Abstract
Mls or superantigen system differs from the conventional peptide antigens as well as mitogens and can be classified as endogenous superantigens, encoded by genes residing in the mouse genome itself, and exogenous superantigens, derived from viral, bacterial, or mycoplasma infection or immunization. In mouse the endogenous superantigens are mouse mammary tumor viral genes, which are scattered throughout the mouse genome. During thymic differentiation, T cells which respond to endogenous superantigens in the context of self MHC class II molecules are clonally deleted. Thus T cells expressing self reactive variable region receptors are eliminated. Studies on the exogenous superantigens demonstrated that superantigens bind to the region on MHC class II which is outside of the conventional peptide binding pocket and stimulate T cells through the interaction with specific Vb chain of T cell receptor. The superantigen system has not been discovered in the human.
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References
Abe, R., Foo-Phillips, M.; and Hodes, R.J.: Analysis of Mlsc genetics. A novel instance of genetic redundancy. J Exp Med 170: 1059–1073, 1989
Acha-Orbea, H., Shakhov, A.N., Scarpellino, L., Kolb, E., Muller, V., Vessaz-Shaw, A., Fuchs, R., Blochlinger, K., Rollini, P., Billotte, J., Sarafidou, M., MacDonald, H.R., and Diggelmann, H.: Clonal deletion of Vb 14-bearing T cells in mice transgenic for mammary tumour virus. Nature 350: 207–211, 1991
Anderson, G.A., Baneijee, S., and David, C.S.: MHC class II Aa and Ea molecules determine the clonal deletion of Vb6+ T cells. J Immunol 143: 1757–1761, 1989
Bentvelzen, P., Daams, J.H., Hageman, P., and Calafat, J.: Genetic transmission of viruses that incite mammary tumour in mice. Proc Natl Acad Sci 67: 377–384, 1970
Bergdoll, M.S.: Enterotoxins. In C.S.F. Easman and C. Adlam (eds.): Staphylococci and Staphylococcal Infections, Vol II, pp. 559–598. Academic Press, New York 1983
Brown, J.H., Jardetzky, T., Saper, M.A., Bamaoui, B., Bjorkman, P.J., and Wiley, D.C.: A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature 332: 845, 1988
Choi, Y.W., Kappler, J.W., Marrack, P.: A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus. Nature 350: 203–207, 1991
Dellabona, P., Peccoud, J., Kappler, LW., Marrack, P., Benoist, C., and Mathis, D.: Superantigens interact with MHC class Πmolecules outside of the antigen groove. Cell 62: 1115–1121, 1990
Dyson, P.J., Knight, A.M., Fairchild, S., Simpson, E., and Tomonari, K.: Genes encoding ligands for deletion of Vb11 T cells cosegregate with mammary tumour virus genomes. Nature 349: 530–531, 1991
Festenstein, H.: Immunogenetic and biological aspects of the in vitro lymphocyte allotransformation (MLR) in the mouse. Transplant Rev 15: 62–88, 1973
Festenstein, H., Bishop, C., and Taylor, B.A.: Location of Mis locus on mouse chromosome 1. Immunogenetics 5: 357–361, 1977
Fleischer, B. and Schrezenmeier, H.: T cell stimulation by Staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells. J Exp Med 67: 1697–1707, 1988
Frankel, W.N., Rudy, C., Coffin, J.M., Huber, D.T.: Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature 349: 526–528, 1991
Fraser, J.D.: High affinity binding of Staphylococcal enterotoxins A and B to HLA-DR. Nature 339: 221–223, 1989
Happ, M.P., Woodland, D.L., and Palmer, Ed: A third T-cell receptor b-chain variable region gene encodes reactivity to Mls-1a gene products. Proc Natl Acad Sci USA 86: 6293–6296, 1989
Herman, A., Croteau, G., Sekaly, R.P., Kappler, J.W., and Marrack, P.: HLA-DR alleles differ in their ability to present Staphylococcal enterotoxins to T cells. J Exp Med 172: 709–717, 1990
Hynes, N.E., van Ooyen, A.J., Kennedy, N., Herrlich, P., Ponta, B., and Groner, B.: Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene. Proc Natl Acad Sci USA 80: 3637–3641, 1983
Janeway, C.A., Yagi, J., Katz, M.E., Jones, B., Vroegop, S., and Buxser, S.: T cell responses to Mis and to bacterial proteins that mimics its behavior. Immunol Rev 107: 62–88, 1989
Kappler, J.W., Roehm, N., and Marrack, P.: T cell tolerance by clonal elimination in the thymus. Cell 49: 273–280, 1987
Kappler, J.W., Staerz, U.D., White, J., and Marrack, P.: Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332: 35–40, 1988
Kappler, J.W., Kotzin, B., Herron, L., Gelfand, E.W., Bigler, R.D., Boylston, A., Carrel, S., Posnett, D.N., Choi, Y., and Marrack, P.: Vb-specific stimulation of human T cells by staphylococcal toxins. Science 244: 811–813, 1989
King, L.B., Lund, F.E., White, D.A., Sharma, S., and Corley, R.B.: Molecular events in B lymphocyte differentiation: inducible expression of the endogenous mouse mammary tumor proviral gene Mtv-9. J Immunol 144: 3218–3227, 1990
Kozak, C., Peters, G., Pauley, R., Morris, V., Michalides, R., Dudley, J., Green, M., Davisson, M., Prakash, O., Vaidya, A., Hilgers, J., Verstraeten, A., Hynes, N., Diggelmann, H., Peterson, D., Cohen, J.C., Dickson, C., Sarkar, N., Husse, R., Varmus, H., and Callahan, R.: A standardized nomenclature for endogenous mouse mammary tumor viruses. J Virol 61: 1651–1654, 1987
Langford, M.P., Stanton, G.J., and Johnson, H.M.: Biological effects of staphylococcal enterotoxin A on human peripheral lymphocytes. Infect Immun 22: 62, 1978
MacDonald, H.R., Schneider, R., Lees, R.K., Howe, R.C., Acha-Orbea, H., Festenstein, H., Zinkemagel, R.M., and Hengartner, H.: T-cell receptor Vb use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature 332: 40–45, 1988
Marrack, P. and Kappler, J.W.: The Staphylococcal enterotoxins and their relatives. Science 248: 705–711, 1990
Marrack, P., Kushnir, E., and Kappler, J.W.: A maternally inherited superantigen encoded by a mammary tumour virus. Nature 349: 524–526, 1991
Muhlbock, O.: Note on a new inbred strain GR/A. Ear J Cancer 1: 123–124, 1965
Pullen, A.M., Marrack, P., and Kappler, J.W.: Evidence that Mls-2 antigens which delete Vb3+ T cells are controlled by multiple genes. J Immunol 142: 3033–3037, 1989
Salmons, B. and Gunzburg, W.H.: Current perspectives in the biology of mouse mammary tumour virus. Virus Res 8: 81–102, 1987
Woodland, D.L., Happ, M.P., Gollob, K.J., and Palmer (eds.): An endogenous retrovirus mediating deletion of ab T cells? Nature 349: 529–530, 1991
Zhou, P., Anderson, G.D., Savarirayan, S., Inoko, H., and David, C.S.: Thymic deletion of Vbl1+, Vb5+ T cells in H-2E negative, HLA-DQb+ single transgenic mice. J Immunol 146: 854–859, 1991a
Zhou, P., Anderson, G.D., Savarirayan, S., Inoko, H., and David, C.S.: Human HLA-DQb chain presents Mis gene products and clonally deletes TCR Vb6+, Vb8.1+ T cells in single transgenic mice. Human Immunol 31: 47–56, 1991b
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© 1991 Springer-Verlag Berlin Heidelberg
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Zhou, P., David, C.S. (1991). Mls Antigens (Superantigens), Class II MHC, and TCR Repertoire: Co-Adaptive Evolution. In: Klein, J., Klein, D. (eds) Molecular Evolution of the Major Histocompatibility Complex. NATO ASI Series, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84622-9_37
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DOI: https://doi.org/10.1007/978-3-642-84622-9_37
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