Molecular Evolution of the Major Histocompatibility Complex

  • Jan Klein
  • Dagmar Klein

Part of the NATO ASI Series book series (volume 59)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Corine Vernet, G. Chimini, J. Boretto, P. Le Bouteiller, P. Pontarotti
    Pages 1-11
  3. Yoko Satta, Naoyuki Takahata, Christian Schönbach, Jutta Gutknecht, Jan Klein
    Pages 51-62
  4. Austin L. Hughes
    Pages 95-101
  5. Keiichiro Hashimoto, Yoshikazu Kurosawa
    Pages 103-109
  6. K. Gustafsson, U. Brunsberg, S. Sigurdardottir, L. Andersson
    Pages 119-130
  7. Ying Ye, Jin-Xiong She, Edward K. Wakeland
    Pages 131-138
  8. L. R. Pease, J. K. Pullen, Z. Cai, R. M. Horton
    Pages 163-170
  9. Z. W. Chen, A. L. Hughes, N. L. Letvin, D. I. Watkins
    Pages 171-175
  10. D. I. Watkins, T. L. Garber, Z. W. Chen, A. L. Hughes, N. L. Letvin
    Pages 177-191
  11. J. Sullivan, C. Kennedy, J. Trejaut, H. Dunckley
    Pages 193-200
  12. Blazenka Grahovac, Colm O’hUigin, Herbert Tichy, Werner E. Mayer, Jan Klein
    Pages 201-212
  13. Marcel Kenter, Jaqueline Anholts, Gabriela Ruff, Nel Otting, Ronald Bontrop
    Pages 213-220
  14. Lakshmi K. Gaur, Eugene R. Heise, Phillip S. Thurtle, Gerald T. Nepom
    Pages 221-229

About these proceedings


From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a new interface has been emerging between Mhc and evolutionary genetics, and particularly the branch of evolutionary genetics dealing with molecular evolution. Mhc research relies upon molecular evolutionary genetics, with its grand superstructure of mathematical formulations, to come to grips with the events leading to and maintaining the Mhc polymorphism. Without the armament of rigorous statistical procedures developed by evolutionary geneticists, the intricate relationships among Mhc genes cannot be resolved. It will undoubtedly be a molecular geneticist who is the final arbiter in the dispute concerning the nature of the selection pressure molding the Mhc genes. And it is doubtful whether the true function of Mhc can ever be comprehended without the vantage point afforded by the elucidation of its evolutionary history.


Phylogenie activation antigen antigen presentation autoimmune disease chromosome evolution gene histocompatibility immune response immunology malaria mutation tissue transplantation

Editors and affiliations

  • Jan Klein
    • 1
  • Dagmar Klein
    • 2
  1. 1.Abt. ImmungenetikMax-Planck-Institut für BiologieTübingenGermany
  2. 2.Dept. of Microbiology and ImmunologyUniversity of Miami School of MedicineMiamiUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84624-3
  • Online ISBN 978-3-642-84622-9
  • About this book