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Tissue Scaffolds As a Local Drug Delivery System for Bone Regeneration

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Cutting-Edge Enabling Technologies for Regenerative Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1078))

Abstract

Healing fractures resulting from bone disorders such as osteoporosis, osteoarthritis, osteomyelitis, and osteosarcoma remain a significant clinical challenge. In this chapter, we focus on scaffold based local drug delivery applications for promoting bone regeneration. For this purpose, we first review bone disorders, which require drug treatment and current fabrication techniques for bone tissue scaffold as a drug carrier. Next, we address the role of antimicrobial agents, anti-inflammatory drugs, anti-cancer drugs and bisphosphonates in promoting vascularized bone regeneration and discuss various local therapeutic delivery strategies for controlled and sustained drug delivery. Specifically, this review addresses the concept of drug loaded scaffold design and local drug release effects on bone regeneration. We conclude this review with a discussion of local drug delivery approaches to bone regeneration and discuss why it has the potential to be more efficient than traditional bone treatment methods.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, Turkey

    Elif Sarigol-Calamak & Canan Hascicek

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  1. Elif Sarigol-Calamak
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  2. Canan Hascicek
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Correspondence to Canan Hascicek .

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  1. The Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. Hallym University, Gangwon-do, Korea (Republic of)

    Chan Hum Park

  3. Kyung Hee University, Seoul, Korea (Republic of)

    Il Keun Kwon

  4. Chonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Sarigol-Calamak, E., Hascicek, C. (2018). Tissue Scaffolds As a Local Drug Delivery System for Bone Regeneration. In: Chun, H., Park, C., Kwon, I., Khang, G. (eds) Cutting-Edge Enabling Technologies for Regenerative Medicine. Advances in Experimental Medicine and Biology, vol 1078. Springer, Singapore. https://doi.org/10.1007/978-981-13-0950-2_25

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