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Iontophoresis for Therapeutic Drug Delivery and Non-invasive Sampling Applications

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Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement

Abstract

Most research concerning iontophoresis has focused on topical and transdermal drug delivery and in non-invasive skin sampling applications. Iontophoresis has been established as a safe, versatile and efficient enhancement technique, and several iontophoretic devices have been marketed for topical (lidocaine) and systemic (fentanyl, sumatriptan) delivery and for non-invasive sampling (glucose). Nevertheless, the last decade has seen an increased interest into the potential use of iontophoresis to deliver drugs through the nail and through the sclera and cornea, the two main barriers to eye drug delivery. This chapter aims to summarize the main progress achieved in these areas.

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Authors and Affiliations

  1. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, University of Valencia, Valencia, Spain

    Virginia Merino

  2. Instituto de Ciencias Biomédicas, Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Valencia, Spain

    Alicia López Castellano

  3. Department of Pharmacy and Pharmacology, University of Bath, Bath, UK

    M. Begoña Delgado-Charro

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  1. Virginia Merino
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  2. Alicia López Castellano
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  3. M. Begoña Delgado-Charro
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Correspondence to M. Begoña Delgado-Charro .

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  1. Apoteka “Beograd”, Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Since the submission of this chapter, a supplemental new drug application (sNDA) Ionsys System was approved by the FDA (April 2015); further this fentanyl iontophoretic system was approved by the EMA (EPAR November 2015).

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Merino, V., Castellano, A.L., Delgado-Charro, M.B. (2017). Iontophoresis for Therapeutic Drug Delivery and Non-invasive Sampling Applications. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53273-7_6

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