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Regulatory B Cells

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B Cells in Immunity and Tolerance

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1254))

Abstract

B cells are typically characterized by their ability to produce antibodies, function as secondary antigen-present cells, and produce various immunoregulatory cytokines. The regulatory B (Breg)-cell population is now widely accepted as an important modulatory component of the immune system that suppresses inflammation. Recent studies indicate that Breg-cell populations are small under physiological conditions but expand substantially in both human patients and murine models of chronic inflammatory diseases, autoimmune diseases, infection, transplantation, and cancer. Almost all B-cell subsets can be induced to form Breg cells. In addition, there are unique Breg-cell subsets such as B10 and Tim-1+ B cells. Immunoregulatory function may be mediated by production of cytokines such as IL-10 and TGF-β and ensuing suppression of T cells, by direct cell–cell interactions, and (or) by altering the immune microenvironment. In this chapter, we describe in detail the discovery of Breg cells, their phenotypes, differentiation, function, contributions to disease, and therapeutic potential.

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Authors and Affiliations

  1. Department of Immunology, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University, No. 138, Yi Xue Yuan Rd, 226, Shanghai, 200032, China

    Luman Wang, Ying Fu & Yiwei Chu

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  1. Luman Wang
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  2. Ying Fu
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  3. Yiwei Chu
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Correspondence to Yiwei Chu .

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  1. Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China

    Ji-Yang Wang

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Wang, L., Fu, Y., Chu, Y. (2020). Regulatory B Cells. In: Wang, JY. (eds) B Cells in Immunity and Tolerance. Advances in Experimental Medicine and Biology, vol 1254. Springer, Singapore. https://doi.org/10.1007/978-981-15-3532-1_8

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