Skip to main content

Zusammenfassung

Das Klimakterium stellt im Leben einer Frau eine Übergangsphase dar zwischen dem Erlöschen der Fortpflanzungsfähigkeit und dem Beginn der späten Postmenopause. Es umfaßt nach neueren Erkenntnissen etwa den Lebensabschnitt zwischen dem 47. und 55. Lebensjahr. Während dieser Zeit erlebt die Frau die letzte von den Eierstöcken gesteuerte Menstruationsblutung, die sog. Menopause. In Mitteleuropa tritt die Menopause durchschnittlich mit 51 Jahren ein. Ein Zeitraum von 5 Jahren vor dieser Menopause wird als Prämenopause bezeichnet, der Zeitraum ab 1 Jahr nach der Menopause heißt Postmenopause. Die Perimenopause stellt die Übergangsphase zwischen Prämenopause und Postmenopause dar, d. h. 2 Jahre vor der Menopause bis 1 Jahr danach.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aertgeerts J (1974). Wirkung oraler Östrogene auf die Haut der Frau in der Postmenopause und nach Kontrazeption. Ther Gegenw 113: 1739

    PubMed  CAS  Google Scholar 

  • Alffram PA, Bauer GCH (1962) Epidemiology of fractures of the forearm. J Bone Joint Surg 44-A: 105–114

    Google Scholar 

  • Alhava EM, Puttinen J (1973) Fractures of the upper end of the femur as an index of senile osteoporosis in Finland. Ann Clin Res 5: 398–403

    PubMed  CAS  Google Scholar 

  • Andersch G, Hahn L (1985) Progesterone treatment of premenopausal tension — a double blind study. J Psychosom Res 29: 489

    Article  PubMed  CAS  Google Scholar 

  • Andersch B, Wendestam C, Hahn L, Ohman R (1986) Premenstrual complaints. I. prevalence of premenstrual symptoms in a Swedish urban population. J Psychosom Obstet Gynaecol 5: 39–49

    Google Scholar 

  • Anderson I, Janzon L, Sigfusson BF (1985) Mammographie breast cancer screening — a randomized trial in Malmö, Sweden. Maturitas 7:21 — 29

    Google Scholar 

  • Anderson E, Hamburger S, Liu JH, Rebar RW (1987) Characteristics of menopausal women seeking assistance. Am J Ob-stet Gynecol 156: 428–433

    CAS  Google Scholar 

  • Arafat ES, Hargrove JT, Maxson WS, Desiderio DM, Wentz AC, Anderson RN (1988) Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites. Am J Obstet Gynecol 159:1203 —1209

    Google Scholar 

  • Aylward M (1976) Estrogens, plasma tryptophan levels in peri-menopausal patients. In: Campbell S (ed) The managment of the menopause and postmenopausal years. MTP Press, Lancaster, 135

    Chapter  Google Scholar 

  • Baker TG (1963) A quantitative and cytological study of germ cells in human ovaries. Proc Soc 158: 417–433

    Article  CAS  Google Scholar 

  • Ballinger CB (1975) Psychiatric morbidity and the menopause: Screening of general population sample. Br Med J 3: 344–346

    Article  PubMed  CAS  Google Scholar 

  • Banzer D (1979) Quantitative Skelettdiagnostik bei demineralisierenden Osteopathien. Röntgenpraxis 32: 158–166

    Google Scholar 

  • Basdevant A, de Lignieres B (1980) Treatment of menopause by topical administration of estradiol. In: Mauvais-Jarvis P, Vickers CFH, Wepierre J (eds) Percutaneous absorption of steroids. Academic Press, London, p 249

    Google Scholar 

  • Batrinos ML, Panitsa-Faflia C, Pitoulis S et al (1979) The clinical features of the menopause and its relation to the length of pregnancies and lactation. Maturitas 1: 26–268

    Google Scholar 

  • Bergkvist L, Adami H-O, Persson I, Hoover R, Schairer C (1989) The risk of breast cancer after estrogen and estrogenprogestin replacement. N Engl J Med 321: 293–297

    Article  PubMed  CAS  Google Scholar 

  • Blair SN, Goodyear NN, Gibbons LW, Cooper KH (1984) Physical fitness and incidence of hypertension in healthy normotensive men and women. JAMA 252: 487–490

    Article  PubMed  CAS  Google Scholar 

  • Block E (1952) Quantitative morphological investigations of the follicular system in women: variation at different ages. Acta Anat (Basel) 14:108 —123

    Google Scholar 

  • Brincat M, Moniz CF, Studd JWW, Darby AJ, Magos A, Cooper D (1983) Sex hormones and skin collagen content in postmenopausal women. Br Med J 287: 1337–1338

    Article  CAS  Google Scholar 

  • Bush TL (1991) Epidemiology of cardiovascular disease in women. In: Redmond GP (ed) Lipids and women’s health. Springer, New York Berlin Heidelberg Tokyo

    Google Scholar 

  • Bush TL, Barret-Connor E, Cowan LD et al (1987) Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program Follow-up Study. Circulation 75: 1102–9

    Article  PubMed  CAS  Google Scholar 

  • Butz S, Wüster C, Scheidt-Nave C, Götz M, Ziegler R (1993) Forearm BMD as measured by peripheral quantitative computed tomography (pQCT) in a German reference population. Osteoporosis Int 1993

    Google Scholar 

  • Caniggia A (1984) The hormonal form of Vitamin D in the pathophysiology and therapy of postmenopausal osteoporosis. J Endocrinol Invest 7/4:373 —378

    Google Scholar 

  • Cardozo L, Gibb DMF, Tuck SM, Thom MH, Studd JWW, Cooper DJ (1984). The effects of subcutaneous hormone implants during the climacteric. Maturitas 5: 177–184

    Article  PubMed  CAS  Google Scholar 

  • Caudron J, Hendrickx B (1988) Comparison of two equine oestrogen-dydrogestrone regimens in the climacteric. Maturitas 10:133 —141

    Google Scholar 

  • Christensen MS. Hagen C. Christiansen C, Transböl I (1982) Dose-response evaluation of cyclic estrogen/gestagen in postmenopausal women: placebo-controlled trial of its gynaecologic and metabolic actions. Am J Obstet Gynaecol 144:873 —879

    Google Scholar 

  • Christenson, CV, Gagnon JH (1965) Sexual behaviour in a group of older women. J Gerontol 20: 351–356

    Google Scholar 

  • Christiansen C, Rus BJ (1990) 17ß-Estradiol and continous norethisterone: a unique treatment for established osteoporosis in elderly women. J Clin Endocrinol Metab 71: 836–841

    Google Scholar 

  • Christiansen C, Christiansen MS, Transböl I (1981) Bone mass in postmenopausal women after withdrawal of oestrogen/gestagen replacement therapy. Lancet I: 459–461

    Google Scholar 

  • Clarkson T (1992) Sex steroids and atherosclerosis in animal models. „Safty aspects of hormone replacement therapy“. International Symposium, 4–5 September, wells Medical Limited Copenhagen, pp 101–108

    Google Scholar 

  • Coopen A, Wood K (1982) 5-Hydroxytryptamine in the pathogenesis of affective disorders. In: Ho BT, Schoolar JC, Us-din E (eds) Serotonin in biological psychiatry. Raven, New York, pp 249–259

    Google Scholar 

  • Coulam CB (1981) Age, estrogens, and the psyche. Clin Obstet Gynecol 24:219 —229

    Google Scholar 

  • Cummings S, Browner W, Grady D et al. (1990) Should prescription of postmenopausal hormone therapy be based on the results of bone densitometry? (Editorial) Ann Intern Med 113: 565–567

    CAS  Google Scholar 

  • Curhan GC, Willett, Rimm EB, Stampfer MJ (1993) A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med 328: 833–838

    Article  PubMed  CAS  Google Scholar 

  • Dambacher MA, Rüegsegger P (1985) Nichtinvasive Untersuchungsmethoden bei Osteoporosen. Ther Umsch 42: 339–350

    PubMed  CAS  Google Scholar 

  • Dambacher MA, Rüegsegger P, Demarmels MA, Fischer JA (1986) Pathogenesis and treatment of osteoporosis. In: Vaganakis A, Soucacos P, Avramides A et al (eds) Osteoporosis. Social and clinical aspects. 2nd International Conference on Osteoporosis. Masson Italia Editori, Mailand, pp 175 —194

    Google Scholar 

  • Dambacher MA, pers. Mitteilung (1994)

    Google Scholar 

  • Dennerstein L, Wood C, Burrows GD (1977) Sexual response following hysterectomy and oophorectomy. Obstet Gynecol 49:92— 96

    Google Scholar 

  • Dequeker J, Roh YS, Dessel D, van Gautama K, Burssens A (1973) Bone mineral estimation in vivo by photon absorptiometry. Influence of skeletal size and its value for detecting osteoporosis. J Belge Med Phys Rhum 28: 293

    Google Scholar 

  • Daring GK (1976) Klimakterische Beschwerden. Teil 1: Typische klimakterische Beschwerden. Fortschr Med 94:1058 —1061

    Google Scholar 

  • Dupont WD, Page DL, Roger LW, Parl FF (1989) Influence of exogenous estrogens, proliferative breast disease, and other variables on breast cancer risk. Cancer 63: 948–957

    Article  PubMed  CAS  Google Scholar 

  • Edman LD (1983) The climacteric. In: Buchsbaum HJ (ed) The menopause. Springer, Berlin Heidelberg New York Tokyo, pp 77–84

    Chapter  Google Scholar 

  • Eggert-Kruse W, Runnebaum B, Kruse W (1990) Hormonprofile in der späten Postmenopause. In: Lauritzen C (Hrsg) Menopause, Hormonsubstitution heute 3. edition informed, München, S 18–25

    Google Scholar 

  • Eriksen EF, Colvard DS, Berg NJ et al. (1988) Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84— 86

    Google Scholar 

  • Ettinger B, Genant HK, Steiger P, Madvig P (1992) Low-doseage micronized 17ß-estradiol prevents bone loss in postmenopausal women. Am J Obstet Gynecol 166: 479–488

    PubMed  CAS  Google Scholar 

  • Felsenberg D 1 991) Comparison of trabecular borie density at different anatomical sites: a prospective clinical study. (Vorgestellt bei der Jahrestagung der Radio! Soc North Am Chicago)

    Google Scholar 

  • Gambrell RD (1978) The prevention of endometrial cancer in postmenopausal women with progestogens. Maturitas 1: 107–112

    Article  PubMed  Google Scholar 

  • Gambrell RD (1986a) Prevention of endometrial cancer with progestogens. Maturitas 8: 159–168

    Article  PubMed  Google Scholar 

  • Gambrell RD (1986b) Role of progestrons in the prevention ob breast cancer. Maturitas 8: 169–176

    Article  PubMed  Google Scholar 

  • Gambrell RD, Maier RC, Sanders BI (1983) Decreased incidence of breast cancer in postmenopausal estrogen-progestogen users. Obstet Gynecol 62:435 —443

    Google Scholar 

  • Glatzner CM, Bailey I, Hull MGR (1985) Effectiveness of vaginal administration of progesterone. Br J Obstet Gynaecol 92: 364

    Article  Google Scholar 

  • Goldfarb AF, Daly MJ, Lieberman D, Reed DM (1970) Round- table: sex and menopause. Med Aspects Hum Sex 64

    Google Scholar 

  • Gordan GS (1977) Postmenopausal osteoporosis, cause, prevention and treatment. In: Greenblatt RB, Studd J (eds) Clinics in obstetrics and gynaecology 4. Saunders, London, p 169

    Google Scholar 

  • Gordan GS (1984) Prevention of bone loss and fractures in women. Maturitas 6:225–242

    Google Scholar 

  • Gray LA, Christopherson WM, Hoover RN (1977) Estrogens and endometrial carcinoma. Obstet Gynecol 49: 385–389

    PubMed  Google Scholar 

  • Greenblatt R (1979) An endocrinologist comments on hormones for sexual dysfunction. Female Patient 4: 43–46

    Google Scholar 

  • Gruber HE, Ivey JL, Baylink DJ, Matthews M, Help WB, Sisom K, Chesnut CH (1984) Long-term calcitonin therapy in postmenopausal osteoporosis. Metabolism 33: 295–304

    Article  PubMed  CAS  Google Scholar 

  • Gruchow HW, Anderson AJ, Barboriak JJ, Sobocinski KA (1988) Postmenopausel use of estrogen and occlusion of coronary arteries. Am Heart J 115: 954–963

    Article  PubMed  CAS  Google Scholar 

  • Hartge P, Hoover R, McGowan L, Lesher L, Norris HJ (1988) Menopause and ovarian cancer. Am J Epidemiol 127: 990 — 998

    Google Scholar 

  • Henderson BE, Ross RK, Paganini-Hill A, Mack TM (1986) Estrogen use and cardiovascular disease. Am J Obstet Gynecol 154: 1181–6

    PubMed  CAS  Google Scholar 

  • Herrmann WM, Beach RC (1978) The psychotropic properties of estrogens. Pharmakopsychiatry 11: 164–176

    Article  CAS  Google Scholar 

  • Heuck F (1989) Qualitative und quantitative radiologische Analyse des Knochens. In: Dihlmann W, Frommhold W (Hrsg) Schinz — Radiologische Diagnostik in Klinik und Praxis, Bd 6 Thieme, Stuttgart, S 151–215

    Google Scholar 

  • Hillard TC, Whitehead MI (1991) Hormon-Substitutionstherapie — Wege der Verabreichung In: Medical Communications Services (Hrsg) Kardiovaskuläre Wirkungen einer Hormonsubstitutionstherapie. Proceedings Internationales Novo Nordisk Symposium Kopenhagen, Dänemark, 1.-2. Februar 1991

    Google Scholar 

  • von Holst T (1982) Hormonelle Diagnostik im Klimakterium der Frau. Habilitationsschrift, Ruprecht-Karls-Universitäts Heidelberg

    Google Scholar 

  • von Holst T (1989) Nebennierenrindenfunktion in der Postmenopause und im Senium. In: Lauritzen C (Hrsg) Menopause, Hormonsubstitution heute 2. edition informed, München, S9–15

    Google Scholar 

  • Horwitz RI, Stewart KR (1984) Effect of clinical features on the association of estrogens and breast cancer. Am J Med 76:192 —198

    Google Scholar 

  • Huber J (1991) Substitutionstherapie im Klimakterium: Soll bei hysterektomierten Frauen auf Progestogene verzichtet werden? Geburtshilfe Frauenheilkd 51: 257–261

    Article  PubMed  CAS  Google Scholar 

  • Hunt K, Vessey M, McPherson K, Coleman M (1987) Long-term surveillance of mortality and cancer incidence in women receiving hormone replacement therapy. Br J Obstet Gynaecol 94: 620–635

    Article  PubMed  CAS  Google Scholar 

  • Hunter MS (1990) Emotional well-being, sexual behaviour and hormone replacement therapy. Maturitas 12: 299–314

    Article  PubMed  CAS  Google Scholar 

  • Husmann F (1993). Der vaso- und kardioprotektive Effekt der Östrogene. In: Schering AG, Pharma (Hrsg) Fachinformation zum Thema Klimakterium. Schering, Berlin

    Google Scholar 

  • Janich H (1993) Die Älterenanteile in den Bundesländern und in den Gebietstypen: regionale Unterschiede in der Betroffenheit der Älteren durch die Einrichtung von Landes-AOK’s. In: Verband der Kriegs- und Wehrdienstopfer, Behinderten und Renter Deutschland, Landesverband Bayern e.V. (Hrsg) Vdk-Forum in der Evangelischen Akademie Tutzing am 17./18. 2. 1993

    Google Scholar 

  • Judd HL (1976) Hormonal dynamics associated with the menopause. Clin Obstet Gynecol 19: 775–788

    Article  PubMed  CAS  Google Scholar 

  • Kaiser R (1984) Duration of the climacteric syndrome in women treated by hormonal substitution and in controls. Maturitas 5: 207–213

    Article  PubMed  CAS  Google Scholar 

  • Kalender WA (1991) Abschätzung der effektiven Dosis bei Knochenmineralmessungen mit Photonenabsorptiometrie und Computertomographie. ROFO 155 /2: 149–154

    Article  PubMed  CAS  Google Scholar 

  • Kampke D, Walcher W (1982) Physik für Mediziner. Teubner, Stuttgart

    Book  Google Scholar 

  • Kannei WB (1987) Metabolic risk factors for coronary artery disease in women: perspective from the Framingham study. Am Heart J 114: 413–9

    Article  Google Scholar 

  • Kannei WB, Hjortland MC, McNamara PM, Gordon T (1976) Menopause and risk of cardiovascular disease. The Framingham Study. Ann Intern Med 85: 447–452

    Google Scholar 

  • van Keep PA, Kellerhals J (1974) Die älter werdende Frau. Therapiewoche 45:5170 — 5194

    Google Scholar 

  • Kendell RE, Wainwright S, Hailey A, Shannon B ( 1976 The influence of childbirth on psychiatric morbidity. Psychol Med 6:297 —302

    Google Scholar 

  • Krokowsky E (1974) Radiologie der Osteoporose. Therapiewoche 34: 3485 —3494

    Google Scholar 

  • Kronenberg F, Cote LJ, Linkie DM, Dyrenfurth I, Downey JA (1984) Menopausal hot flashes: thermoregulatory, cardiovascular, and circulating catecholamine and LH changes. Maturitas 6: 3–43

    Article  Google Scholar 

  • Kuhl H, Taubert, H-D (1987) Das Klimakterium. Pathophysiologie, Klinik, Therapie. Thieme, Stuttgart

    Google Scholar 

  • Lam SY, Baker HWG, Seeman E, Pepperell RJ (1988) Gynaecological disorders and risk factors in premenopausal women predisposing to osteoporosis: a review. Br J Obstet Gynaecol 95: 963–972

    Article  PubMed  CAS  Google Scholar 

  • Lau EMC (1993) Hip fracture in Asia — trends, risk factors and prevention. In: Christiansen C, Riis B (eds) Proceedings 1993, Fourth International Symposium on Osteoporosis, Hong Kong. Aaalborg ApS, pp 58–61

    Google Scholar 

  • Laufer LR, Erlik Y, Meldrum DR, Judd HL (1982) Defect of clonidine on hot flashes in postmenopausal women. Obstet Gynecol 60: 583

    PubMed  CAS  Google Scholar 

  • Lauritzen C (1975) Erfolge der hormonalen Therapie klimakterischer Beschwerden. Dtsch Ärzteblatt 9: 575–580

    Google Scholar 

  • Lauritzen C (1978) Management of the patient at risk. Front Horm Res 5: 230–247

    Google Scholar 

  • Lauritzen C (1980) Climacteric and obesity. I. Int Congress on Menopause and Obesity. Rome

    Google Scholar 

  • Lauritzen C (1982) Treatment of menopausal symptons with low doses of clonidine. Dtsch Med Wochenschr 107 /9, 335–338

    Article  PubMed  CAS  Google Scholar 

  • Lauritzen C (1987) Transdermal delivery of 17ß-estradiol. In: Lauritzen C (ed) Transdermal estrogen substitution. Huber, Bern, pp 82–83

    Google Scholar 

  • Lauritzen C (1990a) Praktische Empfehlungen zur Östrogenprophylaxe in der Prä- und Postmenopause. Gynäkol Praxis 14:679— 688

    Google Scholar 

  • Lauritzen C (1990b) Nichthormonale Therapie klimakterischer Beschwerden. Gynäkol Praxis 14: 43–56

    Google Scholar 

  • Lievertz RW (1987) Pharmacology and pharmakinetics of estrogens. Am J Obstet Gynecol 156: 1289–1293

    PubMed  CAS  Google Scholar 

  • Lind T, Cameron EC, Hunter WM et al (1979) A prospective, controlled trial of six forms of hormone replacement therapy given to postmenopausal women. Br J Obstet Gynaecol [Suppl 3] 86:1— 29

    Google Scholar 

  • Lindsay R, Tohme JF (1990) Estrogen treatment of patients with established postmenopausal osteoporosis. Obstet Gynecol 76: 290–295

    PubMed  CAS  Google Scholar 

  • Lindsay R, Cosman F (1991) The risk of osteoporosis in aging women. In: Sitruk-Ware R, Utian WH (1991) The menopause and hormonal replacement therapy. Marcel Dekker, New York Basel Hong Kong, pp 47–72

    Google Scholar 

  • Lobo RA (1990) Cardiovascular implications of estrogen re- placement therapy. Obstet Gynecol 75 [Suppl]: 18–25

    Google Scholar 

  • Luine VN, Khylchevskaya RI, McEwen B (1975) Effect of gonodal steroids on activities of monoamine oxidase and choline acetylase in rat brain. Brain Res 86:293 — 306

    Google Scholar 

  • Marks R, Shahrad P (1976) Ageing and the effect of estrogen on the skin. In: Beard RS (ed) Menopause. MTP, Lancastert, pp 143–161

    Google Scholar 

  • Marks R, Shahrad P (1977) Skin changes at the time of the climacteric. In: Greenblatt RBB, Studd J (ed) Clinics in Obstetrics and Gynaecology 4. Saunders, London, p 207

    Google Scholar 

  • Marsh MS, Whitehead MI (1992) Managment of the menopause. Br Med Bull, vol 48: 426–458

    PubMed  CAS  Google Scholar 

  • Mattingly RF, Huang WY (1969) Steroidogenesis of the menopausal and postmenopausal ovary. Am J Obstet Gynecol 103:679 — 693

    Google Scholar 

  • Mattson LA, Cullberg G, Samsioe G (1982) Evaluation of a continous oestrogen-progesteron regimen for climacteric complaints. Maturitas 4: 95–102

    Article  Google Scholar 

  • Mc Broon JR, Hayes WC, Edwards WT, Goldberg RP, White III AA (1985) Prediction of vertebral body compression fracture using quantitative computed tomography. J Bone Joint Surg 67: 1206–1214

    Google Scholar 

  • McEwen BS, Biegon A, Fischette CT, Luine VN, Parsons B, Rainbow TC (1984) Towards a neurochemical basis of steroid hormone action. In: Martini L, Ganong W (eds) Frontiers in neuroendocrinology. Raven, New York, pp 1153–1176

    Google Scholar 

  • McEwen BS (1991) Steroid hormones are multifunctional mes- sengers to the brain. Trends Endocrinol Metab 2: 62–67

    Article  PubMed  CAS  Google Scholar 

  • McGregor GA, Best FE, Cam JM et al (1982) Double-blind randomized cross-over trial of moderate sodium restriction in essential hypertension. Lancet 1: 351

    Article  Google Scholar 

  • Meema S, Meema HE (1976) Menopausal bone loss and estrogen replacement. Isr J Med Sci 12: 601–604

    PubMed  CAS  Google Scholar 

  • Melchert F (1987) Comparative clinical study of Estraderm TTS and Presomen (Premarin) in patients with postmenopausal syndrome. 5th International Congress on the Menopause, Sorrent, April 6–10, Panthenon Publishing, Sorrent, Abstr. 98; p 120

    Google Scholar 

  • Minne HW, Leidig G, Wüster CHR et al (1988) A newly developed spine deformity index ( SDI) to quantitate vertebral crush fractures in patients with osteoporosis. Bone Miner 3: 335–349

    Google Scholar 

  • Meuwissen JHJM, van Langen H, Nielen M (1992) Endometriumwachstum während kontinuierlicher, alleiniger Östrogensubstitutionstherapie mit Estraderm TTS (0,05 mg/die) bei 31 postmenopausalen Frauen. Geburtshilfe Frauenheilkd 52:351— 354

    Google Scholar 

  • Muck AO (1990) Transdermales Therapeutisches System zur physiologischen Östrogensubstitution. Therapiewoche 40:41— 51

    Google Scholar 

  • Muck AO, Weber E, Blümner EG, Lippert TH (1994) Transdermale Östrogensubstitution — eine multizentrische Studie mit 15194 Patienten. Münchner Med Wochenschr 136:35 —40

    Google Scholar 

  • Nachtigall LE, Nachtigall RH, Nachtigall RD, Beckmann EM (1979) Estrogen replacement therapy. I. 10-year prospective study in the relationship to osteoporosis. Obstet Gynecol 53:277 — 281

    Google Scholar 

  • Nachtigall LE, Nachtigall NJ, Smilen SW, Nachtigall RH, Nachtigall RH (1993) Incidence of breast cancer in a 22-year study of women receiving estrogen-progestin replacement. (Vortrag 7. Weltkongress Menopause, Stockholm, Schweden) Abstr # 9, p 8

    Google Scholar 

  • Neugarten BL, Krainer RJ (1965) Menopausal symptoms in women of various ages. Psychosom Med 27:266–273 Nordin BEC (1980) The prevention of postmenopausal osteoporosis. Eur J Clin Invest 10 /4: 259–260

    Google Scholar 

  • Osmers R, Völksen M, Rath W, Teichmann A, Kuhn W (1989) Vaginosonographische Messungen des postmenopausalen Endometriums zur Früherkennung des Endometriumkarzinoms Geburtshilfe Frauenheilkd 49: 262–265s

    Article  CAS  Google Scholar 

  • Ott SM, Chesnut III CH (1987) Calcitriol treatment in patients with postmenopausal osteoporosis. In: Christiansen C, Johansen JS, Riis BJ (ed) Osteoporosis. Proceedings of the International Symposium on Osteoporosis, September 27-October 2, 1987. Osteopress 2: 844–849

    Google Scholar 

  • Ott SM, Kilnoyne RF, Chesnut CH (1987) Ability of four different techniques of measuring bone mass to diagnose vertebral fractures in postmenopausal women. J Bone Miner Res 2:201— 210

    Google Scholar 

  • Owen EJ, Siddle NC, McGarrigle T, Pugh MA (1989) Choosing the optimum dose of oestradiol implant — pharmacokinetics and symptom relief with 25 mg oestradiol implantation. Br Soc Obstet Gynaecol, London

    Google Scholar 

  • Paffenberger RS, Wing AL, Hyde RT, Jung DL (1983). Physical activity and incidence of hypertension in college alumni. Am J Epidemiol, 117: 245–257.

    Google Scholar 

  • Paterson MEL, Wade-Evans T, Sturdee DW, Thom MH, Studd JWW (1980) Endometrial disease after treatment with oestrogens and progestogens in the climacteric. Br Med J I:822 — 824

    Google Scholar 

  • Plouffe L, Nolan JR TE, Speroff L, Lorrain J (1993) Continuing medical care of the menopausal woman In: Lorrain J, Plouffe L, Ravnikar Jr V, Speroff L, Watts N (eds) Comprehensive management of menopause, p 384

    Google Scholar 

  • Possinger K, Classen S, Beykirch M, Flath B, Wilmanns W (1991) Hormontherapie beim metastasierten Mammakarzinom der Frau. Dtsch Med Wochenschr 116: 1921–1929

    Article  PubMed  CAS  Google Scholar 

  • Powers MS, Schenkel L, Darley PE, Good WR, Balestra JC (1985) Pharmakokinetics and pharmacodynamics of trans-dermal dosage forms of 17ß-estradiol: comparison with conventional oral estrogens used for hormone replacement. Am J Obstet Gynecol 152: 1099–1106

    PubMed  CAS  Google Scholar 

  • Rabe TH (1990) Gynäkologie und Geburtshilfe. Ed. Medizin, VHC, Weinheim

    Google Scholar 

  • Rauramo L, Punnonen R (1973). Die Wirkung von Kastration und oraler Östrogentherapie auf die Haut der Frau. In: van Keep PA, Lauritzen C (Hrsg) Älter werden und Östrogene. Karger, Basel, S 51

    Google Scholar 

  • Recker RR (1993) Skeletal physiology: growth and aging. In: Lorrain J, Plouffe L, Ravnikar Jr V, Speroff L, Watts N (eds) Comprehensive management of menopause. pp 24

    Google Scholar 

  • Reginald PW, Adams J, Franks S, Wadsworth J, Beard RW (1989) Medroxyprogesterone acetate in the treatment of pelvic pain due to venous congestion. Br J Obstet Gynaecol 96: 1148

    Article  PubMed  CAS  Google Scholar 

  • Reiners C (1991) Nicht-invasive quantitative Knochendichtebestimmung: In: Ringe JD (Hrsg) Osteoporose. de Gruyter, Berlin, S 157–216

    Google Scholar 

  • Riedel M, Rafflenbeul W (1992) Estrogens and cardiovascular diseases in postmenopausal women. Dtsch Med Wochenschr 117/31–32: 1205–1211

    Google Scholar 

  • Riggs BL, Hodgson S, O’Fallon W, Chao E, Wahner H, Muhs J, Cedel S, Melton LJ III (1990) Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med 322: 802–9

    Article  PubMed  CAS  Google Scholar 

  • Riggs BL, O’Fallon W, Hodgson S, Chao E, Wahner H, Muhs J, Melton L (1992) Clinical trial of fluoride in osteoporotic women: extented observation and additional analyses.

    Google Scholar 

  • Ringe JD (1993) Indzidenz der Osteoporosefaktoren steigt weiter. Dtsch Ärztezeitung, S 14

    Google Scholar 

  • Rosemeier, Schultz-Zehden, pers. Mitteilung, 1993

    Google Scholar 

  • Rüegsegger P (1991) Einsatz der Knochendichtemessung in der Diagnostik und der Therapie der Osteoporose. Ther Umsch 48: 113–119

    PubMed  Google Scholar 

  • Rüegsegger P, Durand EP, Dambacher MA (1991a) Differential effects of ageing and disease on trabecular and compact bone density of the radius. Bone 12: 99–105

    Article  PubMed  Google Scholar 

  • Rüegsegger P, Durand E, Dambacher MA (1991b) Localisation of regional forearm bone loss from high resolution computed tomographic images. Osteoporosis Int 1:76 — 80

    Google Scholar 

  • Runnebaum B, Salbach B, von Holst Th (1994) Orale oder transdermale Östrogensubstitutionstherapie im Klimakterium? Geb Fra 54:119— 130

    Google Scholar 

  • Rylance PB, Brincat M, Lafferty K, De Trafford JC, Brincat S, Parsons V, Studd JWW (1985) Natural progesterone and antihypertensive action. Br Med J 290: 13

    Article  CAS  Google Scholar 

  • Sambrook P, Birmingham J, Kelly P, Kempler S, Nguyen T, Pocock N, Esiman J (1993) Prevention of corticosteroid osteoporosis. A comparison of calcium, calcitriol, and calcitonin. N Engl J Med 328: 1747–1752

    Google Scholar 

  • Schenkel L (1985) TTS-Estradiol zur physiologischen Hormonsubstitution in der Menopause. Schweiz Rundsch Med (Praxis) 74: 277–282

    CAS  Google Scholar 

  • Schiff I, Komarov Sela H, Cramer D, Tulchinsky D, Ryan KJ (1982) Endometrial hyperplasia in women on cyclic or continuous estrogen regimens. Fertil Steril 37: 79–82

    PubMed  CAS  Google Scholar 

  • Schneider HPG, Dören M (1993) Osteoporose aus gynäkologischer Sicht. Gynäkologe 26: 83–92

    PubMed  CAS  Google Scholar 

  • Schneider P, Börner W (1990) Indikationen zur Knochendichtemessung und kritische Bewertung. Nuklearmediziner 13: 83–91

    Google Scholar 

  • Schneider P, Börner W (1991) Prediction of vertebral crush fractures in postmenopausal women with peripheral QCT in comparison to DEXA of the spine. Osteoporosis Int 1: 210 (abstract)

    Google Scholar 

  • Schneider P, Berger P, Moll E (1985) Getrennte Messung von Kompakta- und Spongiosadichte mit einem Transverdal-Rotations-Scanner. ROFO 143:178 —182

    Google Scholar 

  • Schneider P, Börner W, Mazess RB, Barden H (1988) The relationship of peripheral to axial bone density. Bone Miner 4:279— 87

    Google Scholar 

  • Schrage R (1985) Therapie des klimakterischen Syndroms. Edition Medizin, Weinheim, S 5–93

    Google Scholar 

  • Seibel MJ, Robins SP, Bilezikian JP (1992) Urinary pyridnium crosslinks of collagen. Specific markers of bone resorption in metabolic bone disease. Trends Endocrinol Metab 4:283 — 291

    Google Scholar 

  • Shangold MM (1983) Sports and exercise. In: Buchsbaum HJ (ed) The menopause. Springer, Berlin Heidelberg New York Tokyo, pp 199 — 203

    Google Scholar 

  • Sherman BM, West JH, Korenman SG (1976) The menopausal transition: analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women. J Clin Endocrinol Metab 42: 629–636

    Google Scholar 

  • Sherwin BB (1991a) The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metab 72: 336–343

    Article  PubMed  CAS  Google Scholar 

  • Sherwin BB (1991b) Estrogen and Refractory Depression. Adv Neuropsychiatry Psychopharmacol 2:209 —218

    Google Scholar 

  • Smith P (1972) Age changes on the female urethra. Br J Urol 44: 667 — 676

    Google Scholar 

  • Staland B (1981) Continous treatment with natural oestrogens and progestogens. A method to avoid endometrial stimulation. Maturitas 3:145 —156

    Google Scholar 

  • Stampfer MJ, Colditz GA (1991) Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiological evidence. Prey Med 20: 47–63

    Article  CAS  Google Scholar 

  • Stanczyk FZ, Shoupe D, Nunez V, Macias-Gonzales P, Vijod MA, Lobo RA (1988) A randomized comparison of nonoral estradiol delivery in postmenopausal women. Am J Obstet Gynecol 159: 1540–1569

    PubMed  CAS  Google Scholar 

  • Steinberg KK, Thacker SB, Smith SJ, Stroup DF, Zack MM, Flanders WD, Berkelman RL (1991) A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. JAMA 265: 1985 —1990

    Google Scholar 

  • Stevenson JC, Abeyasekera G, Hillyard CJ, Phang KG, McIntyre I, Campbell S, Townsend PT, Young O, Whitehead MI (1981) Calcitonin and the calcium-regulating hormones in postmenopausal women: effect of oestrogens. Lancet 1981/1:693 — 695

    Google Scholar 

  • Stevenson JC, White MC, Choplin GF, Macintyre I (1982) Osteoporosis and calcitonin deficiency. Br Med J 285: 1010–1015

    Article  CAS  Google Scholar 

  • Storm T, Thamsborg G, Steiniche T, Genant H, Sorensen OH (1990) Effect of intermittant cyclical etidronate on bone mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med 322: 1265–71

    Article  PubMed  CAS  Google Scholar 

  • Strecker JR (1990) Physiologische Abläufe im Klimakterium. In: Wolf AS, Schneider HPG (Hrsg) Östrogene in Diagnostik and Therapie. Springer, Berlin Heidelberg New York Tokyo, S 67 —76

    Google Scholar 

  • Strecker JR, Lauritzen C (1992) Praxis der Hormonbehandlung im Klimakterium. Enke, Stuttgart ( Bücherei des Frauenarztes, Bd 29 )

    Google Scholar 

  • Studd JWW, Collins WP, Chkavarti S, Newton JR, Oram D, Parson A (1977) Estradiol and testosterone implants in treatment of psychosexual problems in postmenopausal women. Br J Obstet Gynaecol 84: 314–315

    Google Scholar 

  • Sturdee DW, Wade-Evans T, Paterson MEL, Thom M, Studd JWW (1978) Relations between bleeding pattern, endometrial history, and oestrogen treatment in menopausal women. Br Med J L•1575–1577

    Google Scholar 

  • Sullivan JM, Vander Zwaag R, Hughes JP et al (1990) Estrogen replacement and coronary heart disease Arch Intern Med 150: 2557–62

    CAS  Google Scholar 

  • Taggart HM, Chesnut CH, Ivey JL, Baylink DJ, Sisom K, Huber HB, Roos BA (1985) Deficient calcitonin response to calcium stimulation in postmenopausal osteoporosis. Lancet I:475 — 480

    Google Scholar 

  • Teoh ES, Teoh LKK (1991) Improving the quality of life after 45. In: Teoh ES, Ratnam SS (eds) The future of gynaecology and obstetrics. Parthenon, Casterton Hall, Carnforth, Lancs., UK

    Google Scholar 

  • Thomas DB, Chu J (1986) Nutritional and endocrine factors in reproductive organ cancer: Opportunities for primary prevention. J Chron Dis 39: 1031–1050

    Google Scholar 

  • Tiegs RD, Body IJ, Wahner HW, Barta J, Riggs BL, Health III H (1985) Calcitonin secretion in postmenopausal osteoporosis. New Engl Med 312: 1097–1100

    Article  CAS  Google Scholar 

  • Tilyard MW, Spears GFS, Thompson J, Dovey S (1992) Treatment of osteoporosis with calcitriol or calcium. N Engl J Med 326: 357–62

    Article  PubMed  CAS  Google Scholar 

  • Tulandi T, Lal S, Kinch RH (1983) Effect of intravenous clonidine on menopausal flashing and luteinizing hormone secretion. Br J Obstet Gynaecol 90: 854

    Article  PubMed  CAS  Google Scholar 

  • Utian WH (1978) Effects of postmenopausal estrogen therapy on diastolic blood pressure and bodyweight. Maturitas 1: 3–8

    Article  PubMed  CAS  Google Scholar 

  • van Keep PA, Greenblatt RB, Albeauch-Fernet M (eds) (1976) Consensus on menopause research. MTP Press, Lancaster

    Google Scholar 

  • Vermeulen A (1976a) Postmenopausal ovarian function. In: James VHT, Serio M, Gusti G (Eds): The endocrine function of the human ovary. Academic Press, London New York San Francisco

    Google Scholar 

  • Vermeulen A (1976b) The hormonal activity of the postmenopausal ovary. J Clin Endocr 42: 247–253

    Article  PubMed  CAS  Google Scholar 

  • Vermeulen A (1980) Sex hormone status of the postmenopausal woman. Maturitas 3: 81–89

    Article  Google Scholar 

  • Voda AM (1981) Climacteric hot flash. Maturitas 3: 73–90

    Article  PubMed  CAS  Google Scholar 

  • Von Stetten EC, Steiger P, Kelly L, Stein JA (1991) Paired a.p. and lateral spine dual x-ray absorptiometry improves precision of repeat lateral scans. J Bone Miner Res 6 [Supp11]: 171

    Google Scholar 

  • Warren MP, Brooks-Gunn J, Hamilton LH, Warren LF, Hamilton WG (1986) Scoliosis and fractures in young ballet dancers. Releation to delayed menarche and secondary amenorrhea. N Engl J Med 314: 1348–1353

    Google Scholar 

  • Wasnich RD, Ross PD, Heilbrun LK, Vogel JM (1985) Prediction of postmenopausal fracture risk with use of bone mineral measurements. Am J Obstet Gynecol 153: 745–751

    PubMed  CAS  Google Scholar 

  • Watts NB, Harris S, Genant HK et al (1990) Intermittent cyclical etidronate treatment of postmenopausal osteoporosis. N Engl J Med 323: 73–79

    Article  PubMed  CAS  Google Scholar 

  • Weigel M, Schmitt W, Lieder H-J, Inthraphuvasak J (1990) Die Wertigkeit verschiedener Parameter zur sonographischen Beurteilung des postmenopausalen Endometriums hinsichtlich benigner und maligner Neoplasien. Geburtshilfe Frauenheilkd 50: 870–876

    Article  PubMed  CAS  Google Scholar 

  • Winokur G (1973) Depression in the menopause. Am J Psychiatry 130: 92–93

    PubMed  CAS  Google Scholar 

  • Whitehead MI (1986) Prevention of endometrial abnormalities. Acta Obstet Gynecol Scand [Suppl] 134: 81–91

    Article  PubMed  CAS  Google Scholar 

  • Wüster CHR, Duckeck G, Ugurel A, Lojen M, Minne HW, Ziegler R (1990) Increased sensitivity of bone mass measurements by inclusion of body height and surface. In: Christiansen C, Overgaard K (eds) Osteoporosis, Osteopress ApS, Copenhagen, pp 623–625

    Google Scholar 

  • Wüster CHR, Schurr W, Scharla S, Raue F, Minne HW, Ziegler R (1991) Superior tolerability of human versus salmon calcitonin preparations in young healthy volunteers. J Eur Clin Pharmacol 41: 211–215

    Article  Google Scholar 

  • Wüster CHR, Duckeck G, Ugurel A, Lojen M, Minne HW, Ziegler R (1992) Bone mineral content of spine and forearm in osteoporosis and in German normals: influences of sex, age and anthropometric parameters. Eur J Clin Invest 22: 366–370

    Article  PubMed  Google Scholar 

  • Ziegler R (1982). Hormonale Behandlung und Prophylaxe der Osteoporose. In: HPG Schneider (Hrsg) Klimakerium der Frau. Seminar anläßlich des Kongresses für ärztliche Fortbildung, Berlin, 2. Juni 1982

    Google Scholar 

  • Zürcher Gesprächskreis (1994) Dt. Ärzteblatt 91: 11

    Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Runnebaum, B., Rabe, T., v. Holst, T., Wüster, C. (1994). Klimakterium der Frau. In: Gynäkologische Endokrinologie und Fortpflanzungsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07635-4_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-07635-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-07636-1

  • Online ISBN: 978-3-662-07635-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics