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Diketopiperazines Produced by the Halophilic Archaeon, Haloterrigena hispanica, Activate AHL Bioreporters

  • Environmental Microbiology
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Abstract

The generic term “quorum sensing” has been adopted to describe the bacterial cell-to-cell communication mechanism which coordinates gene expression when the population has reached a high cell density. Quorum sensing depends on the synthesis of small molecules that diffuse in and out of bacterial cells. There are few reports about this mechanism in Archaea. We report the isolation and chemical characterization of small molecules belonging to class of diketopiperazines (DKPs) in Haloterrigena hispanica, an extremely halophilic archaeon. One of the DKPs isolated, the compound cyclo-(l-prolyl–l-valine) activated N-acyl homoserine lactone (AHL) bioreporters, indicating that Archaea may have the ability to interact with AHL-producing bacteria within mixed communities.

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Acknowledgements

This work was supported by the International Program “Short Term Mobility (S.T.M.)” of CNR–National Research Council of Italy. The authors also thank Mrs. Ida Romano of Fermentation Service of ICB-CNR for growth of the microorganism and Mr. Alessandro Esposito of NMR Service. A particular acknowledgment to D.ssa Ilaria Finore for the stimulating discussions and suggestions.

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Authors and Affiliations

  1. Institute of Biomolecular Chemistry, CNR–National Research Council of Italy, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy

    Giuseppina Tommonaro, Gennaro Roberto Abbamondi, Carmine Iodice & Salvatore De Rosa

  2. Plymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth, UK

    Karen Tait

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  1. Giuseppina Tommonaro
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  2. Gennaro Roberto Abbamondi
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  3. Carmine Iodice
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  4. Karen Tait
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  5. Salvatore De Rosa
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Correspondence to Giuseppina Tommonaro.

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Tommonaro, G., Abbamondi, G.R., Iodice, C. et al. Diketopiperazines Produced by the Halophilic Archaeon, Haloterrigena hispanica, Activate AHL Bioreporters. Microb Ecol 63, 490–495 (2012). https://doi.org/10.1007/s00248-011-9980-y

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