Zusammenfassung
Die kostbarste Ressource der Transfusionsmedizin ist das von freiwilligen Blutspendern gespendete Blut. Ohne dieses gäbe es keine Therapie mit Blutprodukten. Der Gewinnung ausreichender Mengen an Transfusionsblut kommt deshalb nicht nur medizinische, sondern auch erhebliche gesundheitspolitische Bedeutung zu. Bei dieser Aufgabe steht die Transfusionsmedizin allerdings in einem unlösbaren Dilemma: Einerseits muß sie soviele Bürger wie möglich zur Blutspende motivieren; andererseits steigt mit der Zahl der Spender auch das mögliche Risiko der Übertragung nicht erkannter Erkrankungen an die Empfänger. Mit einem komplizierten Regelwerk wird angestrebt, ein möglichst optimales Nutzen-Risiko-Verhältnis zu erreichen. Hierfür dienen ebenso die Bemühungen um verbesserte Konservierungsmedien und -verfahren wie auch die Erforschung möglichst schonender Lagerungsbedingungen. Diese Zusammenhänge werden nachfolgend dargestellt (s. auch Kap. 5).
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Literatur
Adamson J, Hillmann RS (1986) Blood volume and plasma protein replacement following acute blood loss in normal man. JAMA 205: 609–612
Akerblom O, Kreuger A (1975) Studies on citrate-phosphatedextrose (CPD) blood supplemented with adenine. Vox Sang 29: 90–95
Akerblom A, Verdier de CH, Erikson A, Garby L, Högman C (1969) Late addition of inosine to stored ACD-adenine blood. Effects on erythrocyte viability and metabolism. Folia Haematol 91: 142–150
Arseniev L, Weisswange T, Neumann HJ, Stangel W (1994) Transfusion results of cytapheresis platelet concentrates, stored in two different polyolefin containers for five days. Infusionsther Transfusionsmed 21: 274–277
Aubuchon JP, Davey RJ, Estep T, Miripo J (1984) Effect of the plasticizer di-2-ethylhexal phthalate on survival of stored red cells. Transfusion 24: 422
Aufbereitungsmonographien für Blutprodukte. Bundesanzeiger (1989) 41: 4570–4574; (1992) 44: 1659; (1994) 46: 997–1000
Barras JP, Jung T, Haberthuer C, Koerner K (1989) Vergleichende Untersuchungen der rheologischen Eigenschaften von Erythrozytenkonzentraten während einer Lagerungszeit von sechs Wochen in verschiedenen Konservierungs-Lösungen. Vasa 18: 122–127
Barthels M, Stangel W, Poliwoda H, Trobisch H (1974) Untersuchungen zur Frage der Aktivierung des Gerinnungssystems in Blutkonserven. Blut 29: 289–296
Bergmann H, Blauhut B (1983) Klinische Relevanz der Mikroaggregate in der gelagerten Blutkonserve. Infusionsther Klin Ernähr 10: 246–249
Bertolini F, Marangoni F, Loy A, Marconi M, Almini D, Rebulla P, Sirchia G (1993) Single-donor platelet concentrates stored in synthetic medium. In vitro and in vivo studies. Int J Art Organs 16 Suppl 5: 135–138
Betriebsverordnung für pharmazeutische Unternehmen (Pharm Betr V) Bundesgesetzblatt (1994) I: 1561 vom 22.7. 1994
Beutler E, Duron O (1965) Effect of pH on preservation of red cell ATP. Transfusion 5: 17
Beutler E, West C (1983) Storage of red cell concentrates in CPD-A2 for 42 and 49 days. J Lab Clin Med 102: 53–62
Beutler E, Kuhl W (1988) Volume control of erythrocytes during storage. The role of mannitol. Transfusion 28: 353–357
Bolin RB, Cheney BA, Smith DJ, Gildengorin V, Shigekawa R (1982) An in vivo comparison of CPD and CPD-A2 preserved platelet concentrates after an 8-hour process hold of whole blood. Transfusion 22: 491–495
Brewer GJ, Eaton JW (1971) Erythrocyte metabolism interaction with oxygen transport. Science 171: 1205–1211
Buchholz DH, Porten JH, Grode G, Lin AT, Smith J (1985) Extended storage of single-donor platelet concentrate collected by a blood cell separator. Transfusion 25: 557–562
Button LN, Orlina AR, Kevy SV, Josphson AM (1976) The quality of over-and undercollected blood for transfusion. Transfusion 16: 148–154
Card RT, Mohanda S, Perkins HA, Shohet SB (1982) De-formability of stored red blood cells. Relationship to degree of packing. Transfusion 22: 96–101
Carmen RA, Sohmer PR, Leng BS, Moore GL, Nelson EJ, Simon TL, Myhre BA, Marcus CS, Moroff G, Lewis LM, et al (1988) Five-week red cell storage with preservation of 2,3 DPG. Transfusion 28: 157–161
Davey RJ, Heaton WA, Sweat LT, Stec NM, Nelson EJ, Holme S (1994) Characteristics of white cell–reduced red cells stored in tri-(2-ethylhexyl)trimellitate plastic. Transfusion 34: 895–898
Deutsches Arznei-Buch (DAB) Nr.10 (1994) Hrsg: Arzneibuchkommissionen und Expertengruppen im Auftrag des Bundesministers für Gesundheit. Ergänzungssammlung. Deutscher Apothekerverlag, Stuttgart
DIN-Katalog für technische Regeln (1994) Band 1, Teil I, Sachteil Deutsche Normen und technische Regeln, Deutsches Institut für Normung. Transfusions-, Infusions-und Injektionsgeräte
Estep TN, Pedersen RA, Miller TJ, Stupar KR (1984) Characterization of erythrocyte quality during the refrigerated storage of whole blood containing di-(2-ethylhexyl)phthalate. Blood 64: 1270–1276
Falk JS, Lindglad TO, Westmann BJM (1972) Histopathological studies on kidneys from patients treated with large amounts of blood preserved with ACD-Adenine. Transfusion 12: 376–381
Feo C, Mohandas N (1977) Clarification of role of ATP in red-cell morphology and function. Nature (London) 265: 166–168
Fosse E, Swennevig JL, Harboe M (1985) Cell markers in stored blood. Injury 16: 393–397
Gibson JG, Rees SB, Mc Manus TJ, Scheitlin WA (1957) A citrate-phosphate-dextrose solution for preservation of human blood. Am J Clin Pathol 28: 569–578
Greenwalt TJ, Zehner Sostok C, Dumaswala UJ (1990) Studies in red blood cell preservation. 2. Comparison of vesicle formation, morphology, and membrane lipids during storage in AS-1 and CPDA-1. Vox Sang 58: 90–93
Greenwalt TJ, Mc Guinness CG, Dumaswala UJ, Carter HW (1990) Studies in red blood cell preservation. 3. A phosphateammonium-adenine additive solution. Vox Sang 58: 94–99
Grimm H, Sandritter W, Kleine N, Walker WH (1976) Untersuchungen von menschlichen Organen nach Bluttransfusionen aus PVC-Beuteln. In: Matthes M, Nagel V (Hrsg) Forschungsergebnisse der Transfusionsmedizin and Immunhämatologie, Bd 3. Medicus, Berlin, S 575–577
Gullikson H, Karlmann G, Segerlind A, Gullbring B (1986) Preservation of red blood cells: content of microaggregates and di-2-ethylhexylphthalate (DEHP) in red blood cells stored in saline-adenine-glucose-manitol (SAGM) medium. Vox Sang 50: 16–20
Hamasaki N, Hirota-Chigita C (1983) Acid-citrate-dextrosephosphoenolpyruvate medium as a rejuvenant for blood storage. Transfusion z3: 1–7
Handel KD, Gänshirt KH, Entwistle CC (1987) Plättchen-Monitor-System (PMS). Ein neues Gerät zur noninvasiven Funktionsprüfung von Thrombozyten. In: Kretschmer V, Stangel W (Hrsg) Transfusionsmedizin 1986–Infektionen, Autotransfusionen, Lymphokine, Bd 18 Beitr Infusionsther Klin Ernährung. Karger, Basel, S 160–162
Heaton A, Miripo J, Aster R, Hartmann P, Dehart D, Rzad L, Grapka B, Davisson W, Buchholz DH (1984) Use of Adsol preservation solution for prolonged storage of low viscosity AS-1 red blood cells. Br J Haematol 57: 467–478
Hessel E, Lerche D (1985) Cell surface alterations during blood-storage characterized by arteficial aggregation of washed red blood cells. Vox Sang 49: 86–91
Högmann CF, Hedlund DK (1985) Storage of red cells in a CPD/SAGM system using teruflex PVC. Vox Sang 49: 177–180
Högmann CF, Eriksson L, Gong J, Högmann AB, Vikholm K, Debrauwere J, Payrat JM, Stewart M (1993) Half-strength citrate CPD combined with a new additive solution for improved storage of red blood cells suitable for clinical use. Vox Sang 65: 271–278
Högmann CF, Eriksson L, Ring M (1992) Automated blood component preparation with the Opti system: three years’experience. Beitr Infusionsther 30: 100–107
Högmann CF, Eriksson L, Ericson A, Repucci AJ (1991) Storage of saline-adenine-glucose-mannitol-suspended red cells in a new plastic container: polyvinylchloride plasticized with butyryl-n-trihexyl-citrate. Transfusion 31: 26–29
Högmann CF (1993) Component preparation and quality assurance of stored blood. In: Rock GA, Seghatchian MJ (eds) Quality assurance in transfusion medicine, vol 2. CRC, Boca Raton, pp 59–98
Holme S, Myrphy S (1983) Platelet storage at 22 °C for transfusion: Interrelationship of platelet density and size, medium pH, and viability after in vivo infusion. J Lab Clin Med tot: 161–174
Horejsi J (1967) Effect of reduced glutathions on the dissociation curve of haemoglobin. Haematologia (Budapest) 1: 35–44
Jacobson MS, Kevy SU, Parkmann R, Wesolowski JS (1980) An in vitro evaluation of a new plasticizer for polyvinylchloride medical devices. Transfusion 20: 443–447
Jaeger RJ, Rubin RJ (1970) Plasticizers from plastic devices: extraction, metabolism and accumulation by biological systems. Science 170: 460–462
Jaeger RJ, Rubin RJ (1972) Migration of phthalate ester plasticizer from polyvinyl chloride blood bags into stored blood and its localization in human tissues. N Engl J Med 287: 1114–1118
Kahn RA, Johnson RK, Healton WAL (1979) Effect of prolonged room temperature holding of hole blood intended for preparation of components. Transfusion 19: 539–541
Kao KJ, Mickel M, Braine HG, Davis K, Enright H, Gernsheimer T, Gillespie MJ, Kickler TS, Lee EJ, Mc Cullough JJ, et al. (1995) White cell reduction in platelet concentrates and packed red cells by filtration: a multicenter clinical trial. Transfusion 35: 13–19
Koerner K (1986) Thrombozytenfunktionen bei Lagerung in PVC Beuteln mit erhöhter Gasdurchlässigkeit. In: Kretschmer V, Stangel W (Hrsg) Transfusionsmedizin aktuell-Infektionen, Thrombozyten, Granulozyten, Bd 15 Beitr Infusionsther Klin Ernähr. Karger, Basel, S 118–126
Kretschmer V, Rompf P, Pfeil W, Wagner B, Bähr E, Wesemann W, Rehfisch H, Heinrich D (1986) Thrombozytenfunktion in vitro bei Lagerung über 5 Tage. In: Kretschmer V, Stangel W (Hrsg) Transfusionsmedizin aktuell-Infektionen, Thrombozyten, Granulozyten, Bd 15 Beitr Infusionsther Klin Ernähr. Karger, Basel, S 127–147
Kretschmer V, Marschall R, Schulzki T, Haertel B, Neumann HJ (1992) New polyolefin foil for 5-day storage of platelet concentrates (PC) collected by apheresis. Infusionsther Transfusionsmed 19: 141–144
Krueger A, Akerblom O (1980) Adenine consumption in stored citrate-phosphate-dextrose-adenine blood. Vox Sang 38: 156–160
Krugluger W, Köller M, Hopmeier P (1994) Development of a carbohydrate antigen during storage of red cells. Transfusion 34: 496–50o
Lathmann JT jr., Bove JR, Weirich FL (1982) Chemical and hematologic changes in stored CPDA-1 blood. Transfusion 22: 158–159
Mädler J (1990) SAG-S-Lösung–ein neues Medium zur Re-suspension von Erythrozytenkonzentraten. Z Ges Inn Med Grenzgeb 45: 406–410
Matthes G, Strunk S, Storek W, Strauss D (1990) P-31-NMRUntersuchungen zur In-vivo-Regeneration konservierungsbedingter Veränderungen des 2,3-Diphosphorglyzeratgehaltes roter Blutzellen. Beitr Infusionsther 26: 76–80
Matsuyama H, Niklasson F, de Verdier CH, Högmann CF (1989) Phosphoenolpyruvate in rejuvenation of stored red cells in SAGM medium: optimal conditions and the indirect effect of methemoglobin formation. Transfusion 29: 614–619
Medizin-Produktegesetze (MPG) vom 02. Aug. 1994 Bundesgesetzblatt, Teil I: 1963–1984
Mishler JM, Darley JH, Haworth C, Mollison PL (1979) Viability of red cells stored in diminished concentration of citrate. Br J Haematol 43: 63–67
Mollison PL (1983) Blood transfusion in clinical medicine, 7th edn. Blackwell, Oxford, pp 141–142
Moore GL, Ledford ME, Merydith A (1982) The biochemical effects of CPD-A2-drawn red blood cells of delayed refrigeration prior to component preparation. Transfusion 22: 485487
Moore GL (1987) Additive solutions for better blood preservation. Crit Rev Clin Lab Sci 25: 211–229
Moroff G, Morse EE, Katz AJ, Kahn RA, Dende D, Swatmann L, Staggs SD (1984) Survival and biochemical characteristics of stored red cells preserved with citrate-phosphate-adenineone and two and prepared from whole blood maintaining at 20 to 24 degrees C for eight hours following phlebotomy. Transfusion 24 115–119
Murphy S (1985) Platelet Storage for transfusion. Semin Hemato122: 165–177
Muylle L, Peeterman ME (1994) Effect of prestorage leukocyte removal on the cytokine levels in stored platelet concentrates. Vox Sang 66: 14–17
Myhre BA, Demaniew S, Nelson EJ (1984) Preservation of red cell antigens during storage of blood with different anticoagulant. Transfusion 24: 499–501
Nakao M, Nakao T, Tatibana N, Yoshikawa H (1960) Phosphorus metabolism in human erythrocytes III. Regeneration of adenosine tri-phosphate in long-stored erythrocytes by incubation with iosine and adenine. J Biochem 47: 661–671
Nakao K, Wada T, Kamiyama T (1962) A direct relationship between adenosine triphosphate-level and in vivo viability of erythrocytes. Nature (London) 164: 877–878
Owens M, Werner E, Holme S, Afflerbach C (1994) Membrane glycoproteins in cryopreserved platelets. Vox Sang 67: 28–31
Plasmapheresen: Durchführung apparativer Plasmapheresen zur Gewinnung von Spenderplasma. Empfehlungen der ständigen Hämapheresekommission der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie e. V. (1994) Infusionsther Transfusionsmed 21: 349–354
Prince HE, Arens L (1986) Effect of storage on lymphocyte surface markers in whole blood units. Transplantation 41: 235–238
Richtlinien zur Blutgruppenserologie und Hämotherapie, Fassung 1996. Deutscher Ärzteverlag, Köln (im Druck )
Richtlinien für die Erkennung, Verhütung und Bekämpfung von Krankenhausinfektionen (1985) In: Bundesgesundheitsamt (Hrsg) Anforderungen der Krankenhaushygiene bei Injektionen und Punktionen. Bundesgesundheitsblatt 28: 186–187
Richtlinien der Kommission für Krankenhaushygiene und Infektionsprävention (1995) Bundesgesundheitsblatt 28: 186–187
Rock G, Tittley P, Mc Combie N (1989) 5-day storage of single-donor platelets obtained using a blood cell seperator. Transfusion 29: 288–291
Rueta PP et al (1967) Fainting: A review of its mechanisms and study in blood donors. Medicine (Baltimore) 46: 363–384
Schleuning M, Schmid-Haslbeck M, Utz H, Jochum M, Heim M, Mempel W, Wilmanns W (1992) Complement activation during storage of blood under normal blood bank conditions. Effects of proteinase inhibitors and leukocyte depletion. Blood 79: 3071–3075
Schneider W, Schorer R (1982) Klinische Transfusionsmedizin. Edition Medizin, Weinheim
Seghatchian MJ (1994) An overview of laboratory and clinical aspects of leukocyte-depleted blood components. Trans-fus Sci 1 5: 49–62
Seidl S, Spielmann W (1970) Comparative studies on the effect of different nucleosides in red cell preservation. In: Spielmann W, Seidl S (eds) Modern problems of blood preservation. Fischer, Stuttgart, S 72–77
Seidl S, Gosda W, Reppucci AJ (1991) The in vitro and in vivo evaluation of whole blood and red cell concentrates drawn on CPDA-1 and stored in a non-DEHP plasticized PVC container. Vox Sang 61: 8–13
Shimizu T, Shibata K, Kora S (1992) First autoclave-sterilized platelet-additive solution containing glucose with a physiological pH for the preparation of plasmapoor platelet concentrates. Vox Sang 62: 87–93
Shimizu T, Kouketsu K, Morishima Y, Goto S, Hasegawa I, Kamiya T, Tamura Y, Kora S (1989) A new polyvinylchloride blood bag plasticized with lessleachable phthalate ester analogue, di-n-decyl phthalate, for storage of platelets. Transfusion 29: 292–297
Simon ER (1962) Red cell preservation: further studies with adenine. Blood 20: 485–491
Simon TL (1983) The effect of obstruction of bag surface on platelet concentrate pH. Transfusion 23: 263–264
Simon TL, Sierra ER (1982) Lack of adverse effect of transportation on room temperature stored platelet concentrates. Transfusion 22: 496–497
Snyder EL, Hezzey A, Weirich F, Mosher DF, Davisson W, Buchholz DH (1983) Stability of red cell antigens and plasma coagulation factors stored in new formulation plastic blood containers. Transfusion 2 3: 49–53
Snyder EL, Pope C, Ferri PM, Smith EO, Walter SD (1986) The effect of mode of agitation and type of plastic bag on storage characteristics and in vivo kinetics of platelet concentrates. Transfusion 26: 125–130
Snyder EL, Hedberg SL, Napychank PA, Roberts C, Kagen L, Aster RA, Quinlan K, Strucaly A, Buchholz DH (1993) Stability of red cell antigens and plasma coagulation factors stored in a non-diethylhexyl phthalate-platicized container. Transfusion 33: 515–519
Sohmer PR, Moore GL, Beutler E, Peck CC (1982) In vivo viability of red blood cells stored in CPDA-2. Transfusion 22: 479–484
Stangel W, Seidel J, Mirkani J, Behrmann M, Hülsheger H (1986) Granulozytenfunktionen in gelagerten Blutkonserven. In: Kretschmer V, Stangel W (Hrsg) Transfusionsmedizin aktuell-Infektionen, Thrombozyten, Granulozyten, Bd 15 Beitr Infusionsther Klin Ernähr. Karger, Basel, S 231–252
Strauss D (1981) The two-step preservation of red blood cells. A contribution to improve their viability and therapeutic efficiency. Acta Biol Med Ger 40–5: 721–725
Strauss D, de Verdier CH (1980) Preservation of red blood cells with purines and nucleosides. II. Uptake and utilization of purines and nucleosides by stored red blood cells. Folia Haematol (Leipzig) 107: 417–433
Valeri R (1982) Use of rejuvenation solutions in blood preservation. CRC Crit Rev Clin Lab Sci 17: 299–374
Valeri CR, Zaroulis CG, Vecchione JJ, Valeri DA, Anastasi J, Pivacek LE, Emerson CP (1980) Therapeutic effectiveness and safety of outdated human red blood cells rejuvenated to improve oxygen transport function, frozen for about 1,5 years at–80 °C, washed, and stored at 4 °C for 24 hours prior to rapid infusion. Transfusion 20: 263–276
Valeri CR, Valeri DA, Gray A, Melaragno A, Dennis RC (1982) Viability and function of red blood cell concentrates stored at 4 degrees C for 35 days in CPDA-1, CPDA-2 or CPDA-3. Transfusion 22: 210–216
Verordnung über die Sicherheit medizinisch-technischer Geräte (Medizingeräteverordnung-MedGV) vom 14.01. 1985, BGBI/85, 93ff
Walker WH, Handel KD, Netz M, Gänshirt KH (1986) 49Tage-Lagerung von Erythrozyten-Konzentraten in PAGGSSorbit (Abstr). Infusionsther Klin Ernähr Suppl 1 zu 13: 20
Walker WH, Netz M, Gänshirt KH (1990) 49 Tage Lagerung von Erythrozytenkonzentraten in Blutbeuteln mit der Konservierungslösung PAGGS-Mannitol. Beitr Infusiosther 26: 55–59
Wolfe LC (1985) The membrane and the lesion of storage in preserved red cells. Transfusion 25: 185–203
Wong SC, Rock G (1982) The effect of adenine on platelet storage. Transfusion 22: 283–287
Zellseparation. Durchführung präparativer zellulärer Hämapheresen zur Gewinnung von Blutbestandteilskonserven. Empfehlungen der ständigen Hämapheresekommission der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie (1994) Infusionsther Transfusionsmed 21: 222–231
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Stangel, W. (1996). Gewinnung, Konservierung, Lagerung von Transfusionsblut. In: Mueller-Eckhardt, C. (eds) Transfusionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10599-3_14
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