Skip to main content

Gewinnung, Konservierung, Lagerung von Transfusionsblut

  • Chapter
Transfusionsmedizin
  • 55 Accesses

Zusammenfassung

Die kostbarste Ressource der Transfusionsmedizin ist das von freiwilligen Blutspendern gespendete Blut. Ohne dieses gäbe es keine Therapie mit Blutprodukten. Der Gewinnung ausreichender Mengen an Transfusionsblut kommt deshalb nicht nur medizinische, sondern auch erhebliche gesundheitspolitische Bedeutung zu. Bei dieser Aufgabe steht die Transfusionsmedizin allerdings in einem unlösbaren Dilemma: Einerseits muß sie soviele Bürger wie möglich zur Blutspende motivieren; andererseits steigt mit der Zahl der Spender auch das mögliche Risiko der Übertragung nicht erkannter Erkrankungen an die Empfänger. Mit einem komplizierten Regelwerk wird angestrebt, ein möglichst optimales Nutzen-Risiko-Verhältnis zu erreichen. Hierfür dienen ebenso die Bemühungen um verbesserte Konservierungsmedien und -verfahren wie auch die Erforschung möglichst schonender Lagerungsbedingungen. Diese Zusammenhänge werden nachfolgend dargestellt (s. auch Kap. 5).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Adamson J, Hillmann RS (1986) Blood volume and plasma protein replacement following acute blood loss in normal man. JAMA 205: 609–612

    Article  Google Scholar 

  2. Akerblom O, Kreuger A (1975) Studies on citrate-phosphatedextrose (CPD) blood supplemented with adenine. Vox Sang 29: 90–95

    Google Scholar 

  3. Akerblom A, Verdier de CH, Erikson A, Garby L, Högman C (1969) Late addition of inosine to stored ACD-adenine blood. Effects on erythrocyte viability and metabolism. Folia Haematol 91: 142–150

    CAS  Google Scholar 

  4. Arseniev L, Weisswange T, Neumann HJ, Stangel W (1994) Transfusion results of cytapheresis platelet concentrates, stored in two different polyolefin containers for five days. Infusionsther Transfusionsmed 21: 274–277

    PubMed  CAS  Google Scholar 

  5. Aubuchon JP, Davey RJ, Estep T, Miripo J (1984) Effect of the plasticizer di-2-ethylhexal phthalate on survival of stored red cells. Transfusion 24: 422

    Google Scholar 

  6. Aufbereitungsmonographien für Blutprodukte. Bundesanzeiger (1989) 41: 4570–4574; (1992) 44: 1659; (1994) 46: 997–1000

    Google Scholar 

  7. Barras JP, Jung T, Haberthuer C, Koerner K (1989) Vergleichende Untersuchungen der rheologischen Eigenschaften von Erythrozytenkonzentraten während einer Lagerungszeit von sechs Wochen in verschiedenen Konservierungs-Lösungen. Vasa 18: 122–127

    PubMed  CAS  Google Scholar 

  8. Barthels M, Stangel W, Poliwoda H, Trobisch H (1974) Untersuchungen zur Frage der Aktivierung des Gerinnungssystems in Blutkonserven. Blut 29: 289–296

    Article  PubMed  Google Scholar 

  9. Bergmann H, Blauhut B (1983) Klinische Relevanz der Mikroaggregate in der gelagerten Blutkonserve. Infusionsther Klin Ernähr 10: 246–249

    Google Scholar 

  10. Bertolini F, Marangoni F, Loy A, Marconi M, Almini D, Rebulla P, Sirchia G (1993) Single-donor platelet concentrates stored in synthetic medium. In vitro and in vivo studies. Int J Art Organs 16 Suppl 5: 135–138

    Google Scholar 

  11. Betriebsverordnung für pharmazeutische Unternehmen (Pharm Betr V) Bundesgesetzblatt (1994) I: 1561 vom 22.7. 1994

    Google Scholar 

  12. Beutler E, Duron O (1965) Effect of pH on preservation of red cell ATP. Transfusion 5: 17

    Article  PubMed  CAS  Google Scholar 

  13. Beutler E, West C (1983) Storage of red cell concentrates in CPD-A2 for 42 and 49 days. J Lab Clin Med 102: 53–62

    PubMed  CAS  Google Scholar 

  14. Beutler E, Kuhl W (1988) Volume control of erythrocytes during storage. The role of mannitol. Transfusion 28: 353–357

    Article  PubMed  CAS  Google Scholar 

  15. Bolin RB, Cheney BA, Smith DJ, Gildengorin V, Shigekawa R (1982) An in vivo comparison of CPD and CPD-A2 preserved platelet concentrates after an 8-hour process hold of whole blood. Transfusion 22: 491–495

    Google Scholar 

  16. Brewer GJ, Eaton JW (1971) Erythrocyte metabolism interaction with oxygen transport. Science 171: 1205–1211

    Article  PubMed  CAS  Google Scholar 

  17. Buchholz DH, Porten JH, Grode G, Lin AT, Smith J (1985) Extended storage of single-donor platelet concentrate collected by a blood cell separator. Transfusion 25: 557–562

    Google Scholar 

  18. Button LN, Orlina AR, Kevy SV, Josphson AM (1976) The quality of over-and undercollected blood for transfusion. Transfusion 16: 148–154

    Article  PubMed  CAS  Google Scholar 

  19. Card RT, Mohanda S, Perkins HA, Shohet SB (1982) De-formability of stored red blood cells. Relationship to degree of packing. Transfusion 22: 96–101

    Article  PubMed  CAS  Google Scholar 

  20. Carmen RA, Sohmer PR, Leng BS, Moore GL, Nelson EJ, Simon TL, Myhre BA, Marcus CS, Moroff G, Lewis LM, et al (1988) Five-week red cell storage with preservation of 2,3 DPG. Transfusion 28: 157–161

    Article  PubMed  CAS  Google Scholar 

  21. Davey RJ, Heaton WA, Sweat LT, Stec NM, Nelson EJ, Holme S (1994) Characteristics of white cell–reduced red cells stored in tri-(2-ethylhexyl)trimellitate plastic. Transfusion 34: 895–898

    Google Scholar 

  22. Deutsches Arznei-Buch (DAB) Nr.10 (1994) Hrsg: Arzneibuchkommissionen und Expertengruppen im Auftrag des Bundesministers für Gesundheit. Ergänzungssammlung. Deutscher Apothekerverlag, Stuttgart

    Google Scholar 

  23. DIN-Katalog für technische Regeln (1994) Band 1, Teil I, Sachteil Deutsche Normen und technische Regeln, Deutsches Institut für Normung. Transfusions-, Infusions-und Injektionsgeräte

    Google Scholar 

  24. Estep TN, Pedersen RA, Miller TJ, Stupar KR (1984) Characterization of erythrocyte quality during the refrigerated storage of whole blood containing di-(2-ethylhexyl)phthalate. Blood 64: 1270–1276

    PubMed  CAS  Google Scholar 

  25. Falk JS, Lindglad TO, Westmann BJM (1972) Histopathological studies on kidneys from patients treated with large amounts of blood preserved with ACD-Adenine. Transfusion 12: 376–381

    PubMed  CAS  Google Scholar 

  26. Feo C, Mohandas N (1977) Clarification of role of ATP in red-cell morphology and function. Nature (London) 265: 166–168

    Article  CAS  Google Scholar 

  27. Fosse E, Swennevig JL, Harboe M (1985) Cell markers in stored blood. Injury 16: 393–397

    Google Scholar 

  28. Gibson JG, Rees SB, Mc Manus TJ, Scheitlin WA (1957) A citrate-phosphate-dextrose solution for preservation of human blood. Am J Clin Pathol 28: 569–578

    Google Scholar 

  29. Greenwalt TJ, Zehner Sostok C, Dumaswala UJ (1990) Studies in red blood cell preservation. 2. Comparison of vesicle formation, morphology, and membrane lipids during storage in AS-1 and CPDA-1. Vox Sang 58: 90–93

    Google Scholar 

  30. Greenwalt TJ, Mc Guinness CG, Dumaswala UJ, Carter HW (1990) Studies in red blood cell preservation. 3. A phosphateammonium-adenine additive solution. Vox Sang 58: 94–99

    Google Scholar 

  31. Grimm H, Sandritter W, Kleine N, Walker WH (1976) Untersuchungen von menschlichen Organen nach Bluttransfusionen aus PVC-Beuteln. In: Matthes M, Nagel V (Hrsg) Forschungsergebnisse der Transfusionsmedizin and Immunhämatologie, Bd 3. Medicus, Berlin, S 575–577

    Google Scholar 

  32. Gullikson H, Karlmann G, Segerlind A, Gullbring B (1986) Preservation of red blood cells: content of microaggregates and di-2-ethylhexylphthalate (DEHP) in red blood cells stored in saline-adenine-glucose-manitol (SAGM) medium. Vox Sang 50: 16–20

    Article  Google Scholar 

  33. Hamasaki N, Hirota-Chigita C (1983) Acid-citrate-dextrosephosphoenolpyruvate medium as a rejuvenant for blood storage. Transfusion z3: 1–7

    Article  Google Scholar 

  34. Handel KD, Gänshirt KH, Entwistle CC (1987) Plättchen-Monitor-System (PMS). Ein neues Gerät zur noninvasiven Funktionsprüfung von Thrombozyten. In: Kretschmer V, Stangel W (Hrsg) Transfusionsmedizin 1986–Infektionen, Autotransfusionen, Lymphokine, Bd 18 Beitr Infusionsther Klin Ernährung. Karger, Basel, S 160–162

    Google Scholar 

  35. Heaton A, Miripo J, Aster R, Hartmann P, Dehart D, Rzad L, Grapka B, Davisson W, Buchholz DH (1984) Use of Adsol preservation solution for prolonged storage of low viscosity AS-1 red blood cells. Br J Haematol 57: 467–478

    Google Scholar 

  36. Hessel E, Lerche D (1985) Cell surface alterations during blood-storage characterized by arteficial aggregation of washed red blood cells. Vox Sang 49: 86–91

    Article  PubMed  CAS  Google Scholar 

  37. Högmann CF, Hedlund DK (1985) Storage of red cells in a CPD/SAGM system using teruflex PVC. Vox Sang 49: 177–180

    Article  Google Scholar 

  38. Högmann CF, Eriksson L, Gong J, Högmann AB, Vikholm K, Debrauwere J, Payrat JM, Stewart M (1993) Half-strength citrate CPD combined with a new additive solution for improved storage of red blood cells suitable for clinical use. Vox Sang 65: 271–278

    Google Scholar 

  39. Högmann CF, Eriksson L, Ring M (1992) Automated blood component preparation with the Opti system: three years’experience. Beitr Infusionsther 30: 100–107

    Google Scholar 

  40. Högmann CF, Eriksson L, Ericson A, Repucci AJ (1991) Storage of saline-adenine-glucose-mannitol-suspended red cells in a new plastic container: polyvinylchloride plasticized with butyryl-n-trihexyl-citrate. Transfusion 31: 26–29

    Article  Google Scholar 

  41. Högmann CF (1993) Component preparation and quality assurance of stored blood. In: Rock GA, Seghatchian MJ (eds) Quality assurance in transfusion medicine, vol 2. CRC, Boca Raton, pp 59–98

    Google Scholar 

  42. Holme S, Myrphy S (1983) Platelet storage at 22 °C for transfusion: Interrelationship of platelet density and size, medium pH, and viability after in vivo infusion. J Lab Clin Med tot: 161–174

    Google Scholar 

  43. Horejsi J (1967) Effect of reduced glutathions on the dissociation curve of haemoglobin. Haematologia (Budapest) 1: 35–44

    Google Scholar 

  44. Jacobson MS, Kevy SU, Parkmann R, Wesolowski JS (1980) An in vitro evaluation of a new plasticizer for polyvinylchloride medical devices. Transfusion 20: 443–447

    Article  PubMed  CAS  Google Scholar 

  45. Jaeger RJ, Rubin RJ (1970) Plasticizers from plastic devices: extraction, metabolism and accumulation by biological systems. Science 170: 460–462

    Article  PubMed  CAS  Google Scholar 

  46. Jaeger RJ, Rubin RJ (1972) Migration of phthalate ester plasticizer from polyvinyl chloride blood bags into stored blood and its localization in human tissues. N Engl J Med 287: 1114–1118

    Article  PubMed  CAS  Google Scholar 

  47. Kahn RA, Johnson RK, Healton WAL (1979) Effect of prolonged room temperature holding of hole blood intended for preparation of components. Transfusion 19: 539–541

    Google Scholar 

  48. Kao KJ, Mickel M, Braine HG, Davis K, Enright H, Gernsheimer T, Gillespie MJ, Kickler TS, Lee EJ, Mc Cullough JJ, et al. (1995) White cell reduction in platelet concentrates and packed red cells by filtration: a multicenter clinical trial. Transfusion 35: 13–19

    Google Scholar 

  49. Koerner K (1986) Thrombozytenfunktionen bei Lagerung in PVC Beuteln mit erhöhter Gasdurchlässigkeit. In: Kretschmer V, Stangel W (Hrsg) Transfusionsmedizin aktuell-Infektionen, Thrombozyten, Granulozyten, Bd 15 Beitr Infusionsther Klin Ernähr. Karger, Basel, S 118–126

    Google Scholar 

  50. Kretschmer V, Rompf P, Pfeil W, Wagner B, Bähr E, Wesemann W, Rehfisch H, Heinrich D (1986) Thrombozytenfunktion in vitro bei Lagerung über 5 Tage. In: Kretschmer V, Stangel W (Hrsg) Transfusionsmedizin aktuell-Infektionen, Thrombozyten, Granulozyten, Bd 15 Beitr Infusionsther Klin Ernähr. Karger, Basel, S 127–147

    Google Scholar 

  51. Kretschmer V, Marschall R, Schulzki T, Haertel B, Neumann HJ (1992) New polyolefin foil for 5-day storage of platelet concentrates (PC) collected by apheresis. Infusionsther Transfusionsmed 19: 141–144

    PubMed  CAS  Google Scholar 

  52. Krueger A, Akerblom O (1980) Adenine consumption in stored citrate-phosphate-dextrose-adenine blood. Vox Sang 38: 156–160

    Article  Google Scholar 

  53. Krugluger W, Köller M, Hopmeier P (1994) Development of a carbohydrate antigen during storage of red cells. Transfusion 34: 496–50o

    Google Scholar 

  54. Lathmann JT jr., Bove JR, Weirich FL (1982) Chemical and hematologic changes in stored CPDA-1 blood. Transfusion 22: 158–159

    Article  Google Scholar 

  55. Mädler J (1990) SAG-S-Lösung–ein neues Medium zur Re-suspension von Erythrozytenkonzentraten. Z Ges Inn Med Grenzgeb 45: 406–410

    Google Scholar 

  56. Matthes G, Strunk S, Storek W, Strauss D (1990) P-31-NMRUntersuchungen zur In-vivo-Regeneration konservierungsbedingter Veränderungen des 2,3-Diphosphorglyzeratgehaltes roter Blutzellen. Beitr Infusionsther 26: 76–80

    PubMed  CAS  Google Scholar 

  57. Matsuyama H, Niklasson F, de Verdier CH, Högmann CF (1989) Phosphoenolpyruvate in rejuvenation of stored red cells in SAGM medium: optimal conditions and the indirect effect of methemoglobin formation. Transfusion 29: 614–619

    Article  PubMed  CAS  Google Scholar 

  58. Medizin-Produktegesetze (MPG) vom 02. Aug. 1994 Bundesgesetzblatt, Teil I: 1963–1984

    Google Scholar 

  59. Mishler JM, Darley JH, Haworth C, Mollison PL (1979) Viability of red cells stored in diminished concentration of citrate. Br J Haematol 43: 63–67

    Article  PubMed  CAS  Google Scholar 

  60. Mollison PL (1983) Blood transfusion in clinical medicine, 7th edn. Blackwell, Oxford, pp 141–142

    Google Scholar 

  61. Moore GL, Ledford ME, Merydith A (1982) The biochemical effects of CPD-A2-drawn red blood cells of delayed refrigeration prior to component preparation. Transfusion 22: 485487

    Google Scholar 

  62. Moore GL (1987) Additive solutions for better blood preservation. Crit Rev Clin Lab Sci 25: 211–229

    Article  PubMed  CAS  Google Scholar 

  63. Moroff G, Morse EE, Katz AJ, Kahn RA, Dende D, Swatmann L, Staggs SD (1984) Survival and biochemical characteristics of stored red cells preserved with citrate-phosphate-adenineone and two and prepared from whole blood maintaining at 20 to 24 degrees C for eight hours following phlebotomy. Transfusion 24 115–119

    Article  PubMed  CAS  Google Scholar 

  64. Murphy S (1985) Platelet Storage for transfusion. Semin Hemato122: 165–177

    Google Scholar 

  65. Muylle L, Peeterman ME (1994) Effect of prestorage leukocyte removal on the cytokine levels in stored platelet concentrates. Vox Sang 66: 14–17

    Article  PubMed  CAS  Google Scholar 

  66. Myhre BA, Demaniew S, Nelson EJ (1984) Preservation of red cell antigens during storage of blood with different anticoagulant. Transfusion 24: 499–501

    Google Scholar 

  67. Nakao M, Nakao T, Tatibana N, Yoshikawa H (1960) Phosphorus metabolism in human erythrocytes III. Regeneration of adenosine tri-phosphate in long-stored erythrocytes by incubation with iosine and adenine. J Biochem 47: 661–671

    CAS  Google Scholar 

  68. Nakao K, Wada T, Kamiyama T (1962) A direct relationship between adenosine triphosphate-level and in vivo viability of erythrocytes. Nature (London) 164: 877–878

    Article  Google Scholar 

  69. Owens M, Werner E, Holme S, Afflerbach C (1994) Membrane glycoproteins in cryopreserved platelets. Vox Sang 67: 28–31

    Google Scholar 

  70. Plasmapheresen: Durchführung apparativer Plasmapheresen zur Gewinnung von Spenderplasma. Empfehlungen der ständigen Hämapheresekommission der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie e. V. (1994) Infusionsther Transfusionsmed 21: 349–354

    Google Scholar 

  71. Prince HE, Arens L (1986) Effect of storage on lymphocyte surface markers in whole blood units. Transplantation 41: 235–238

    Google Scholar 

  72. Richtlinien zur Blutgruppenserologie und Hämotherapie, Fassung 1996. Deutscher Ärzteverlag, Köln (im Druck )

    Google Scholar 

  73. Richtlinien für die Erkennung, Verhütung und Bekämpfung von Krankenhausinfektionen (1985) In: Bundesgesundheitsamt (Hrsg) Anforderungen der Krankenhaushygiene bei Injektionen und Punktionen. Bundesgesundheitsblatt 28: 186–187

    Google Scholar 

  74. Richtlinien der Kommission für Krankenhaushygiene und Infektionsprävention (1995) Bundesgesundheitsblatt 28: 186–187

    Google Scholar 

  75. Rock G, Tittley P, Mc Combie N (1989) 5-day storage of single-donor platelets obtained using a blood cell seperator. Transfusion 29: 288–291

    Google Scholar 

  76. Rueta PP et al (1967) Fainting: A review of its mechanisms and study in blood donors. Medicine (Baltimore) 46: 363–384

    Google Scholar 

  77. Schleuning M, Schmid-Haslbeck M, Utz H, Jochum M, Heim M, Mempel W, Wilmanns W (1992) Complement activation during storage of blood under normal blood bank conditions. Effects of proteinase inhibitors and leukocyte depletion. Blood 79: 3071–3075

    PubMed  CAS  Google Scholar 

  78. Schneider W, Schorer R (1982) Klinische Transfusionsmedizin. Edition Medizin, Weinheim

    Google Scholar 

  79. Seghatchian MJ (1994) An overview of laboratory and clinical aspects of leukocyte-depleted blood components. Trans-fus Sci 1 5: 49–62

    Google Scholar 

  80. Seidl S, Spielmann W (1970) Comparative studies on the effect of different nucleosides in red cell preservation. In: Spielmann W, Seidl S (eds) Modern problems of blood preservation. Fischer, Stuttgart, S 72–77

    Google Scholar 

  81. Seidl S, Gosda W, Reppucci AJ (1991) The in vitro and in vivo evaluation of whole blood and red cell concentrates drawn on CPDA-1 and stored in a non-DEHP plasticized PVC container. Vox Sang 61: 8–13

    Article  PubMed  CAS  Google Scholar 

  82. Shimizu T, Shibata K, Kora S (1992) First autoclave-sterilized platelet-additive solution containing glucose with a physiological pH for the preparation of plasmapoor platelet concentrates. Vox Sang 62: 87–93

    Google Scholar 

  83. Shimizu T, Kouketsu K, Morishima Y, Goto S, Hasegawa I, Kamiya T, Tamura Y, Kora S (1989) A new polyvinylchloride blood bag plasticized with lessleachable phthalate ester analogue, di-n-decyl phthalate, for storage of platelets. Transfusion 29: 292–297

    Article  PubMed  CAS  Google Scholar 

  84. Simon ER (1962) Red cell preservation: further studies with adenine. Blood 20: 485–491

    Google Scholar 

  85. Simon TL (1983) The effect of obstruction of bag surface on platelet concentrate pH. Transfusion 23: 263–264

    Article  PubMed  CAS  Google Scholar 

  86. Simon TL, Sierra ER (1982) Lack of adverse effect of transportation on room temperature stored platelet concentrates. Transfusion 22: 496–497

    Google Scholar 

  87. Snyder EL, Hezzey A, Weirich F, Mosher DF, Davisson W, Buchholz DH (1983) Stability of red cell antigens and plasma coagulation factors stored in new formulation plastic blood containers. Transfusion 2 3: 49–53

    Google Scholar 

  88. Snyder EL, Pope C, Ferri PM, Smith EO, Walter SD (1986) The effect of mode of agitation and type of plastic bag on storage characteristics and in vivo kinetics of platelet concentrates. Transfusion 26: 125–130

    Article  PubMed  CAS  Google Scholar 

  89. Snyder EL, Hedberg SL, Napychank PA, Roberts C, Kagen L, Aster RA, Quinlan K, Strucaly A, Buchholz DH (1993) Stability of red cell antigens and plasma coagulation factors stored in a non-diethylhexyl phthalate-platicized container. Transfusion 33: 515–519

    Google Scholar 

  90. Sohmer PR, Moore GL, Beutler E, Peck CC (1982) In vivo viability of red blood cells stored in CPDA-2. Transfusion 22: 479–484

    Google Scholar 

  91. Stangel W, Seidel J, Mirkani J, Behrmann M, Hülsheger H (1986) Granulozytenfunktionen in gelagerten Blutkonserven. In: Kretschmer V, Stangel W (Hrsg) Transfusionsmedizin aktuell-Infektionen, Thrombozyten, Granulozyten, Bd 15 Beitr Infusionsther Klin Ernähr. Karger, Basel, S 231–252

    Google Scholar 

  92. Strauss D (1981) The two-step preservation of red blood cells. A contribution to improve their viability and therapeutic efficiency. Acta Biol Med Ger 40–5: 721–725

    Google Scholar 

  93. Strauss D, de Verdier CH (1980) Preservation of red blood cells with purines and nucleosides. II. Uptake and utilization of purines and nucleosides by stored red blood cells. Folia Haematol (Leipzig) 107: 417–433

    Google Scholar 

  94. Valeri R (1982) Use of rejuvenation solutions in blood preservation. CRC Crit Rev Clin Lab Sci 17: 299–374

    Google Scholar 

  95. Valeri CR, Zaroulis CG, Vecchione JJ, Valeri DA, Anastasi J, Pivacek LE, Emerson CP (1980) Therapeutic effectiveness and safety of outdated human red blood cells rejuvenated to improve oxygen transport function, frozen for about 1,5 years at–80 °C, washed, and stored at 4 °C for 24 hours prior to rapid infusion. Transfusion 20: 263–276

    Article  PubMed  CAS  Google Scholar 

  96. Valeri CR, Valeri DA, Gray A, Melaragno A, Dennis RC (1982) Viability and function of red blood cell concentrates stored at 4 degrees C for 35 days in CPDA-1, CPDA-2 or CPDA-3. Transfusion 22: 210–216

    Article  PubMed  CAS  Google Scholar 

  97. Verordnung über die Sicherheit medizinisch-technischer Geräte (Medizingeräteverordnung-MedGV) vom 14.01. 1985, BGBI/85, 93ff

    Google Scholar 

  98. Walker WH, Handel KD, Netz M, Gänshirt KH (1986) 49Tage-Lagerung von Erythrozyten-Konzentraten in PAGGSSorbit (Abstr). Infusionsther Klin Ernähr Suppl 1 zu 13: 20

    Google Scholar 

  99. Walker WH, Netz M, Gänshirt KH (1990) 49 Tage Lagerung von Erythrozytenkonzentraten in Blutbeuteln mit der Konservierungslösung PAGGS-Mannitol. Beitr Infusiosther 26: 55–59

    CAS  Google Scholar 

  100. Wolfe LC (1985) The membrane and the lesion of storage in preserved red cells. Transfusion 25: 185–203

    Article  PubMed  CAS  Google Scholar 

  101. Wong SC, Rock G (1982) The effect of adenine on platelet storage. Transfusion 22: 283–287

    Article  PubMed  CAS  Google Scholar 

  102. Zellseparation. Durchführung präparativer zellulärer Hämapheresen zur Gewinnung von Blutbestandteilskonserven. Empfehlungen der ständigen Hämapheresekommission der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie (1994) Infusionsther Transfusionsmed 21: 222–231

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Stangel, W. (1996). Gewinnung, Konservierung, Lagerung von Transfusionsblut. In: Mueller-Eckhardt, C. (eds) Transfusionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10599-3_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-10599-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10600-6

  • Online ISBN: 978-3-662-10599-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics