Abstract
Some MHC molecules from nonmammalian vertebrates have been identified and characterized at the level of protein or DNA or both. We summarize comparisons between B-F sequences (chicken β2-microglobulin and class I a chains) and the sequences of other MHC-like molecules. As we naively expected, many residues that are involved in interactions (within and between domains, and with peptide, T cell receptor and CD8) are conserved. However, we also found certain conserved surface patches with no known function as well as differential evolution and codon usage in different domains. A speculative model is presented.
The Basel Institute for Immunology was founded and is supported by Hoffmann-La Roche, Basel, Switzerland.
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Kaufman, J., Salomonsen, J., Skjødt, K. (1991). Evolution of MHC Molecules in Nonmammalian Vertebrates. In: Klein, J., Klein, D. (eds) Molecular Evolution of the Major Histocompatibility Complex. NATO ASI Series, vol 59. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84622-9_28
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DOI: https://doi.org/10.1007/978-3-642-84622-9_28
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