Abstract
High-grade gliomas (HGG) are the most challenging brain tumors to treat. Even though various sophisticated options exist to treat patients with gliomas, the disease invariably leads to death over months or years. The major obstacles encountered in treating gliomas are in determining the exact location, extent, and metabolic activity of the tumor. Molecular imaging of energy metabolism, amino acid transport, cell proliferation and cell death have been found helpful in identifying the biologically active tumor tissues for therapy. It allows a better understanding of pathology at the molecular level. This ability is especially useful in brain tumors where tissue sampling in vivo is associated with significant risks. Positron emission tomography (PET) is one of the most prominent molecular imaging modalities utilized for imaging pathophysiology of tumors at an early stage. In this chapter, the applicability of PET in assessing the biologically active tumor volumes in high-grade glioma patients for radiation therapy treatment planning and therapy monitoring will be reviewed. We will focus on the concept of biological target volume (BTV) and associated methods of image segmentation available for delineating tumor volumes in connection with their applicability in high-grade gliomas.
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References
Benard F, Romsa J, Hustinx R (2003) Imaging gliomas with positron emission tomography and single-photon emission computed tomography. Semin Nucl Med 33:148–162
Boss A, Bisdas S, Kolb A, Hofmann M, Ernemann U, Claussen CD, Pfannenberg C, Pichler BJ, Reimold M, Stegger L (2010) Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT. J Nucl Med 51:1198–1205
Fueger BJ, Czernin J, Cloughesy T, Silverman DH, Geist CL, Walter MA, Schiepers C, Nghiemphu P, Lai A, Phelps ME, Chen W (2010) Correlation of 6-18F-Fluoro-L-Dopa PET uptake with proliferation and tumor grade in newly diagnosed and recurrent gliomas. J Nucl Med 51:1532–1538
Gregoire V, Haustermans K, Geets X, Roels S, Lonneux M (2007) PET-based treatment planning in radiotherapy: a new standard?. J Nucl Med 48(Suppl 1):68S–77S
Grosu AL, Piert M, Weber WA, Jeremic B, Picchio M, Schratzenstaller U, Zimmermann FB, Schwaiger M, Molls M (2005a) Positron emission tomography for radiation treatment planning. Strahlenther Onkol 181:483–499
Grosu AL, Weber WA, Franz M, Stark S, Piert M, Thamm R, Gumprecht H, Schwaiger M, Molls M, Nieder C (2005b) Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy. Int J Radiat Oncol Biol Phys 63:511–519
Grosu AL, Weber WA, Riedel E, Jeremic B, Nieder C, Franz M, Gumprecht H, Jaeger R, Schwaiger M, Molls M (2005c) L-(methyl-11C) methionine positron emission tomography for target delineation in resected high-grade gliomas before radiotherapy. Int J Radiat Oncol Biol Phys 63:64–74
Guha C, Alfieri A, Blaufox MD, Kalnicki S (2008) Tumor biology-guided radiotherapy treatment planning: gross tumor volume versus functional tumor volume. Semin Nucl Med 38:105–113
Hustinx R, Pourdehnad M, Kaschten B, Alavi A (2005) PET imaging for differentiating recurrent brain tumor from radiation necrosis. Radiol Clin N Am 43:35–47
Jacobs AH, Dittmar C, Winkeler A, Garlip G, Heiss WD (2002) Molecular imaging of gliomas. Mol Imaging 1:309–335
Lecchi M, Fossati P, Elisei F, Orecchia R, Lucignani G (2008) Current concepts on imaging in radiotherapy. Eur J Nucl Med Mol Imaging 35:821–837
Ling CC, Humm J, Larson S, Amols H, Fuks Z, Leibel S, Koutcher JA (2000) Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality. Int J Radiat Oncol Biol Phys 47:551–560
Nestle U, Weber W, Hentschel M, Grosu A-L (2009) Biological imaging in radiation therapy: role of positron emission tomography. Phys Med Biol 54:R1–R25
Patronas NJ, Di Chiro G, Brooks RA, DeLaPaz RL, Kornblith PL, Smith BH, Rizzoli HV, Kessler RM, Manning RG, Channing M, Wolf AP, O’Connor CM (1982) Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain. Radiology 144:885–889
Pichler R, Dunzinger A, Wurm G, Pichler J, Weis S, Nussbaumer K, Topakian R, Aigner RM (2010) Is there a place for FET PET in the initial evaluation of brain lesions with unknown significance?. Eur J Nucl Med Mol Imaging 37:1521–1528
Pirzkall A, McKnight TR, Graves EE, Carol MP, Sneed PK, Wara WW, Nelson SJ, Verhey LJ, Larson DA (2001) MR-spectroscopy guided target delineation for high-grade gliomas. Int J Radiat Oncol Biol Phys 50:915–928
Reinhardt MJ, Kubota K, Yamada S, Iwata R, Yaegashi H (1997) Assessment of cancer recurrence in residual tumors after fractionated radiotherapy: a comparison of fluorodeoxyglucose, L-methionine and thymidine. J Nucl Med 38:280–287
Rickhey M, Moravek Z, Eilles C, Koelbl O, Bogner L (2010) 18F-FET-PET-based dose painting by numbers with protons. Strahlenther Onkol 186:320–326
Sun X, Niu G, Chan N, Shen B, Chen X (2011) Tumor hypoxia imaging. Mol Imaging Biol 2010 Sep 14. [Epub ahead of print] DOI: 10.1007/s11307-010-0420-z
Tsien CI, Cao Y, Lawrence TS (2009) Functional and metabolic magnetic resonance imaging and positron emission tomography for tumor volume definition in high-grade gliomas. Semin Radiat Oncol 19:155–162
Vees H, Senthamizhchelvan S, Miralbell R, Weber DC, Ratib O, Zaidi H (2009) Assessment of various strategies for 18F-FET PET-guided delineation of target volumes in high-grade glioma patients. Eur J Nucl Med Mol Imaging 36:182–193
Weber DC, Zilli T, Buchegger F, Casanova N, Haller G, Rouzaud M, Nouet P, Dipasquale G, Ratib O, Zaidi H, Vees H, Miralbell R (2008) [(18)F]Fluoroethyltyrosine- positron emission tomography-guided radiotherapy for high-grade glioma. Radiat Oncol 3:44
Weissleder R (2006) Molecular imaging in cancer. Science 312:1168–1171
Yamane T, Sakamoto S, Senda M (2010) Clinical impact of (11)C-methionine PET on expected management of patients with brain neoplasm. Eur J Nucl Med Mol Imaging 37:685–690
Yap JT, Carney JP, Hall NC, Townsend DW (2004) Image-guided cancer therapy using PET/CT. Cancer J 10:221–233
Zaidi H, El Naqa I (2010) PET-guided delineation of radiation therapy treatment volumes: a survey of image segmentation techniques. Eur J Nucl Med Mol Imaging 37:2165–2187
Zaidi H, Vees H, Wissmeyer M (2009) Molecular PET/CT imaging-guided radiation therapy treatment planning. Acad Radiol 16:1108–1133
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Zaidi, H., Senthamizhchelvan, S. (2011). Assessment of Biological Target Volume Using Positron Emission Tomography in High-Grade Glioma Patients. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 2. Tumors of the Central Nervous System, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0618-7_15
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