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Physiological Modelling and the Effect Site

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On the Study and Practice of Intravenous Anaesthesia

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Abstract

Traditional pharmacokinetic/pharmacodynamic (PK/PD) modelling is based on a concept introduced by Segre1 more than thirty years ago: the concentration in the plasma compartment, C(t), of a mammillary compartmental model is linked to the time course of the pharmacological effect, E(t), via a simple first order delay (time constant τ = 1/k eo) determining a hypothetical concentration-time curve at the effect site [biophase level, C B (t)] and a static, nonlinear C B (t) -effect relationship (figure 1).

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Authors and Affiliations

  1. Halle-Wittenberg, Germany

    Michael Weiss

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  1. Michael Weiss
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Editors and Affiliations

  1. Leiden University Medical Center, Leiden, The Netherlands

    Jaap Vuyk  & Frank Engbers  & 

  2. Leyenburg Hospital, The Hague, The Netherlands

    Sandra Groen-Mulder

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© 2000 Springer Science+Business Media Dordrecht

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Weiss, M. (2000). Physiological Modelling and the Effect Site. In: Vuyk, J., Engbers, F., Groen-Mulder, S. (eds) On the Study and Practice of Intravenous Anaesthesia. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9604-6_1

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  • DOI: https://doi.org/10.1007/978-94-015-9604-6_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5366-4

  • Online ISBN: 978-94-015-9604-6

  • eBook Packages: Springer Book Archive

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