Skip to main content
SpringerLink
Log in

Quorum Sensing and Quorum Quenching Metabolites in Actinomycetes

  • Chapter
  • First Online:
Natural Products from Actinomycetes

Abstract

Quorum sensing or cell-to-cell communication in bacteria regulates gene expression and phenotype production based on population density. Basically, there are four classes of signaling molecules, which are also known as autoinducers. Gram-negative bacteria synthesize the acyl-homoserine lactones (AHLs) or autoinducer type 1, whereas Gram-positive bacteria produce small peptides or autoinducer type 4 signaling molecules. Similarly, autoinducer type 2 is used by bacteria for interspecies signaling and autoinducer type 3 is synthesized by gut bacteria and has a role in host-pathogen interaction. However, the actinomycetes comprised of Streptomyces and non-Streptomyces genus, unlike other Gram-positive bacteria produce γ-butyrolactones (GBLs) as signal molecules. These molecules structurally resemble AHLs and regulate morphological development and secondary metabolite production in actinomycetes. The first γ-butyrolactone characterized and studied was the A-factor. In recent years, several other γ-butyrolactones have been identified in different species of Streptomyces and non-Streptomyces. Apart from GBLs, certain actinomycetes also utilize peptides and antibiotics as signal molecules. In this chapter, we describe the quorum sensing signal mechanism in actinomycetes and the various types of signal molecules produced by Streptomyces and non-Streptomyces genus. The regulatory role of the signal molecules has also been discussed. The advantages and limitation of conventional and new techniques used for the detection of QS signals and receptors in actinomycetes have been listed. The quorum quenching enzymes and QS inhibitory compounds produced by actinomycetes are also mentioned.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdalla MA, Win HY, Islam MT, Von Tiedemann A, Schüffler A, Laatsch H (2011) Khatmiamycin, a motility inhibitor and zoosporicide against the grapevine downy mildew pathogen Plasmopara viticola from Streptomyces sp. ANK313. J Antibiot 64(10):655–659

    Article  CAS  Google Scholar 

  • Albuquerque P, Casadevall A (2012) Quorum sensing in fungi—a review. Med Mycol 50(4):337–345

    Article  CAS  PubMed  Google Scholar 

  • Ando N, Ueda K, Horinouchi S (1997) A Streptomyces griseus gene (sgaA) suppresses the growth disturbance caused by high osmolality and a high concentration of A-factor during early growth. Microbiology 143(8):2715–2723

    Article  CAS  PubMed  Google Scholar 

  • Anisova LN, Blinova IN, Efremenkova OV, Smirnova GM, Khokhlov AS (1984) Regulators of differentiation in Streptomyces cyaneofuscatus. Mikrobiologiia 53(6):890–895

    CAS  PubMed  Google Scholar 

  • Arakawa K, Mochizuki S, Yamada K, Noma T, Kinashi H (2007) γ-Butyrolactone autoregulator-receptor system involved in lankacidin and lankamycin production and morphological differentiation in Streptomyces rochei. Microbiology 153(6):1817–1827

    Article  CAS  PubMed  Google Scholar 

  • Arakawa K, Tsuda N, Taniguchi A, Kinashi H (2012) The butenolide signaling molecules SRB1 and SRB2 induce lankacidin and lankamycin production in Streptomyces rochei. ChemBioChem 13(10):1447–1457

    Article  CAS  PubMed  Google Scholar 

  • Augustine N, Kerkar S, Thomas S (2012) Arctic actinomycetes as potential inhibitors of Vibrio cholerae biofilm. Curr Microbiol 64(4):338–342

    Article  CAS  PubMed  Google Scholar 

  • Azuma M, Nishi K, Horinouchi S, Beppu T (1990) Ribonucleases catalyze the synthesis of B-factor (3′-butylphosphoryl AMP), an inducer of rifamycin production in a Nocardia sp. J Antibiot 43(3):321–323

    Article  CAS  Google Scholar 

  • Balasubramanian S, Othman EM, Kampik D, Stopper H, Hentschel U, Ziebuhr W, Oelschlaeger TA, Abdelmohsen UR (2017) Marine sponge-derived Streptomyces sp. SBT343 extract inhibits staphylococcal biofilm formation. Front Microbiol 8:236

    Article  PubMed  PubMed Central  Google Scholar 

  • Barbey C, Crépin A, Cirou A, Budin-Verneuil A, Orange N, Feuilloley M, Faure D, Dessaux Y, Burini J-F, Latour X (2012) Catabolic pathway of gamma-caprolactone in the biocontrol agent Rhodococcus erythropolis. J Proteome Res 11(1):206–216

    Article  CAS  PubMed  Google Scholar 

  • Barbey C, Crépin A, Bergeau D, Ouchiha A, Mijouin L, Taupin L, Orange N et al (2013) In planta biocontrol of Pectobacterium atrosepticum by Rhodococcus erythropolis involves silencing of pathogen communication by the rhodococcal gamma-lactone catabolic pathway. PLoS One 8(6):e66642

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barreales EG, Payero TD, Jambrina E, Aparicio JF (2020) The Streptomyces filipinensis gamma-butyrolactone system reveals novel clues for understanding the control of secondary metabolism. Appl Environ Microbiol 86(18)

    Google Scholar 

  • Bauermeister A, Pereira F, Grilo IR, Godinho CC, Paulino M, Almeida V, Gobbo-Neto L et al (2019) Intra-clade metabolomic profiling of MAR4 Streptomyces from the Macaronesia Atlantic region reveals a source of anti-biofilm metabolites. Environ Microbiol 21(3):1099–1112

    Article  CAS  PubMed  Google Scholar 

  • Beppu T (1992) Secondary metabolites as chemical signals for cellular differentiation. Gene 115(1–2):159–165

    Article  CAS  PubMed  Google Scholar 

  • Bhukya H, Bhujbalrao R, Bitra A, Anand R (2014) Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3 (2). Nucleic Acids Res 42(15):10122–10133

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Biarnes-Carrera M, Breitling R, Takano E (2015) Butyrolactone signalling circuits for synthetic biology. Curr Opin Chem Biol 28:91–98

    Article  CAS  PubMed  Google Scholar 

  • Bibb MJ (2005) Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol 8(2):208–215

    Article  CAS  PubMed  Google Scholar 

  • Bignell DRD, Bate N, Cundliffe E (2007) Regulation of tylosin production: role of a TylP-interactive ligand. Mol Microbiol 63(3):838–847

    Article  CAS  PubMed  Google Scholar 

  • Birkó Z, Bialek S, Buzás K, Szájli E, Medzihradszky KF, Rigali S, Vijgenboom E et al (2007) The secreted signaling protein factor C triggers the A-factor response regulon in Streptomyces griseus: overlapping signaling routes. Mol Cell Proteomics 6(7):1248–1256

    Article  CAS  PubMed  Google Scholar 

  • Braun D, Pauli N, Sequin U, Zähner H (1995) New butenolides from the photoconductivity screening of Streptomyces antibioticus (Waksman and Woodruff) Waksman and Henrici 1948. FEMS Microbiol Lett 126(1):37–42

    Article  CAS  PubMed  Google Scholar 

  • Chankhamhaengdecha S, Hongvijit S, Srichaisupakit A, Charnchai P, Panbangred W (2013) Endophytic actinomycetes: a novel source of potential acyl homoserine lactone degrading enzymes. Biomed Res Int 2013

    Google Scholar 

  • Chi W-J, Jin X-M, Jung S-C, Oh EA, Hong S-K (2011) Characterization of Sgr3394 produced only by the A-factor-producing Streptomyces griseus IFO 13350, not by the A-factor deficient mutant. J Microbiol 49(1):155–160

    Article  CAS  PubMed  Google Scholar 

  • Cho KW, Lee H-S, Rho J-R, Kim TS, Mo SJ, Shin J (2001) New lactone-containing metabolites from a marine-derived bacterium of the genus Streptomyces. J Nat Prod 64(5):664–667

    Article  CAS  PubMed  Google Scholar 

  • Choi S-U, Lee C-K, Hwang Y-I, Kinosita H, Nihira T (2003) γ-Butyrolactone autoregulators and receptor proteins in non-Streptomyces actinomycetes producing commercially important secondary metabolites. Arch Microbiol 180(4):303–307

    Article  CAS  PubMed  Google Scholar 

  • Choi S-U, Lee C-K, Hwang Y-I, Kinoshita H, Nihira T (2004) Cloning and functional analysis by gene disruption of a gene encoding a γ-butyrolactone autoregulator receptor from Kitasatospora setae. J Bacteriol 186(11):3423–3430

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Choudhary S, Schmidt-Dannert C (2010) Applications of quorum sensing in biotechnology. Appl Microbiol Biotechnol 86(5):1267–1279

    Article  CAS  PubMed  Google Scholar 

  • Corre C, Song L, O’Rourke S, Chater KF, Challis GL (2008) 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc Natl Acad Sci 105(45):17510–17515

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de Jong W, Vijgenboom E, Dijkhuizen L, Wösten HAB, Claessen D (2012) SapB and the rodlins are required for development of Streptomyces coelicolor in high osmolarity media. FEMS Microbiol Lett 329(2):154–159

    Article  CAS  PubMed  Google Scholar 

  • De Kievit TR, Iglewski BH (2000) Bacterial quorum sensing in pathogenic relationships. Infect Immun 68(9):4839–4849

    Article  PubMed  PubMed Central  Google Scholar 

  • Desouky SE, Shojima A, Singh RP, Matsufuji T, Igarashi Y, Suzuki T, Yamagaki T et al (2015) Cyclodepsipeptides produced by actinomycetes inhibit cyclic-peptide-mediated quorum sensing in Gram-positive bacteria. FEMS Microbiol Lett 362(14):fnv109

    Article  CAS  PubMed  Google Scholar 

  • Distler J, Mansouri K, Mayer G, Stockmann M, Piepersberg W (1992) Streptomycin biosynthesis and its regulation in Streptomycetes. Gene 115(1–2):105–111

    Article  CAS  PubMed  Google Scholar 

  • Driche EH, Sabaou N, Bijani C, Zitouni A, Pont F, Mathieu F, Badji B (2017) Streptomyces sp. AT37 isolated from a Saharan soil produces a furanone derivative active against multidrug-resistant Staphylococcus aureus. World J Microbiol Biotechnol 33(6):105

    Article  CAS  PubMed  Google Scholar 

  • Du Y-L, Shen X-L, Yu P, Bai L-Q, Li Y-Q (2011) Gamma-butyrolactone regulatory system of Streptomyces chattanoogensis links nutrient utilization, metabolism, and development. Appl Environ Microbiol 77(23):8415–8426

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Du Y, Sun J, Gong Q, Wang Y, Fu P, Zhu W (2018) New α-pyridones with quorum-sensing inhibitory activity from diversity-enhanced extracts of a Streptomyces sp. derived from marine algae. J Agric Food Chem 66(8):1807–1812

    Article  CAS  PubMed  Google Scholar 

  • Fatin SN, Boon-Khai T, Shu-Chien AC, Khairuddean M, Abdullah AA-A (2017) A marine actinomycete rescues Caenorhabditis elegans from Pseudomonas aeruginosa infection through restitution of Lysozyme 7. Front Microbiol 8:2267

    Article  PubMed  PubMed Central  Google Scholar 

  • Fu P, Liu P, Gong Q, Wang Y, Wang P, Zhu W (2013) α-Pyrones from the marine-derived actinomycete Nocardiopsis dassonvillei subsp. dassonvillei XG-8-1. RSC Adv 3(43):20726–20731

    Article  CAS  Google Scholar 

  • Fukumoto A, Murakami C, Anzai Y, Kato F (2016) Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025. J Antibiot 69(5):395–399

    Article  CAS  Google Scholar 

  • Gomez-Escribano JP, Song L, Fox DJ, Yeo V, Bibb MJ, Challis GL (2012) Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145. Chem Sci 3(9):2716–2720

    Article  CAS  Google Scholar 

  • Gopikrishnan V, Radhakrishnan M, Shanmugasundaram T, Pazhanimurugan R, Balagurunathan R (2016) Antibiofouling potential of quercetin compound from marine-derived actinobacterium, Streptomyces fradiae PE7 and its characterization. Environ Sci Pollut Res 23(14):13832–13842

    Article  CAS  Google Scholar 

  • Gottelt M, Hesketh A, Bunet R, Puri P, Takano E (2012) Characterisation of a natural variant of the γ-butyrolactone signalling receptor. BMC Res Notes 5(1):1–17

    Article  CAS  Google Scholar 

  • Grandclément C, Tannières M, Moréra S, Dessaux Y, Faure D (2016) Quorum quenching: role in nature and applied developments. FEMS Microbiol Rev 40(1):86–116

    Article  CAS  PubMed  Google Scholar 

  • Hahn D (2013) Induction of cryptic natural product fungicides from actinomycetes. Pest Manag Nat Prod 217–236

    Google Scholar 

  • Hara O, Beppu T (1982) Mutants blocked in streptomycin production in Streptomyces griseus-the role of A-factor. J Antibiot 35(3):349–358

    Article  CAS  Google Scholar 

  • Hassan R, Shaaban MI, Abdel Bar FM, El-Mahdy AM, Shokralla S (2016) Quorum sensing inhibiting activity of Streptomyces coelicoflavus isolated from soil. Front Microbiol 7:659

    Article  PubMed  PubMed Central  Google Scholar 

  • Healy FG, Eaton Kevin P, Prajit L, Aldrich Joel F, Plowman Alaina K, King RR (2009) Characterization of gamma-butyrolactone autoregulatory signaling gene homologs in the angucyclinone polyketide WS5995B producer Streptomyces acidiscabies. J Bacteriol 191(15):4786–4797

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holden MTG, Chhabra SR, De Nys R, Stead P, Bainton NJ, Hill PJ, Manefield M et al (1999) Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria. Molecular Microbiology 33(6):1254–1266

    Article  CAS  PubMed  Google Scholar 

  • Horinouchi S (1996) Streptomyces genes involved in aerial mycelium formation. FEMS Microbiol Lett 141(1):1–9

    Google Scholar 

  • Horinouchi S (2002) A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus. Front Biosci 7:2045–2057

    Google Scholar 

  • Horinouchi S, Beppu T (1992) Autoregulatory factors and communication in actinomycetes. Annu Rev Microbiol 46(1):377–392

    Article  CAS  PubMed  Google Scholar 

  • Horinouchi S, Beppu T (2007) Hormonal control by A-factor of morphological development and secondary metabolism in Streptomyces. Proc Jpn Acad Ser B 83(9+10):277–295

    Article  CAS  Google Scholar 

  • Horinouchi S, Ueda K, Nakayama J, Ikeda T (2010) Cell-to-cell communications among microorganisms. In: Comprehensive natural products II: chemistry and biology. Elsevier Ltd, pp 283–337

    Chapter  Google Scholar 

  • Hsiao N-H, Nakayama S, Merlo ME, de Vries M, Bunet R, Kitani S, Nihira T, Takano E (2009) Analysis of two additional signaling molecules in Streptomyces coelicolor and the development of a butyrolactone-specific reporter system. Chem Biol 16(9):951–960

    Article  CAS  PubMed  Google Scholar 

  • Iwatsuki M, Uchida R, Yoshijima H, Ui H, Shiomi K, Matsumoto A, Takahashi Y, Abe A, Tomoda H, Ōmura S (2008) Guadinomines, type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. J Antibiot 61(4):222–229

    Article  CAS  Google Scholar 

  • Jauri PV, Bakker MG, Salomon CE, Kinkel LL (2013) Subinhibitory antibiotic concentrations mediate nutrient use and competition among soil Streptomyces. PLoS One 8(12):e81064

    Article  CAS  Google Scholar 

  • Kadowaki T, Kitano S, Baba A, Takii R, Hashimoto M, Katunuma N, Yamamoto K (2003) Isolation and characterization of a novel and potent inhibitor of Arg-gingipain from Streptomyces sp. strain FA-70. Biol Chem 384:911–920

    Article  CAS  PubMed  Google Scholar 

  • Kamarudheen N, Bhaskara KV, Rao. (2019) Fatty acyl compounds from marine Streptomyces griseoincarnatus strain HK12 against two major bio-film forming nosocomial pathogens; an in vitro and in silico approach. Microb Pathog 127:121–130

    Article  CAS  PubMed  Google Scholar 

  • Kang JE, Han JW, Jeon BJ, Kim BS (2016) Efficacies of quorum sensing inhibitors, piericidin A and glucopiericidin A, produced by Streptomyces xanthocidicus KPP01532 for the control of potato soft rot caused by Erwinia carotovora subsp. atroseptica. Microbiol Res 184:32–41

    Article  CAS  PubMed  Google Scholar 

  • Kawachi R, Akashi T, Kamitani Y, Sy A, Wangchaisoonthorn U, Nihira T, Yamada Y (2000) Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance. Mol Microbiol 36(2):302–313

    Article  CAS  PubMed  Google Scholar 

  • Kawaguchi T, Asahi T, Satoh T, Uozumi T, Beppu T (1984) B-factor, an essential regulatory substance inducing the production of rifamycin in a Nocardia sp. J Antibiot 37(12):1587–1595

    Article  CAS  Google Scholar 

  • Khokhlov AS, Tovarova II, Borisova LN, Pliner SA, Shevchenko LN, EIa K, Ivkina NS, Rapoport IA (1967) The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini. Dokl Akad Nauk SSSR 177(1):232–235

    CAS  PubMed  Google Scholar 

  • Kim, Yong-Guy, Jin-Hyung Lee, Chang-Jin Kim, Jae-Chan Lee, Yoon Jung Ju, Moo Hwan Cho, and Jintae Lee. "Antibiofilm activity of Streptomyces sp. BFI 230 and Kribbella sp. BFI 1562 against Pseudomonas aeruginosa." Appl Microbiol Biotechnol 96, no. 6 (2012): 1607–1617

    Google Scholar 

  • Kinoshita H, Ipposhi H, Okamoto S, Nakano H, Nihira T, Yamada Y (1997) Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae. J Bacteriol 179(22):6986–6993

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kiss Z, Ward AC, Birko Z, Chater KF, Biro S (2008) Streptomyces griseus 45H, a producer of the extracellular autoregulator protein factor C, is a member of the species Streptomyces albidoflavus. Int J Syst Evol Microbiol 58(4):1029–1031

    Article  CAS  PubMed  Google Scholar 

  • Kitani S, Kinoshita H, Nihira T, Yamada Y (1999) In vitro analysis of the butyrolactone autoregulator receptor protein (FarA) of Streptomyces lavendulae FRI-5 reveals that FarA acts as a DNA-binding transcriptional regulator that controls its own synthesis. J Bacteriol 181(16):5081–5084

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kitani S, Yamada Y, Nihira T (2001) Gene replacement analysis of the butyrolactone autoregulator receptor (FarA) reveals that FarA acts as a novel regulator in secondary metabolism of Streptomyces lavendulae FRI-5. J Bacteriol 183(14):4357–4363

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kitani S, Iida A, Izumi T-a, Maeda A, Yamada Y, Nihira T (2008) Identification of genes involved in the butyrolactone autoregulator cascade that modulates secondary metabolism in Streptomyces lavendulae FRI-5. Gene 425(1–2):9–16

    Article  CAS  PubMed  Google Scholar 

  • Kitani S, Doi M, Shimizu T, Maeda A, Nihira T (2010) Control of secondary metabolism by farX, which is involved in the γ-butyrolactone biosynthesis of Streptomyces lavendulae FRI-5. Arch Microbiol 192(3):211–220

    Article  CAS  PubMed  Google Scholar 

  • Kitani S, Miyamoto KT, Takamatsu S, Herawati E, Iguchi H, Nishitomi K, Uchida M et al (2011) Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc Natl Acad Sci 108(39):16410–16415

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kodani S, Hudson ME, Durrant MC, Buttner MJ, Nodwell JR, Willey JM (2004) The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor. Proc Natl Acad Sci 101(31):11448–11453

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kondo K, Higuchi Y, Sakuda S, Nihira T, Yamada Y (1989) New virginiae butanolides from Streptomyces virginiae. J Antibiot 42(12):1873–1876

    Article  CAS  Google Scholar 

  • Kurniawan YN, Kitani S, Maeda A, Nihira T (2014) Differential contributions of two SARP family regulatory genes to indigoidine biosynthesis in Streptomyces lavendulae FRI-5. Appl Microbiol Biotechnol 98(23):9713–9721

    Article  CAS  PubMed  Google Scholar 

  • Kwasiborski A, Mondy S, Chong TM, Barbey C, Chan KG, Beury-Cirou A, Latour X, Faure D (2015) Transcriptome of the quorum-sensing signal-degrading Rhodococcus erythropolis responds differentially to virulent and avirulent Pectobacterium atrosepticum. Heredity 114(5):476–484

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Latour X, Barbey C, Chane A, Groboillot A, Burini J-F (2013) Rhodococcus erythropolis and its γ-lactone catabolic pathway: an unusual biocontrol system that disrupts pathogen quorum sensing communication. Agronomy 3(4):816–838

    Article  CAS  Google Scholar 

  • Leadbetter JR, Peter Greenberg E (2000) Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus. J Bacteriol 182(24):6921–6926

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee YJ, Kitani S, Kinoshita H, Nihira T (2008) Identification by gene deletion analysis of barS2, a gene involved in the biosynthesis of γ-butyrolactone autoregulator in Streptomyces virginiae. Arch Microbiol 189(4):367–374

    Article  CAS  PubMed  Google Scholar 

  • Lee YJ, Kitani S, Nihira T (2010) Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the γ-butyrolactone autoregulator in Streptomyces virginiae. Microbiology 156(1):206–210

    Article  CAS  PubMed  Google Scholar 

  • Lee S-H, Moon K, Kim H, Shin J, Oh D-C, Oh K-B (2014) Bahamaolide A from the marine-derived Streptomyces sp. CNQ343 inhibits isocitrate lyase in Candida albicans. Bioorg Med Chem Lett 24(17):4291–4293

    Article  CAS  PubMed  Google Scholar 

  • Lee J-H, Kim Y-G, Lee K, Kim C-J, Park D-J, Ju Y, Lee J-C, Wood TK, Lee J (2016) Streptomyces-derived actinomycin D inhibits biofilm formation by Staphylococcus aureus and its hemolytic activity. Biofouling 32(1):45–56

    Article  CAS  PubMed  Google Scholar 

  • Lee J-H, Kim E, Choi H, Lee J (2017) Collismycin C from the Micronesian marine bacterium Streptomyces sp. MC025 inhibits Staphylococcus aureus biofilm formation. Mar Drugs 15(12):387

    Article  CAS  PubMed Central  Google Scholar 

  • Leetanasaksakul K, Thamchaipenet A (2018) Potential anti-biofilm producing marine actinomycetes isolated from sea sediments in Thailand. Agric Nat Resour 52(3):228–233

    Google Scholar 

  • Lezhava A, Kameoka D, Sugino H, Goshi K, Shinkawa H, Nimi O, Horinouchi S, Beppu T, Kinashi H (1997) Chromosomal deletions in Streptomyces griseus that remove the afsA locus. Mol Gen Genet MGG 253(4):478–483

    Article  CAS  PubMed  Google Scholar 

  • Martin JF, Liras P (2012) Cascades and networks of regulatory genes that control antibiotic biosynthesis. In: Reprogramming microbial metabolic pathways. pp 115–138

    Google Scholar 

  • Mary TR, Jabila RR, Kannan AMI, Ramachandran D, Vincent SGP (2021) Cell wall distraction and biofilm inhibition of marine Streptomyces derived angucycline in methicillin resistant Staphylococcus aureus. Microb Pathog 150:104712

    Article  CAS  Google Scholar 

  • Mast Y, Wohlleben W (2014) Streptogramins–two are better than one! Int J Med Microbiol 304(1):44–50

    Article  CAS  PubMed  Google Scholar 

  • Mast Y, Guezguez J, Handel F, Schinko E (2015) A complex signaling cascade governs pristinamycin biosynthesis in Streptomyces pristinaespiralis. Appl Environ Microbiol 81(19):6621–6636

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Matselyukh B, Mohammadipanah F, Laatsch H, Rohr J, Efremenkova O, Khilya V (2015) N-methylphenylalanyl-dehydrobutyrine diketopiperazine, an A-factor mimic that restores antibiotic biosynthesis and morphogenesis in Streptomyces globisporus 1912-B2 and Streptomyces griseus 1439. J Antibiot 68(1):9–14

    Article  CAS  Google Scholar 

  • Matsuno K, Yamada Y, Lee C-K, Nihira T (2004) Identification by gene deletion analysis of barB as a negative regulator controlling an early process of virginiamycin biosynthesis in Streptomyces virginiae. Arch Microbiol 181(1):52–59

    Article  CAS  PubMed  Google Scholar 

  • Miao L, Xu J, Yao Z, Jiang Y, Zhou H, Jiang W, Dong K (2017) The anti-quorum sensing activity and bioactive substance of a marine derived Streptomyces. Biotechnol Biotechnol Equipm 31(5):1007–1015

    Article  CAS  Google Scholar 

  • Miller MB, Bassler BL (2001) Quorum sensing in bacteria. Annu Rev Microbiol 55(1):165–199

    Article  CAS  PubMed  Google Scholar 

  • Mingyar E, Lubomira F, Renata N, Carmen B, Jan K (2015) A γ-butyrolactone autoregulator-receptor system involved in the regulation of auricin production in Streptomyces aureofaciens CCM 3239. Appl Microbiol Biotechnol 99(1):309–325

    Article  CAS  PubMed  Google Scholar 

  • Miyake K, Horinouchi S, Yoshida M, Chiba N, Mori K, Nogawa N, Morikawa N, Beppu T (1989) Detection and properties of A-factor-binding protein from Streptomyces griseus. J Bacteriol 171(8):4298–4302

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Miyake K, Tomohisa K, Sueharu H, Beppu T (1990) The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation. J Bacteriol 172(6):3003–3008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mukku VJRV, Speitling M, Laatsch H, Helmke E (2000) New butenolides from two marine streptomycetes. J Nat Prod 63(11):1570–1572

    Article  CAS  PubMed  Google Scholar 

  • Mutenko H, Makitrinskyy R, Tsypik O, Walker S, Ostash B, Fedorenko V (2014) Genes for biosynthesis of butenolide-like signalling molecules in Streptomyces ghanaensis, their role in moenomycin production. Russ J Genet 50(6):563–568

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Naik DN, Wahidullah S, Meena RM (2013) Attenuation of Pseudomonas aeruginosa virulence by marine invertebrate–derived Streptomyces sp. Lett Appl Microbiol 56(3):197–207

    Article  CAS  PubMed  Google Scholar 

  • Nakano H, Takehara E, Nihira T, Yamada Y (1998) Gene replacement analysis of the Streptomyces virginiae barA gene encoding the butyrolactone autoregulator receptor reveals that BarA acts as a repressor in virginiamycin biosynthesis. J Bacteriol 180(13):3317–3322

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Namwat W, Lee C-K, Kinoshita H, Yamada Y, Nihira T (2001) Identification of the varr gene as a transcriptional regulator of virginiamycin s resistance in Streptomyces virginiae. J Bacteriol 183(6):2025–2031

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Namwat W, Kamioka Y, Kinoshita H, Yamada Y, Nihira T (2002) Characterization of virginiamycin S biosynthetic genes from Streptomyces virginiae. Gene 286(2):283–290

    Article  CAS  PubMed  Google Scholar 

  • Natsume R, Ohnishi Y, Senda T, Horinouchi S (2004) Crystal structure of a γ-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3 (2). J Mol Biol 336(2):409–419

    Article  CAS  PubMed  Google Scholar 

  • Nealson KH (1977) Autoinduction of bacterial luciferase. Arch Microbiol 112(1):73–79

    Article  CAS  PubMed  Google Scholar 

  • Nieselt K, Battke F, Herbig A, Bruheim P, Wentzel A, Jakobsen ØM, Sletta H et al (2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics 11(1):1–9

    Article  CAS  Google Scholar 

  • Nishida H, Ohnishi Y, Beppu T, Horinouchi S (2007) Evolution of γ-butyrolactone synthases and receptors in Streptomyces. Environ Microbiol 9(8):1986–1994

    Article  CAS  PubMed  Google Scholar 

  • Nithyanand P, Thenmozhi R, Rathna J, Pandian SK (2010) Inhibition of Streptococcus pyogenes biofilm formation by coral-associated actinomycetes. Curr Microbiol 60(6):454–460

    Article  CAS  PubMed  Google Scholar 

  • Niu G, Chater KF, Tian Y, Zhang J, Tan H (2016) Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp. FEMS Microbiol Rev 40(4):554–573

    Article  CAS  PubMed  Google Scholar 

  • Nodwell JR (2014) Are you talking to me? A possible role for γ-butyrolactones in interspecies signalling. Mol Microbiol 94(3):483–485

    Article  CAS  PubMed  Google Scholar 

  • Ohnishi Y, Horinouchi S (2004) The A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces. Biofilms 1(4):319

    Article  Google Scholar 

  • Ohnishi Y, Yamazaki H, Kato J-Y, Tomono A, Horinouchi S (2005) AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Biosci Biotechnol Biochem 69(3):431–439

    Article  CAS  PubMed  Google Scholar 

  • Oja T, Galindo PSM, Taguchi T, Manner S, Vuorela PM, Ichinose K, Metsä-Ketelä M, Fallarero A (2015) Effective antibiofilm polyketides against Staphylococcus aureus from the pyranonaphthoquinone biosynthetic pathways of Streptomyces species. Antimicrob Agents Chemother 59(10):6046–6052

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Onaka H, Horinouchi S (1997) DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences. Mol Microbiol 24(5):991–1000

    Article  CAS  PubMed  Google Scholar 

  • Onaka H, Ando N, Nihira T, Yamada Y, Beppu T, Horinouchi S (1995) Cloning and characterization of the A-factor receptor gene from Streptomyces griseus. J Bacteriol 177(21):6083–6092

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Onaka H, Nakagawa T, Horinouchi S (1998) Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3 (2) in the regulation of secondary metabolism and morphogenesis. Mol Microbiol 28(4):743–753

    Article  CAS  PubMed  Google Scholar 

  • Ooka K, Fukumoto A, Yamanaka T, Shimada K, Ishihara R, Anzai Y, Kato F (2013) Piericidins, novel quorum-sensing inhibitors against Chromobacterium violaceum CV026, from Streptomyces sp. TOHO-Y209 and TOHO-O348. Open J Med Chem 2013

    Google Scholar 

  • Pang X, Bertrand A, Jean-Michel G, Sophie M, Jean-Luc P, Bernard D, Pierre L (2004) Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome. Antimicrob Agents Chemother 48(2):575–588

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Papenfort K, Bassler BL (2016) Quorum sensing signal–response systems in Gram-negative bacteria. Nat Rev Microbiol 14(9):576

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Park S-Y, Kang H-O, Jang H-S, Lee J-K, Koo B-T, Yum D-Y (2005) Identification of extracellular N-acylhomoserine lactone acylase from a Streptomyces sp. and its application to quorum quenching. Appl Environ Microbiol 71(5):2632–2641

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Park S-Y, Hwang B-J, Shin M-H, Kim J-A, Kim H-K, Lee J-K (2006) N-acylhomoserine lactonase producing Rhodococcus spp. with different AHL-degrading activities. FEMS Microbiol Lett 261(1):102–108

    Article  CAS  PubMed  Google Scholar 

  • Park J-H, Lee J-H, Kim C-J, Lee J-C, Cho MH, Lee J (2012) Extracellular protease in Actinomycetes culture supernatants inhibits and detaches Staphylococcus aureus biofilm formation. Biotechnol Lett 34(4):655–661

    Article  CAS  PubMed  Google Scholar 

  • Pawlik K, Kotowska M, Chater KF, Kuczek K, Takano E (2007) A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3 (2). Arch Microbiol 187(2):87–99

    Article  CAS  PubMed  Google Scholar 

  • Pereira CS, Thompson JA, Xavier KB (2013) AI-2-mediated signalling in bacteria. FEMS Microbiol Rev 37(2):156–181

    Article  CAS  PubMed  Google Scholar 

  • Polkade AV, Mantri SS, Patwekar UJ, Jangid K (2016) Quorum sensing: an under-explored phenomenon in the phylum Actinobacteria. Front Microbiol 7:131

    Article  PubMed  PubMed Central  Google Scholar 

  • Rajivgandhi GN, Ramachandran G, Kanisha CC, Li J-L, Yin L, Manoharan N, Alharbi NS, Kadaikunnan S, Khaled JM, Li W-J (2020) Anti-biofilm compound of 1, 4-diaza-2, 5-dioxo-3-isobutyl bicyclo [4.3. 0] nonane from marine Nocardiopsis sp. DMS 2 (MH900226) against biofilm forming K. pneumoniae. J King Saud Univ Sci 32(8):3495–3502

    Article  Google Scholar 

  • Recio E, Colinas Á, Rumbero Á, Aparicio JF, Martín JF (2004) PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis. J Biol Chem 279(40):41586–41593

    Article  CAS  PubMed  Google Scholar 

  • Rutherford ST, Bassler BL (2012) Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med 2(11):a012427

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sabu R, Soumya KR, Radhakrishnan EK (2017) Endophytic Nocardiopsis sp. from Zingiber officinale with both antiphytopathogenic mechanisms and antibiofilm activity against clinical isolates. 3 Biotech 7(2):1–13

    Article  Google Scholar 

  • Sakr MM, Aboshanab KMA, Aboulwafa MM, Hassouna NA-H (2015) Characterization of the quorum quenching activity of Streptomyces minutiscleroticus: a new approach for infection control. Afr J Microbiol Res 9(8):492–502

    Article  Google Scholar 

  • Salehi-Najafabadi Z, Barreiro C, Rodríguez-García A, Cruz A, López GE, Martín JF (2014) The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control. Appl Microbiol Biotechnol 98(11):4919–4936

    Article  CAS  PubMed  Google Scholar 

  • Sanchez LM (2016) Quorum sensing in Streptomyces coelicolor: regulation of the SCB signalling system that controls the synthesis of antibiotics, Thesis. University of Groningen, Groningen, 231 p

    Google Scholar 

  • Santos CL, Correia-Neves M, Moradas-Ferreira P, Mendes MV (2012) A walk into the LuxR regulators of Actinobacteria: phylogenomic distribution and functional diversity. PLoS One 7(10):e46758

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sheir DH, Hafez MA (2017) Antibiofilm activity of Streptomyces toxytricini Fz94 against Candida albicans ATCC 10231. Microb Biosyst 2(1):26–39

    Article  Google Scholar 

  • Sturme MHJ, Kleerebezem M, Nakayama J, Akkermans ADL, Vaughan EE, De Vos WM (2002) Cell to cell communication by autoinducing peptides in gram-positive bacteria. Antonie Van Leeuwenhoek 81(1):233–243

    Article  CAS  PubMed  Google Scholar 

  • Suzuki T, Mochizuki S, Yamamoto S, Arakawa K, Kinashi H (2010) Regulation of lankamycin biosynthesis in Streptomyces rochei by two SARP genes, srrY and srrZ. Biosci Biotechnol Biochem 74(4):819–827

    Article  CAS  PubMed  Google Scholar 

  • Suzuki N, Ohtaguro N, Yoshida Y, Hirai M, Matsuo H, Yamada Y, Imamura N, Tsuchiya T (2015) A compound inhibits biofilm formation of Staphylococcus aureus from Streptomyces. Biol Pharm Bull 38(6):889–892

    Article  CAS  PubMed  Google Scholar 

  • Takano E (2006) γ-Butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation. Curr Opin Microbiol 9(3):287–294

    Article  CAS  PubMed  Google Scholar 

  • Takano E, Nihira T, Hara Y, Jones JJ, Gershater CJL, Yamada Y, Bibb M (2000) Purification and structural determination of SCB1, a γ-butyrolactone that elicits antibiotic production in Streptomyces coelicolor A3 (2). J Biol Chem 275(15):11010–11016

    Article  CAS  PubMed  Google Scholar 

  • Takano E, Chakraburtty R, Nihira T, Yamada Y, Bibb MJ (2001) A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3 (2). Mol Microbiol 41(5):1015–1028

    Article  CAS  PubMed  Google Scholar 

  • Takano E, Kinoshita H, Mersinias V, Bucca G, Hotchkiss G, Nihira T, Smith CP, Bibb M, Wohlleben W, Chater K (2005) A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor. Mol Microbiol 56(2):465–479

    Article  CAS  PubMed  Google Scholar 

  • Tommonaro G, Abbamondi GR, Iodice C, Tait K, De Rosa S (2012) Diketopiperazines produced by the halophilic archaeon, Haloterrigena hispanica, activate AHL bioreporters. Microb Ecol 63(3):490–495

    Article  CAS  PubMed  Google Scholar 

  • Tomono A, Tsai Y, Yamazaki H, Ohnishi Y, Horinouchi S (2005a) Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus. J Bacteriol 187(16):5595–5604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tomono A, Tsai Y, Ohnishi Y, Horinouchi S (2005b) Three chymotrypsin genes are members of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus. J Bacteriol 187(18):6341–6353

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Uroz S, D’Angelo-Picard C, Carlier A, Elasri M, Sicot C, Petit A, Oger P, Faure D, Dessaux Y (2003) Novel bacteria degrading N-acylhomoserine lactones and their use as quenchers of quorum-sensing-regulated functions of plant-pathogenic bacteria. Microbiology 149(8):1981–1989

    Article  CAS  PubMed  Google Scholar 

  • Uroz S, Chhabra SR, Camara M, Williams P, Oger P, Dessaux Y (2005) N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities. Microbiology 151(10):3313–3322

    Article  CAS  PubMed  Google Scholar 

  • Uroz S, Oger PM, Chapelle E, Adeline M-T, Faure D, Dessaux Y (2008) A Rhodococcus qsdA-encoded enzyme defines a novel class of large-spectrum quorum-quenching lactonases. Appl Environ Microbiol 74(5):1357–1366

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vera-Cabrera L, Ortiz-Lopez R, Elizondo-Gonzalez R, Ocampo-Candiani J (2013) Complete genome sequence analysis of Nocardia brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis. PLoS One 8(6):e65425

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Viegelmann C, Margassery LM, Kennedy J, Zhang T, O’Brien C, O’Gara F, Morrissey JP, Dobson ADW, Edrada-Ebel RA (2014) Metabolomic profiling and genomic study of a marine sponge-associated Streptomyces sp. Mar Drugs 12(6):3323–3351

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vujaklija D, Ueda K, Hong S-K, Beppu T, Horinouchi S (1991) Identification of an A-factor-dependent promoter in the streptomycin biosynthetic gene cluster of Streptomyces griseus. Mol Gen Genet MGG 229(1):119–128

    Article  CAS  PubMed  Google Scholar 

  • Waki M, Nihira T, Yamada Y (1997) Cloning and characterization of the gene (farA) encoding the receptor for an extracellular regulatory factor (IM-2) from Streptomyces sp. strain FRI-5. J Bacteriol 179(16):5131–5137

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang L, Tian X, Wang J, Yang H, Fan K, Xu G, Yang K, Tan H (2009) Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator. Proc Natl Acad Sci 106(21):8617–8622

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Wang W, Wang L, Zhang G, Fan K, Tan H, Yang K (2011) A novel role of ‘pseudo’ γ-butyrolactone receptors in controlling γ-butyrolactone biosynthesis in Streptomyces. Mol Microbiol 82(1):236–250

    Article  CAS  PubMed  Google Scholar 

  • Wang J-B, Zhang F, Pu J-Y, Zhao J, Zhao Q-F, Tang G-L (2014a) Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. Biotechnol Lett 36(4):813–819

    Article  CAS  PubMed  Google Scholar 

  • Wang T, Jiang Y, Ma K-X, Li Y-Q, Huang R, Xie X-S, Wu S-H (2014b) Two new butenolides produced by an actinomycete Streptomyces sp. Chem Biodivers 11(6):929–933

    Article  CAS  PubMed  Google Scholar 

  • Wang W, Ji J, Li X, Wang J, Li S, Pan G, Fan K, Yang K (2014c) Angucyclines as signals modulate the behaviors of Streptomyces coelicolor. Proc Natl Acad Sci 111(15):5688–5693

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Nong X-H, Amin M, Qi S-H (2018) Hygrocin C from marine-derived Streptomyces sp. SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonian. Appl Microbiol Biotechnol 102(3):1417–1427

    Article  CAS  PubMed  Google Scholar 

  • Weber T, Welzel K, Pelzer S, Vente A, Wohlleben W (2003) Exploiting the genetic potential of polyketide producing streptomycetes. J Biotechnol 106(2–3):221–232

    Article  CAS  PubMed  Google Scholar 

  • Willey JM, Gaskell AA (2011) Morphogenetic signaling molecules of the streptomycetes. Chem Rev 111(1):174–187

    Article  CAS  PubMed  Google Scholar 

  • Willey JM, Willems A, Kodani S, Nodwell JR (2006) Morphogenetic surfactants and their role in the formation of aerial hyphae in Streptomyces coelicolor. Mol Microbiol 59(3):731–742

    Article  CAS  PubMed  Google Scholar 

  • Williams P (2007) Quorum sensing, communication and cross-kingdom signalling in the bacterial world. Microbiology 153(12):3923–3938

    Article  CAS  PubMed  Google Scholar 

  • Wuster A, Madan Babu M (2007) Chemical molecules that regulate transcription and facilitate cell-to-cell communication. In: Wiley encyclopedia of chemical biology. pp 1–11

    Google Scholar 

  • Xie TT, Zeng H, Ren XP, Wang N, Chen ZJ, Zhang Y, Chen W (2019) Antibiofilm activity of three Actinomycete strains against Staphylococcus epidermidis. Lett Appl Microbiol 68(1):73–80

    Article  CAS  PubMed  Google Scholar 

  • Xu G, Wang J, Wang L, Tian X, Yang H, Fan K, Yang K, Tan H (2010a) “Pseudo” γ-butyrolactone receptors respond to antibiotic signals to coordinate antibiotic biosynthesis. J Biol Chem 285(35):27440–27448

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu D, Seghezzi N, Esnault C, Virolle M-J (2010b) Repression of antibiotic production and sporulation in Streptomyces coelicolor by overexpression of a TetR family transcriptional regulator. Appl Environ Microbiol 76(23):7741–7753

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yamada Y (1999) Autoregulatory factors and regulation of antibiotic production in Streptomyces. Microb Signal Commun 57:177

    Google Scholar 

  • Yamada Y, Sugamura K, Kondo K, Yanagimoto M, Okada H (1987) The structure of inducing factors for virginiamycin production in Streptomyces virginias. J Antibiot 40(4):496–504

    Article  CAS  Google Scholar 

  • Yamamoto S, He Y, Arakawa K, Kinashi H (2008) γ-butyrolactone-dependent expression of the Streptomyces antibiotic regulatory protein gene srrY plays a central role in the regulatory cascade leading to lankacidin and lankamycin production in Streptomyces rochei. J Bacteriol 190(4):1308–1316

    Article  CAS  PubMed  Google Scholar 

  • Yamazaki H, Tomono A, Ohnishi Y, Horinouchi S (2004) DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus. Mol Microbiol 53(2):555–572

    Article  CAS  PubMed  Google Scholar 

  • Yang Y-H, Joo H-S, Lee K, Liou K-K, Lee H-C, Sohng J-K, Kim B-G (2005) Novel method for detection of butanolides in Streptomyces coelicolor culture broth, using a His-tagged receptor (ScbR) and mass spectrometry. Appl Environ Microbiol 71(9):5050–5055

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang Y-H, Kim T-W, Park S-H, Lee K, Park H-Y, Song E, Joo H-S, Kim Y-G, Hahn J-S, Kim B-G (2009) Cell-free Escherichia coli-based system to screen for quorum-sensing molecules interacting with quorum receptor proteins of Streptomyces coelicolor. Appl Environ Microbiol 75(19):6367–6372

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang R, Liu X, Wen Y, Song Y, Chen Z, Li J (2015) The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. Appl Microbiol Biotechnol 99(24):10547–10557

    Article  CAS  PubMed  Google Scholar 

  • Yoon J-H, Lee JK, Jung SY, Kim JA, Kim HK, Oh TK (2006) Nocardioides kongjuensis sp. nov., an N-acylhomoserine lactone-degrading bacterium. Int J Syst Evol Microbiol 56(8):1783–1787

    Google Scholar 

  • You JL, Xue XL, Cao LX, Lu X, Wang J, Zhang LX, Zhou SN (2007) Inhibition of Vibrio biofilm formation by a marine actinomycete strain A66. Appl Microbiol Biotechnol 76(5):1137–1144

    Article  CAS  PubMed  Google Scholar 

  • Younis KM, Usup G, Ahmad A (2016) Secondary metabolites produced by marine Streptomyces as antibiofilm and quorum-sensing inhibitor of uropathogen Proteus mirabilis. Environ Sci Pollut Res 23(5):4756–4767

    Article  CAS  Google Scholar 

  • Zou Z, Du D, Zhang Y, Zhang J, Niu G, Tan H (2014) A γ-butyrolactone-sensing activator/repressor, JadR3, controls a regulatory mini-network for jadomycin biosynthesis. Mol Microbiol 94(3):490–505

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology, School of Life Sciences, JSS AHER, Mysore, Karnataka, India

    Jamuna A. Bai

  2. Department of Studies in Microbiology, University of Mysore, Mysore, Karnataka, India

    Ravishankar V. Rai

Authors
  1. Jamuna A. Bai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ravishankar V. Rai
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Studies in Microbiology, University of Mysore, Mysore, Karnataka, India

    Ravishankar V. Rai

  2. Department of Microbiology, School of Life Sciences, JSS AHER, Mysore, Karnataka, India

    Jamuna A. Bai

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Bai, J.A., Rai, R.V. (2022). Quorum Sensing and Quorum Quenching Metabolites in Actinomycetes. In: Rai, R.V., Bai, J.A. (eds) Natural Products from Actinomycetes. Springer, Singapore. https://doi.org/10.1007/978-981-16-6132-7_10

Download citation

Publish with us

Policies and ethics

Search

Navigation