Abstract
1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT1C receptors with an ED50 of approximately 500 µg/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 µg of the drug ICV or infusing 0.5 µg into the hippocampus. Both responses were dose dependent. Infusion of 1 µg mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety.
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Whitton, P., Curzon, G. Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus. Psychopharmacology 100, 138–140 (1990). https://doi.org/10.1007/BF02245806
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DOI: https://doi.org/10.1007/BF02245806