Summary
Assessment of pharmacokinetics in terms of circulatory drug transport is proposed using the methods of linear system theory. In this model-independent approach drug distribution and disposition are characterized by the total extraction ratio, the mean residence time in the body and the volume of distribution at steady state. In analyzing concentration(c)-time(t) data, the procedure requires calculation only of the areas under the c(t)-and c(t)×t-curves to estimate kinetic parameters, and for prediction of the steady state concentration following continuous infusion or multiple doses. Pulmonary clearance of drugs is included in the theory.
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Weiss, M., Förster, W. Pharmacokinetic model based on circulatory transport. Eur J Clin Pharmacol 16, 287–293 (1979). https://doi.org/10.1007/BF00608408
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DOI: https://doi.org/10.1007/BF00608408