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Biopolymers as Potential Carrier for Effervescent Reaction Based Drug Delivery System in Gastrointestinal Condition

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Cardiovascular Engineering

Part of the book series: Series in BioEngineering ((SERBIOENG))

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Abstract

Biopolymers are naturally occurring materials formed in nature during the life cycles of organisms. Biopolymers include the polysaccharides, carbohydrates and protein such as cellulose, starch, wool, silk, gelatine and collagen. In recent years, biopolymer-based hydrogels become important area of research in pharmaceutical aspects because of their promising properties in drug delivery system. These properties include low toxicity, biodegradability, stability and renewable nature. Numerous studies have been carried out in order to develop carrier from biopolymers with better controlled release properties. This is important to ensure precisely desired concentration of drug or essential nutrient absorption into the blood or tissue could be achieved. Among other different approaches, floating system is one of the most convenient, economical, and effective drug delivery system. Floating delivery system could potentially achieve longer retention time of carrier with capsulated bioactive drug or functional nutrients in the gastrointestinal tract. The floating behaviour of carrier could be induced by effervescent reactions. Effervescent reaction occurs between acidic gastric content and pore forming agent such as carbonates or bicarbonates salts incorporated into the carrier. This chapter discusses some of the use of biopolymers in drug delivery systems for effervescent reaction in gastrointestinal tract.

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Acknowledgements

The authors would like to thank the Ministry of Science, Technology and Innovation of Malaysia, Ministry of Higher Education of Malaysia and Research Management Centre of Universiti Teknologi Malaysia (UTM) for the support of this project.

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Authors and Affiliations

  1. Department of Bioprocess and Polymer Engineering, School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia

    I. I. Muhamad, M. A. M. Sis, N. Pa’e & M. H. Salehudin

  2. Cardiac Biomaterials Cluster, IJN-UTM Cardiovascular Engineering Center, Level 2, Block B, Building V01/FBME, UTM, 81310, Johor Bahru, Johor, Malaysia

    I. I. Muhamad

  3. Department of Biotechnology, School of Science and Engineering, Manipal University, Nilai, Negeri Sembilan, Malaysia

    S. Selvakumaran

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Editors and Affiliations

  1. School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia

    Dyah Ekashanti Octorina Dewi

  2. School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia

    Yuan Wen Hau

  3. School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia

    Ahmad Zahran Mohd Khudzari

  4. School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia

    Ida Idayu Muhamad

  5. School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia

    Eko Supriyanto

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Muhamad, I.I., Selvakumaran, S., Sis, M.A.M., Pa’e, N., Salehudin, M.H. (2020). Biopolymers as Potential Carrier for Effervescent Reaction Based Drug Delivery System in Gastrointestinal Condition. In: Dewi, D., Hau, Y., Khudzari, A., Muhamad, I., Supriyanto, E. (eds) Cardiovascular Engineering. Series in BioEngineering. Springer, Singapore. https://doi.org/10.1007/978-981-10-8405-8_10

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