Zusammenfassung
Die Low density-Lipoproteinfraktion des Plasmas kann als sicherster Risikofaktor der koronaren Herzerkrankung angesehen werden. In dieser Fraktion werden bis zu 80% des Plasmacholesterins transportiert. Bisher gab es weder Verfahren, diese Komponente im Plasma direkt und zuverlässig zu messen, noch bestand die Möglichkeit, LDL selektiv und ohne Anwendung immunologischer Techniken in einem extrakorporalen System zu eliminieren. Wir beschreiben eine Methode, die beides ermöglicht.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Castelli WP, Doyle JT, Gordon T, Hames C, Hjortland MC, Hulley SB, Kagan A, Zukel WJ (1977) HDL-cholesterol and other lipids in coronary heart disease. Circulation 55: 767–772
Goldstein JL, Brown MS (1977) The LDL-pathway and its relation to atherosclerosis. Annu Rev Biochem 46: 897–930
Brown MS, Goldstein JL (1976) Familial hypercholesterolemia. A genetic defect in the LDL-receptor. N Engl J Med 294: 1386–1390
Brown MS, Goldstein JL (1980) The hyperlipoproteinemias and other disorders of lipid metabolism. In: Isselbacher et al. (eds) Harrison’s principles of internal medicine, 9th ed., p 508
Stoffel W, Bode C (1983) LDL-apheresis: selective removal of low density lipoproteins. In: Pineda A (ed) Selective removal of plasma-components (in press)
Stoffel W, Demani T (1981) Selective removal of apolipoprotein B-containing serumlipoproteins from blood plasma. Proc Natl Acad Sci USA 78: 611–615
King ME, Breslow JL, Lees RS (1978) Plasma exchange therapy in homozygous familial hypercholesterolemia. N Engl J Med 302: 1457–1459
Stoffel W, Bode C, Borberg H, Tauchert M, Oette K, Fuchs M (1982) Selective removal of plasma LDL by combined extracorporeal plasma separation-immunoabsorption. Proc. 6th Int. Congress on Atherosclerosis, Berlin, p 502
Literatur
Basu KS et al. (1982) Biochemical and genetic studies of the Apoprotein E secreted by mouse macrophages and human monocytes. J Biol Chem 257: 9788–9795
Danielsson B et al. (1978) Isolation of a high density lipoprotein with high contents of Arginine-rich Apoprotein (Apo E) from rat plasma. FEBS Lett 86: 299–302
Fielding PE, Fielding CJ (1980) Evidence for a cholesteryl ester transfer complex in human plasma. Proc Natl Acad Sci USA 77: 3327
Nicoll A et al. (1980) High-density lipoprotein metabolism. Adv Lipid Res 17: 53–106
Patsch JR et al. (1978) Formation of high-density lipoprotein-like particles during lipolysis of very low density lipoproteins in vitro. Proc Natl Acad Sci USA 75: 4519–4523
Patsch W et al. (1980) Characterization of human high density lipoproteins by zonal ultracentrifugation. J Biol Chem 255: 3178–3185
Röschlau P et al. (1974) Enzymatische Bestimmung des Gesamt-Cholesterins im Serum. J Clin Chem Clin Biochem 12: 403–407
Rouser G et al. (1970) Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 5: 494–496
Sata T et al. (1972) Characterization of subfractions separated by gel chromatography from blood plasma of normolipemic and hyperlipemic humans. J Lipid Res 13: 757–768
Zöllner N (1959) Die Normalwerte der Plasmalipoide. Dtsch Med Wochenschr 84: 386–392
Literatur
Kane JP, Sata T, Hamilton RL, Havel RJ (1975) Apoprotein composition of very low density lipoproteins of human serum. J Clin Invest 56: 1622–1634
Kane JP, Hardman DA, Paulus HE (1980) Heterogenity of apolipoprotein B: Isolation of a new species from human chylomicrons. Proc Natl Acad Sci USA 77: 2465–2469
Schwandt P, Richter WO (1980) Purification of porcine neurophysins I and II by high performance liquid chromatography. Biochim Biophys Acta 626: 376–382
Literatur
Diekstall F (1982) Hyperalpha/Hyperbetalipoproteinämie: Familienstudie. Dissertation, Medizinische Hochschule Hannover
Koschinsky T (1982) Angeborene und erworbene Stoffwechselstörungen in arteriellen glatten Muskelzellen und Fibroblasten bei Diabetes mellitus und Hyperlipoproteinämien — Zellkulturuntersuchungen zu Faktoren der Arterioskleroseentwicklung — Habilitationsschrift, Universität Düsseldorf
Mahley RW, Innerarity TL (1977) Interaction of canine and swine lipoproteins with low density lipoprotein receptor of fibroblasts as correlated with heparin/manganese precipitability. J Biol Chem 252: 2980
Literatur
Adam O, Dill-Wiesner M, Wolfram G, Zöllner N (1980) Plättchenaggregation und Prostaglandinumsatz beim Menschen unter definierter Linolsäurezufuhr mit Formeldiäten. Res Exp Med (Berl) 177: 227–235
Adam O, Wolfram G, Zöllner N (1979) Quantitative evaluation of phospholipid fractions in serum by tubular thin-layer chromatography. In: Frigerio A, Renoz L (eds) Recent developments in chromatography and electrophoresis. Elsevier, Amsterdam, pp 267–272
Chambaz J, Robert A, Wolf C, Béréziat G, Polonovski J (1979) Different acylation and accumulation in free form of arachidonic acid or its sodium salt in human platelets. Thromb Res 15: 743–754
Moncada S, Vane JR (1979) The role of prostacyclin in vascular tissue. Fed Proc 38: 66–71
Kook AJ, Rubinstein D (1970) The role of serum lipoproteins in the release of phospholipids by rat liver slices. Biochim Biophys Acta 202: 396–398
Smith JB (1981) Prostaglandins and platelet aggregation. Acta Med Scand 651: 91–97
Stoffel W, Därr W, Assmann G (1978) Pleomorphe Funktionen von hochungesättigten Phospholipiden in biologischen Membranen und Serumlipiden. Med Welt 29: 124–132
Vallee E, Gougat J, Ageron M (1980) Inhibition of platelet phospholipase A2 as a mechanism for the anti-aggregating effect of linoleic acid. Agents Actions 10: 57–62
Zilversmit DB (1950) Microdetermination of plasma phospholipids by trichloracetic acid precipitation. J Lab Clin Med 35: 155–162
Literatur
Beaumont JL, Carlson LA, Cooper GR, Fejfar Z, Fredrickson DS, Strasser T (1970) Classification of hyperlipidemias and hyperlipoproteinemias. Bull WHO 43: 891–915
Beil U, Grundy SM, Crouse JR, Zech L (1981) Triglyceride and cholesterol metabolism in primary hypertriglyceridemia. Arteriosclerosis 2: 44–57
Fielding CJ (1978) Origin and properties of remnant lipoproteins. In: Wietschy J (ed) Disturbances in lipid and lipoprotein metabolism. Am Physiol Soc, Bethesda, Md, p 83
Gianturco SH, Brown FB, Gotto AM Jr, Bradley WA (1982) Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts. J Lipid Res 23: 984–993
Mahley RW, Innerarity TL, Bersot TP, Lipson A, Margolis S (1980) Cholesterol feeding: effects on lipoprotein structure and metabolism. In: Gotto AM Jr, Smith LC, Allen B (eds) Atherosclerosis V. Springer, New York, p 641
Maxwell RE, Nawrocki JW, Uhlendorf PD (1982) Some differences in effects of gemfibrozil, clofibrate, benzafibrate, cholestyramine and ML-236B on lipid metabolism in rats. Res Clin Forums 4: 43–52
Schwandt P, Weisweiler P, Neureuther G (1979) Serum lipoprotein lipids after gemfibrozil treatment. Artery 5: 117–124
Vessby B, Lithell H (1982) Drug treatment of hyperlipoproteinemia-effects on serum lipoprotein composition. Res Clin Forums 4: 21–29
Weisweiler P, Drosner M, Janetschek P, Schwandt P (1983) Changes in very low and low density lipoproteins with dietary modification (zur Veröffentlichung eingereicht)
Weisweiler P, Schwandt P, Friedl C (1983) Immunonephelometric quantitation of apolipoprotein E in human serum. J Clin Chem Clin Biochem (in press)
Literatur
Kritchevsky D (1980) Pharmacology of Probucol. In: Noseda G (ed) Diet and drugs in atherosclerosis. Raven Press, New York
Riesen WF et al. (1980) Probucol in hypercholesterolaemia, a double blind studie. Atherosclerosis 36: 201–207
Mellies M et al. (1980) Effects of Probucol on plasma cholesterol. Metabolism 29: 956–964
Simons LA et al. (1981) Metabolic studies with Probucol in hypercholesterolaemia. Atherosclerosis 40: 299–308
Gordon T et al. (1977) High density lipoprotein as a protective factor against coronary heart disease: Framingham Studie. Am J Med 62: 707
Miller, Miller (1975) Plasma high density lipoprotein concentrations and development of ischemic heart disease. Lancet 1: 16
Tedeschi et al. (1982) Safety and effectiveness of Probucol as a cholesterol lowering agent. Artery 10: 22–34
Klein L (1981) QT-interval prolongation produced by Probucol. Arch Intern Med 141: 1102–1107
Troendle G (1982) Letter to the Editor. Lancet 1: 1179
Baker SG et al. (1982) Treatment of homozygous familial hypercholesterolaemia with Probucol. S Afr Med 62: 7–11
Miettinen TA et al. (1975) Treatment of severe and mild hypercholesterolaemia with Probucol and Neomycin. Postgrad Med J (Suppl 8) 51: 71–75
Literatur
Wilhelmsen L et al. (1981) β-Blockers versus saluretics in hypertension. Prev Med 10: 38–49
Lopes-Virella MF et al. (1977) Cholesterol determination in HDL-Lipoproteins separated by 3 different methods. Clin Chem 23: 882
Literatur
Albers JJ, Grundy SM, Cleary PA et al. (1982) National Cooperative Gallstone Study. The effect of chenodeoxycholic acid on lipoproteins and apolipoproteins. Gastroenterology 82: 638–646
Angelin B, Einarsson K, Leijd B (1979) Biliary lipid composition during treatment with differant hypolipidaemic drugs. Eur J Clin Invest 9: 185–190
Bartlett GR (1959) Phosphorous assay in column chromatography. J Biol Chem 234: 466–468
Bateson MC, Bouchier IAD, Trash DB, Maugdal DP, Northfield TC (1981) Calcification of radiolucent gall stones during treatment with ursodeoxycholic acid. Br Med J 283: 645–646
Bell GD, Bradshaw JP, Burgess A, Ellis W, Hatton J et al. (1980) Elevation of serum high density lipoprotein cholesterol by Rowachol, a proprietary mixture of six pure monoterpenes. Atherosclerosis 36: 47–54
Bell GD, Doran J (1979) Gall stone dissolution in man using an essential oil preparation. Br Med J 279: 24
Benko S, Macher A, Szarvas F, Tiboldi T (1961) Effect of essential oils on atherosclerosis of cholesterol-fed rabbits. Nature 190: 731–732
Bouchier IAD (1980) The medical treatment of gallstones. Annu Rev Med 31: 59–77
Carey M, Small DM (1978) The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. J Clin Invest 61: 998–1026
Coyne MJ, Bonorris GG, Goldstein LJ, Schoenfield LJ (1976) Effect of chenodeoxycholic acid and phenobarbital on the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in patients with gallstones. J Lab Clin Med 87: 281–291
Doran J, Kreighley MRB, Bell GD (1979) Rowachol — a possible treatment for cholesterol gallstones. Gut 20: 312–317
Egge H, Murawski U, Müller J, Zilliken F (1970) Mikrolipidanalysen aus Serum mit dem Eppendorfsystem 3000. J Clin Chem Clin Biochem 8: 488–491
Einarsson K, Grundy SM (1980) Effects of feeding cholic acid and chenodeoxycholic acid on cholesterol absorption and hepatic secretion of biliary lipids in man. J Lipid Res 21: 23–34
Ellis WR, Bell GD (1981) Treatment of biliary duct stones with a terpene preparation. Br Med J 282: 611
Ellis WR, Bell GD, Middleton B, White DA (1981) Adjunct to bile-acid treatment for gall-stone dissolution: low-dose chenodeoxycholic acid combined with a terpene preparation. Br Med J 282: 611–612
Gerolami A, Sarles H (1975) Beta-sitosterol and chenodeoxycholic acid in the treatment of cholesterol gallstones. Lancet 2: 721
Grundy SM, Metzger AL (1972) A physiological method for estimation of hepatic secretion of biliary lipids in man. Gastroenterology 62: 1200–1217
Grundy SM, Mok HYI, Zech L, Berman M (1981) Influence of nicotinic acid on metabolism of cholesterol and triglycerides in man. J Lipid Res 22: 24–36
Hegardt FG, Dam H (1971) The solubility of cholesterol in aqueous solutions of bile salts and lecithin. Z Ernaehrungswiss 10: 223–233
Holzbach RT, Marsh M, Olzewski M, Holan K (1973) Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. J Clin Invest 52: 1467–1479
Hordinsky BZ (1971) Terpenes in the treatment of gallstones. Minn Med 54: 649–652
Hordinsky BZ, Hordinsky W (1979) Rowachol — seine Verwendung bei Hyperlipämie. Arch Arzneitherapie 1: 45–51
Hunninghake DB, Probstfield JL (1977) Drug treatment of hyperlipoproteaemia. In: Rifkind BM, Levy RI (eds) Hyperlipidemia — diagnosis and therapy. Grune and Stratton, New York, pp 327–362
Igimi H, Hisatsugu T, Nishimura M (1976) The use of d-limonen preparation as a dissolving agent of gallstones. Dig Dis 21: 926–939
Klose G, Mordasini R , Middelhoff G, Augustin J, Greten H (1978) Medikamentöse Behandlung primärer Hyperlipoproteinämien. Klin Wochenschr 56: 99–110
Kutz K, Leiß O, von Bergmann K (1982) Einfluß von Bezafibrat und Fenofibrat auf lithogenen Index und individuelle Gallensäuren in der Galle. Verh Dtsch Ges Inn Med 88: 567–569
Leiß O, Murawski U, Egge H (1979) Mikrobestimmung von Lipoproteinlipiden im Serum. J Clin Chem Clin Biochem 17: 619–625
Levy RJ (1980) Drugs used in the treatment of hyperlipoproteinaemias. In: Goodman Gilman A, Goodman LS, Gilman A (eds) Goodman an Gilman’s The pharmacological basis of therapeutics, 6th ed. Macmillan Publ. Co., New York, pp 834–847
Maugdal DP, Bird R, Blackwood WS, Northfield TC (1978) Low-cholesterol diet: enhancement of effect of CDCA in patients with gall stones. Br Med J 2: 851–853
Miller NE, Nestel PJ, Clifton-Bligh P (1976) Relationships between plasma lipoprotein cholesterol concentrations and the pool size and metabolism of cholesterol in man. Atherosclerosis 23: 535–547
Mörsdorf K (1966) Cyclische Terpene und ihre choleretische Wirkung. Bulletin de Chimie Therapeutique 1966, pp 442–443
Mörsdorf K, Wolf G (1966) Untersuchungen zur Wirkungspotenz einiger Choleretika. Dtsch Med J 10: 303–306
Mok HYI, von Bergmann K, Grundy SM (1979) Effects of continuous and intermittend feeding on biliary lipid outputs in man: application for measurements of intestinal absorption of cholesterol and bile acids. J Lipid Res 20: 389–398
Mordasini R, Riesen W, Oster P, Riva G (1982) Verhalten der High-density-Lipoproteine (HDL) unter medikamentöser lipidsenkender Behandlung. Schweiz Med Wochenschr 112: 95–98
Paumgartner G, Horak W, Probst P, Grabner G (1971) Effect of phenobarbital on bile salt excretion in the rat. Naunyn-Schmiedebergs Arch Pharmacol 270: 98–102
Pearlman BJ, Marks JW, Bonorris GG, Schoenfield LJ (1979) Gallstone dissolution — a progress report. Clin Gastroenterol 8: 123–140
Pertsemlidis D, Panveliwalla D, Ahrens EH Jr (1974) Effects of clofibrate and of an estrogen-progestin combination on fasting biliary lipids and cholic acid kinetics in man. Gastroenterology 66: 565–573
Schlierf G, Oster P, Heuck CC, Raetzer H, Schellenberg B (1978) Sitosterol in juvenille type II hyperlipoproteinemia. Atherosclerosis 30: 245–248
Small DM, Atkinson D, Redgrave T, Shipley GG, Tall AR (1979) A biophysical approach to cholesterol transport from tissues to bile. In: Fisher MM, Goresky CA, Shaffer EA, Strassberg SM (eds) Gallstones. Plenum Press, New York London, pp 113–129
Von Bergmann J, von Bergmann K, Hadorn B, Paumgartner G (1975) Biliary lipid compostion in early childhood. Clin Chim Acta 64: 241
Von Bergmann K, Leiß O, Kutz K (1981) Effects of lipid lowering substances on biliary lipid metabolism in hyperlipidaemic patients. In: Lipoproteins and Coronary Atherosclerosis, Lugano, October 1–3, 1981. Abstract Book, p 190
Weisweiler P, Neureuther G, Schwandt P (1979) The effect of cholestyramine on lipoprotein lipids in patients with primary type II A hyperlipoproteinemia. Atherosclerosis 33: 295–300
Literatur
Assmann G, Schriewer H (1980) Screening und Therapiekontrolle von Lipidstoffwechselstörungen in der Praxis. Münch Med Wochenschr 122: 449–452
DeVoe RD (1974) Principles of cell homeostasis. In: Mountcastle VB (ed) Medical physiology, vol 1. Mosby, St. Louis, pp 3–33
Karoff Ch, Zidek W, Schlegel M, Vetter H (1982) Das Verhalten von Serumlipiden, intra- und extrazellulären Elektrolyten und hormonaler Faktoren bei Gewichtsreduktion. Med Klinik (im Druck)
Losse H, Wehmeyer H, Wessels F (1960) Der Wasser- und Elektrolytgehalt von Erythrozyten bei arterieller Hypertonic Klin Wochenschr 38: 393–395
Losse H, Zidek W, Zumkley H, Wessels F, Vetter H (1981) Intracellular Na+ as a genetic marker of essential hypertension. Clin Exp Hypertension 3: 627–640
de Luise M, Blackburn GL, Flier JS (1980) Reduced activity of the red-cell sodium-potassium pump in human obesity. N Engl J Med 303: 1017–1022
Nicolaou KC, Barnette WE, Magolda RL (1980) Synthesis and biological properties of prostacyclins. In: Scriabine A, Lefer AM, Kuehl FA (eds) Prostaglandins in cardiovascular and renal function. MTP Press, Lancaster, pp 9–28
Rayssiguier Y (1981) Magnesium and lipids: Interrelationships in the pathogenesis of vascular disease. Magnesium Bulletin la: 165–177
Vanroelen W, De Leeuw I, D’Hollander M (1981) Plasma and RBC Mg in the obese. Magnesium Bulletin 1b: 47
Zidek W, Vetter H, Zumkley H, Losse H (1981) Intracellular cation activities and concentrations in spontaneously hypertensive and normotensive rats. Clin Sci 61: 41s–43s
Zidek W, Losse H, Dorst KG, Zumkley H, Vetter H (1982) Intracellular sodium and calcium in essential hypertension. Klin Wochenschr (im Druck)
Zidek W, Vetter H, Losse H (1982) Intracellular mono- and divalent cations in spontaneously hypertensive rats. In: Ganten D et al. (eds) 4th International Symposium on rats with spontaneous hypertension and related studies. Schattauer, Stuttgart (in press)
Literatur
Björntorp P, Sjoström L (1978) Carbohydrate storage in man. Speculations and some quantitative considerations. Metabolism (Suppl 2) 27: 1853–1863
Bratusch-Marrain P, Björkman O, Hagenfeldt L, Waldhäusl W, Wahren J (1979) Influence of arginine on splanchnic glucose metabolism in man. Diabetes 28: 126–131
DeFronzo RA, Tobin J, Andres R (1979) The glucose clamp technique. A method for the quantification of beta cell sensitivity to glucose and of tissue sensitivity to insulin. Am J Physiol 23: E214–E223
Doar JWH, Stamp TCB, Wynn V, Path FC, Audhya TK (1969) Effects of oral and intravenous glucose loading in thyrotoxicosis. Studies of plasma glucose, free fatty acid, plasma insulin and blood pyruvate levels. Diabetes 18: 633–639
Ferrannini E, Wahren J, Felig P, DeFronzo R (1980) The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man. Metabolism 29: 28–35
Kreines F, Jett M, Knowles HC (1965) Observations in hyperthyroidism of abnormal glucose tolerance and other traits related to diabetes mellitus. Diabetes 14: 740–743
Saunders J, Hall SEH, Sönksen PH (1980) Glucose and free fatty acid turnover in thyrotoxicosis and hyperthyroidism before and after treatment. Clin Endocrinol 13: 33–44
Sestoft L, Heding LG (1981) Hypersecretion of proinsulin in thyrotoxicosis. Diabetologia 21: 103–107
Literatur
Sachs L (1974) Angewandte Statistik. Springer, Berlin Heidelberg New York, S 212
Seegmiller JE, Grayzel AI, Laster L, Liddle L (1961) Uric acid production in gout. J Clin Invest 40: 1304–1314
Zöllner N (1963) Eine einfache Modifikation der enzymatischen Harnsäurebestimmung. J Clin Chem Clin Biochem 1: 178–182
Literatur
Bartels O, Reiß M (1982) Infusionsbehandlung mit einer Leberkoma-Lösung. Biochemische und klinische Ergebnisse. In: Holm E (Hrsg) Aminosäuren- und Ammoniakstoffwechsel bei Leberinsuffizienz. G. Witzstrock, Baden-Baden Köln New York, S 211–219
Sieg A, Gärtner U, Striebel JP et al. (1979) Parenterale Aminosäurenbehandlung bei Patienten mit Leberzirrhose. Inn Med 6: 209–216
Holm E, Fiene R, Striebel JP et al. (1978) Spontane und infusionsabhängige Konzentrationen der Plasmaaminosäuren bei Leberinsuffizienz. Biochemische Daten und EEG. In: Wewalka F, Dragovics B (Hrsg) Aminosäuren, Ammoniak und hepatische Enzephalopathie. Fischer, Stuttgart New York, S 176–182
Andres R, Zierler KL, Anderson HM et al. (1954) Measurement of blood flow and volume in the forearm of man; with notes on the theory of indicator dilution and on production of turbulence, hemolysis, and vasodilatation by intra-vascular injection. J Clin Invest 33: 482–504
Felig P (1975) Amino acid metabolism in man. Annu Rev Biochem 44: 933–955
Abumrad NN, Patrick L, Rannels SL et al. (1981) Branched chain amino acids, and α-ketoisocaproate balance across human forearm muscle. In: Walser M, Williamson JR (eds) Metabolism and clinical implications of branched chain amino and ketoacids. Elsevier/North-Holland, New York Amsterdam Oxford, pp 317–322
Chua B, Siehl DL, Morgan HE (1979) Effect of leucine and metabolites of branched chain amino acids on protein turnover in heart. J Biol Chem 254: 8358–8362
Buse MG, Reid SS (1975) Leucine. A possible regulator of protein turnover in muscle. J Clin Invest 56: 1250–1261
Li JB, Jefferson CS (1978) Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochim Biophys Acta 544: 351–359
Malaisse WJ, Sener A (1981) Branched chain amino and ketoacids: effects upon insulin secretion. In: Walser M, Williamson JR (eds) Metabolism and clinical implications of branched chain amino and ketoacids. Elsevier/North-Holland, New York Amsterdam Oxford, pp 181–185
Literatur
Brandt A, Doss M (1981) Hereditary porphobilinogen synthase deficiency in human associated with acute hepatic porphyria. Hum Genet 58: 194–197
Doss M (1978) Differentialdiagnose der hepatischen Porphyrien. Verh Dtsch Ges Inn Med 84: 1165–1169
Doss M, Becker U, Sixel F, Geisse S, Solcher H, Schneider J, Kufner G, Schlegel H, Stoeppler M (1982) Persistent protoporphyrinemia in hereditary porphobilinogen synthase (δ-aminolevulinic acid dehydrase) deficiency under low lead exposure. A new molecular basis for the pathogenesis of lead intoxication. Klin Wochenschr 60: 599–606
Doss M, Müller WA (1982) Acute lead poisoning in inherited porphobilinogen synthase (δ-aminolevulinic acid dehydrase) deficiency. Blut 45: 131–139
Doss M, Schneider J, von Tiepermann R, Brandt A (1982) New type of acute porphyria with porphobilinogen synthase (δ-aminolevulinic acid dehydratase) defect in the homozygous state. Clin Biochem 15: 52–55
Doss M, von Tiepermann R, Schneider J, Schmid H (1979) New type of hepatic porphyria with porphobilinogen synthase defect and intermittent acute clinical manifestation. Klin Wochenschr 57: 1123–1127
Doss M, von Tiepermann R, Schneider J (1980) Acute hepatic porphyria syndrome with porphobilinogen synthase defect. Int J Biochem 12: 823–826
Doss M, Verspohl F (1981) The „Glucose Effect“ in acute hepatic porphyrias and in experimental porphyria. Klin Wochenschr 59: 727–735
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 J. F. Bergmann Verlag, München
About this paper
Cite this paper
Seidel, D. et al. (1983). Stoffwechsel. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 89. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-85456-9_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-85456-9_14
Publisher Name: J.F. Bergmann-Verlag
Print ISBN: 978-3-8070-0335-1
Online ISBN: 978-3-642-85456-9
eBook Packages: Springer Book Archive