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Brain Serotonin Subsystem Complexity and Receptor Heterogeneity: Therapeutic Potential of Selective Serotonin Agonists and Antagonists

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Clinical Pharmacology in Psychiatry

Part of the book series: Psychopharmacology Series ((PSYCHOPHARM,volume 10))

Abstract

Gaddum and Picarelli (1957) initially suggested the existence of more than one serotonin (5-HT) receptor over 30 years ago. Subsequently, neurophysiological, pharmacological, and other investigative techniques provided evidence that 5-HT could act at presynaptic and postsynaptic sites and could be either excitatory or inhibitory in different systems; however, more definitive evidence of 5-HT receptor heterogeneity did not begin to emerge until the beginning of the last decade (Peroutka and Snyder 1979; Sanders-Bush 1988; Whitaker-Azmitia and Peroutka 1990). There is now molecular and functional evidence for the existence of eight 5-HT receptors, designated 5-HT1A-E, 5-HT2, 5-HT3 and 5-HT4; in addition, there is increasingly compelling data indicative of additional 5-HT receptor subtypes or subforms (Sanders-Bush 1988; Schmidt and Peroutka 1989; Frazer et al. 1990). While studies of the multiple 5-HT receptor subtypes and their signal transduction mechanisms have dominated many recent investigations of this neurotransmitter system, there have also been substantial advances in the development of selective receptor subtype agonists and antagonists with therapeutic potentials in a variety of neuropsychiatric disorders.

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Authors and Affiliations

  1. Laboratory of Clinical Science, National Institute of Mental Health, NIH Clinical 10-3D41, 9000 Rockville Pike, Bethesda, MD, 20892, USA

    K. P. Lesch, C. S. Aulakh & D. L. Murphy

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  1. K. P. Lesch
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  2. C. S. Aulakh
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  3. D. L. Murphy
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Editors and Affiliations

  1. Dept. of Clinical Pharmacology, Odense University, Winsløwparken 19, 5000, Odense C, Denmark

    Lars F. Gram

  2. I.U.P.G., Unité de Recherche Clinique, 47, Rue du XXXI Décembre, 1207, Genève, Switzerland

    Luc P. Balant

  3. Department of Psychiatry, Case Western Res. Univ., 2040 Abington Road, Cleveland, Ohio, 44106, USA

    Herbert Y. Meltzer

  4. Institute of Medicinal Biology, University of Tromsø, P.O. Box 977, 9037, Tromsø, Norway

    Svein G. Dahl

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© 1993 Springer-Verlag Berlin Heidelberg

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Lesch, K.P., Aulakh, C.S., Murphy, D.L. (1993). Brain Serotonin Subsystem Complexity and Receptor Heterogeneity: Therapeutic Potential of Selective Serotonin Agonists and Antagonists. In: Gram, L.F., Balant, L.P., Meltzer, H.Y., Dahl, S.G. (eds) Clinical Pharmacology in Psychiatry. Psychopharmacology Series, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78010-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-78010-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78012-7

  • Online ISBN: 978-3-642-78010-3

  • eBook Packages: Springer Book Archive

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