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Molecular Determinants of Cancer-Related Inflammation

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Prostate Cancer: Shifting from Morphology to Biology

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Abstract

Tumor cells communicate with the cells of their microenvironment via a series of molecular and cellular interactions to aid their progression to a malignant state and ultimately their metastatic spread. Of the cells in the microenvironment with a key role in cancer development, tumor associated macrophages (TAMs) are among the most notable. Tumor cells release a range of chemokines, cytokines and growth factors to attract macrophages, and these in turn release numerous factors (e.g. VEGF, MMP-9 and EGF) that are implicated in invasion-promoting processes such as tumor cell growth, flicking of the angiogenic switch and immunosuppression (Rogers and Holen, J Transl Med 9:177, 2011).

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  1. Department of Advanced Biomedical Sciences, Pathology Section, Faculty of Medicine and Surgery, University of Naples “Federico II”, via S. Pansini, n.5, Naples, Italy

    Stefania Staibano

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    Stefania Staibano

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Staibano, S. (2013). Molecular Determinants of Cancer-Related Inflammation. In: Staibano, S. (eds) Prostate Cancer: Shifting from Morphology to Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7149-9_2

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