Zusammenfassung
Auf der Suche nach einem Ergot-Alkaloid mit ausgeprägt blockierender Wirkung auf alpha-adrenerge Rezeptoren wurde in den 60er Jahren das halbsynthetische Ergolinderivat Nicergolin entwickelt. Dem damaligen Verständnis der Ätiologie dementieller Erkrankungen folgend, konzentrierten sich pharmakologische Untersuchungen auf vasodilatatorische Effekte, die aus der alpha-1-rezeptorblockierenden Wirkung der Substanz resultieren: Neben zahlreichen tierexperimentellen Studien (Le Pocin-Lafitte et al. 1984) wiesen auch Untersuchungen am Menschen eine Verbesserung der durchschnittlichen zerebralen Hemisphären-Durchblutung nach (Iliff et al. 1979).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Aliprandi Von G, Tantalo V (1979) Physiopathologie des Innenohres und Therapie der Perzeptionstaubheit. Arzneimittelforschung/Drug Res 29: 1287–1295
Arcamone F, Glasser AG, Grafnetterova J, Minghetti A, Nicolella V (1972) Studies on the metabolism of ergoline derivatives. Metabolism of nicergoline in man and in animals. Biochem Pharmacol 21: 2205–2213
Arnold JD (1977) Unveröffentlichte Archivdaten (Farmitalia, Freiburg, Deutschland)
Arrigo A, Moglia A, Borsotti L, Massarini M, Alfonsi E, Battaglia A, Saccetfi GA (1982) Doubleblind, placebo-controlled, crossover trial with nicergoline in patients with senile dementia. Int J Clin Pharm Res [Suppl 1] 2: 33–41
Battaglia A, Bruni G, Ardia A, Sacchetti G (1989) Nicergoline in mild to moderate dementia. A multicenter, double-blind, placebocontrolled study. Jags 37: 295–302
Benzi G, De Bernardi M, Manzo L, Ferrara A, Panceri P, Arrigoni E, Berte F (1972) Effect of lysergide and nicergoline on glucose metabolism investigated on the dog brain isolated in situ. J Pharm Sci 61, N 3: 348–352
Benzi G, Arrigoni E, Pastoris O, Villa RF, Dagani F, Marzatico F, Agnoli A (1979) Effect of some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia. Biochem Pharmacol 28: 435–439
Beyer HH (1980) Die Verwendung von Nicergolin (Sermion®) bei Tinnitus aurium. Therapiewoche 30: 935–938
Bianchine JR (1983) Unveröffentlichte Archivdaten (Farmitalia, Freiburg, Deutschland)
Boismare F, Lorenzo J (1975) Study of the protection afforded by nicergoline against the effects of cerebral ischemia in the cat. Arzneimittelforschung 25: 410–413
Bolli R, Ware JA, Brandon TA, Weilbaecher DG, Mace ML (1984) Platelet-mediated thrombosis in stenosed canine coronary arteries: inhibition by nicergoline, a platelet-active alpha-adrenergic antagonist. J Am Coll Cardiol 3: 1417— 1426
Borromei A (1989) Adjuvant therapy for Parkinson’s disease. Preliminary data of a multicentre study with nicergoline. Funct Neurol 4: 63–67
Chandra P, Paul A (1985) The effects of nicergoline and other vaso-active substances on molecular biological processes in the brain and their effects on the learning abilities of rats. In: Heidrich H (ed) Proof of therapeutical effectiveness of nootropic and vasoactive drugs. Springer, Berlin Heidelberg New York Tokyo, pp 119–130
De Agopian P, Rosa A, Gautier JC, Lhermitte F (1973) Thromboses arteriélles expêrimentales. Effect d’un alpha-bloquant: la nicergoline. Nouv Presse Med 2: 2521–2524
Dolce G, Zamponi A, Cecconi V, Pola P(1984) Clinicical and EEG assessment of neurodynamic effect of nicergoline in cerebral functions recovery after brain hemisphere lesions. Proceedings of the 14th C.1.N.P. Congress — Florence, June 23
Dolce G, Cecconi V, Zamponi A, Zylbergmann R, Maggi L, Battaglia A (1985) Terapia farmacologica associata a riabilitazione neuromotoria nel paziente: un nuovo approccio metodologica per la valutazione clinica di farmaci nootropi. Giorn Geront [Suppl] 62: 55–63
Domzat T, Tutaj A, Zydecka B (1989) Nicergoline in the treatment of ischaemic cerebral stroke. Funct Neurol 4: 131–133
Ehrly AM, Lardgraf H (1985) Einfluß von Nicergolin auf die Filtrabilität hyperosmolaren Blutes. In: Heidrich H (Hrsg) Therapeutische Wirksamkeitsnachweise bei nootropen und vasoaktiven Substanzen: Fortschritte in der klinischen und experimentellen Nicergolin-Forschung. Springer, Berlin Heidelberg New York Tokyo, S 189 ff
Fabbrini G, Martucci N, Baitaglia A, Novellini R (1989) Nicergoline as a possible dopaminergic agent. Effects of serum prolactin levels. XIVth World Congress on Neurology, New Dehli, October 1989
Fariello RG, Carfagna N (1991) Biological basis for synergism between pharmacological and behavioural intervention in the aging brain. Geriatria y Gerontologia 26 [Suppl 1]: 33
Farmitalia Carlo Erba (1984) Plasma and brain levels of nicergoline and its metabolites in the rat. Confidential report 6714/818i, June 1984
Farmitalia Carlo Erba(1988) Comparative study of the bioavailability of three oral preparations of nicergoline in healthy volunteers. Confidential report 6714/649i
Fujihara M, Hirakoso K, Takahashi M, Nakamura T, Harigaya S (1986 a) Biological fate of nicergoline (3). Placental transfer and mammary excretion. Oyo Yakuri (Pharmacometrics) 32: 49–56
Fujihara M, Hirakoso K, Takahashi M, Nakamura T, Harigaya S (1986 b) Biological fate of nicergoline (2). Biological fate in rats and dogs after oral administration. Oyo Yakuri (Pharmacometrics) 32: 31–48
Granata M, Dondero D, Tomasinelli R (1984) Studio clinico controllato della nicergolina dell’ insufficienza cerebrale senile. Atti Accad Med Lomb 39: 33–40
Greiner GF (1980) Therapeutische Wirkung von Nicergolin (Sermion®) im HNO-Bereich. Therapiewoche 30: 348–351
Gruppo Cooperativo Italiano Per Lo Studio Della NICERGOLINA (1985) Attivita della nicergolina nel deterioramento cerebrale senile: ricerche cliniche controlatte verso placebo. Giorn Geront [Suppl] 62: 27–43
Heitz C, Descombes JJ, Miller RC, Steclet JC (1986) Alpha-adrenoceptor antagonistic and calcium antagonistic effects of nicergoline in the rat isolated aorta. Eur J Pharmacol 123: 279–285
Iliff LD, Du Boulay GH, Marshall JR, Ross RW, Symon L (1979) Wirkung von Nicergolin auf die Gehirndurchblutung. Arzneimittelforschung/Drug Res 29: 1277–1278
Jori MC, De Paolis C, Battaglia A, Ardia A, Praga C (1985) Studio controllato multinazionale: nicergolina nel trattamento sintomatologico dell’invecchiamento cerebrale patologico. Giorn Geront 33: 1185
Kohlenberg-Mller K, meier GH, Kunz K, wauschkuhn CH, s (1991) Vergleichende Untersuchungen zur Bioverfügbarkeit von Nicergolin aus zwei unterschiedlichen Darreichungsformen im Steady State. Arzneimittelforschung/Drug Res 41: 28 ff
Kugler J(1988) Electroencephalographic and psychometric measurements during treatment of cerebral insufficiency with nicergoline and co-dergocrine mesylate. In: Kugler J, Agnoli A(eds) Ergot alkaloids and aging brain: an update on nicergoline. Proceedings of an international symposium. Rome, October 1987, Excerpta Medica
Kuzuya F, Hayakawa M (1985) Einfluß von Nicergolin auf die Thrombozytenaggregation und Erythrozytenverformbarkeit. In: Heidrich H (Hrsg) Therapeutische Wirksamkeitsnachweise bei nootropen und vasoaktiven Substanzen: Fortschritte in der klinischen und experimentellen Nicergolin-Forschung. Springer, Berlin Heidelberg New York Tokyo, S 193
Lagarde M, Guichardant M, Ghazi I, Dechavanne M (1980) Nicergoline, an anti-aggregating agent which inhibits release of arachidonic acid from human platelet phospholipids. Prostaglandins 19: 551–557
Latkowsky B et al (1987) Experience with Sermion® in the treatment of some inner ear diseases. Symposium of the Polish Neurological Society (Section of Therapy). Warsaw, March 27 (Abstracts, pp 72)
Le Poncin-Lafitte M, Grosdemouge C, Billon C, Rapin JR (1981) Nicergoline: deoxyglucose uptake and cerebral blood flow under hypoxia. In: Les alpha-bloquants, pharmacologie experimentale et clinique. Masson, Paris, pp 321–325
Le Poncin-Lafitte M, Grosdemouge C, Duterte D, Rapin JR (1984) Simultaneous study of haemodynamic, metabolic and behavioural sequelae in a model of cerebral ischaemia in aged rats: effects of nicergoline. Gerontology 30: 109–119
Maiolo AT, Bianchi Porro G, Galli C, Sessma M (1972) Effects de la nicergoline sur l’hémodynamique cérébrale et la metabolisme cérébral dans l’hypertension artérielle essentielle et l’arteriosclerose. Clin Thér 62: 239–252
Martucci N, Battaglia A (1989) A review of italian studies with Nicergoline in the aging brain. Funct Neurol 4: 27–32
Martucci N, Manna V, Battaglia A (1985) Eine placebokontrollierte Studie mit Nicergolin an Patienten mit organischem Hirnsyndrom, die an kochleären und vestibulären Störungen leiden. In: Heidrich H (Hrsg) Therapeutische Wirksamkeitsnachweise bei nootropen und vasoaktiven Substanzen. Springer, Berlin Heidelberg New York Tokyo. 57–66
Megna G, Calabrese S, Monitillo V, Craca A, Del Prete M (1989) Nootropic and psychotropic drugs in hemiplegic patients during rehabilitation. Funct Neurol 4: 143–147
Moglia A, Arrigo A(1989) Ergot derivatives in the aging brain correlation between EEG spectral analysis and clinical findings. Funct Neurol 4: 23–26
Moglia A, Arrigo A, Battaglia A, Sacchetti G (1985) Correlation between computerized EEG and clinical findings in patients with senile dementia. In: Heidrich H (ed) Proof of therapeutical effectiveness of nootropic and vasoactive drugs. Springer, Berlin Heidelberg New York Tokyo, pp 45–50
Moretti A, Arcari G, Pegrassi L (1979) Übersicht über pharmakologische Studien mit Nicergolin. Arzneimittelforschung/Drug Res 29 (II), 8a
Moretti A, Carfagna N, Caccia C, Carpentieri M, Amigo A, Marchi G, Trunzo F (1985) Neurochemical effects of ergoline derivatives. In: Heidrich H (ed) Proof of therapeutical effectiveness of nootropic and vasoactive drugs. Springer, Berlin Heidelberg New York Tokyo, pp 103–110
Moretti A, Carfagna N, Caccia C, Carpentieri M (1988) Effects of ergolines on neurotransmitter systems in the rat brain. Arch Int Pharmacodyn 294: 33–45
Nicergoline Cooperative Study Group (1990) A double-blind randomized study of two ergot derivatives in mild to moderate dementia. Curr Ther Res 48: 597–612
Pasqui AL, Mancini A (1984) Relazione sull’attivita e tollerabilita della nicergolina dell’insufficienza cerebrale senile: confronto con placebo secondo un disegno crossover. Relazione per Ministero di Sanita
Paul A, Chandia P (1979) Einfluß von Nicergolin auf molekularbiologische Prozesse im Gehirn und seine Auswirkung auf die Lernfähigkeit der Ratte. (Effect of nicergoline on molecular biological processes in the brain and its effect on the learning ability of the rat.) arzneimittelforschung 29: 1238–1251
Pogliani E, Della Volpe A, Ferrari R, Recalcati P, Praga C(1975) Inhibition of human platelet aggregation by oral administration of nicergoline. A double-blind study. Il Farmaco (Prat) 30: 630–640
Rafelson ME, Migne J, Santonja R, Derouette JC, Robert L (1980) Effect of an alpha-blocking agent, nicergoline, on the interaction between blood platelets, elastin and endothelial cells. Biochem Pharmacol 29: 943–947
Renon P, LE Mouel C (1990) Injizierbares Nicergolin bei der Behandlung cochlearer Notfälle. In: Heidrich H (Hrsg) Therapeutische Wirksamkeitsnachweise bei nootropen und vasoaktiven Substanzen. Springer, Berlin Heidelberg New York Tokyo, S 207–215
Rossi AC, Carfagna N, Caccia C, Carpentieri M, Moretti A (1988) Neurochemical effects of ergoline derivatives. In: Kugler J, Agnoli A (eds) Ergot alkaloids and aging brain an update on nicergoline. Proceedings of an international symposium. Rome, 1987. Excerpta Medica, pp 16–24
Rossi A, Battaglia A, Novellini R, Buonamici M, Carfagna N, Orlando N, Pamparana F (1990) Nicergoline: pharmacological properties and clinical studies in aging brain. In: Alan R Aging brain and dementia: new trends in diagnosis and therapy. Liss New York, pp 549–576
Rubegni M, Provvedi D (1984) Nicergoline nell’insufficienza cerebrale senile. Risultati di due studi clinici controllati verso placebo. Relazione per Ministero di Sanita
Saletu B (1991) Codergocrinetype drugs in the pharmacotherapyof mental and cognitive disorders in aging. Proceedings of the 5th World Congress of Biological Psychiatry, Florence, 9–14 June, 1991 (Excerpta Medica International Congress Series)
Saletu B, Grunberger J, Linzmayer L, Anderer P (1990a) Brain protection of nicergoline against hypoxia: EEG brain mapping and psychometry. J Neural Transm (P-D Sect) 2: 305–325
Saletu B, Anderer P, Grünberger J (1990 b) Topographic brain mapping of EEG after acute application of ergotalkaloids in the elderly. Arch Gerontol Geriatr 11: 1–22
Shintomi K, Egon H, Tanaka T, Itakura T, Yoshimoto K, Matsamoto M, Matsuoka Y(1986) Pharmacological study of nicergoline (I). Protective effect against anoxic brain damages in animals. Folia Pharmacol Jpn 87: 445–456
Shintomi K, Yoshimoto K, Ogawa Y, Itakura T, Ikezawa K, Narita H, Ishizuka T, Yamaguchi I, Yamada K (1987) Pharmacological effects of nicergoline and its metabolites, decomposition products and impurities in animals. J Pharmacobiodyn 10: 35–48
Split W et al. (1987) Treatment of insufficiency of the vertebro-basilar arterial system with Sermion® (Nicergolin). Symposium of the Polish Neurological Society (Section of Therapy), Warsaw, March 27 (Abstracts, pp 53)
Turchiaro GG, Scornaienghi D (1984) Impiego della nicergolina nel trattamento dell’insufficienza cerebrale senile. Studio clinico controllato verso placebo. Relazione per Ministero di Sanita
Voronina TA, Nerobkova LN, Garibova TL, Dikova M, Nikolov R, Nikolova M, Markina NV (1988) Effect of nicergoline on learning and memory. Meth Find Exp Clin Pharmacol 10: 431–435
Zappoli R, Versari A, Paganini M, Arnetoli G, Battaglia A, Ardia A, Maniero A (1988) Effect of long-term nicergoline treatment on contingent negative variation activity and clinical status of patients with presenile idiopathic mental deterioration: preliminary findings. In: Kugler J, Agnoli A (eds) Ergot alkaloids and aging brain: an update on nicergoline. Proceedings of an international symposium. Rome, October 1987. Excerpta Medica, pp 72–83
Zylberman MR, Fontana MDolce G (1988), Effects of Nicergoline on learning, mood and behaviour in hemiplegic patients undergoing rehabilitation. In: Kugler J, Agnoli A (eds) Ergot alkaloids and aging brain: an update on Nicergoline. Proceedings of an international symposium. Rome, October 1987. Excerpta Medica, pp 57–63
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Wien
About this chapter
Cite this chapter
Herrschaft, H. (1992). Nicergolin. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3330-9_20
Download citation
DOI: https://doi.org/10.1007/978-3-7091-3330-9_20
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-3331-6
Online ISBN: 978-3-7091-3330-9
eBook Packages: Springer Book Archive