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Tumor Angiogenesis: Fishing for Screening Models

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Angiogenesis and Vascularisation

Abstract

The process of de novo vessel formation, called angiogenesis, is essential for tumor progression and metastasis. The identification and targeting of the molecular pathways involved in this process are becoming critical issues for anti-angiogenic cancer therapies. To pursue these molecular and pharmacological approaches, researchers need to develop better preclinical models to study tumor angiogenesis and then test anti-angiogenic therapies. As a vertebrate, the zebrafish model system is equipped with easy and powerful transgenesis and imaging tools to investigate not only angiogenesis but also tumor development and its progression. In this chapter we will illustrate how a small tropical fish can help to better understand the tumor angiogenesis process and identify new pharmacological therapies for tumor angiogenesis. Lastly, we describe in what way this model can act as a preclinical model for screening new chemical compounds which are able to selectively block tumors but not the normal healthy angiogenesis in vivo.

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Acknowledgments

Support in MMS lab come from HFSP, Marie Curie Action, Telethon, and AIRC. We thank Ellen Jane Corcoran for editorial assistance.

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Authors and Affiliations

  1. Department of Molecular Biotechnology and Health Science, Molecular Biotechnology Center, University of Torino, Torino, Italy

    Dafne Gays, Vera Mugoni & Massimo M. Santoro

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  1. Dafne Gays
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  2. Vera Mugoni
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  3. Massimo M. Santoro
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Correspondence to Massimo M. Santoro .

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Editors and Affiliations

  1. Department of Medical Biotechnology, Jagiellonian University, Kraków, Poland, Kraków, Poland

    Józef Dulak

  2. Department of Medical Biotechnology, Jagiellonian University, Krakow, Poland, Krakow, Poland

    Alicja Józkowicz

  3. Department of Medical Biotechnology, Jagiellonian University, Kraków, Poland

    Agnieszka Łoboda

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Gays, D., Mugoni, V., Santoro, M.M. (2013). Tumor Angiogenesis: Fishing for Screening Models. In: Dulak, J., Józkowicz, A., Łoboda, A. (eds) Angiogenesis and Vascularisation. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1428-5_14

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