Abstract
Estrogen replacement therapy has been scrutinized closely and the biologic effects of various estrogens have been examined extensively during the past 5 years.1–14 During the early 1960s, estrogens were used liberally in an attempt to perpetuate youth for menopausal women. It was common practice at that time to prescribe estrogens routinely to nearly every postmenopausal woman on the premise that estrogens protected women against the ravages of aging. This “feminine forever” concept was challenged in the mid-1970s when several investigators noted an increased incidence of endometrial cancer in the United States.15,16 They suggested that the prolonged exposure of women with uteri to unopposed estrogen was responsible for these findings. These suggestions provoked widespread concern among laypersons and physicians about the potential risks of estrogen replacement therapy.
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References
Shoemaker ES, Forney JP, MacDonald PC. Estrogen treatment of postmenopausal women: benefits and risks. JAMA. 1977; 238:1524–1530.
Greenblatt RB, Causa H, Studd J (eds). The menopause. Clin Obstet Gynecol. 1977; 4(1): 1–258.
Hulka BS. Effect of exogenous estrogen on postmenopausal women: the epidemiologic evidence. Obstet Gynecol Survey 1980; 35:389–399.
Schiff I, Ryan KJ. Benefits of estrogen replacement. Obstet Gynecol Survey 1980; 35:400–411.
Geola FL, Frumar AM, Tataryn IV, et al. Biological effects of various doses of conjugated equine estrogens in postmenopausal women. J Clin Endocrinol Metab. 1980; 51:620–625.
Worley FJ (ed). The menopause. Clin Obstet Gynecol. 1981; 24(1): 163–324.
Mosher BA, Whelan EM. Postmenopausal estrogen therapy: a review. Obstet Gynecol Survey 1981; 36:467–475.
Judd HL, Cleary RE, Creasman WT, et al. Estrogen replacement therapy. Obstet Gynecol. 1981; 58:267–275.
Hammond CB, Maxson WS. Current status of estrogen therapy for the menopause. Fertil Steril. 1982; 37:5–25.
Gambrell RD. The menopause; benefits and risks of estrogen-progestogen replacement therapy. Fertil Steril. 1982; 37:457–473.
Mandel FP, Geola FL, Lu JK, et al. Biologic effects of various doses of ethinyl estradiol in postmenopausal women. Obstet Gynecol. 1982; 59:673–679.
Upton GV. The perimenopause: physiologic correlates and clinical management. J Reprod Med. 1982; 27:1–28.
Carr BR, MacDonald PC (1983) Estrogen treatment of postmenopausal women. In: Siperstein MD, Advances in internal medicine, 28:491. Chicago: Year Book Medical.
Elkik F, Gompel A, Mercier-Bodard C, et al. Effects of percutaneous estradiol and conjugated estrogens on the level of plasma proteins and triglycerides in postmenopausal women. Am J Obstet Gynecol. 1982; 143:888–892.
Smith DC, Prentice R, Thompson DJ, Henmann WL. Association of exogenous estrogen and endometrial carcinoma. N Engl J Med 293: 1164–1167, 1975.
Mack TM, Pike MC, Henderson BE, et al: Estrogens and endometrial carcinoma in a retirement community. N Engl J Med 294:1262–1267, 1976.
Mandel FP, Davidson BJ, Erlik Y, et al. Effects of progestins on bone metabolism in postmenopausal women. J Reprod Med. 1982; 27:511–514.
Schiff I. The effects of progestins on vasomotor flushes. J Reprod Med. 1982; 27:498–502.
Riggs BL, Seeman E, Hodgson SF, et al. Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis. N Engl J Med. 1982; 306:446–450.
Ross RK, Paganini-Hill A, Gerkins VR, et al. A case-control study of menopausal estrogen therapy and breast cancer. JAMA 1980; 243:1635–1639.
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© 1983 Springer-Verlag New York Inc.
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Edman, C.D. (1983). Estrogen Replacement Therapy. In: Buchsbaum, H.J. (eds) The Menopause. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5525-3_6
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DOI: https://doi.org/10.1007/978-1-4612-5525-3_6
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