Abstract
Infectious diseases has remained one of the leading causes of morbidity and mortality in the past decade. The problem has further exacerbated due to the lack of newer antibiotics and emergence of antimicrobial drug resistance among the pathogens. Bacteria have evolved diverse mechanisms which make them resistant to many antimicrobials simultaneously. These alarming situations have triggered worldwide initiatives in the direction of developing novel strategies, effective antimicrobial agents, and efficient targeting systems. One of the fields which holds promise to provide solutions as efficient antibacterial agents is nanotechnology. The field of nanotechnology is rapidly evolving with more applications being developed in the pharmaceutical and biomedical domains. Nanoparticles such as metallic and metal-oxide, have gained tremendous attention owing to intrinsic antibacterial properties. These properties have been further enhanced by their surface functionalization approaches. They are being explored as delivery agents to inhibit bacterial population and also to combat drug resistance mechanisms in pathogens. The present chapter summarizes recent scientific advances on metal, metal oxide nanoparticles, and nanocomposites-preparation methods along with their antibacterial potential evaluated in prokaryotic bacterial model systems.
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Sangave, P.C., Matkar, N.M., Suvarna, V. (2020). Antimicrobial Activity of Metallic Nanoparticles Using Prokaryotic Model Organisms. In: Siddhardha, B., Dyavaiah, M., Kasinathan, K. (eds) Model Organisms to Study Biological Activities and Toxicity of Nanoparticles. Springer, Singapore. https://doi.org/10.1007/978-981-15-1702-0_4
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