893.2009.01083.x
Chihara G, Hamuro J, Maeda YY et al (1987) Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview. Cancer Detect Prev Suppl 1:423–443
Chung KS, Cho SH, Shin JS et al (2013) Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-beta expression. Carcinogenesis 34:331–340. https://doi.org/10.1093/carcin/bgs341
Clifford G, Franceschi S, Diaz M et al (2006) Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine 24(Suppl 3):26–34. https://doi.org/10.1016/j.vaccine.2006.05.026
Colombo MP, Chiodoni C (2013) Osteopontin produced by myeloid cells determines the outcome of breast cancer metastases. Mol Cancer Res 11. https://doi.org/10.1158/1557-3125.ADVBC-A102
Cui T, Chisti Y (2003) Polysaccharopeptides of Coriolus versicolor: physiological activity, uses, and production. Biotechnol Adv 21:109–122. https://doi.org/10.1016/S0734-9750(03)00002-8
Cui FJ, Zan XY, Li YH et al (2016) Grifola frondosa glycoprotein GFG-3a arrests S phase, alters proteome, and induces apoptosis in human gastric cancer cells. Nutr Cancer 68:267–279. https://doi.org/10.1080/01635581.2016.1134599
Cunha-Oliveira T, Rego AC, Oliueira CR (2008) Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Brain Res Rev 58:192–208. https://doi.org/10.1016/j.brainresrev.2008.03.002
Dasgupta P, Henshaw C, Youlden DR et al (2020) Global trends in incidence rates of primary adult liver cancers: a systematic review and meta-analysis. Front Oncol 10:171. https://doi.org/10.3389/Fonc.2020.00171
De Leval L, Jaffe ES (2020) Lymphoma classification. Cancer J 26:176–185. https://doi.org/10.1097/Ppo.0000000000000451
Ding YR, Xiao C, Wu QP et al (2016) The mechanisms underlying the hypolipidaemic effects of grifola frondosa in the liver of rats. Front Microbiol 7:1186. https://doi.org/10.3389/Fmicb.2016.01186
Duan TX, Hu T, Wu CY et al (2020) PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling. Toxicol In Vitro 66:104857. https://doi.org/10.1016/J.Tiv.2020.104857
Eric A, Juranic Z, Milovanovic Z et al (2009) Effects of humoral immunity and calreticulin overexpression on postoperative course in breast cancer. Pathol Oncol Res 15:89–90. https://doi.org/10.1007/s12253-008-9112-2
Farmer JA (1998) Aggressive lipid therapy in the statin era. Prog Cardiovasc Dis 41:71–94. https://doi.org/10.1016/S0033-0620(98)80006-6
Feng J, Wang XH, Ye XC et al (2022) Mitochondria as an important target of metformin: the mechanism of action, toxic and side effects, and new therapeutic applications. Pharmacol Res 177:106114. https://doi.org/10.1016/J.Phrs.2022.106114
Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Pineros M (2020) Global cancer observatory: cancer today. https://gco.iarc.fr/today
Finimundy TC, Abreu RMV, Bonetto N et al (2018) Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines. Food Chem Toxicol 112:383–392. https://doi.org/10.1016/j.fct.2018.01.015
Fraiser LH, Kanekal S, Kehrer JP (1991) Cyclophosphamide toxicity. Characterising and avoiding the problem. Drugs 42:781–795. https://doi.org/10.2165/00003495-199142050-00005
Fridman WH, Pages F, Sautes-Fridman C et al (2012) The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 12:298–306. https://doi.org/10.1038/nrc3245
Gadducci A, Barsotti C, Cosio S et al (2011) Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature. Gynecol Endocrinol 27:597–604. https://doi.org/10.3109/09513590.2011.558953
Gill BS, Navgeet MR et al (2018) Ganoderic acid, lanostanoid triterpene: a key player in apoptosis. Investig New Drugs 36:136–143. https://doi.org/10.1007/s10637-017-0526-0
Gines P, Castera L, Lammert F et al (2022) Population screening for liver fibrosis: toward early diagnosis and intervention for chronic liver diseases. Hepatology 75:219–228. https://doi.org/10.1002/hep.32163
Gordon DJ, Rifkind BM (1989) High-density lipoprotein--the clinical implications of recent studies. N Engl J Med 321:1311–1316. https://doi.org/10.1056/NEJM198911093211907
Gorynia S, Bandeiras TM, Pinho FG et al (2011) Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex. J Struct Biol 176:279–291. https://doi.org/10.1016/j.jsb.2011.09.001
Goudarzi M, Fatemi I, Siahpoosh A et al (2018) Protective effect of ellagic acid against sodium arsenite-induced cardio- and hematotoxicity in rats. Cardiovasc Toxicol 18:337–345. https://doi.org/10.1007/s12012-018-9446-2
Guo L, Xie J, Ruan Y, Zhou L, Zhu H, Yun X, Jiang Y, Lü L, Chen K, Min Z et al (2009) Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum. Int Immunopharmacol 9:1175–1182
Gutfeld O, Prus D, Ackerman Z et al (2006) Expression of serum amyloid A, in normal, dysplastic, and neoplastic human colonic mucosa: implication for a role in colonic tumorigenesis. J Histochem Cytochem 54:63–73. https://doi.org/10.1369/jhc.5A6645.2005
Hanahan D (2022) Hallmarks of cancer: new dimensions. Cancer Discov 12:31–46. https://doi.org/10.1158/2159-8290.CD-21-1059
Hassan MA, Rouf R, Tiralongo E et al (2015) Mushroom lectins: specificity, structure and bioactivity relevant to human disease. Int J Mol Sci 16:7802–7838. https://doi.org/10.3390/ijms16047802
Hermeking H, Benzinger A (2006) 14-3-3 proteins in cell cycle regulation. Semin Cancer Biol 16:183–192. https://doi.org/10.1016/j.semcancer.2006.03.002
Hesketh PJ (2008) Chemotherapy-induced nausea and vomiting. N Engl J Med 358:2482–2494. https://doi.org/10.1056/NEJMra0706547
Holecek M (2010) Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition 26:482–490. https://doi.org/10.1016/j.nut.2009.06.027
Hu Q, Du H, Ma G et al (2018) Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii. Food Funct 9:3764–3775. https://doi.org/10.1039/c8fo00604k
Hu T, Shen L, Huang Q et al (2021) Protective effect of dictyophora polysaccharides on sodium arsenite-induced hepatotoxicity: a proteomics study. Front Pharmacol 12:749035. https://doi.org/10.3389/fphar.2021.749035
Hwang HJ, Baek YM, Kim SW et al (2007) Differential expression of kidney proteins in streptozotocin-induced diabetic rats in response to hypoglycemic fungal polysaccharides. J Microbiol Biotechnol 17:2005–2017
International Diabetes Federation (2021) IDF Diabetes Atlas, 10th edn. International Diabetes Federation, Brussels, Belgium
Ishizaki H, Togawa A, Tanaka-Okamoto M et al (2006) Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta. J Immunol 177:8512–8521. https://doi.org/10.4049/jimmunol.177.12.8512
Ismail NA, Ragab SH, Abd Elbaky A et al (2011) Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults. Arch Med Sci 7:501–507. https://doi.org/10.5114/aoms.2011.23418
Jain SK, Micinski D, Huning L et al (2014) Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type 2 diabetic patients. Eur J Clin Nutr 68:1148–1153. https://doi.org/10.1038/ejcn.2014.114
Jakopovic B, Horvatic A, Klobucar M et al (2020a) Treatment with medicinal mushroom extract mixture inhibits translation and reprograms metabolism in advanced colorectal cancer animal model as evidenced by tandem mass tags proteomics analysis. Front Pharmacol 11:1202. https://doi.org/10.3389/fphar.2020.01202
Jakopovic B, Orsolic N, Kraljevic Pavelic S (2020b) Antitumor, immunomodulatory and antiangiogenic efficacy of medicinal mushroom extract mixtures in advanced colorectal cancer animal model. Molecules 25. https://doi.org/10.3390/molecules25215005
Jakopovich I (2011) New dietary supplements from medicinal mushrooms: Dr Myko San: a registration report. Int J Med Mushrooms 13:307–313. https://doi.org/10.1615/intjmedmushr.v13.i3.110
Jayson GC, Kohn EC, Kitchener HC et al (2014) Ovarian cancer. Lancet 384:1376–1388. https://doi.org/10.1016/S0140-6736(13)62146-7
Jemal A, Simard EP, Dorell C et al (2013) Annual report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus(HPV)-associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst 105:175–201. https://doi.org/10.1093/jnci/djs491
Jeong MK, Yoo HS, Kang IC (2019) The extract of cordyceps militaris inhibited the proliferation of cisplatin-resistant A549 lung cancer cells by downregulation of H-Ras. J Med Food 22:823–832. https://doi.org/10.1089/jmf.2018.4232
Jhunjhunwala S, Jiang Z, Stawiski EW et al (2014) Diverse modes of genomic alteration in hepatocellular carcinoma. Genome Biol 15:436. https://doi.org/10.1186/s13059-014-0436-9
Jin H, Jin F, Jin JX et al (2013) Protective effects of Ganoderma lucidum spore on cadmium hepatotoxicity in mice. Food Chem Toxicol 52:171–175. https://doi.org/10.1016/j.fct.2012.05.040
Kampan NC, Madondo MT, Mcnally OM et al (2017) Interleukin 6 present in inflammatory ascites from advanced epithelial ovarian cancer patients promotes tumor necrosis factor receptor 2-expressing regulatory T cells. Front Immunol 8:1482. https://doi.org/10.3389/fimmu.2017.01482
Kan L, Cui D, Chai Y et al (2020) TMT-based quantitative proteomic analysis of antitumor mechanism of Sporisorium reilianum polysaccharide WM-NP-60 against HCT116 cells. Int J Biol Macromol 165:1755–1764. https://doi.org/10.1016/j.ijbiomac.2020.10.056
Kang C, Xu Q, Martin TD et al (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 349:aaa5612. https://doi.org/10.1126/science.aaa5612
Kang MA, Jeon YK, Nam MJ (2020) Auricularia auricula increases an apoptosis in human hepatocellular carcinoma cells via a regulation of the peroxiredoxin1. J Food Biochem. https://doi.org/10.1111/jfbc.13373
Karvonen M, Viik-Kajander M, Moltchanova E et al (2000) Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 23:1516–1526. https://doi.org/10.2337/diacare.23.10.1516
Kim KR, Choi HN, Lee HJ et al (2007) A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. Oncol Rep 18:825–832
Kim SW, Hwang HJ, Baek YM et al (2008) Proteomic and transcriptomic analysis for streptozotocin-induced diabetic rat pancreas in response to fungal polysaccharide treatments. Proteomics 8:2344–2361. https://doi.org/10.1002/pmic.200700779
Kim SW, Hwang HJ, Baek YM et al (2009) Proteomic analysis in ob/ob mice before and after hypoglycemic polysaccharide treatments. J Microbiol Biotechnol 19:1109–1121
Ko JL, Hsu CI, Lin RH et al (1995) A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence. Eur J Biochem 228:244–249
Krobthong S, Yingchutrakul Y, Visessanguan W et al (2021) Study of the lipolysis effect of nanoliposome-encapsulated ganoderma lucidum protein hydrolysates on adipocyte cells using proteomics approach. Foods 10. https://doi.org/10.3390/foods10092157
Krysko DV, Garg AD, Kaczmarek A et al (2012) Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer 12:860–875. https://doi.org/10.1038/nrc3380
Kuo HC, Kuo YR, Lee KF et al (2017) A comparative proteomic analysis of erinacine A’s inhibition of gastric cancer cell viability and invasiveness. Cell Physiol Biochem 43:195–208. https://doi.org/10.1159/000480338
Kurashige S, Akuzawa Y, Endo F (1997) Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine. Immunopharmacol Immunotoxicol 19:175–183. https://doi.org/10.3109/08923979709007657
Kustatscher G, Collins T, Gingras AC et al (2022) Understudied proteins: opportunities and challenges for functional proteomics. Nat Methods 19:774–779. https://doi.org/10.1038/s41592-022-01454-x
Laverty HG, Wakefield LM, Occleston NL et al (2009) TGF-beta3 and cancer: a review. Cytokine Growth Factor Rev 20:305–317. https://doi.org/10.1016/j.cytogfr.2009.07.002
Lee CL, Jiang PP, Sit WH et al (2007) Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: analysis of significant proteins that manipulate T cells proliferation and immunosuppression. Int Immunopharmacol 7:1311–1324. https://doi.org/10.1016/j.intimp.2007.05.013
Lee KC, Kuo HC, Shen CH et al (2017) A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells' aggressiveness. J Cell Mol Med 21:588–599. https://doi.org/10.1111/jcmm.13004
Li YB, Wang R, Wu HL et al (2008) Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells. Oncol Rep 20:549–556
Li H, Zhang M, Ma G (2010) Hypolipidemic effect of the polysaccharide from Pholiota nameko. Nutrition 26:556–562. https://doi.org/10.1016/j.nut.2009.06.009
Li YG, Ji DF, Zhong S et al (2013) Polysaccharide from Phellinus linteus induces S-phase arrest in HepG2 cells by decreasing calreticulin expression and activating the P27kip1-cyclin A/D1/E-CDK2 pathway. J Ethnopharmacol 150:187–195. https://doi.org/10.1016/j.jep.2013.08.028
Li S, Nie Y, Ding Y et al (2014) Recombinant expression of a novel fungal immunomodulatory protein with human tumor cell antiproliferative activity from Nectria haematococca. Int J Mol Sci 15:17751–17764. https://doi.org/10.3390/ijms151017751
Lin TY, Hua WJ, Yeh H et al (2021) Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells. Phytomedicine 80:153384. https://doi.org/10.1016/j.phymed.2020.153384
Lindstrom MS (2011) NPM1/B23: a multifunctional chaperone in ribosome biogenesis and chromatin remodeling. Biochem Res Int 2011:195209. https://doi.org/10.1155/2011/195209
Liu J, Shen JX, Hu JL et al (2014) Significance of interleukin-33 and its related cytokines in patients with breast cancers. Front Immunol 5:141. https://doi.org/10.3389/fimmu.2014.00141
Liu YJ, Du JL, Cao LP et al (2015) Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides on carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio L.). Int Immunopharmacol 25:112–120. https://doi.org/10.1016/j.intimp.2015.01.023
Liu G, Wang K, Kuang S et al (2018) The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death. Cell Death Dis 9:689. https://doi.org/10.1038/s41419-018-0731-6
Liu HJ, Qin Y, Zhao ZH et al (2020) Lentinan-functionalized selenium nanoparticles target tumor cell mitochondria via TLR4/TRAF3/MFN1 pathway. Theranostics 10:9083–9099. https://doi.org/10.7150/thno.46467
Llovet JM, Kelley RK, Villanueva A et al (2021) Hepatocellular carcinoma. Nat Rev Dis Primers 7:6. https://doi.org/10.1038/s41572-020-00240-3
Ma C, Guan SH, Yang M et al (2008) Differential protein expression in mouse splenic mononuclear cells treated with polysaccharides from spores of Ganoderma lucidum. Phytomedicine 15:268–276. https://doi.org/10.1016/j.phymed.2007.11.015
Ma C, Yue QX, Guan SH et al (2009) Proteomic analysis of possible target-related proteins of cyclophosphamide in mice thymus. Food Chem Toxicol 47:1841–1847. https://doi.org/10.1016/j.fct.2009.04.041
Ma N, Du H, Ma G et al (2020) Characterization of the immunomodulatory mechanism of a Pleurotus eryngii protein by isobaric tags for relative and absolute quantitation proteomics. J Agric Food Chem 68:13189–13199. https://doi.org/10.1021/acs.jafc.0c00219
Maekawa M, Ishizaki T, Boku S et al (1999) Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285:895–898. https://doi.org/10.1126/science.285.5429.895
Mahmood RI, Abbass AK, Razali N et al (2021) Protein profile of MCF-7 breast cancer cell line treated with lectin delivered by CaCO3NPs revealed changes in molecular chaperones, cytoskeleton, and membrane-associated proteins. Int J Biol Macromol 184:636–647. https://doi.org/10.1016/j.ijbiomac.2021.06.144
Mclennan SV, Heffernan S, Wright L et al (1991) Changes in hepatic glutathione metabolism in diabetes. Diabetes 40:344–348. https://doi.org/10.2337/diab.40.3.344
Mhawech P (2005) 14-3-3 proteins: an update. Cell Res 15:228–236. https://doi.org/10.1038/sj.cr.7290291
Michalak M, Groenendyk J, Szabo E et al (2009) Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem J 417:651–666. https://doi.org/10.1042/BJ20081847
Miletic AV, Swat M, Fujikawa K et al (2003) Cytoskeletal remodeling in lymphocyte activation. Curr Opin Immunol 15:261–268. https://doi.org/10.1016/s0952-7915(03)00054-2
Mobley JA, Leav I, Zielie P et al (2003) Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro. Cancer Epidemiol Biomark Prev 12:775–783
Morris PJ (1991) Cyclosporine, FK-506 and other drugs in organ transplantation. Curr Opin Immunol 3:748–751. https://doi.org/10.1016/0952-7915(91)90107-c
Nam SW, Han JY, Kim JI et al (2005) Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. J Gastroenterol Hepatol 20:488–492. https://doi.org/10.1111/j.1440-1746.2005.03243.x
Norata GD, Ongari M, Garlaschelli K et al (2007) Plasma resistin levels correlate with determinants of the metabolic syndrome. Eur J Endocrinol 156:279–284. https://doi.org/10.1530/eje.1.02338
Olofsson B (1999) Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal 11:545–554. https://doi.org/10.1016/s0898-6568(98)00063-1
O’Meara NM, Devery RA, Owens D et al (1991) Serum lipoproteins and cholesterol metabolism in two hypercholesterolaemic rabbit models. Diabetologia 34:139–143. https://doi.org/10.1007/BF00418266
Oprea TI, Bologa CG, Brunak S et al (2018) Unexplored therapeutic opportunities in the human genome. Nat Rev Drug Discov 17:317–332. https://doi.org/10.1038/nrd.2018.14
Ou HT, Shieh CJ, Chen JY, Chang HM (2005) The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms. J Agric Food Chem 53:300–305
Ouyang F, Wang G, Guo W et al (2013) AKT signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and G1 or S phase arrest in human hepatoma cells. Food Chem 138:2130–2139. https://doi.org/10.1016/j.foodchem.2012.10.047
Ozawa M, Muramatsu T (1993) Reticulocalbin, a novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence. J Biol Chem 268:699–705
Panchal K, Tiwari AK (2019) Mitochondrial dynamics, a key executioner in neurodegenerative diseases. Mitochondrion 47:151–173. https://doi.org/10.1016/j.mito.2018.11.002
Pandey R, Rai V, Mishra J et al (2017) From the cover: arsenic induces hippocampal neuronal apoptosis and cognitive impairments via an up-regulated BMP2/Smad-dependent reduced BDNF/TrkB signaling in rats. Toxicol Sci 159:137–158. https://doi.org/10.1093/toxsci/kfx124
Paula Santos N, Colaco A, Gil Da Costa RM et al (2014) N-diethylnitrosamine mouse hepatotoxicity: time-related effects on histology and oxidative stress. Exp Toxicol Pathol 66:429–436. https://doi.org/10.1016/j.etp.2014.07.002
Peng F, Huang Y, Li MY et al (2016) Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer. World J Gastroenterol 22:4515–4528. https://doi.org/10.3748/wjg.v22.i18.4515
Prescott SM, Zimmerman GA, Stafforini DM et al (2000) Platelet-activating factor and related lipid mediators. Annu Rev Biochem 69:419–445. https://doi.org/10.1146/annurev.biochem.69.1.419
Rabinovich GA, Alonso CR, Sotomayor CE et al (2000) Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2. Cell Death Differ 7:747–753. https://doi.org/10.1038/sj.cdd.4400708
Ramm G, Larance M, Guilhaus M et al (2006) A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160. J Biol Chem 281:29174–29180. https://doi.org/10.1074/jbc.M603274200
Rezaei M, Keshtzar E, Khodayar MJ et al (2019) SirT3 regulates diabetogenic effects caused by arsenic: an implication for mitochondrial complex II modification. Toxicol Lett 301:24–33. https://doi.org/10.1016/j.toxlet.2018.10.025
Rong B, Yang S (2018) Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: new discoveries and developments (review). Int J Oncol 52:321–336. https://doi.org/10.3892/ijo.2017.4214
Sakurai K, Katoh M, Someno K et al (2001) Apoptosis and mitochondrial damage in INS-1 cells treated with alloxan. Biol Pharm Bull 24:876–882. https://doi.org/10.1248/bpb.24.876
Shamtsyan M, Konusova V, Maksimova Y et al (2004) Immunomodulating and anti-tumor action of extracts of several mushrooms. J Biotechnol 113:77–83. https://doi.org/10.1016/j.jbiotec.2004.04.034
Shenton D, Grant CM (2003) Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae. Biochem J 374:513–519. https://doi.org/10.1042/BJ20030414
Shoji-Kawata S, Sumpter R, Leveno M et al (2013) Identification of a candidate therapeutic autophagy-inducing peptide. Nature 494:201–206. https://doi.org/10.1038/nature11866
Spychala MS, Venna VR, Jandzinski M et al (2018) Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome. Ann Neurol 84:23–36. https://doi.org/10.1002/ana.25250
Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249. https://doi.org/10.3322/caac.21660
Tian X, Li Y, Shen Y et al (2015) Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin. Oncol Lett 10:595–599. https://doi.org/10.3892/ol.2015.3273
Toro JR, Travis LB, Wu HJ et al (2006) Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978-2001: an analysis of 26,758 cases. Int J Cancer 119:2922–2930. https://doi.org/10.1002/ijc.22239
Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8:579–591. https://doi.org/10.1038/nrd2803
Tsukumo Y, Tomida A, Kitahara O et al (2007) Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. J Biol Chem 282:29264–29272. https://doi.org/10.1074/jbc.M705038200
Vasaikar S, Huang C, Wang X et al (2019) Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities. Cell 177(1035–1049):e1019. https://doi.org/10.1016/j.cell.2019.03.030
Wang C, Youle RJ (2012) Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1’s inhibitory effect on Bak. Oncogene 31:3177–3189. https://doi.org/10.1038/onc.2011.497
Wang PY, Kitchens RL, Munford RS (1998) Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide. J Biol Chem 273:24309–24313. https://doi.org/10.1074/jbc.273.38.24309
Wang YT, Huang ZJ, Chang HM (2004) Proteomic analysis of human leukemic U937 cells incubated with conditioned medium of mononuclear cells stimulated by proteins from dietary mushroom of Agrocybe aegerita. J Proteome Res 3:890–896. https://doi.org/10.1021/pr049922h
Wang H, Wu G, Park HJ et al (2012) Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis. Chin Med 7:23. https://doi.org/10.1186/1749-8546-7-23
Wang H, Zhang J, Sit WH et al (2014) Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study. Chin Med 9:15. https://doi.org/10.1186/1749-8546-9-15
Wang PW, Hung YC, Li WT et al (2016) Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics. Oncotarget 7:60270–60289. https://doi.org/10.18632/oncotarget.11201
Wang Y, Han X, Li YD et al (2017) Lentinan dose dependence between immunoprophylaxis and promotion of the murine liver cancer. Oncotarget 8:95152–95162. https://doi.org/10.18632/oncotarget.19808
Wang W, Yang X, Li C et al (2022) Immunogenic cell death (ICD) of murine H22 cells induced by lentinan. Nutr Cancer 74:640–649. https://doi.org/10.1080/01635581.2021.1897632
WHO (2022a) Diabetes. https://www.who.int/news-room/fact-sheets/detail/diabetes. Accessed 5 June 2022
WHO (2022b) The top 10 causes of death. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Accessed 6 June 2022
Wolf G (2007) Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes. Nutr Rev 65:251–256. https://doi.org/10.1111/j.1753-4887.2007.tb00302.x
Wong MCS, Huang J, Chan PSF et al (2021) Global incidence and mortality of gastric cancer, 1980-2018. JAMA Netw Open 4:e2118457. https://doi.org/10.1001/jamanetworkopen.2021.18457
Wu G, Fang YZ, Yang S et al (2004) Glutathione metabolism and its implications for health. J Nutr 134:489–492. https://doi.org/10.1093/jn/134.3.489
Wu YW, Fang HL, Lin WC (2010) Post-treatment of Ganoderma lucidum reduced liver fibrosis induced by thioacetamide in mice. Phytother Res 24:494–499. https://doi.org/10.1002/ptr.2949
Wu CT, Lin TY, Hsu HY et al (2011) Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway. Carcinogenesis 32:1890–1896. https://doi.org/10.1093/carcin/bgr221
Wu H, Tang S, Huang Z et al (2016) Hepatoprotective effects and mechanisms of action of triterpenoids from Lingzhi or Reishi medicinal mushroom ganoderma lucidum (agaricomycetes) on alpha-amanitin-induced liver injury in mice. Int J Med Mushrooms 18:841–850. https://doi.org/10.1615/IntJMedMushrooms.v18.i9.80
Xian H, Li J, Zhang Y et al (2021) Antimetastatic effects of Ganoderma lucidum polysaccharide peptide on B16-F10-luc-G5 melanoma mice with sleep fragmentation. Front Pharmacol 12:650216. https://doi.org/10.3389/fphar.2021.650216
Xie Y, Li S, Sun L et al (2018) Fungal immunomodulatory protein from nectria haematococca suppresses growth of human lung adenocarcinoma by inhibiting the PI3K/Akt pathway. Int J Mol Sci 19. https://doi.org/10.3390/ijms19113429
Xiong Y, Chen ZH, Zhang FL et al (2021) A specific selenium-chelating peptide isolated from the protein hydrolysate of Grifola frondosa. RSC Adv 11:10272–10284. https://doi.org/10.1039/d0ra10886c
Xu JW, Zhao W, Zhong JJ (2010) Biotechnological production and application of ganoderic acids. Appl Microbiol Biotechnol 87:457–466. https://doi.org/10.1007/s00253-010-2576-5
Yan L, Shen J, Wang J et al (2020) Nanoparticle-based drug delivery system: a patient-friendly chemotherapy for oncology. Dose Response 18:1559325820936161. https://doi.org/10.1177/1559325820936161
Yang X, Li Y, Wang W, Li C, Zhao D, Hu G, Rao H, Hao J, Han X (2020) Antigens from H22 cell mutation induced by lentinan are correlated with HCC immunoprophylaxis. https://www.researchsquare.com/article/rs-43542/v1. Accessed 12 May 2022
Yang J, Pan G, Guan L et al (2022) The burden of primary liver cancer caused by specific etiologies from 1990 to 2019 at the global, regional, and national levels. Cancer Med 11:1357–1370. https://doi.org/10.1002/cam4.4530
Ying H, Zhang Y (2019) Systems biology of selenium and complex disease. Biol Trace Elem Res 192:38–50. https://doi.org/10.1007/s12011-019-01781-9
Yu CL, Burakoff SJ (1997) Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. J Biol Chem 272:14017–14020. https://doi.org/10.1074/jbc.272.22.14017
Yu ACY, Chern YJ, Zhang P et al (2021) Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT. Cancer Biol Ther 22:112–123. https://doi.org/10.1080/15384047.2020.1839278
Yue QX, Cao ZW, Guan SH et al (2008a) Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics 7:949–961. https://doi.org/10.1074/mcp.M700259-MCP200
Yue QX, Xie FB, Guan SH et al (2008b) Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes. Cancer Sci 99:1461–1470. https://doi.org/10.1111/j.1349-7006.2008.00824.x
Yue QX, Song XY, Ma C et al (2010) Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. Phytomedicine 17:606–613. https://doi.org/10.1016/j.phymed.2009.12.013
Zacharakis M, Xynos ID, Lazaris A et al (2010) Predictors of survival in stage IV metastatic colorectal cancer. Anticancer Res 30:653–660
Zaidman BZ, Yassin M, Mahajna J et al (2005) Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67:453–468. https://doi.org/10.1007/s00253-004-1787-z
Zeng H, Botnen JH (2007) Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors 31:155–164. https://doi.org/10.1002/biof.5520310302
Zhang HN, Lin ZB (2004) Hypoglycemic effect of Ganoderma lucidum polysaccharides. Acta Pharmacol Sin 25:191–195
Zhang X, Zhang H (2018) Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME. Sci China Life Sci 61:739–740. https://doi.org/10.1007/s11427-017-9158-x
Zhang L, Qiao Q, Tuomilehto J et al (2009) Blood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: the DECODA study. Diabetes Metab Res Rev 25:549–557. https://doi.org/10.1002/dmrr.994
Zhang Y, Wu W, Qu H (2019) Integrated analysis of the gene expression changes during colorectal cancer progression by bioinformatic methods. J Comput Biol 26:1168–1176. https://doi.org/10.1089/cmb.2019.0056
Zhang T, Chen X, Sun L et al (2021) Proteomics reveals the function reverse of MPSSS-treated prostate cancer-associated fibroblasts to suppress PC-3 cell viability via the FoxO pathway. Cancer Med 10:2509–2522. https://doi.org/10.1002/cam4.3825
Zhang J, Hu T, Wang Y et al (2022) Investigating the neurotoxic impacts of arsenic and the neuroprotective effects of dictyophora polysaccharide using SWATH-MS-based proteomics. Molecules 27. https://doi.org/10.3390/molecules27051495
Zhao C, Fan J, Liu Y et al (2019) Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis. Food Chem 271:148–156. https://doi.org/10.1016/j.foodchem.2018.07.115
Zhu T, Kim SH, Chen CY (2008) A medicinal mushroom: Phellinus linteus. Curr Med Chem 15:1330–1335. https://doi.org/10.2174/092986708784534929
Zickermann V, Drose S, Tocilescu MA et al (2008) Challenges in elucidating structure and mechanism of proton pumping NADH:ubiquinone oxidoreductase (complex I). J Bioenerg Biomembr 40:475–483. https://doi.org/10.1007/s10863-008-9171-9
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Jakopovic, B., Oršolić, N., Kraljević Pavelić, S., Jakopovich, I. (2023). Proteomic Research on the Therapeutic Properties of Medicinal Mushrooms. In: Agrawal, D.C., Dhanasekaran, M. (eds) Mushrooms with Therapeutic Potentials. Springer, Singapore. https://doi.org/10.1007/978-981-19-9550-7_11
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